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Chinese Journal of Aeronautics 2024年第1期37卷 138-152页

作者： xin xue Guojian SHEN Juan liao Institute of Metal Rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350116China Fujian Shuikou Power Generation Group Co. LTDFuzhou 350000China

As a new addition to lightweight composite structures,the sandwich cylindrical shell with a metallic wire mesh core has emerged as a promising solution for thermodynamic performance analysis at elevated *** intricate interwoven cellular formations within the metallic wire mesh pose difficulties for thermo-mechanical modeling and property ***,the constitutive models employed to characterize hysteresis phenomena were presented,comprising isotropic elasticity,Bergstrom-Boyce model,Ogden hyper-elasticity,and parameter identification through mechanical examinations at varying ***,the finite element modeling of cylindrical shell structures was determined for modal and steady-state dynamic ***,the experimental procedures were carried out,including the preparation of the sandwich cylindrical shell and the dynamic testing *** first-order natural frequency of the cylindrical shell structure is close to the resonance frequency of the dynamic test results,with a maximum error of 6.5%,demonstrating the accuracy of the simulation *** compared to the solid-core cylindrical shell,the average insertion loss of the sandwich cylindrical shell structure within the frequency range of 10–1000 Hz at room temperature is up to 11.09 ***,at elevated temperatures,the average insertion loss of the sandwich cylindrical shell decreases but fluctuates as the temperature changes.

关键词： Energy dissipation Metallic matrix composites Numerical analysis Sandwich structure Thermodynamic properties

Interface property of dissimilar Ti-6Al-4V/AA1050 composite laminate made by non-equal channel lateral co-extrusion and heat treatment

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Defence Technology（防务技术） 2024年第3期33卷 197-208页

作者： Juan liao Mengmeng Tian xin xue School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China

The purpose of this paper is to examine the effect of processing parameters and subsequent heat treatments on the microstructures and bonding strengths of Ti-6Al-4V/AA1050 laminations formed via a non-equal channel lateral co-extrusion *** microstructural evolution and growth mechanism in the diffusion layer were discussed further to optimize the bonding quality by appropriately adjusting process *** electron microscopes(SEM),energy dispersive spectrometer(EDS),and X-ray diffraction(XRD)were used to characterize interfacial diffusion *** shear test was used to determine the mechanical properties of the interfacial diffusion *** experimental results indicate that it is possible to co-extrusion Ti-6Al-4V/AA1050 compound profiles using non-equal channel lateral *** heat treatment processes affect the thickness of the diffusion *** the temperature and time of heat treatment increase,the thickness of the reaction layers increases ***,the shear strength of the Ti-6Al-4V/AA1050 composite interface is proportional to the diffusion layer *** is observed that a medium interface thickness results in superior mechanical performance when compared to neither a greater nor a lesser interface *** characterization of all heat treatments reveals that the only intermetallic compound observed in the diffusion layers is TiAl_(3).Due to the inter-diffusion of Ti and Al atoms,the TiAl_(3) layer grows primarily at AA1050/TiAl_(3) interfaces.

关键词： Shear strength Co-extrusion Heat treatment Microstructure Intermetallic compounds

Causal effect of education on type 2 diabetes:A network Mendelian randomization study

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World Journal of Diabetes 2021年第3期12卷 261-277页

作者： Li-Zhen liao Zhi-Chong Chen Wei-Dong Li Xiao-Dong Zhuang xin-xue liao Department ofHealth Guangdong Pharmaceutical UniversityGuangzhou 510275Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina Department of Cardiology The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND The causality between education and type 2 diabetes(T2DM)remains *** To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total cholesterol,lowdensity lipoprotein,triglycerides(TG),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),fasting insulin,fasting glucose,and glycated hemoglobin]from summarized genome-wide association study(GWAS)data used a network Mendelian randomization(MR).METHODS Two-sample MR and network MR were performed to obtain the causality between education-T2DM,education-mediator,and *** statistics from the Social Science Genetic Association Consortium(discovery data)and Neale Lab consortium(replication data)were used for education and DIAGRAMplusMetabochip for *** The odds ratio for T2DM was 0.392(95%CI:0.263-0.583)per standard deviation increase(3.6 years)in education by the inverse variance weighted method,without heterogeneity or horizontal *** was genetically associated with CHD,TG,BMI,WC,and WHR in the discovery phase,yet only the results for CHD,BMI,and WC were replicated in the replication ***,BMI was genetically associated with *** Short education was found to be associated with an increased T2DM *** might serve as a potential mediator between them.

