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Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence

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World Journal of Psychiatry 2024年第9期14卷 1346-1353页

作者： Wei-Min He xin-yuan zhang Wei-Gen Xie Dan-Ping Lv Qun-Di Shen Department of Rehabilitation Ward Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Laboratory Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Medical Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of General Affairs Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Schizophrenic patients are prone to violence,frequent recurrence,and difficult to *** and behavioral abnormalities during the onset of the disease,resulting in active myocardial enzyme *** To explored the expression level of myocardial enzymes in patients with schizo-phrenia and its predictive value in the occurrence of *** A total of 288 patients with schizophrenia in our hospital from February 2023 to January 2024 were selected as the research object,and 100 healthy people were selected as the control ***’information,clinical data,and labo-ratory examination data were *** to Modified Overt Aggression Scale score,patients were further divided into the violent(123 cases)and non-violent group(165 cases).RESULTS The comparative analysis revealed significant differences in serum myocardial enzyme levels between patients with schizophrenia and healthy *** the schizophrenia group,the violent and non-violent groups also exhibited different levels of serum myocardial *** levels of myocardial enzymes in the non-violent group were lower than those in the violent group,and the patients in the latter also displayed aggressive behavior in the *** Previous aggressive behavior and the level of myocardial enzymes are of great significance for the diagnosis and prognosis analysis of violent behavior in patients with *** detecting changes in these indicators,we can gain a more comprehensive understanding of a patient’s condition and treatment.

关键词： Schizophrenia Myocardial enzyme index Act of violence Predict Violence prediction Aggressive behavior Clinical data analysis Biochemical markers

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Different efficiency toward the biomimetic aerobic oxidation of benzyl alcohol in microchannel and bubble column reactors: Hydrodynamic characteristics and gas–liquid mass transfer

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Chinese Journal of Chemical Engineering 2023年第3期55卷 84-92页

作者： Qi Han xin-yuan zhang Hai-Bo Wu Xian-Tai Zhou Hong-Bing Ji Fine Chemical Industry Research Institute School of Chemical Engineering and TechnologySun Yat-sen UniversityZhuhai 519082China Fine Chemical Industry Research Institute School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Huizhou Research Institute Sun Yat-sen UniversityHuizhou 516081China

The selective aerobic oxidation of benzyl alcohol to benzaldehyde has attracted considerable attention because benzaldehyde is a high value-added product. The rate of this typical gas–liquid reaction is significantly affected by mass transfer. In this study, CoTPP-mediated(CoTPP: cobalt(II) mesotetraphenylporphyrin) selective benzyl alcohol oxidation with oxygen was conducted in a membrane microchannel(MMC) reactor and a bubble column(BC) reactor, respectively. We observed that 83% benzyl alcohol was converted within 6.5 min in the MMC reactor, but only less than 10% benzyl alcohol was converted in the BC reactor. Hydrodynamic characteristics and gas–liquid mass transfer performances were compared for the MMC and BC reactors. The MMC reactor was assumed to be a plug flow reactor,and the dimensionless variance was 0.29. Compared to the BC reactor, the gas–liquid mass transfer was intensified significantly in MMC reactor. It could be ascribed to the high gas holdup(2.9 times higher than that of BC reactor), liquid film mass transfer coefficient(8.2 times higher than that of BC reactor), and mass transfer coefficient per unit interfacial area(3.8 times higher than that of BC reactor). Moreover,the Hatta number for the MMC reactor reached up to 0.61, which was about 15 times higher than that of the BC reactor. The computational fluid dynamics calculations for mass fractions in both liquid and gas phases were consistent with the experimental data.

关键词： Membrane microchannel reactor Gas-liquid flow Mass transfer Benzyl alcohol Computational fluid dynamics(CFD) Bubble column reactor

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Plasmon-enhanced fluorescence of gold nanoparticle/graphene quantum dots for detection of Cr^(3+)ions

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Photonics Research 2023年第10期11卷 1781-1790页

作者： YOU-LONG CHEN YI-HUA HU xinG YANG YOU-LIN GU xin-YU WANG YU-HAO XIA xin-yuan zhang YU-SHUANG zhang State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037China Key Laboratory of Electronic Restriction of Anhui Province National University of Defense TechnologyHefei 230037China Advanced Laser Technology Laboratory of Anhui Province Hefei 230037China

Graphene quantum dots(GQDs),fascinating semiconductors with stable photoluminescence(PL),have important potential applications in the fields of biology,medicine,and new semiconductor ***,it is still challenging to overcome the weak PL ***,we report a strategy for selective resonance enhancement of GQD fluorescence using gold nanoparticles(AuNPs)as ***,the addition of low concentration AuNP makes AuNP/GQDs exhibit significant fluorescence enhancement of 2.67 times in the visible *** addition of high concentration AuNP leads to the formation of an excitation peak at 421 nm and selectively enhances certain radiation *** concluded that the main reason for the selective enhancement of PL intensity in high concentration AuNP is the transfer of generous hot electrons at high energy states from AuNP to GQD and relaxation to the ground *** electron resonance of low concentration AuNP transfers to GQD and relaxes to lower energy levels,exhibiting an overall enhancement of PL *** apply it for detection of the heavy metal ion Cr^(3+),and verify that it has a correlation coefficient of 97.36%.We believe AuNP/GQDs can be considered excellent candidates for heavy metal detection and high fluorescence bio-imaging.

