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Intramolecular O-Sn coordination in (Z)-1-(triphenylstannyl)-3-phenyl-1-buten-3-ol: Evidence by X-ray diffracation analysis and bromination

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Chinese Journal of Chemistry 1994年第4期12卷 365-371页

作者： fu, Fang-xin fu, yu-Jie ZHU, Dong-Sheng FANG, Qun-xin PAN, Hua-DeChemistry Department, Northeast Normal University, Changchun, Jilin 130024, ChinaLIN, Yong-Hua JIN, Song-Chun Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun, Jilin 130022, China 1Chemistry Department Northeast Normal University Changchun Jilin 130024 China2Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China

The synthesis and properties of (Z)-1-(triphenylstannyl)-3-phenyl-1-buten-3-ol (1) are described. Compound 1 crystallizes from alcohol in the monoclinic space group P21/c with unit-cell dimensions a=9.296(2), 6=14.081(3), c=18.390(5) A,B=97.70(2), V=2385.5(1) A3, Z=4, F(000)=1008, Dc=1.38 ***-3,u=10.88 cm-1, final R=0.0359 for 3079 observed reflection [I > 3(I)]. The X-ray diffraction analysis of this compound shows the presence of an intramolecular coordination to the tin atom giving rise to a five-membered ring in which the metal exhibits a distroted trignoal bipyramidal geometry; as a consequence, a phenyl group, probably the apical one, is cleaved more easily by bromine than the vinyl substituent.

关键词： Sythesis X-ray diffraction analysis (Z)-l-(triphenylstannyl)-3-phenyl-l-buten-3-ol.

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强化车站组织提高运输效率

铁道运输与经济 2007年第2期29卷 44-46页

作者：俞新夫上海铁路局乔司站浙江杭州310010

铁路局直管站段体制改革实施和生产力布局调整后,乔司站的管辖范围扩大,车站增多,运输组织难度加大。针对改进基础工作制度、挖掘运输组织潜力、加强两级调度沟通等,提出规范基础管理工作、完善信息传递机制,加强日常运输组织、提高运... 详细信息

铁路局直管站段体制改革实施和生产力布局调整后,乔司站的管辖范围扩大,车站增多,运输组织难度加大。针对改进基础工作制度、挖掘运输组织潜力、加强两级调度沟通等,提出规范基础管理工作、完善信息传递机制,加强日常运输组织、提高运输效益效率,建立调度沟通机制、确保运输安全畅通的改进措施。

关键词：铁路直属站提高运输效率

Effectiveness and safety of endoscopic resection for duodenal gastrointestinal stromal tumors:A single center analysis

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 684-693页

作者： Zhen-Zhen Wang Xiao-Dan Yan Hai-Deng Yang xin-Li Mao yue Cai xin-yu fu Shao-Wei Li Key Laboratory of Minimally Invasive Techniques&Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province Taizhou Hospital Affiliated to Wenzhou Medical UniversityLinhai 315000Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityLinhai 315000Zhejiang ProvinceChina Institute of Digestive Disease Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityLinhai 315000Zhejiang ProvinceChina Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityLinhai 315000Zhejiang ProvinceChina

BACKGROUND Endoscopic resection for duodenal gastrointestinal stromal tumors(GISTs)is still considered a great challenge with a high risk of complications,including perforation,bleeding,tumor rupture,and residual *** To assess the effectiveness and safety of endoscopic resection for duodenal *** Between January 2010 and January 2022,11 patients with duodenal GISTs were treated with endoscopic *** were extracted for the incidence of complete resection,bleeding,perforation,postoperative infection,recurrence,and distant *** The incidence of successful complete resection of duodenal GISTs was 100%.Three cases(27.3%)had suspected positive margins,and the other 8 cases(72.7%)had negative vertical and horizontal *** occurred in all 11 *** success rate of perforation closure was 100%,while 1 patient(9.1%)had suspected delayed *** bleeding during the procedure was managed by endoscopic *** case(9.1%)had delayed *** infection occurred in 6 patients(54.5%),including 1 who developed septic shock and 1 who developed a right iliac fossa *** 11 patients recovered and were *** mean hospital stay was 15.3 *** the follow-up period(14-80 mo),duodenal stenosis occurred in 1 case(9.1%),and no local recurrence or distant metastasis were *** Endoscopic resection for duodenal GISTs appears to be an effective and safe minimally invasive treatment when performed by an experienced endoscopist.

关键词： Duodenal tumor Gastrointestinal stromal tumors Treatment Endoscopic resection Effectiveness Safety

New hope for esophageal stricture prevention:A prospective singlecentertrial on acellular dermal matrix

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World Journal of Gastrointestinal Endoscopy 2023年第12期15卷 725-734页

作者： xin-yu fu Zhen-yu Jiang Chen-Yang Zhang Ling-Yan Shen Xiao-Dan Yan Xiao-Kang Li Jia-Ying Lin Yi Wang xin-Li Mao Shao-Wei Li Department of Gastr-oenterology Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014000Inner Mongolia Autonomous RegionChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Key Laboratory of Minimally Invasive Techniques&Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Division of Transplantation Immunology National Research Institute for Child Health and DevelopmentTokyo 1540001Japan Institute of Digestive Disease Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