关键词： Mendelian randomization Education Type 2 diabetes mellitus Genome-wide association study Coronary heart disease Body mass index

Screening COVID-19 from chest X-ray images by an optical diffractive neural network with the optimized F number

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Photonics Research 2024年第7期12卷 1410-1426页

作者： JIALONG WANG SHOUYU CHAI WENTING GU BOYI LI xue JIANG YUNXIANG ZHANG HONGEN liao xin LIU DEAN TA Academy for Engineering and Technology Fudan UniversityShanghai 200433China Center for Biomedical Engineering Fudan UniversityShanghai 200433China Department of Chemistry Fudan UniversityShanghai 200433China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China

The COVID-19 pandemic continues to significantly impact people's lives worldwide, emphasizing the critical need for effective detection methods. Many existing deep learning-based approaches for COVID-19 detection offer high accuracy but demand substantial computing resources, time, and energy. In this study, we introduce an optical diffractive neural network(ODNN-COVID), which is characterized by low power consumption, efficient parallelization, and fast computing speed for COVID-19 detection. In addition, we explore how the physical parameters of ODNN-COVID affect its diagnostic performance. We identify the F number as a key parameter for evaluating the overall detection capabilities. Through an assessment of the connectivity of the diffractive network, we established an optimized range of F number, offering guidance for constructing optical diffractive neural networks. In the numerical simulations, a three-layer system achieves an impressive overall accuracy of 92.64% and 88.89% in binary-and threeclassification diagnostic tasks. For a single-layer system, the simulation accuracy of 84.17% and the experimental accuracy of 80.83% can be obtained with the same configuration for the binary-classification task, and the simulation accuracy is 80.19% and the experimental accuracy is 74.44% for the three-classification task. Both simulations and experiments validate that the proposed optical diffractive neural network serves as a passive optical processor for effective COVID-19 diagnosis, featuring low power consumption, high parallelization, and fast computing capabilities. Furthermore, ODNN-COVID exhibits versatility, making it adaptable to various image analysis and object classification tasks related to medical fields owing to its general architecture.

关键词： neural network offering

Effects of microenvironment and biological behavior on the paracrine function of stem cells

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Genes & Diseases 2024年第1期11卷 135-147页

作者： Zhixin xue Yunjun liao Ye Li The Department of Plastic and Cosmetic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal ***-based thera-pies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore *** increasing body of evidence demonstrates that paracrine func-tion is central to the effects of MsC-based *** factors,cytokines,chemokines,extracellular matrix components,and extracellular vehicles all contribute to the beneficial ef-fects of MSCs on tissue regeneration and *** paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological *** this review,we discuss the bioactive substances secreted by MsCs depending on the microenvironment and biological behavior and their regulatory mechanisms,which explain their potential to treat human diseases,to provide new ideas for further research and clinical cell-free therapy.

关键词： Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome

Heterogeneous body compositions and all-cause mortality in acute coronary syndrome patients:a ten-year retrospective cohort study

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Journal of Geriatric Cardiology 2024年第5期21卷 534-541页

作者： Guang-Zhi liao Lin BAI Yu-Yang YE xue-Feng CHEN xin-Ru HU Yong PENG Department of Cardiology West China HospitalSichuan UniversityChengduSichuanChina

