检索结果-南通市图书馆

Efficacy of Yiqi Jianpi anti-cancer prescription combined with chemotherapy in patients with colorectal cancer after operation

引用

World Journal of Clinical Cases 2021年第32期9卷 9869-9877页

作者： Zheng Li Dong-Feng Yin wei Wang xin-wei zhang Li-Jiang Zhou Jun Yang Graduate School Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Oncology Department The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Liaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina

BACKGROUND At present,colorectal cancer is routinely treated with adjuvant radiotherapy and chemotherapy *** adverse effects(AEs)of chemotherapy usually interrupt the treatment of *** Chinese medicine(TCM)has demonstrated great potential in improving patients'clinical symptoms,regulating the immune function,improving the life quality,and reducing the AEs of *** To observe the clinical efficacy of Yiqi Jianpi anti-cancer prescription combined with chemotherapy in patients with colorectal cancer after *** Data from patients diagnosed with colorectal cancer between January 2019 and February 2021 were collected from Liaoning Cancer Hospital and Institute and the Second Affiliated Hospital of Liaoning University of Traditional Chinese *** receiving the chemotherapy regimen of capecitabine plus oxaliplatin(CAPOX)after radical resection of colorectal cancer were prospectively collected and randomly divided into an experimental group and a control *** experimental group was given Yiqi Jianpi anti-cancer prescription combined with the CAPOX regimen,while the control group was given the CAPOX regimen *** six cycles of chemotherapy,the scores of TCM symptoms,Karnofsky performance scale(KPS)score,levels of T-cell subsets,and AEs after chemo therapy of the two groups were *** A total of 70 patients were randomly divided into either an experimental group(n=35,no dropout)or a control group(n=33,with 2 dropouts).Compared with the control group,the experimental group improved significantly(P<0.05)in scores of TCM symptoms,KPS score,levels of T-cell subsets,and AEs of *** Yiqi Jianpi anti-cancer prescription can effectively improve spleen deficiency,regulate the immune function,and alleviate the AEs of chemotherapy,so as to improve the life quality of patients with good therapeutic effects and application prospect in clinical practice.

关键词： Yiqi Jianpi Anti-cancer Postoperative colorectal cancer Immune function Life quality Chemotherapy Adverse effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

引用

China Ocean Engineering 2024年第3期38卷 453-466页

作者： zhang Guo-xing XIA xin-lu GUO Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improving hydrogen storage thermodynamics and kinetics of Ce-Mg-Ni-based alloy by mechanical milling with TiF_(3)

引用

Journal of Magnesium and Alloys 2024年第4期12卷 1593-1607页

作者： Hongwei Shang wei zhang xin wei Yaqin Li Zeming Yuan Jun Li Yanghuan zhang School of Mechanical and Electrical Engineering Chuzhou UniversityChuzhou 239000China Department of Functional Material Research Central Iron and Steel Research InstituteNo.76 Xueyuannan RoadHaidian DistrictBeijing 100081China Key Laboratory of Integrated Exploitation of Bayan-Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China China Rare Earth New Material(weishan)Co. Ltd.Jining 277600China

Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not *** efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and *** this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental *** alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%*** phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and *** revealed that nanocrystalline appeared in the as-milled *** with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase *** addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more *** milling and adding TiF_(3)distinctly improved the activation and kinetics of the ***,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.

关键词： Mg-based hydrides TiF_(3) Ball milling Thermodynamics Kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congenital agenesis of seminal vesicle

引用

Asian Journal of Andrology 2005年第4期7卷 449-452,页

作者： Hong-Fei Wu Di Qiao Li-xin Qian Ning-Hong Song Ning-Han Feng Li-xin Hua wei zhang Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Congenital agenesis of the seminal vesicle （CASV） is frequently associated with congenital absence of the vas deferens （CAVD） or ipsilateral congenital vasoureteral communication. We reported two cases of a rare condition that the vas deferens open ectopically into Mullerian duct cyst associated with agenesis of the ipsilateral seminal vesicle. The diagnosis was confirmed by vasography. Transurethral unroofing of the Mullerian duct cyst was performed in both patients with favourable results, however, assisted reproductive technology （ART） was still necessary for them to father children.