BACKGROUNDGiven the high incidence of esophageal cancer in China,an increasing number ofpatients there are undergoing endoscopic mucosal dissection(ESD).Although the5-year survival rate after ESD can exceed 95%,esophageal stricture,the mostcommon and serious postoperative complication,affects the long-term prognosisof patients and the quality of *** mucosal grafts have proven to besuccessful in preventing stricture after ESD for early esophageal *** examine the viability of acellular dermal matrix(ADM)as an alternative to autologous mucosa for the prevention of stricture after *** is a prospective,single-center,controlled *** patients who underwent ESD surgery and werewilling to undergo autologous mucosal transplantation were recruited between January 1 and December 31,*** patients who underwent ESD surgery and were willing to undergo ADM transplantation wererecruited between January 1 to December 31,2019.A final three-year follow-up of patients who receivedtransplants was *** on the current incidence of esophageal stricture,the sample size required for both the autologous mucosalgraft group and the ADM group was calculated to be 160 *** to various factors,a total of 20 patients withautologous mucosal grafts and 25 with ADM grafts were *** on the inclusion exclusion andwithdrawal criteria,9 patients ultimately received autologous mucosal grafts and completed the follow-up,while11 patients received ADM grafts and completed the ***,there were 2 cases of stenosis in theautologous mucosal transplantation group with a stenosis rate of 22.22%and 2 cases of stenosis in the ADMtransplantation group with a stenosis rate of 18.18%,with no significant difference noted between the groups(P=0.94).CONCLUSIONIn this prospective,single-center,controlled trial,we compared the effectiveness of autologous mucosatransplantation and ADM for the prevention of esophageal strictur

关键词： Over-the-scope clip Duodenal subepithelial lesion Endoscopic resection Perforation

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Anisotropic spin transport and photoresponse characteristics detected by tip movement in magnetic single-molecule junction

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Chinese Physics B 2024年第4期33卷 640-648页

作者：陈登辉羊志付新宇秦申奥严岩王传奎李宗良邱帅 Shandong Key Laboratory of Medical Physics and Image Processing&Shandong Provincial Engineering and Technical Center of Light Manipulations School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

Orientation-dependent transport properties induced by anisotropic molecules are enticing in single-molecule ***,using the first-principles method,we theoretically investigate spin transport properties and photoresponse characteristics in trimesic acid magnetic single-molecule junctions with different molecular adsorption orientations and electrode contact *** transport calculations indicate that a single-molecule switch and a significant enhancement of spin transport and photoresponse can be achieved when the molecular adsorption orientation changes from planar geometry to upright *** maximum spin polarization of current and photocurrent in upright molecular junctions exceeds 90%.Moreover,as the Ni tip electrode moves,the tunneling magnetoresistance of upright molecular junctions can be increased to 70%.The analysis of the spin-dependent PDOS elucidates that the spinterfaces between organic molecule and ferromagnetic electrodes are modulated by molecular adsorption orientation,where the molecule in upright molecular junctions yields higher spin *** theoretical work paves the way for designing spintronic devices and optoelectronic devices with anisotropic functionality base on anisotropic molecules.

关键词： molecular spintronics spin polarization tunneling magnetoresistance photocurrent single-molecule junctions

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu Yi-Hua Wang Yi-xin Liu Lu Xu Lin fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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淄博市某职业学校实训楼空调冷热源系统设计

工程建设与设计 2018年第17期 98-101页

作者：辛玉富淄博市建筑设计研究院山东淄博255037

针对实际工程详细介绍了地源热泵空调系统的冷热源设计,论述了地源热泵空调系统原理、优缺点,分析了采用的冷热源机组形式,制冷负荷和制热负荷参数,空调水系统的形式及空调水系统供回水温度等,论述了地埋管换热器系统的设计方法,地埋管... 详细信息

针对实际工程详细介绍了地源热泵空调系统的冷热源设计,论述了地源热泵空调系统原理、优缺点,分析了采用的冷热源机组形式,制冷负荷和制热负荷参数,空调水系统的形式及空调水系统供回水温度等,论述了地埋管换热器系统的设计方法,地埋管的埋深,集分水器的设置,管材选择和连接方法。详细介绍了室外地埋管的施工要求,聚乙烯(PE)管道系统电熔焊接操作工艺,套管式热熔焊接和对接式热熔焊接焊接方法,说明了地源热泵机房空调自控系统要求。

关键词：空调冷热源地源热泵空调水系统可再生能源地埋管换热器

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淄博市妇幼保健院空调设计

建筑热能通风空调 2018年第6期37卷 103-105,84页

作者：辛玉富淄博市建筑设计研究院

根据医院工程的特殊性,建筑功能布局性质的复杂性,本工程主要采用的空调系统形式为地源热泵系统与离心式冷水机组相结合的形式,同时在手术室、ICU监护中心、免疫二级生物安全实验室等房间采用小型的空气源热泵系统;传染病门诊采用变制... 详细信息

根据医院工程的特殊性,建筑功能布局性质的复杂性,本工程主要采用的空调系统形式为地源热泵系统与离心式冷水机组相结合的形式,同时在手术室、ICU监护中心、免疫二级生物安全实验室等房间采用小型的空气源热泵系统;传染病门诊采用变制冷剂流量空调系统。

关键词：医院空调空调冷热源地源热泵