BACKGROUND The association of different body components,including lean mass and body fat,with the risk of death in acute coronary syndrome(ACS)patients are *** We enrolled adults diagnosed with ACS at our center between January 2011 and December 2012 and obtained fol-low-up outcomes via telephone *** used restricted cubic splines(RCS)with the Cox proportional hazards model to analyze the associations between body mass index(BMI),predicted lean mass index(LMI),predicted body fat percentage(BF),and the value of LMI/BF with 10-year *** also examined the secondary outcome of death during *** During the maximum 10-year follow-up of 1398 patients,331 deaths(23.6%)occurred,and a U-shaped relationship was found between BMI and death risk(P_(nonlinearity)=0.03).After adjusting for age and history of diabetes,the overweight group(24≤BMI<28 kg/m^(2))had the lowest mortality(HR=0.53,95%CI:0.29-0.99).Predicted LMI and LMI/BF had an inverse linear relationship with a 10-year death risk(P_(nonlinearity)=0.24 and P_(nonlinearity)=0.38,respectively),while an increase in BF was associ-ated with increased mortality(P_(nonlinearity)=0.64).During hospitalization,31 deaths(2.2%)were recorded,and the associations of the indicators with in-hospital mortality were consistent with the long-term outcome *** Our study provides new insight into the“obesity paradox”in ACS patients,highlighting the importance of considering body composition *** LMI and BF may serve as useful tools for assessing nutritional status and predicting the prognosis of ACS,based on their linear associations with all-cause mortality.

关键词： patients mortality coronary

Engineering the axial coordination of cobalt single atom catalysts for efficient photocatalytic hydrogen evolution

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Nano Research 2024年第6期17卷 5114-5121页

作者： Ning Kang Lingwen liao xue Zhang Zhen He Binlu Yu Jiahong Wang Yongquan Qu Paul KChu Seeram Ramakrishna xue-Feng Yu xin Wang Licheng Bai Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen 518055China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsChinese Academy of SciencesHefei 230031China Department of Chemistry City University of Hong KongKowloonHong Kong 999077China Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongKowloonHong Kong 999077China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Physics and Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 999077China National University of Singapore(NUS)Centre for Nanofibers and Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117542Singapore

Improving the catalytic activity of non-noble metal single atom catalysts(SACs)has attracted considerable attention in materials *** optimizing the local electronic structure of single atom can greatly improve their catalytic activity,it often involves in-plane modulation and requires high ***,we report a novel strategy to manipulate the local electronic structure of SACs via the modulation of axial Co-S bond anchored onto graphitic carbon nitride(C_(3)N_(4))at room temperature(RT).Each Co atom is bonded to four N atoms and one S atom(Co-(N,S)/C_(3)N_(4)).Owing to the greater electronegativity of S in the Co-S bond,the local electronic structure of the Co atoms is available to be controlled at a relatively moderate ***,when employed for the photocatalytic hydrogen evolution reaction,the adsorption energy of intermediate hydrogen(H*)on the Co atoms is remarkably *** the presence of the Co-(N,S)/C_(3)N_(4)SACs,the hydrogen evolution rates reach up to 10 mmol/(g·h),which is nearly 10 and 2.5 times greater than the rates in the presence of previously reported transition metal/C_(3)N_(4)and noble platinum nanoparticles(PtNPs)/C_(3)N_(4)catalysts,*** to the tailorable axial Co-S bond in the SAC,the local electronic structure of the Co atoms can be further optimized for other photocatalytic *** axial coordination engineering strategy is universal in catalyst designing and can be used for a variety of photocatalytic applications.

关键词： transition metal single-atom local electronic structure photocatalytic hydrogen evolution graphitic carbon nitride axial coordination environment

Optical scattering imaging with sub-nanometer precision based on position-ultra-sensitive giant Lamb shift

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 96-105页

作者： Zeyang liao Yu-Wei Lu Wei Li xue-Hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The Lamb shift of a quantum emitter in close proximity to a plasmonic nanostructure can be three or more orders of magnitude larger than that in the free space and is ultra-sensitive to the emitter position and *** demonstrate that this large Lamb shift can be sensitively observed from the scattering or absorption spectrum dip shift of the coupled system when the plasmonic nanoparticle or tip scans the *** these observations,we propose a scanning optical scattering imaging method based on the plasmonic-enhanced Lamb shift with achieves sub-nanometer *** method is based on the scattering or absorption spectrum of the plasmon-emitter coupling system,which is free of the fluorescence quenching problem and easier to implement in a plasmon-emitter coupling *** addition,our scheme works even if the quantum emitter is slightly below the dielectric surface,which can bring about broader applications,such as detecting atoms and molecules or quantum dots above or under a surface.