关键词： seminal vesicle vas deferens congenital abnormalities vasography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regional Differences and Characteristics of Soil Organic Carbon Density Between Dry Land and Paddy Field in China

引用

Agricultural Sciences in China 2007年第8期6卷 981-987页

作者： XU Quan RUI Wen-yi BIAN xin-min zhang wei-jian Institute of Applied Ecology Nanjing Agricultural University Nanjing 210095 P.R.China

Study on the regional characteristics of soil organic carbon （SOC） density in farmland will not only contribute greatly to the technique of soil productivity enhancement, but also give evidences of technique selection and policy making for carbon sequestration in soils. Based on the second national soil survey of China, the situation of SOC density in the plow layer of farmland was analyzed under different land use patterns. Results showed that SOC density in the plow layer was about 3.15 kg m^-2 in average ranging from 0.81 to 12.68 kg m^-2. The highest density was found in the southeastern region with an average of 3.63 kg ma, while the lowest occurring in the northwestern region with an average of 3.00 kg m^-2. The variation coefficient of SOC density in the plow layer of farmland was 57%, which was 35% lower than that of non-farmland soils. Compared to SOC density in the dry land, SOC density in paddy soils was 13% higher with a lower variation coefficient between different regions. In addition, the relationships between the climatic factors （annual average temperature and precipitation） and SOC density were lower in farmland than those in non-farmland soils, as well as lower in paddy soils than those in dry land of farmland. These results suggest that anthropogenic disturbances have great impacts on SOC density in farmland soils, especially in paddy soils, indicating that Chinese rice cropping may contribute greatly to the SOC stability and sequestration in paddy field.

关键词： land use pattern organic carbon density carbon sequestration regional difference global change

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Subchronic Toxicity Study on Soy Isoflavones in Rats

引用

Biomedical and Environmental Sciences 2009年第3期22卷 259-264页

作者： WEN-ZHONG zhang WEN-MING CUI xin zhang wei WANG XU-DONG JIA XIAO-PENG zhang NING LI Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100021 China

Objective To investigate the subchronic toxicity of soy isoflavones （SIF） in male rats. Method Fifty Sprague-Dawley rats were randomly divided into 5 groups, 10 rats per group. SIF were given to rats in different groups by gavage at dose of 0, 0.2, 0.5, 1.5, and 4.5 g/kg bw, respectively for 13 weeks. Clinical manifestations, body weight, and food consumption were observed weekly. At the end of the study, urinalysis, hematology, clinical chemistry, total testosterone, and follicle-stimulating hormone were tested, and histopathological examinations were performed. Results No mortality, ophthalmic abnormalities or treatment-related clinical signs were identified during the study. As compared with the control group, significantly lower body weights and food consumption were observed in 1.5 and 4.5 g/kg bw groups. In clinical chemistry tests, triglyceride was significantly decreased and high-density lipoprotein cholesterol was significantly increased in all SIF-treated groups. Total testosterone levels were significantly lower in 0.50, 1.50, and 4.5 g/kg bw dose groups than in the control group. Microscopic examination showed that the mammary glands exhibited hyperplasia and excreted latex in rats of the 4.5 g/kg bw group. No changes attributable to treatment of SIF in other parameters were found. Conclusion SIF at high dosages caused significant endocrine disruption in male rats. The no observed adverse effect level （NOAEL） of SIF to male rats in this study is considered to be 0.20 g/kg bw.

关键词： Soy isoflavone Rat Subchronic toxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimal Strategy for Aircraft Pursuit-evasion Games via Self-play Iteration

引用

Machine Intelligence Research 2024年第3期21卷 585-596页

作者： xin Wang Qing-Lai wei Tao Li Jie zhang State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Institute of Systems Engineering Macao University of Science and TechnologyMacao999078China

In this paper,the pursuit-evasion game with state and control constraints is solved to achieve the Nash equilibrium of both the pursuer and the evader with an iterative self-play *** the condition where the Hamiltonian formed by means of Pontryagin’s maximum principle has the unique solution,it can be proven that the iterative control law converges to the Nash equilibrium ***,the strong nonlinearity of the ordinary differential equations formulated by Pontryagin’s maximum principle makes the control policy difficult to figured *** the system dynamics employed in this manuscript contains a high dimensional state vector with *** practical applications,such as the control of aircraft,the provided overload is ***,in this paper,we consider the optimal strategy of pursuit-evasion games with constant constraint on the control,while some state vectors are restricted by the function of the *** address the challenges,the optimal control problems are transformed into nonlinear programming problems through the direct collocation ***,two numerical cases of the aircraft pursuit-evasion scenario are given to demonstrate the effectiveness of the presented method to obtain the optimal control of both the pursuer and the evader.

关键词： Differential games pursuit-evasion games nonlinear control optimal control Nash equilibrium solution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced thermoelectric and mechanical properties of Bi_(0.5)Sb_(1.5)Te_(3) alloy with dispersed yttrium oxide ceramic nanoparticles

引用

Rare Metals 2024年第4期43卷 1758-1768页

作者： Cun-Cheng Li Ming-wei zhang Ji-Wu xin Lei wei Wen-Yu Zhao School of Materials Science and Engineering Shandong University of TechnologyZibo255000China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China

Reducing thermal conductivity while avoiding adverse interfacial reactions during sintering is crucial for improving the thermoelectric performance of Bi_(2)Te_(3)based *** ceramic nanoparticles are good candidates for achieving this *** this study,we designed and prepared a series of p-type Bi_(0.5)Sb_(1.5)Te_(3)nanocomposites decorated with Y_(2)O_(3)ceramic nanoparticles via ball-milling dispersion and spark-plasma *** to the chemical stability of the ceramics,no traces of atomic doping or interfacial reactions were *** measurements revealed that the Y_(2)O_(3)nanoparticles distributed along the grain boundaries acted as energy-dependent carrier-filtering centers to improve the scattering parameter and Seebeck coefficient,contributing to the elevated power factor even with a decreased electrical ***,the incorporated Y_(2)O_(3)nanoparticles and various defect structures they induced effectively strengthened the phonon scattering and suppressed the lattice thermal ***,a peak figure of merit(ZT)of 1.23 at 313 K was achieved for 0.4%Y_(2)O_(3)/Bi_(0.5)Sb_(1.5)Te_(3),which is 13%higher than that of the *** addition,the Vickers hardness of the composite material was 35%higher than that of the *** study demonstrates the effectiveness of ceramic nanoparticles in synergistic ally improving the thermoelectric and mechanical properties,which may be further extended to other thermoelectric systems.

关键词： Bi_(0.5)Sb_(1.5)Te_3 alloy Y_(2)O_(3) ceramic nanoparticles Microstructures Thermoelectric performance Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis

引用

Cancer Biology & Medicine 2015年第2期12卷 126-139页

作者： Jie-Ying Chen Ya-Nan Cheng Lei Han Feng wei Wen-Wen Yu xin-wei zhang Shui Cao Jin-Pu Yu Department of Immunology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Immunology and Biotherapy Cancer Molecular Diagnostic Core Laboratory Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Immunology and Biotherapy Biotherapy Center Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Immunology and Biotherapy

Objective： A meta-analysis was performed to augment the insufficient data on the impact of mutative EGFR downstream phosphatidylinositol-3-kinase （PI3K） and mitogen-activated protein kinase （MAPK） pathways on the clinical efficiency of epidermal growth factor receptor tyrosine kinase inhibitor （EGFR-TKI） treatment of non-small cell lung cancer （NSCLC） patients. Methods： Network databases were explored in April, 2015. Papers that investigated the clinical outcomes of NSCLC patients treated with EGFR-TKIs according to the status of K-ras and/or PIK3CA gene mutation were included. A quantitative meta-analysis was conducted using standard statistical methods. Odds ratios （ORs） for objective response rate （ORR） and hazard ratios （HRs） for progression-free survival （PFS） and overall survival （OS） were calculated. Results： Mutation in K-ras significantly predicted poor ORR [OR =0.22; 95% confidence interval （CI）, 0.13-0.35], shorter PFS （HR =1.56; 95% CI, 1.27-1.92）, and shorter OS （HR =1.59; 95% CI, 1.33-1.91） in NSCLC patients treated with EGFR-TKIs. Mutant PIK3CA significantly predicted shorter OS （HR =1.83; 95% CI, 1.05-3.20）, showed poor ORR （OK =0.70; 95% CI, 0.22-2.18）, and shorter PFS （HR = 1.79; 95% CI, 0.91-3.53） in NSCLC patients treated with EGFR-TKIs. Conclusion： K-ras mutation adversely affected the clinical response and survival of NSCLC patients treated with EGFR- TKIs. PIK3CA mutation showed similar trends. In addition to EGFR, adding K-ras and PIK3CA as routine gene biomarkers in clinical genetic analysis is valuable to optimize the effectiveness of EGFR-TKI regimens and identify optimal patients who will benefit from EGFR-TKI treatment.

关键词： Non-small cell lung cancer (NSCLC) tyrosine kinase inhibitor (TKI) targeted therapy K-ras PIK3CA meta-analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of pre-pregnancy body mass index on pregnancy outcomes

引用

Chinese Medical Journal 2013年第23期126卷 4585-4587页

作者： LI Chun-ming LI Guang-hui CHEN Yi RUAN Yan WANG xin zhang wei-yuan Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Prevalence of overweight and obesity has continued to increase among women of child bearing age all over the world in recent decades. Its impact on short-term and long-term maternal and fetal outcomes continued to grow, such as increased risk of gestational diabetes mellitus, gestational hypertension, preeclampsia, fetal macrosomia, perinatal mortality and chance for cesarean deliveries） What＇s more, underweight before pregnancy also has some hazardous effects on pregnant women and fetus, such as increased risk of delivering infants small for gestational age and preterm delivery.2 The present study determined the prevalence of each body mass index （BMI） group of an obstetric population of the mainland of China, and effects of the maternal pre-pregnancy BMI on multiple antepartum, intrapartum and neonatal outcomes.

关键词： body mass index obesity gestational diabetes mellitus preeclampsia fetal macrosomia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：