检索结果-南通市图书馆

Toxic metals and metalloids:Uptake,transport,detoxification,phytoremediation,and crop improvement for safer food

Molecular Plant 2022年第1期15卷 27-44页

作者： Fang-Jie Zhao Zhong Tang Jia-Jun Song xin-yuan huang Peng Wang State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjingJiangsu 210095China

Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities,leading to excessive accumulation of arsenic(As),cadmium(Cd),lead(Pb),and mercury(Hg)in food crops that poses significant risks to human health.Understanding how these toxic metals and their methylated species are taken up,translocated,and detoxified is prerequisite to developing strategies to limit their accumulation for safer food.Toxic metals are taken up and transported across different cellular compart-ments and plant tissues via various transporters for essential or beneficial nutrients,e.g.As by phosphate and silicon transporters,and Cd by manganese(Mn),zinc(Zn),and iron(Fe)transporters.These transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational levels.Complexation with thiol-rich compounds,such as phytochelatins,and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation.A num-ber of genes involved in toxic metal uptake,transport,and detoxification have been identified,offering tar-gets for genetic manipulation via gene editing or transgenic technologies.Natural variations in toxic metal accumulation exist within crop germplasm,and some of the quantitative trait loci underlying these variations have been cloned,paving the way for marker-assisted breeding of low metal accumulation crops.Using plants to extract and remove toxic metals from soil is also possible,but this phytoremediation approach requires metal hyperaccumulation for efficiency.Knowledge gaps and future research needs are also discussed.

关键词： toxic metals/metalloids heavy metals transporters detoxification phytoremediation food safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Ionomics： From Elemental Profiling to Environmental Adaptation

引用

Molecular Plant 2016年第6期9卷 787-797页

作者： xin-yuan huang David E. Salt Institute of Biological and Environmental Sciences University of Aberdeen Cruickshank Building St Machar Drive Aberdeen AB24 3UU UK

Ionomics is a high-throughput elemental profiling approach to study the molecular mechanistic basis underlying mineral nutrient and trace element composition （also known as the ionome） of living organisms. Since the concept of ionomics was first introduced more than 10 years ago, significant progress has been made in the identification of genes and gene networks that control the ionome. In this update, we summa- rize the progress made in using the ionomics approach over the last decade, including the identification of genes by forward genetics and the study of natural ionomic variation. We further discuss the potential application of ionomics to the investigation of the ecological functions of ionomic alleles in adaptation to the environment.

关键词： nutrient homeostasis natural variation ionomics Arabidopsis thaliana Casparian strip adaptation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

QTL pyramiding for producing nutritious and safe rice grains

引用

Journal of Integrative Plant Biology 2020年第3期62卷 264-268页

作者： xin-yuan huang Fang-Jie Zhao State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China

Breeding of rice varieties that are enriched with essential micronutrients and simultaneously have reduced levels of toxic elements in grains is largely unexplored in rice breeding practice.In this issue of JIPB,Liu et al.(2020)developed two rice lines with a low level of cadmium and simultaneously high levels of zinc or selenium accumulation in the grains,thus providing elite genetic materials for breeding rice varieties that are important for addressing mineral malnutrition and ensuring food safety.

关键词： breeding elite pyramid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cadmium Phytoremediation： Call Rice CALl

引用

Molecular Plant 2018年第5期11卷 640-642页

作者： Fang-Jie Zhao xin- yuan huang State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China

Cadmium （Cd） is a toxic heavy metal that has no known biological functions except in some marine diatoms, such as Thalassiosira weissflogii, which can use Cd as a catalytic metal atom in their carbonic anhydrase, presumably conferring an adaptive advantage for diatoms that grow fast in the zinc-poor environment of the ocean surface （Xu et al., 2008）. In the terrestrial environment, Cd is known as a notorious toxin, causing phytotoxicity and human diseases such as renal dysfunction, osteoporosis, and cancers. The best known Cd-induced disease, Itai-itai （renal tubular osteomalacia）, is caused by chronic exposure to Cd via consumption of rice grown in Cd-contaminated paddy soil.

