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Self-Supervised Task Augmentation for Few-Shot Intent Detection

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Journal of Computer Science & Technology 2022年第3期37卷 527-538页

作者： Peng-Fei Sun Ya-Wen Ouyang Ding-Jie Song xin-yu dai National Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210093China

Few-shot intent detection is a practical challenge task,because new intents are frequently emerging and collecting large-scale data for them could be ***-learning,a promising technique for leveraging data from previous tasks to enable efficient learning of new tasks,has been a popular way to tackle this ***,the existing meta-learning models have been evidenced to be overfitting when the meta-training tasks are *** overcome this challenge,we present a novel self-supervised task augmentation with meta-learning framework,namely ***,we introduce the task augmentation,which explores two different strategies and combines them to extend meta-training ***,we devise two auxiliary losses for integrating self-supervised learning into meta-learning to learn more generalizable and transferable *** results show that STAM can achieve consistent and considerable performance improvement to existing state-of-the-art methods on four datasets.

关键词： self-supervised learning task augmentation meta-learning few-shot intent detection

Pillar[5]arene and Azine Derivative Assembly Improved Dual-Channel Detection of CN^(-)

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Chinese Journal of Chemistry 2024年第20期42卷 2471-2478页

作者： Qing-Ling Su Jin-Fa Chen Xiao-Mei Sun Juan Liu xin-yu dai Tai-Bao Wei Hong Yao Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu 730070China Key Laboratoryof Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest Universityfor Nationalities)Xibei XincunLanzhouGansu 73000oChina

The cyanide anion(CN^(–))is known to be one of the most toxic ***,there is an urgent need to develop a reliable,sensitive,selective,rapid and effective method for the detection of CN^(–).Here,a self-assembly strategy based on pillar[5]arene P5 and azine derivative AZ was used to construct supramolecular sensors,and it was found that the detection effect of CN^(–)was significantly improved by the assembly *** sensitivity of the assembled sensor P5-AZ to CN^(–)is more than 10 times higher than that of *** detect mechanism was further investigated by theoretical calculations and 1H *** results showed that AZ detects CN–by a deprotonation process with fluorescence enhancement,while P5-AZ improves the sensitivity of CN^(–)recognition through hydrogen bonding,anion-πand anion-dipole interactions,as well as the strong bonding ability of the *** assembly P5-AZ has the advantages of low toxicity,high sensitivity,and more importantly,it provides a method to detect CN^(–)sensitivity in the aqueous phase and organisms by host-guest assembly.

关键词： Host-guest assembly Improves sensing sensitivity Pillararene Azine derivative Cyanide Supramolecular sensors Energy transfer Colorimetric fluorescence dual-channel Fluorescence cell imaging

Sampling informative context nodes for network embedding

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Science China(Information Sciences) 2021年第11期64卷 120-130页

作者： Danhao ZHU xin-yu dai Jiajun CHEN Jie YIN Department of Computer Science and Technology Nanjing University Library Jiangsu Police Institute

Several modern network embedding methods learn vector representations from sampled context nodes. The sampling strategies are often carefully designed and controlled by specific parameters that enable them to adapt to different networks. However, the following fundamental question remains: what is the key factor that causes some sampling context results to yield better vectors than others on a certain network? We attempted to answer the question from the perspective of information theory. First, we defined the weighted entropy of the sampled context matrix, which denotes the amount of information it takes. We discovered that context matrices with higher weighted entropy generally produce better vectors. Second, we proposed maximum weighted entropy sampling methods for sampling more informative context nodes; thus, it can be used to produce more informative vectors. Herein, the results of the extensive experiments on the link prediction and node classification tasks confirm the effectiveness of the proposed methods.

关键词： network embedding representation learning random walk entropy weighted entropy

Pulmonary deportation of hydatidiform mole:a 12-year,single tertiary center experience in China

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Chinese Medical Journal 2020年第16期133卷 1930-1934页

作者： yu-xin dai Yang Xiang Feng-Zhi Feng Tong Ren Jun-Jun Yang Jun Zhao Xi-Run Wan Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Pulmonary deportation of hydatidiform mole is an exceedingly rare *** underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six *** study aimed to investigate the clinical features and rational treatment of patients with benign molar pregnancies with pulmonary deportation based on our ***:Medical records of 20 cases of hydatidiform mole with pulmonary deportation were retrospectively reviewed at Peking Union Medical College Hospital from November 2006 to May *** detailed information of all patients was recorded and *** were divided into different groups according to their characteristics and Mann-Whitney U test was used to compare the duration to achieve a normal b-human chorionic gonadotrophin(b-hCG)level after the first evacuation among ***:Initial pulmonary computed tomography scans showed suspected bilateral,left and right chest deportation of hydatidiform mole in 12,four,and four patients,respectively,with the maximum nodular diameter ranging from 0.6 to 1.2 *** patients achieved lesion resolution while the remaining ten patients achieved decreases in the size of their pulmonary *** median duration to achieve a normal b-hCG level after the first evacuation was 15.5(13.0,21.9)*** was no significant difference in the duration to achieve a normal b-hCG level after the first evacuation between two groups based on age(≥40 years vs.0.5 cm vs.0.5 cm:13.0[11.3,17.2]weeks vs.16.0[14.5,23.8]weeks,Z=1.815,P=0.070),and number of uterine evacuations(once *** or three time

关键词： Hydatidiform mole Pulmonary deportation Human chorionic gonadotrophin Computed tomography

Mechanism of AsperosaponinⅥRelated to EGFR/MMP9/AKT/PI3K Pathway in Treatment of Rheumtoid Arthritis

