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Chinese Journal of Aeronautics 2025年第1期38卷 185-201页

作者： Guijian XIAO Zhengyu yang Kun ZHOU Yi he xin LI College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmissions for Advanced Equipment Chongqing UniversityChongqing 400044China

To improve the application and service of C_(f)/SiC composites as advanced hightemperature structural materials,it is critical to achieve their high-efficiency and low-damage *** this study,the laser-ablating assisted grinding(LAAG)method was presented,and the connection of damage behavior and removal mechanism with laser and grinding processes was *** results demonstrated that the surface of C_(f)/SiC composites after laser ablation was covered with a substantial number of loose oxides primarily composed of *** ablating process,grinding parameter and abrasive belt selection have a significant impact on the machining *** fabricating an ablative layer with small laser scanning spacing,and selecting small abrasive grains and feed rate during grinding,the machinability was improved and a relatively lowerdamage grinding surface could be *** the optimal combination of process parameters,the grinding force and temperature of LAAG could be reduced by up to 85%and 35%,*** this case,the subsurface damage of C_(f)/SiC composites occurred only in the form of microcracks rather large-scale fracture,and the formation of interface debonding and matrix cracking was significantly ***,the grinding chips were mostly shown as micron-sized powders,indicating that the removal mechanism of C_(f)/SiC composites was primarily the microfractured and attrition wear of laser-ablated layer.

关键词： Ceramic matrix composites Laser ablating Grinding Material removal Fracture damage

Optimization of cerebral organoids:a more qualified model for Alzheimer’s disease research

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Translational Neurodegeneration 2021年第3期10卷 346-358页

作者： Feng-Chen Bi xin-he yang Xiao-Yu Cheng Wen-Bin Deng Xiao-Li Guo Hui yang Yin Wang Juan Li Yao Yao School of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750004China Key Laboratory of Traditional Chinese Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004China School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated HospitalSoochow UniversitySuzhou 215004China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityGuangzhou 510275China Research Center of Medical Science and Technology Ningxia Medical UniversityYinchuan 750004China

Alzheimer’s disease(AD)is a neurodegenerative disease that currently cannot be cured by any drug or intervention,due to its complicated *** animal and cellular models of AD are unable to meet research needs for ***,recent three-dimensional(3D)cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of *** this review,we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models,and propose possible solutions,in order to improve their application in AD *** concerns associated with human cerebral organoids are also *** also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.

关键词： Cerebral organoids Alzheimer’s disease Pluripotent stem cells

Effect of reorganized-human growth hormone on cell cycle kinetics in liver cancer in vitro

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hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 224-227页

作者： xin-yang he Ge-Liang Xu Rong-Nan Xu Zhi-Min Ze Department of Surgery Anhui Provincial Hospital Hefei 230001 China. xugelian@***

Objective: To study the effect of reorganized-humangrowth hormone （r-hGH） on cycle kinetics and apo-ptosis of liver cancer cells or 7402 ***: Liver cancer cells were cultured for 24hours with r-hGH at different concentrations with orwithout cisplatin （DDP）. Cells undergoing apoptosisand differentiation were determined by flow cytome-try （FCM）.Results: Comparison of the results in culture withand without r-hGH showed that the percentage ofcells in G0-G1 phase dropped （Phereasin S phase increased （Phe culture medium increased the apop-tosis of liver cancer cells more significantly thanadding DDP only （PhehGH receptor. In vitro r-hGH might induce the dif-ferentiation of liver cancer cells, stimulate the combi-nation of DNA, and reduce the cells in G0-G1 pha-ses. These improve the sensibility of tumors to thespecial-staged chemical treatment. Chemotherapy to-gether with r-hGH may increase the apoptosis of livercancer cells.

关键词： reorgamized-human growth hormone liver cancer cell cycle kinetics apoptosis

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing

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Energy Engineering 2025年第1期122卷 349-378页

作者： xin Zhang Mingming Yao Daiwen he Jihong Zhang Peihong yang Xiaoming Zhang School of Automation and Electrical Engineering Inner Mongolia University of Science and TechnologyBaotou014010China

In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load *** to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption *** price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption *** benefits and win-win situations are achieved between the upper and lower ***,CPLEX is used to iteratively solve the bilevel optimization *** optimal solution is selected according to the joint optimal discrimination *** results indicate that the sourceload coordinate operation can reduce the upper and lower operation *** the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.

关键词： Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism

TREATMENT OPTIONS FOR PATIENTS WITH RECURRENT OVARIAN CANCER:A REVIEW OF 54 CASES

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Chinese Medical Sciences Journal 2006年第1期21卷 11-15页

作者： Ying Jin Ling-ya Pan Hui-fang Huang Keng Shen Ming Wu Jia-xin yang Jing-he Lang Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the efficacy of treatment options for patients with recurrent ovarian *** From 1990 to 2000, 54 patients with recurrent ovarian cancer primarily treated in Peking Union Medical College Hospital were selected and *** the clinical data related to the recurrent tumor were ***-side P values for differences in survival were calculated by the Cox regression *** The platinum-free interval >6 months and the surgery followed by salvage chemotherapy prolonged survival time of the patients with recurrent ovarian cancer (95% CI=0.153-0.987, P=0.047; 95% CI=1.611-10.914, P=0.003, respectively).The increased number of chemotherapy cycles (> 10 months) offered some benefit on the survival (95% CI=0.110-1.090, P=0.070).The initiation of treatment and chemotherapy regiments failed to demonstrate an improvement in *** The treatment options for patients with recurrent ovarian cancer depend on the platinum-free-interval of the patients.A strategy of secondary surgical cytoreduction followed by salvage chemotherapy is suggested for the patients with platinum-sensitive disease.

