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Chemical Research in Chinese Universities 2024年第1期40卷 136-144页

作者： DU Xiaohui li Encheng WANG Qi YOU xin Lung Cancer Transitional Medicine Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Scientific Research Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Respiratory Medicine The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China

Lung cancer produces a high incidence of malignant *** have been many studies on lung cancer using mass spectrometry(MS)***,most studies have focused on humoral *** this work,26 pairs of tissue samples(tumor ***-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition *** total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor ***-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,*** results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung *** is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

关键词： Lung cancer Proteome Data-independent aquisition

Crocus genome reveals the evolutionary origin of crocin biosynthesis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1878-1891页

作者： Zhichao xu Shanshan Chen Yalin Wang Ya Tian Xiaotong Wang Tianyi xin Zishan li xin Hua Shengnan Tan Wei Sun Xiangdong Pu Hui Yao Ranran Gao Jingyuan Song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Engineering Research Center of Chinese Medicine ResourceMinistry of EducationBeijing 100193China College of life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia MedicaBeijing 100700China Analysis and Testing Center of Northeast Forestry University Harbin 150040China School of Pharmacy Anhui Medical UniversityInflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230032China

Crocus sativus (saffron) is a globally autumn-flowering plant, and its stigmas are the most expensive spice and valuable herb medicine. Crocus specialized metabolites, crocins, are biosynthesized in distant species, Gardenia (eudicot) and Crocus (monocot), and the evolution of crocin biosynthesis remains poorly understood. With the chromosome-level Crocus genome assembly, we revealed that two rounds of lineage-specific whole genome triplication occurred, contributing important roles in the production of carotenoids and apocarotenoids. According to the kingdom-wide identification, phylogenetic analysis, and functional assays of carotenoid cleavage dioxygenases (CCDs), we deduced that the duplication, site positive selection, and neofunctionalization of Crocus-specific CCD2 from CCD1 members are responsible for the crocin biosynthesis. In addition, site mutation of CsCCD2 revealed the key amino acids, including I143, L146, R161, E181, T259, and S292 related to the catalytic activity of zeaxanthin cleavage. Our study provides important insights into the origin and evolution of plant specialized metabolites, which are derived by duplication events of biosynthetic genes.

关键词： Crocus sativus WGT Crocin biosynthesis Carotenoids Apocarotenoids CCDs

High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-Yu Si Zhong-liang li Wen-Hong Jia lian xue Hong-xin Luo Jian-Cai xu Bai-Fei Shen lin-Gang Zhang liang-liang Ji Yu-xin Leng Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a Si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was *** result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet ***,this is the firstly systematic study on the hard X-ray polarimeter in China,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

Cucurbit[n]uril-based nanostructure construction and modification

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Chinese Chemical Letters 2024年第8期35卷 138-148页

作者： lijun Mao Shuo li xin Zhang Zhan-Ting li Da Ma School of Pharmaceutical Engineering&Institute for Advanced Studies Taizhou UniversityJiaojiang 318000China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

New fabrication method of nanostructures is of great importance for the applications of nanoscience and *** review summarizes cucurbit[n]uril(CB[n])-based nanostructure fabrication and modification *** strategies include the use of CB[n]s as building blocks and supramolecular crosslinkers to fabricate nanostructures,to surface modify nanostructures,and as gatekeepers to control the release of encapsulated *** nanostructures are used for drug delivery,bioimaging,chemical sensing,catalysis and other ***[n]s often play a vital role in the fabrication of these nanos-tructures,and the realization of the applications.

关键词： Cucurbit[n]uril Nanostructure Host-guest interaction Nanofabrication

Primary pulmonary meningioma and minute pulmonary meningothelial-like nodules: Rare pulmonary nodular lesions requiring more awareness in clinical practice

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World Journal of Clinical Cases 2024年第11期12卷 1857-1862页

作者： li-Dan liu Ke-xin Zhang Hai-Ning Zhang Yi-Wen Zheng Hong-Tao xu Department of Pathology The First Hospital and College of Basic Medical Sciences of China Medical UniversityShenyang 110001Liaoning ProvinceChina

In this editorial,we comment on an article by Ruan et al published in a recent issue of the World Journal of Clinical *** meningothelial proliferative lesions,including primary pulmonary meningiomas,minute pulmonary meningothelial-like nodules,and metastatic pulmonary meningiomas are rare pulmonary *** lesions are difficult to differentiate from lung cancers based on clinical and imaging ***,we briefly introduce the clinical,imaging,and pathological characteristics of these lesions and discuss their pathogenesis to strengthen the current understanding of pulmonary meningothelial proliferative lesions in clinical diagnosis and therapy.

关键词： Pulmonary meningothelial proliferation Primary pulmonary meningioma Minute pulmonary meningothelial-like nodule Lung neoplasm Rare pulmonary nodular lesion

Basal physiological parameters in domesticated tree shrews(Tupaia belangeri chinensis)

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Zoological Research 2013年第2期34卷 69-74页

作者： Jing WANG xin-li xu Ze-Yang DING Rong-Rong MAO Qi-xin ZHOU Long-Bao LV li-Ping WANG Shuang WANG Chen ZHANG lin xu Yue-Xiong YANG Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and MemoryKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 100049China School of life Sciences Anhui UniversityHefei 230601China Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Tree Shrew Inbreeding Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational *** advantages such as simplicity of breeding,low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model *** features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human ***,basal physiological indexes of tree shrew,especially those related to human disease,have not been systematically ***,we established important basal physiological indexes of domesticated tree shrews including several factors:(1)body weight,(2)core body temperature and rhythm,(3)diet metabolism,(4)locomotor rhythm,(5)electroencephalogram,(6)glycometabolism and(7)serum and urinary hormone level and urinary cortisol *** compared the physiological parameters of domesticated tree shrew with that of rats and *** showed that(a)the core body temperature of the tree shrew was 39.59±0.05°C,which was higher than that of rats and macaques;(b)Compared with wild tree shrews,with two activity peaks,domesticated tree shrews had only one activity peak from 17:30 to 19:30;(c)Compared with rats,tree shrews had poor carbohydrate metabolism ability;and(d)Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews,which matched activity peaks in wild tree *** results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.

关键词： Domesticated tree shrew Basal physiological indexes Rhythm Glycometabolism Stress-related hormone

A GMDA clustering algorithm based on evidential reasoning architecture

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG xin GUAN Xiao YI Shuangming li Guidong SUN Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-EC)is ***,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is ***,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the ***,the performance of the algorithm is verified by the synthetic dataset and the measured *** experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model

Tensile strength behavior of cement-stabilized dredged sediment reinforced by polypropylene fiber

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 380-392页

作者： Lei LANG Jiangshan li xin CHEN lijun HAN Ping WANG State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicChinese Academy of SciencesWuhan 430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

This study evaluated the feasibility of using polypropylene fiber(PF)as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment(CDS).The effects of cement content,water content,PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength ***,the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS(CPFDS)were clarified via analyzing macro failure and microstructure *** results indicate that the highest tensile strengths of 7,28,60,and 90 d CPFDS were reached at PF contents of 0.6%,1.0%,1.0%,and 1.0%,exhibiting values 5.96%,65.16%,34.10%,and 35.83%higher than those of CDS,***,3 mm,PF of showed the best reinforcement *** CPFDS exhibited obvious tensile strain-hardening characteristic,and also had better ductility than *** mix factor(C_(C)^(a)/C_(w)^(b))and time parameter(q_(t0)(t))of CDS,and the reinforcement index(k_(t-PF))of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS,considering multiple *** PF“bridge effect”and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior *** key findings contribute to the use of CPFDS as recycled engineering soils.

关键词： dredged sediment chemical stabilization fiber reinforcement splitting tensile strength micro-mechanisms

基于1∶80缩比实验机的离心熔铸模拟实验研究

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兵工学报 2018年第8期39卷 1601-1606页

作者：徐鑫莉张心明蔡鹏于阳赵立新长春理工大学机电工程学院吉林长春130022 长春工程学院吉林长春130012 中国第一汽车集团有限公司吉林长春130011 中国科学院长春光学精密机械与物理研究所吉林长春130033 吉林省留学回国人员和专家服务中心吉林长春130022

在实验室环境下进行非球面镜离心熔铸实验,研究大口径非球面镜的离心熔铸技术,并验证研究方法的可行性。通过对大口径非球面镜离心熔铸工艺的温度场相似准则和缩比模型参数匹配方法的研究,设计1∶80离心熔铸环境相似缩比实验机,进行物... 详细信息

在实验室环境下进行非球面镜离心熔铸实验,研究大口径非球面镜的离心熔铸技术,并验证研究方法的可行性。通过对大口径非球面镜离心熔铸工艺的温度场相似准则和缩比模型参数匹配方法的研究,设计1∶80离心熔铸环境相似缩比实验机,进行物理模拟实验。测量了缩比实验的温度场、应力场以及最终的镜胚面形偏差。实验结果与仿真结果对比显示,温度场测量结果与仿真结果的相对误差在1.0%~1.4%之间。非球面镜在转变温度附近采取适当保温工艺后,最大压应力降为0.98 MPa.通过轮廓仪检测制得的非球面镜面形偏差为-83.823 3μm,与仿真结果相符。采用仿真联合缩比实验的方法对离心熔铸工艺中的不可观测量进行研究,为离心熔铸工艺提供了理论参考依据和实验指导。

关键词：非球面镜离心熔铸相似性准则缩比模型温度场

Laminar Flame Instability of n-Hexane,n-Octane,and n-Decane in Spherical Expanding Flames

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Journal of Thermal Science 2024年第3期33卷 1189-1199页

作者： YIN Geyuan HU Erjiang li Xiaotian LV xin HUANG Zuohua State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China United Automotive Electronic Systems Co. LtdShanghai201206China Chongqing Changan Automobile Co. Ltd.Chongqing401120China

This paper focuses on the laminar flame instability of three high molecular weight n-alkanes,namely n-hexane,n-octane,and *** experiment was carried out in a constant volume combustion bomb to get the flame *** critical radius under different conditions was extracted using the image processing *** with the existing critical Peclet number theory,the dominant factors of flame instability under current conditions for three n-alkanes can be figured ***,the average cell size(equivalent cell radius,R_(cell))was extracted to provide quantitative analysis of the flame cellular structure,based on the method developed in this *** theoretical R_(cell)were also calculated and compared with the experimental results to validate the proposed method.

关键词： cellular instability equivalent cell radius critical Peclet number spherical flame