关键词： Lamb shift plasmon optical scattering imaging

Association between serum cystatin C level and hemodynamically significant aortic stenosis: a prospective cohort study

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Journal of Geriatric Cardiology 2021年第12期18卷 986-995页

作者： Odong Christopher xing-Feng XU Yi-Fen LIN Shao-Zhao ZHANG Yi-Quan HUANG Xiang-Bin ZHONG Zhen-Yu XIONG Tara Scarlett Rosalyn CHEN Chao-Guang XU Xiao-Dong ZHUANG xin-xue liao Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina NHC Key Lab-oratory of Assisted Circulation Sun Yat-Sen UniversityGuangzhouChina Department of Rehabilitation Medicine the Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhenChina

BACKGROUND Cystatin C(CysC)is a cysteine protease inhibitor involved in proteins catabolism and plays an essential role in human vascular *** may also increase the risk of aortic stenosis(AS),but limited studies have reported on this *** study aimed to investigate if elevated serum CysC levels are associated with hemodynamically significant *** Serum CysC levels were estimated in 4,791 participants,samples were collected in 1990−*** study popula-tion was divided into quintile ***-up continued in 2011-2013 when participants returned for echocardiography *** of aortic valve disease(AVD)was ascertained by Doppler echocardiography through the end of *** defined in hemodynamic progression was assessed and classified as aortic sclerosis,mild stenosis,and moderate-to-severe *** Overall,a total of 4,791 participants(mean age:54.8±5.0 years,females:57.6%,blacks:8.2%)were included in this *** a follow-up of 21 years,we identified 736 cases(15.4%)of aortic sclerosis,194 cases(4.0%)of mild stenosis,and 42 cases(0.7%)of moderate-to-severe *** with serum CysC levels within individual quintile groups,the odds ratio(OR)was per standard deviation associated with an increased incidence of AVD(OR=1.15,95%CI:1.05−1.26,P=0.002).CONCLUSIONS In this large population-based study,an increased serum CysC levels is independently associated with the incidence of hemodynamically significant ***,this association appears not to extend to patients with extremely high serum CysC levels and necessitate further investigation.

关键词： stenosis aortic hemodynamic

Near-infrared organic lasers with ultra-broad emission bands by simultaneously harnessing four-level and six-level systems

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Chinese Chemical Letters 2024年第8期35卷 288-293页

作者： Lei Wang Jun-Jie Wu Chang-Cun Yan Wan-Ying Yang Zong-Lu Che xin-Yu Xia xue-Dong Wang Liang-Sheng liao Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao SAR 999078China

Organic lasers with broad emission bands in near-infrared(NIR)region are crucial for their applications in laser communication,night-vision as well as bioimaging owing to the abundance of selectable lasing ***,for most organic gain materials,gain regions are limited in a small wavelength range because of the fixed energy level ***,we design a strategy to realize NIR organic lasers with broad emission bands based on tunable energy level systems induced by cascaded excited-state intramolecular proton transfer(ESIPT).A novel gain material named DHNN was developed,which can undergo a cascaded double-ESIPT process supporting four-level and six-level systems *** doping DHNN into polystyrene microspheres,NIR lasers with tunable emission bands can be achieved based on the careful modulation of ***,organic lasers with an ultra-broad emission band ranging from 700 nm to 900 nm was successfully achieved by harnessing four-level and six-level systems simultaneously.

关键词： Excited-state intramolecular proton transfer Organic solid-state laser Wide gain interval Near-infrared emission Molecular design