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Chinese Journal of Integrative Medicine 2025年第2期31卷 131-141页

作者： LUO Jin-fang yu Yang LIU Jian-xin School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Sino-Pakistan Center on Traditional Chinese Medicine China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan ProvinceSchool of Pharmaceutical SciencesHunan University of MedicineHuaihua CityHunan Province(418000)China

Objective:To explore the mechanism of action of asperosaponinⅥ(AⅥ)in the treatment of rheumatoid arthritis(RA)and validate it in ex vivo experiments using network pharmacology and molecular docking ***:The predicted targets of AⅥwere obtained from PharmMaper,UniProt and Swiss Target Prediction platforms,the disease targets were collected from Online Mendelian Inheritance in Man,Therapeutic Target Database and Gene Cards databases,the intersection targets of AⅥand RA were obtained from Venny 2.1.0,and the protein-protein interaction(PPI)network was obtained from STRING database,which was analyzed by Cytoscape software and screened to obtain the core *** software was used to analyze PPI network and screen the core *** on the Database for Annotation,Visualization and Integrated Discovery database,Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed,and Cytoscape software was used to construct the"DiseasePathway-Target-Drug"network,which was finally verified by molecular docking and animal ***:Network pharmacological studies showed that AⅥwas able to modulate 289 targets,with 102 targets for the potential treatment of RA,with the core pathway being the AKT/PI3K signaling pathway,and the core targets being the epidermal growth factor receptor(EGFR)and matrix metalloproteinase 9(MMP9).Molecular docking results showed that AⅥcould produce strong binding with both of the 2 core *** vitro cellular experiments showed that AⅥreduced nitric oxide,prostaglandin E_2,tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1βlevels(P<0.05)and inhibited cyclooxygenase-2,nitric oxide synthase,EGFR,MMP9,phosphorylated phosphoinositide 3-kinase(p-PI3K),and phosphorylated serine-threonine kinase(p-AKT)proteins(P<0.05).The results of in vivo studies showed that AⅥimproved RA score and foot swelling thickness and decreased TNF-α,IL-6,p-PI3K and p-AKT levels in RA rat

关键词： inflammation rheumatoid arthritis network pharmacology asperosaponinⅥ EGFR/MMP9/AKT/PI3K pathway

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Hyperbranched Poly(α-aminonitrile)s Constructed via Catalyst-Free Multicomponent Polymerization of Trialdehydes, Diamines and Trimethylsilyl Cyanide

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 341-349页

作者： Cheng, Tian-yu Ding, Jian-Qing Tong, yu-xin Fang, Jun-Guo Wang, Jia Anhui Polytech Univ Sch Chem & Environm Engn Wuhu 241000 Peoples R China Songshan Lake Mat Lab Dongguan 523808 Peoples R China

Functional hyperbranched polymers, as an important class of materials, are widely applied in diverse areas. Therefore, the development of simple and efficient reactions to prepare hyperbranched polymers is of great significance. In this work, trialdehydes, diamines, and trimethylsilyl cyanide could easily undergo multicomponent polymerization under mild conditions, producing hyperbranched poly(alpha-aminonitrile)s with high molecular weights (Mw up to 4.87x104) in good yields (up to 85%). The hyperbranched poly(alpha-aminonitrile)s have good solubility in commonly used organic solvents, high thermal stability as well as morphological stability. Furthermore, due to the numerous aldehyde groups in their branched chains, these hb-poly(alpha-aminonitrile)s can undergo one-pot, two-step, four-component post-polymerization with high efficiency. This work not only confirms the efficiency of our established catalyst-free multicomponent polymerization of aldehydes, amines and trimethylsilyl cyanide, but also provides a versatile and powerful platform for the preparation of functional hyperbranched polymeric materials.

关键词： Catalyst-free Multicomponent polymerization Hyperbranched polymer Post-polymerization

Acupuncture Combined with Periocular Injection for Treatment of Hydroxychloroquine Retinopathy with Cystoid Macular Edema:A Case Report

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Chinese Journal of Integrative Medicine 2025年第1期31卷 68-72页

作者： LI Tian-tian WU Yan YANG Ying-xin XUE yu-xin MA Chao-ting Department of Ophthalmology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China

Hydroxychloroquine(HCQ)is widely used in the treatment of autoimmune disorders such as systemic lupus erythematosus(SLE)and rheumatoid arthritis,and in recent years it has also been used in diseases such as cancer,neurodegenerative diseases,metabolic diseases,and microbial infections.(1)Due to the complex pharmacokinetic characteristics of HCQ,overdose or long-term use of the drug will lead to accumulation in the tissue of organism,and severe HCQ-related retinal toxicity may occur.A cohort study in America showes that after 10 and 15 years of HCQ use,the incidence of HCQ retinopathy will be 2.5%and 8.6%,respectively.(2)The clinical manifestations of HCQ retinopathy are various,mainly photoreceptor and retinal pigment epithelium(RPE)defects,some combined with cystoid macular edema(CME),and ireversible central vision loss.

关键词： Acupuncture diseases epithelium

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou yunfeng Bao Xueshang xin yu Qi Tengfeng Xie Fuxiang Zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 116029China College of Chemistry Jilin UniversityChangchun 130012China

Constructing typeⅡheterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated(oxy)nitrides with low thermal ***,we synthesized a homologous heterostructure(denoted as YTON_H)based on the oxynitrides of YTaO_(4-x)N_(y)and YTa ON_(2).This heterostructure exhibits type Ⅱ band structure alignment and intimate interface achieved through a magnesium(Mg)powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON_H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO_(4-x)N_(y)and YTaON_(2)).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light