关键词： DEFENSIN PLANT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructures and mechanical properties of a commercial Mg-Al-Zn-Mn alloy with various hot-extrusion processes

引用

Rare Metals 2024年第3期43卷 1329-1336页

作者： He Ma Fan-Zhi Meng Qiang Yang Ze-Feng Xie yuan-Ding huang xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China MagIC-Magnesium Innovation Center Helmholtz-Zentrum Geesthacht21502GeesthachtGermany Engineering Research Center of Optoelectronic Functional Materials Ministry of EducationChangchun University of Science and TechnologyChangchun130022China

Mg-Al-Zn-Mn(AZ)system alloys have become widely used due to their good castability,excellent formability and outstanding corrosion resistance[1-6].However,their strength is still much lower than that of traditional Mg... 详细信息

关键词： alloys alloy corrosion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

引用

Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng yuan Yao Tang Tianwen huang Lining Ke En huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SDGNN: Symmetry-Preserving Dual-Stream Graph Neural Networks

引用

IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1717-1719页

作者： Jiufang Chen Ye yuan xin Luo the College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing 400065 the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China the College of Computer and Information Science Southwest UniversityChongqing 400715China IEEE

Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) are influential instruments for representation learning to a UWG, they invariably adopt a unique node feature matrix for illustrating the sole node set of a UWG.

关键词： representation preserving undirected

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening

引用

Acta Pharmaceutica Sinica B 2024年第4期14卷 1827-1844页

作者： Zinan Zhang Wenbin Cao Huanchun xing Shuai Guo Lijuan huang Lin Wang xin Sui Kui Lu yuan Luo Yongan Wang Jun Yang State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institutes of Pharmacology and ToxicologyBeijing 100850China Tianjin University of Science and Technology Tianjin 300222China Hebei University of Science and Technology Shijiazhuang 050018China

In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on selective opening of the BBB.This strategy allows some simple bare nanoparticles to enter the brain when mixed with special opening material;however,the BBB still maintains the ability to completely block molecules from passing through.Based on the screening of BBB opening and matrix delivery mate-rials,we determined that phospholipase A2-catalyzed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine li-posomes can efficiently carry drugs into the brain immediately.At an effective dose,this delivery system is safe,especially with its effect on the BBB being reversible.This mix&act delivery system has a simple structure and rapid preparation,making it a strong potential candidate for drug delivery across the BBB.

关键词： Liposomes Phospholipase A2 Phosphoserine Blood-brainbarrier Selectively open Mix&act

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Analysis of Heat Transfer Characteristics to Supercritical CO_(2) in a Vertical Mini-Channel:Transition and Pseudo-Boiling

引用

Journal of Thermal Science 2024年第1期33卷 101-113页

作者： yuan Baoqiang WANG Wei xin Gongming DU Wenjing School of Energy and Power Engineering Shandong UniversityJi'nan 250061China

Large eddy simulations have been conducted to study upward transitional flows and heat transfer characteristics of supercritical CO_(2) in a vertical mini-channel.The numerical simulation was carried out on a modified buoyantPimpleFOAM solver in OpenFOAM 7,and was verified using experiment data.Numerical results indicate that increasing the Grashof numbers can reduce the flow stability and make the flow transition earlier.There are four stages of heat transfer in the transition process,i.e.,weakened,improved,recovered and normal heat transfer.These heat transfer phenomena in the transition process were explained from three perspectives:thermal boundary layer theory,turbulent transport and pseudo-boiling theory.Heat transfer enhancement during transition is related to the transport of supercritical molecular clusters,and these molecular clusters are regarded as pseudo-bubbles in pseudo-boiling theory.The flow pattern of the pseudo-phases in the dia-Widom process contains single-phase flow,steady pseudo-film flow,unsteady pseudo-film flow,partial pseudo-bubbles flow and flocculent pseudo-film flow.Pseudo-bubbles have similar behaviors to subcritical bubbles,i.e.,break-up,deformation,condensation and coalescence.Relevant researches in this work are favorable for understanding the heat transfer mechanism of supercritical fluids during flow transition.

关键词： supercritical heat transfer large eddy simulation transition pseudo-boiling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive security control of time-varying constraints nonlinear cyber-physical systems with false data injection attacks

引用

Journal of Control and Decision 2024年第1期11卷 50-59页

作者： Yue-Ming Wang yuan-xin Li Department of Science Liaoning University of TechnologyJinzhouPeople’s Republic of China

In this article,an adaptive security control scheme is presented for cyber-physical systems(CPSs)suffering from false data injection(FDI)attacks and time-varying state constraints.Firstly,an adaptive bound estimation mechanism is introduced in the backstepping control design to mitigate the effect of FDI attacks.Secondly,to solve the unknown sign time-varying statefeedback gains aroused by the FDI attacks,a type of Nussbaum function is employed in the adaptive security control.Then,by constructing a barrier Lyapunov function,it can be ensured that all signals of controlled system are bounded and the time-varying state constraints are not transgressed.Finally,the provided simulation examples demonstrate the effectiveness of the proposed controller.

关键词： Neural networks backstepping technology false data injection(FDI)attacks nonlinear cyber-physical systems controls

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：