关键词： recurrent ovarian cancer surgery chemotherapy

Reconstructing forest and grassland cover changes in China over the past millennium

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Science China Earth Sciences 2025年第1期68卷 94-110页

作者： Fanneng he Fan yang Yafei WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China Key Research Institute of Yellow River Civilization and Sustainable Development Henan UniversityKaifeng475001China University of Chinese Academy of Sciences Beijing100049China

Historical forest and grassland cover changes not only are critical indicators for quantifying ecological and environmental change processes but also serve as fundamental data for long-term climate change simulations and terrestrial ecosystem carbon emission ***,because of limitations in historical data,quantitative estimations and spatially gridded reconstructions of these changes remain challenging,necessitating further methodological *** study focused on China's present-day land area over the past millennium,objectively capturing the characteristics and drivers of forest and grassland cover *** this basis,using the forest transition theory and the space-for-time substitution method,we depicted the historical deforestation process as an inverted“S”curve and developed a model to reconstruct historical forest area changes based on the functional relationship between the forest area and population size ***,a gridded forest allocation model was established on the basis of deforestation *** the grassland cover,we implemented regionspecific methods,such as the cropland area deduction method and the habitat constraint method,to quantitatively reconstruct historical ***,we obtained provincial forest and grassland area changes over the past millennium and mapped 10-km-resolution gridded data of forest and grassland *** results indicated the following.(1)The methods developed using population data as a proxy objectively reproduced the spatiotemporal evolution of forest and grassland cover in China over the past *** feasible methods offer a novel pathway for the quantitative reconstruction of historical forest and grassland cover changes.(2)The data indicated that China's forest area generally decreased over the past millennium,characterized by a“decrease-then-increase”*** forest area experienced three distinct phases:a slow decline(AD 1000–1650),a rapid decline(AD 16

关键词： Land use and land cover change Forest Grassland Quantitative reconstruction Gridded reconstruction China historical period

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao Jian-xin Dong Yong-sheng he he Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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Support effect and confinement effect of porous carbon loaded tin dioxide nanoparticles in high-performance CO_(2) electroreduction towards formate

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Chinese Chemical Letters 2025年第1期36卷 597-602页

作者： xingxing Jiang Yuxin Zhao Yan Kong Jianju Sun Shangzhao Feng xin Lu Qi Hu hengpan yang Chuanxin he College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Leveraging the interplay between the metal component and the supporting material represents a cornerstone strategy for augmenting electrocatalytic efficiency,e.g.,electrocatalytic CO_(2)reduction reaction(CO_(2)RR).herein,we employ freestanding porous carbon fibers(PCNF)as an efficacious and stable support for the uniformly distributed SnO_(2)nanoparticles(SnO_(2)PCNF),thereby capitalizing on the synergistic support effect that arises from their strong *** one hand,the interaction between the SnO_(2)nanoparticles and the carbon support optimizes the electronic configuration of the active *** interaction leads to a noteworthy shift of the d-band center toward stronger intermediate adsorption energy,consequently lowering the energy barrier associated with CO_(2)*** a result,the Sn O_(2)PCNF realizes a remarkable CO_(2)RR performance with excellent selectivity towards formate(98.1%).On the other hand,the porous carbon fibers enable the uniform and stable dispersion of SnO_(2)nanoparticles,and this superior porous structure of carbon supports can also facilitate the exposure of the SnO_(2)nanoparticles on the reaction interface to a great ***,adequate contact between active sites,reactants,and electrolytes can significantly increase the metal utilization,eventually bringing forth a remarkable7.09 A/mg mass *** work might provide a useful idea for improving the utilization rate of metals in numerous electrocatalytic reactions.

关键词： CO_(2)electroreduction Support effect Porous carbon fiber Formate Mass activity

Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： xin LI Yibo ZHOU Tao ZHAO xingjian he Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material CyclingCentre for Research and Education on Biological Evolution and Environment and Frontiers ScienceSchool of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Institute of Palaeontology Yunnan Key Laboratory of Earth System ScienceYunnan Key Laboratory for PalaeobiologyYunnan UniversityKunming650500China

Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the ***,the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep *** address this,we conducted taphonomic experiments to simulate the transformation process of black *** changes in the morphological structure,microscopic characteristics,and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy,Fourier transform infrared(FTIR)spectroscopy,and Raman *** results revealed that damage to the morphology of hair began at a mild temperature(150–175℃),and hair transformed into a fluid-like mass at a relatively high temperature(200℃).In addition,the morphological structure of melanosomes had relatively greater preservation potential than keratins did,and the microscopic features of melanosomes were persistently *** Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature *** the chemical signals were not lost completely,the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200℃),whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable,even at high temperatures(>200℃).These results were confirmed by principal component analysis(PCA)and principal component analysis linear discriminant analysis(PCA–LDA).In addition,the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid),which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy