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Syndiotactic Polymerization of Styrene and Copolymerization with Ethylene Catalyzed by Chiral Half-sandwich Rare-earth Metal Dialkyl Complexes

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Chinese Journal of Polymer Science 2018年第2期36卷 222-230页

作者： De-Qian Peng xin-wen yan Shao-wen Zhang Xiao-Fang Li Key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical Engineering Beijing Institute of Technology

The syndiotactic polymerization of styrene（St） and the copolymerization of St with ethylene（E） were carried out by using a series of chiral half-sandwich rare-earth metal dialkyl complexes（Cp^x＊） as the catalysts. The complexes are Ln（CH2SiMe3）2（THF）（1-4： Ln = Sc（1）, Ln = Lu（2）, Ln = Y（3）, Ln = Dy（4）） bearing chiral cyclopentadienyl ligand containing bulky cylcohexane derivatives in the presence of activator and AliBu3. For the St polymerization, a high activity up to 3.1 × 10^6 g of polymer mol Ln^-1·h^-1 and a high syndiotactic selectivity more than 99% were achieved. The resulting syndiotactic polystyrenes（sPSs） have the molecular weights（Mn） ranging from 3700 g·mol^-1 to 6400 g·mol^-1 and the molecular weight distributions（Mw/Mn） from 1.40 to 5.03. As for the copolymerization of St and E, the activity was up to 2.4 × 10^6 g of copolymer mol Sc^-1·h^-1·MPa^-1, giving random St-E copolymers containing syndiotactic polystyrene sequences with different St content in the range of 15 mol%-58 mol%. These results demonstrate that the bulky cyclopentadienyl ligands of the chiral half-sandwich rare-earth metal complexes effectively inhibit the continued insertion of St monomers into the（co）polymer chain to some extent in comparison with the known half-sandwich rare-earth metal complexes.

关键词： Half-sandwich Rare-earth metal complex Syndiotacti cpolymerization Copolymerization Styrene Ethylene

Follicular dendritic cell sarcoma detected in hepatogastric ligament:A case report and review of the literature

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World Journal of Clinical Cases 2019年第1期7卷 116-121页

作者： wen-xin yan You-Xi Yu Ping Zhang xing-Kai Liu yan Li Department of Hepatobiliary and Pancreatic Surgery the First Hospital of Jilin University Department of Surgery School of Medicine University of Louisville

The most common organ where follicular dendritic cell sarcoma(FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that FDCS occurs in the hepatogastric ligament. To our knowledge, there is no such case that has been reported previously. A 47-year-old male patient was found to have an intraabdominal mass during an annual physical examination. Computed tomography showed a 4.2 cm × 4.1 cm mass located at the lesser curvature of the stomach, above the pancreas. During operation, a tumor mass was found in the hepatogastric ligament and a radical resection was performed. The tumor was diagnosed as FDCS by pathology and immunohistochemical testing. The patient had a favorable recovery, and no obvious abnormality was found 3 months postoperation.

关键词： Follicular dendritic cell sarcoma Hepatogastric ligament Pathology Immunohistochemistry Computed tomography Case report

Prevalence and impact of diabetes in patients with COVID-19 in China

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World Journal of Diabetes 2020年第10期11卷 468-480页

作者： Min Du Yu-xin Lin wen-xin yan Li-Yuan Tao Min Liu Jue Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100083China

BACKGROUND Coronavirus disease 2019(COVID-19)is an emerging infectious disease that has spread rapidly around the *** studies have indicated that COVID-19 patients with diabetes are prone to having poor clinical *** To systematically evaluate the prevalence of diabetes among COVID-19 patients in China and its impact on clinical outcomes,including ICU admission,progression to severe cases,or *** We searched studies published in PubMed,Web of Science,and EMBASE from December 1,2019 to March 31,2020 to identify relevant observational study that investigated the prevalence of diabetes among COVID-19 patients or its impact on clinical *** used a random-effects or fixed-effects model to estimate the pooled prevalence of diabetes and risk ratio(RR)and its 95%confidence interval(CI)of diabetes on *** plots were used to evaluate the publication bias and the heterogeneity was evaluated by I2 *** Twenty-three eligible articles including 49564 COVID-19 patients(1573 with and 47991 without diabetes)were finally *** pooled prevalence of diabetes was 10%(95%CI:7%-15%)in COVID-19 *** the subgroup analyses,the pooled prevalence of diabetes was higher in studies with patients aged>50 years(13%;95%CI:11%-16%)than in studies with patients aged≤50 years(7%;95%CI:6%-8%),in severe patients(17%;95%CI:14%-20%)than in non-severe patients(6%;95%CI:5%-8%),and in dead patients(30%;95%CI:13%-46%)than in survivors(8%;95%CI:2%-15%)(P<0.05 for all).Compared with patients without diabetes,the risk of severe cases was higher(RR=2.13,95%CI:1.76-2.56,I2=49%)in COVID-19 patients with *** risk of death was also higher in COVID-19 patients with diabetes(RR=3.16,95%CI:2.64-3.78,I2=34%).However,diabetes was not found to be significantly associated with admission to ICU(RR=1.16,95%CI:0.15-9.11).CONCLUSION Nearly one in ten COVID-19 patients have diabetes in *** is associated with a higher risk of severe illne

关键词： Diabetes COVID-19 Systematic review Meta-analysis

Absorption,Accumulation and Distribution of Zinc in Highly-Yielding Winter Wheat

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Agricultural Sciences in China 2010年第7期9卷 965-973页

作者： DANG Hong-kai,LI Rui-qi,SUN Ya-hui,ZHANG xin-wen and LI yan-ming College of Agronomy,Agricultural University of Hebei,Baoding 071000,P.R.China College of Agronomy Agricultural University of Hebei Baoding 071000 P.R. China

Zinc（Zn） is an important essential microelement for *** order to study the characteristics of Zn absorption,accumulation and distribution in highly-yielding winter wheat（with a grain yield of 9 000 kg ha-1）,field experiments were conducted in Gaocheng County of Hebei Province,*** winter wheat cultivars,i.e.,Shimai 14,Jifeng 703,Shimai 12,and Shixin 828,and four cultivars,i.e.,Temai 1,Shimai 12,Shixin 531,and Shixin 828,were used in the experiment,during 2004-2005 and 2005-2006,*** samples were taken from the plots at each growing stage for Zn concentration *** main results showed that the concentration of Zn in various above-ground organs of wheat was 9.5-112.5 mg kg-1 at different growing *** organ with the highest Zn concentration differed with the change of growth center at different growing *** of Zn in leaf blades was the highest among all the organs during early growing period,and more than 50% of the Zn accumulation was distributed to leaf blades before jointing,and higher than that to other *** late growing period,however,the accumulation of Zn in grains was the highest,and 58.1% of the Zn accumulation was distributed in grains at *** total accumulation of Zn in wheat plant during its life span ranged from 384.9 to 475.9 g *** amount of Zn required for the formation of 100 kg grain yield ranged from 4.3 to 5.2 *** the organs were ordered in such a sequence that leaf blades 〉 spikes 〉 leaf sheaths 〉 stems according to their net absorption and transportation of Zn as well as their contribution to Zn accumulation in grains.58.2-60.3% of the Zn accumulated in grains was redistributed from other organs,mostly from leaf *** and accumulation of Zn in all the organs of wheat was high during early and middle growing periods,while accumulation of Zn in grains during late growing period mainly depended on the redistribution from other *** to these characterist

关键词： winter wheat highly-yielding zinc (Zn) absorption accumulation distribution

2005-2013年中国肿瘤登记地区肺癌流行和疾病负担时间趋势分析

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中华肿瘤防治杂志 2019年第15期26卷 1059-1065页

作者：辛雯艳黄磊闫贻忠石河子大学医学院第一附属医院呼吸内科新疆石河子832000 石河子大学医学院第一附属医院超声科新疆石河子832000 石河子大学医学院预防医学系新疆石河子832000

目的通过分析中国肿瘤登记地区2005-2013年肺癌发病率、死亡率和疾病负担的时间趋势,为中国肺癌的防控和预测工作提供依据.方法利用国家肿瘤登记中心发布的2008-2016年《中国肿瘤登记年报》中的肺癌相关数据,分析肺癌发病率、死亡率... 详细信息

目的通过分析中国肿瘤登记地区2005-2013年肺癌发病率、死亡率和疾病负担的时间趋势,为中国肺癌的防控和预测工作提供依据.方法利用国家肿瘤登记中心发布的2008-2016年《中国肿瘤登记年报》中的肺癌相关数据,分析肺癌发病率、死亡率及伤残调整寿命年(disability adjusted life year,DALY)等指标,并通过Joinpoint回归进行时间趋势分析.结果 2005-2013年,肺癌发病率整体呈上升趋势〔年度变化百分比(annual percent change,APC)=1·76%,P0.05).其中,肺癌发病率的男女、城乡比值(APC分别为-1·78%和-1.02%,均P0.05.结论 2005-2013年,中国肺癌流行趋势及造成的疾病负担均严峻,且呈增长趋势,尤其是女性和农村居民,应重点关注.

关键词：肺癌发病率死亡率疾病负担 Joinpoint回归

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

2010—2018年新疆生产建设兵团第八师肺癌流行特征与疾病负担研究

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中国肿瘤 2020年第7期29卷 514-519页

作者：高岩王蓓赵京辛雯艳石河子大学医学院第一附属医院新疆石河子832002 石河子市疾病预防控制中心新疆石河子832002

[目的]分析2010—2018年新疆生产建设兵团第八师肺癌的发病、死亡及疾病负担情况。[方法]根据2010—2018年第八师肿瘤登记数据计算相关指标,包括肺癌发病率、死亡率、年龄标化率、伤残调整寿命年(disability adjusted life year,DALY)... 详细信息

[目的]分析2010—2018年新疆生产建设兵团第八师肺癌的发病、死亡及疾病负担情况。[方法]根据2010—2018年第八师肿瘤登记数据计算相关指标,包括肺癌发病率、死亡率、年龄标化率、伤残调整寿命年(disability adjusted life year,DALY)及年度变化百分比(annual percentage change,APC)等。[结果]2010—2018年第八师居民肺癌发病率、死亡率分别为37.22/10万和23.84/10万,男性均高于女性(P均40岁的人群中上升明显,且主要集中在≥60岁的人群。2010—2018年第八师居民肺癌发病率、死亡率呈上升趋势,APC分别为9.02%、11.83%。第八师居民肺癌每千人早死所致寿命损失率(YLL)、伤残所致健康寿命损失年(YLD)、DALY分别为2.85、0.06、2.90,男性均高于女性(P均<0.05)。男性、女性疾病负担高峰值均在75~79岁组。[结论]2010—2018年第八师居民肺癌发病和死亡水平较高,早死是其疾病负担的主要来源,应重点对60岁及以上人群开展早诊早治,降低第八师肺癌流行水平。

关键词：肺癌发病率死亡率疾病负担新疆

2005-2014年中国老年人肺癌发病的时间趋势分析

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现代预防医学 2020年第12期47卷 2113-2116页

作者：辛雯艳黄磊闫贻忠石河子大学医学院第一附属医院石河子大学医学院预防医学系

目的分析2005-2014年我国老年人肺癌发病的时间趋势,为我国肺癌的防控工作提供依据。方法根据2008-2017年《中国肿瘤登记年报》中肺癌的相关数据,分析2005-2014年我国老年人肺癌的发病情况,并通过年度变化百分比(annual percentage chan... 详细信息

目的分析2005-2014年我国老年人肺癌发病的时间趋势,为我国肺癌的防控工作提供依据。方法根据2008-2017年《中国肿瘤登记年报》中肺癌的相关数据,分析2005-2014年我国老年人肺癌的发病情况,并通过年度变化百分比(annual percentage change,APC)分析其时间变化趋势。结果 2005-2014年我国老年人肺癌的发病率呈上升趋势(APC=0.71%,P<0.05),其中农村老年人肺癌的发病率从198.9/105上升至250.7/105,上升趋势更明显(APC=2.81%,P<0.05),尤以农村老年女性肺癌发病率的上升趋势最为明显(APC=5.26%,P<0.05)。2005-2014年中国老年人肺癌的发病在60～64岁和65～69岁组呈上升趋势(APC分别为2.83%和2.04%,均P<0.05),而在农村地区,老年人所有年龄组的肺癌发病率都呈明显上升趋势(APC分别为3.49%,3.86%,1.66%,2.31%,3.49%及6.37%,均P<0.05)。结论2005-2014年我国老年人肺癌发病上升趋势明显,以农村老年女性最为突出,国家应针对高危人群及早开展筛查等工作,降低我国老年人肺癌的流行水平。

关键词：老年人肺癌发病时间趋势

Stochastic Comparisons of Excess Lifetimes of Renewal Processes Based upon Generalized Stochastic Orderings

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Stochastic Comparisons of Excess Lifetimes of Renewal Proces...