关键词： quantum overcome excitation

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Fecal microbiota transplantation:whole grain highland barley improves glucose metabolism by changing gut microbiota

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Food Science and Human Wellness 2024年第4期13卷 2014-2024页

作者： xin Ren Fulong zhang Min zhang yuan Fang Zenglong Chen Meili Huan Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Grain Industry Highland Barley Deep Processing Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China COFCO Nutrition and Health Research Institute Beijing 102209China

Highland barley(HB)is a high-altitude cereal with rich nutritional components and potential health *** clarify its hypoglycemic effect and mechanism,we investigated the effect of whole grain HB and fecal microbiota transplantation(FMT)on glucose metabolism and gut microbiota in high-fat diet and streptozotocin(HFD/STZ)-induced diabetic *** results showed that HB(40%)significantly decreased fasting blood glucose and the area under the glucose tolerance curve,significantly increased insulin secretion and improved insulin resistance in HFD/STZ-induced diabetic mice(P<0.05).Inflammatory factors and blood lipid indices were also significantly alleviated after 12 weeks of 40%HB intervention(P<0.05).Additionally,beneficial bacteria,such as Bifidobacterium and Akkermansia,were significantly enriched in the gut of diabetic mice after whole grain HB ***,the results of further FMT experiments verified that the fecal microbiota after the 40%HB intervention not only significantly increased the relative abundance of Bifidobacterium and Akkermansia but also effectively improved glucose metabolism and alleviated the inflammatory state in HFD/STZ-induced diabetic ***,our study confirmed the bridge role of gut microbiota in improving glucose metabolism of whole grain HB,which could promote the development of precision nutrition.

关键词： Highland barley Diabetes Glucose metabolism Gut microbiota Fecal bacteria transplantation

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More Than Lightening:A Self-Supervised Low-Light Image Enhancement Method Capable for Multiple Degradations

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 622-637页

作者： Han Xu Jiayi Ma Yixuan yuan Hao zhang xin Tian Xiaojie Guo the Electronic Information School Wuhan UniversityWuhan 430072China IEEE the Department of Electronic Engineering Chinese University of Hong KongHong Kong 999077China the College of Intelligence and Computing Tianjin UniversityTianjin 300350China

Low-light images suffer from low quality due to poor lighting conditions,noise pollution,and improper settings of *** enhance low-light images,most existing methods rely on normal-light images for guidance but the collection of suitable normal-light images is *** contrast,a self-supervised method breaks free from the reliance on normal-light data,resulting in more convenience and better *** self-supervised methods primarily focus on illumination adjustment and design pixel-based adjustment methods,resulting in remnants of other degradations,uneven brightness and *** response,this paper proposes a self-supervised enhancement method,termed as *** can handle multiple degradations including illumination attenuation,noise pollution,and color shift,all in a self-supervised *** attenuation is estimated based on physical principles and local neighborhood *** removal and correction of noise and color shift removal are solely realized with noisy images and images with color ***,the comprehensive and fully self-supervised approach can achieve better adaptability and *** is applicable to various low light conditions,and can reproduce the original color of scenes in natural *** experiments conducted on four public datasets demonstrate the superiority of SLIE to thirteen state-of-the-art *** code is available at https://***/hanna-xu/SLIE.

关键词： Color correction low-light image enhancement self-supervised learning.

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Improving hydrogen storage thermodynamics and kinetics of Ce-Mg-Ni-based alloy by mechanical milling with TiF_(3)

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Journal of Magnesium and Alloys 2024年第4期12卷 1593-1607页

作者： Hongwei Shang Wei zhang xin Wei Yaqin Li Zeming yuan Jun Li Yanghuan zhang School of Mechanical and Electrical Engineering Chuzhou UniversityChuzhou 239000China Department of Functional Material Research Central Iron and Steel Research InstituteNo.76 Xueyuannan RoadHaidian DistrictBeijing 100081China Key Laboratory of Integrated Exploitation of Bayan-Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China China Rare Earth New Material(Weishan)Co. Ltd.Jining 277600China

Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not *** efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and *** this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental *** alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%*** phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and *** revealed that nanocrystalline appeared in the as-milled *** with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase *** addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more *** milling and adding TiF_(3)distinctly improved the activation and kinetics of the ***,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.

