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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen Feng-Lin Chen ying-Jie Zhang Xiao-cong Liu Xiao-Yan Yang Shan-Shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

Underwater RGB-D imaging system with millimetric precision

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Science China(Information Sciences) 2024年第10期67卷 383-385页

作者： Yajun GAO Yang cong Xu TANG Mingxue LI State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences University of Chinese Academy of Sciences College of Automation Science and Engineering South China University of Technology

In recent years, underwater fine three-dimensional reconstruction technology has emerged as a focal point in research, exhibiting extensive potential applications, particularly in underwater archaeology and resource e... 详细信息

关键词： SINGLE CAMERA

同方期刊数据库

Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3932-3954页

作者： Guo-Qing Chen Yi Nan Na Ning Shi-cong Huang Yu-Ting Bai Zi-ying Zhou Gu Qian Wei-Qiang Li Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pharmacy Ningxia Chinese Medicine Research CenterYinchuan 750021Ningxia Hui Autonomous RegionChina Department of Pharmacy General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastroenterology The Affiliated TCM Hospital of Ningxia Medical UniversityWuzhong 751100Ningxia Hui Autonomous RegionChina

BACKGROUND Cancer is one of the most serious threats to human health *** treatments such as surgery and chemotherapy are associated with some *** recent years,traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians,and has become an indispensable part of the comprehensive treatment for gastric *** To investigate the mechanism of Xiaojianzhong decoction(XJZ)in the treatment of gastric cancer(GC)by utilizing network pharmacology and experimental validation,so as to provide a theoretical basis for later experimental *** We analyzed the mechanism and targets of XJZ in the treatment of GC through network pharmacology and ***,we verified the impact of XJZ treatment on the proliferative ability of GC cells through CCK-8,apoptosis,cell cycle,and clone formation ***,we performed Western blot analysis and real-time quantitative PCR to assess the protein and mRNA expression of the core *** XJZ mainly regulates IL6,PTGS2,CCL2,MMP9,MMP2,HMOX1,and other target genes and pathways in cancer to treat *** inhibition of cell viability,the increase of apoptosis,the blockage of the cell cycle at the G0/G1 phase,and the inhibition of the ability of cell clone formation were observed in AGS and HGC-27 cells after XJZ *** addition,XJZ induced a decrease in the mRNA expression of IL6,PTGS2,MMP9,MMP2,and CCL2,and an increase in the mRNA expression of *** significantly inhibited the expression of IL6,PTGS2,MMP9,MMP2,and CCL2 proteins and promoted the expression of the heme oxygenase-1 *** XJZ exerts therapeutic effects against GC through multiple components,multiple targets,and multiple *** findings provide a new idea and scientific basis for further research on the molecular mechanisms underlying the therapeutic effects of XJZ in the treatment of GC.

关键词： Xiaojianzhong decoction Gastric cancer Network pharmacology Molecular mechanism In vitro experiment

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考虑需求扰动的港口物流服务供应链协调策略

大连海事大学学报 2021年第4期47卷 47-55页

作者：王嘉浩陈子根信聪颖杨昂大连海事大学交通运输工程学院辽宁大连116026 大连海事大学航运经济与管理学院辽宁大连116026

为更有效地管理与协调供应链,研究需求扰动频繁发生对港口物流服务供应链中各类协调模式和利益主体产生的不同影响,运用两阶段博弈方法,构建了考虑需求扰动下由港口和海运承运人组成的港口物流服务供应链模型,研究需求扰动对不同协调模... 详细信息

为更有效地管理与协调供应链,研究需求扰动频繁发生对港口物流服务供应链中各类协调模式和利益主体产生的不同影响,运用两阶段博弈方法,构建了考虑需求扰动下由港口和海运承运人组成的港口物流服务供应链模型,研究需求扰动对不同协调模式下海运各主体的决策影响.研究结果表明:需求扰动分配比例仅对分散决策模式下承运人的服务质量和价格决策产生影响;当服务质量成本系数较大时,集中决策模式在承运人价格波动上具有更高的鲁棒性,当服务质量成本系数较小时,承运人联盟决策模式能更好地降低需求扰动对承运人价格的影响.最后,通过数值分析探讨了需求扰动量和需求扰动分配比例对不同模式下港口物流服务供应链成员的决策影响.

关键词：港口物流服务供应链供应链协调两阶段博弈需求扰动服务竞争

维普期刊数据库

Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： Chu Xie cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

Effects of vibration conditions,spatial confinement and friction on mixing and segregation characteristics of mixed pebble beds for CFETR WCCB blanket

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Particuology 2024年第2期85卷 268-279页

作者： Yong Liu Chongyang He cong Wang Lei Chen Songlin Liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230027China Chengdu University Chengdu610106China Zhejiang Lab Hangzhou310000China

This paper presents the study of the dynamic characteristics of confined mixed pebble beds with different friction under different vibration conditions using the discrete element ***λsegre-gation index is used to quantify the degree of particle mixing or *** percolation,convection and diffusion mechanisms are responsible for the segregation patterns of the mixed *** results show the degree of segregation can be suppressed by decreasing the vibration acceleration or free space height below a *** simulation reveals the threshold of vibration acceleration or free space height both are related to the bed height increment which determines the strength of the percolation *** addition,the strength of percolation and convection becomes weaker by decreasing the friction of particles and walls,which makes the pebbled bed remains in a mixed state under *** findings are significant to clarify the main factors behind the three segregation mechanisms and hence provide solutions to retaining the mixed state of the Li2TiO3&Be12Ti mixed pebble bed.

关键词： Vibration Segregation Binary pebble bed Discrete element method

Ferromagnetism and insulating behavior with a logarithmic temperature dependence of resistivity in Pb_(10-x)Cux(PO_(4))_(6)O

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 106-111页

作者： Yuhang Zhang cong Liu Xiyu Zhu Hai-Hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Recent claim of discovering above-room-temperature superconductivity(Tc≈400 K)at ambient pressure in copper doped apatite Pb10(PO_(4))_(6)O has stimulated world-wide enthusiasm and impulse of motion.A lot of follow-up works have been carried out with controversial *** check whether superconductivity is really present or absent in the material,we need samples which should have a rather pure phase of Pb_(10-x)Cux(PO_(4))_(6)*** we report the characterization results from the Pb_(10-x)Cux(PO_(4))_(6)O with a fraction of about 97 wt.%inferred from the fitting to the X-ray diffraction pattern,if assuming Cu2S as the only *** resistivity measurements show that it is a semiconductor characterized roughly by a ln(1/T)temperature dependence in wide temperature region without trace of *** measurements show that it has a general ferromagnetic signal with a weak superparamagnetic *** grains of the sample show clear interactions with a Nb Fe B *** detected Cu concentration is much lower than the expected nominal *** results show the absence of metallicity and superconductivity in Pb_(10-x)Cux(PO_(4))_(6)O at ambient pressure,and suggest the presence of strong correlation effect.

关键词： superconductivity Pb10(PO4)6O ferromagnetic correlation effect

维普期刊数据库

Dynamical pattern recognition for univariate time series and its application to an axial compressor

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Control Theory and Technology 2024年第1期22卷 39-55页

作者： Jingtao Hu Weiming Wu Zejian Zhu cong Wang Center for Intelligent Medical Engineering School of Control Science and TechnologyShandong UniversityJinan250061ShandongChina School of Automation Science and Engineering South China University of TechnologyGuangzhou510641GuangdongChina

In this paper, a learning and recognition approach is proposed for univariate time series composed of output measurements of general nonlinear dynamical systems. Firstly, a class of dynamical systems in the canonical form is derived to describe the univariate time series by introducing coordinate transformation. An observer-based deterministic learning technique is then adopted to achieve dynamical modeling of the associated transformed systems of the training univariate time series, and the modeling results in the form of radial basis function network (RBFN) models are stored in a pattern library. Subsequently, multiple observer-based dynamical estimators containing the RBFN models in the pattern library are constructed for a test univariate time series, and a recognition decision scheme is proposed by the derived recognition indicator. On this basis, more concise recognition conditions are provided, which is beneficial for verifying the recognition results. Finally, simulation studies on the Rossler system and aero-engine stall warning verify the effectiveness of the proposed approach.

关键词： Dynamical pattern recognition Deterministic learning Stall warning Radial basis function network Sampled-data observer

A practical guide for fast implementation of SNARE-mediated liposome fusion

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Biophysics Reports 2024年第1期10卷 31-40页

作者： Shen Wang cong Ma Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNAER) family proteins are the engines of most intra-cellular and exocytotic membrane fusion pathways(Jahn and Scheller 2006).Over the past two decades, in-vitro liposome fusion has been proven to be a powerful tool to reconstruct physiological SNARE-mediated membrane fusion processes(Liu et al. 2017). The reconstitution of the membrane fusion process not only provides direct evidence of the capability of the cognate SNARE complex in driving membrane fusion but also allows researchers to study the functional mechanisms of regulatory proteins in related pathways(Wickner and Rizo 2017). Heretofore, a variety of delicate methods for in-vitro SNARE-mediated liposome fusion have been established(Bao et al. 2018;Diao et al. 2012; Duzgunes 2003; Gong et al. 2015; Heo et al. 2021; Kiessling et al. 2015; Kreye et al.2008; Kyoung et al. 2013; Liu et al. 2017; Scott et al. 2003). Although technological advances have made reconstitution more physiologically relevant, increasingly elaborate experimental procedures, instruments, and data processing algorithms nevertheless hinder the non-experts from setting up basic SNARE-mediated liposome fusion assays. Here, we describe a low-cost, timesaving, and easy-to-handle protocol to set up a foundational in-vitro SNARE-mediated liposome fusion assay based on our previous publications(Liu et al. 2023; Wang and Ma 2022). The protocol can be readily adapted to assess various types of SNARE-mediated membrane fusion and the actions of fusion regulators by using appropriate alternative additives(e.g., proteins, macromolecules, chemicals, etc.). The total time required for one round of the assay is typically two days and could be extremely compressed into one day.

关键词： Liposome fusion SNARE In-vitro reconstitution Protocol