关键词： Mg-based hydrides TiF_(3) Ball milling Thermodynamics Kinetics

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Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： yuan-xin Zhou Xian Kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China Yuan-Xin Zhou&Xian Kong

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

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Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(Life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng yuan Xihao Liao Shuang Li xin-Hui xing Chong zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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Assessment of the Characteristics of Demersal Fish Communities Using Species-and Trait-Based Approaches in the Coastal Habitats Along Rongcheng Bay,Shandong Peninsula,China

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Journal of Ocean University of China 2024年第3期23卷 786-796页

作者： yuan Shunjie SUN xin TU Zhong SUN Jie WANG Xianning zhang Peidong Key Laboratory of Mariculture(Ocean University of China) Ministry of EducationQingdao 266003China Shandong Fisheries Development and Resource Conservation Center Yantai 264003China

Biodiversity declines have motivated many studies on the relationship between species diversity and ecosystem *** this study,we described the spatial-temporal characteristics of demersal fish communities along a coastal habitat in Rongcheng Bay,Shandong Peninsula,China with both species-based and biological trait-based *** field survey was carried out monthly using traps from April to October of 2018,and divided into three seasons(spring:April and May;summer:June,July and August;autumn:September,October and November).The study area included five distinct habitats:seagrass bed,natural rocky reef,bare sand,artificial reef together with natural rocky reef,and artificial reef together with bare *** analyzed the fish communities with three taxonomic diversity indices,including Shannon-Wiener,Simpson,and Pielou Evenness,as well as four functional diversity indices,including FRic,FEve,FDiv,and FDis,based on 7 functional groups which are categorized into 27 *** results showed that there were no significant differences in taxonomic diversity indices among different habitats in the three ***,significant differences were found in the functional richness of fish communities among different habitats in three *** bed represented the highest functional richness in spring and *** study demonstrates that seagrass bed is very important in enhancing the functional diversity of fish communities in a complex *** study also indicates that the combination of taxonomic diversity and functional diversity will provide a more detailed description of the characteristics of fish communities.

关键词： complex habitat biological traits biodiversity fish communities

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Orbit and clock products for quad-system satellites with undifferenced ambiguity fixing approach

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Satellite Navigation 2024年第1期5卷 125-139页

作者： Jiaqi Wu xingxing Li Yongqiang yuan Keke zhang xin Li Jiaqing Lou Yun Xiong School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079China Hubei Luojia Laboratory 129 Luoyu RoadWuhan430079China German Research Centre for Geosciences GFZ Telegrafenberg14473PotsdamGermany Technische Universitat Berlin(TUB) Straße Des 17.Juni10623BerlinGermany

Integer Ambiguity Resolution(IAR)can significantly improve the accuracy of GNSS Precise Orbit Determination(POD).Traditionally,the IAR in POD is achieved at the Double Differenced(DD)*** this contribution,we develop an Un-Differenced(UD)IAR method for Global Positioning System(GPS)+BeiDou Navigation Satellite System(BDS)+Galileo navigation satellite system(Galileo)+Global'naya Navigatsionnaya Sputnikovaya Sistema(GLONASS)quad-system POD by calibrating UD ambiguities in the raw carrier phase and generating the so-called carrier *** on this method,we generate the UD ambiguity-fixed orbit and clock products for the Wuhan Innovation Application Center(IAC)of the International GNSS Monitoring and Assessment System(iGMAS).One-year observations in 2020 from 150 stations are employed to investigate performance of orbit and clock ***,the UD Ambiguity Resolution(AR)yields more resolved integer ambiguities than the traditional DD AR,scaling up to 9%,attributable to its avoidance of station baseline *** from the removal of ambiguity parameters,the computational efficiency of parameter estimation undergoes a substantial 70%*** with the float solution,the orbit consistencies of UD AR solution achieve the accuracy of 1.9,5.2,2.8,2.1,and 2.7 cm for GPS,BeiDou-2 Navigation Satellite System(BDS-2),BeiDou-3 Navigation Satellite System(BDS-3),Galileo,and GLONASS satellites respectively,reflecting enhancements of 40%,24%,54%,34%,and 42%.Moreover,the standard deviations of Satellite Laser Ranging(SLR)residuals are spanning 2.5–3.5 cm,underscoring a comparable accuracy to the DD AR solution,with discrepancies below 5%.A notable advantage of UD AR lies in its capability to produce the Integer Recovered Clock(IRC),facilitating Precise Point Positioning(PPP)AR without requiring additional Uncalibrated Phase Delay(UPD)*** assess the performance of quad-system kinematic PPP based on IRC,a network comprising 120 stations is uti

关键词： Multi-GNSS Precise orbit determination Integer recover clock Undifferenced ambiguity resolution iGMAS innovation application center

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