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Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys

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Zoological Research 2020年第4期41卷 444-448页

作者： Zhen-hui Li Xia-Ping He Hao Li Rong-Qiao He xin-tian hu Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingVt/nnan 650204China School of Basic Medical Sciences Dali UniversityDaliYunnan 671000China CAS Center for Excellence in Brain Science Chinese Academy of SciencesShanghai 200031China Kunming Primate Research Center and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Chinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of ScienceBeijing 100101China

DEAR EDITOR,Rhesus monkeys(Macaca mulatta)are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans(Zhang et al.,2014).Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans,including formation of senile plaques in the brain(Beckman et al.,2019;Paspalas et al.,2018).

关键词： al. senile amyloid

Transmission characteristics of EM wave in a finite thickness plasma

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Acta Mechanica Sinica 2013年第2期29卷 189-195页

作者： Nai-Yi Zhu Li-Shun huang Bin Wu Xi-Long Yu Run-hui Wu Gang Meng Ai-Min Ren xin-tian hu State Key Lab of High Temperature Gas Dynamics(LHD) Institute of MechanicsChinese Academy of Sciences State Key Lab of Experimental Physics and Computational Mathematics China Aerospace Technology Corporation

One of the key factors for solving the problems of re-entry communication interruption is electromagnetic（EM） wave transmission characteristics in a *** and experimental studies were carried out on specific transmission characteristics for different plasma sheath characteristic under thin sheath condition in re-entry *** paper presents systematic studies on the variations of wave attenuation characteristics versus plasma sheath thickness L,collision frequency ν,electron density n e and wave working frequency f in a φ 800 mm high temperature shock *** experiments,L is set to 4 cm and 38 cm.ν is 2 GHz and 15 GHz.n e is from 1×10 10 cm（-3） to 1×10 13 cm（-3）,and f is set to 2,5,10,14.6 GHz,***,Wentzel-Kramers-Brillouin（WKB） and finite-difference time-domain（FDTD） methods are adopted to carry out theoretical simulation for comparison with experimental *** is found that when L is much larger than EM wavelength λ（thick sheath） and ν is large,the theoretical result is in good agreement with experimental one,when sheath thickness L is much larger than λ,while ν is relatively small,two theoretical results are obviously different from the experimental *** means that the existing theoretical model can not fully describe the contribution of ν.Furthermore,when L and λ are of the same order of magnitude（thin sheath）,the experimental result is much smaller than the theoretical values,which indicates that the current model can not properly describe the thin sheath effect on EM attenuation characteristics.

关键词： Plasma·Electromagnetic wave·Shock tube·Numerical simulation

Engrafted newborn neurons could functionally integrate into the host neuronal network

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Zoological Research 2017年第1期38卷 5-6页

作者： Zheng-Bo Wang Dong-Dong Qin xin-tian hu Key Laboratory of Animal Models and human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan 650223 China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China

The limited capability to regenerate new neurons following injuries of the central neural system（CNS）still remains a major challenge for basic and clinical *** stem cells（NSCs）could nearly have the potential to di... 详细信息

关键词： cell NSCs Engrafted newborn neurons could functionally integrate into the host neuronal network

Direct sunlight exposure reduces hair cortisol levels in rhesus monkeys(Macaca mulatta)

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Zoological Research 2019年第6期40卷 583-586页

作者： Xiao-Li Feng He-Long Che Xi Ning Xue-Ying Ba Juan-Li Jing-Fang Zhang Yun Wang Zheng-Fei hu xin-tian hu Xiao-Feng Ren School of Basic Medical Sciences Kunming Medical UniversityKunming Yunnan 650500China Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Department of General Surgery 908th Hospital of Chinese PLA Joint Logistic Support ForceYingtan Jiangxi 335000China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China

DEAR EDITOR,Major depressive disorder (MDD), commonly known as depression, is a mental disease characterized by a core symptom of low mood. It lasts at least two weeks (Badamasi et al., 2019;Wang et al., 2019) and is frequently accompanied by low self-esteem, loss of interest in routinely enjoyable activities, low energy, and unexplained pain (huey et al., 2018;Park et al., 2012;Post & Warden, 2018;Rice et al., 2019;Xiao et al., 2018). Approximately 2%–8% of adults with MDD commit suicide (Richards & O'Hara, 2014;Strakowski & Nelson, 2015), and around half of suicidal individuals suffer depression or other mood disorders (Bachmann, 2018).

关键词： rhesus monkeys hair cortisol levels

Transient neurogenesis in ischemic cortex from Sox2^(+)astrocytes

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Neural Regeneration Research 2023年第7期18卷 1521-1526页

作者： Jia-Lei Yang Hong Fan Fan-Fan Fu Bao-Lin Guo Ying huang Li Sun Wen-Ting Wang Jun-Ling xing xin-tian hu Yu-Qiang Ding Kun Zhang Ying-Zhou hu Ya-Zhou Wang Department of Neurobiology and Institute of Neurosciences School of Basic MedicineFourth Military Medical UniversityXi’anShaanxi ProvinceChina China National Clinical Research Center for Neurological Diseases Department of NeurologyBeijing Tiantan HospitalBeijingChina Department of Neurology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina Key Laboratory of Animal Models and human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan ProvinceChina

The adult cortex has long been regarded as *** injury can induce neurogenesis in the adult cortex is still ***,we report that focal ischemia stimulates a transient wave of local *** 5′-bromo-2′-deoxyuridine labeling,we demonstrated a rapid generation of doublecortin-positive neuroblasts that died quickly in mouse cerebral cortex following ***-Cre^(ER)-based cell ablation and fate mapping showed a small contribution of neuroblasts by subventricular zone neural stem *** a mini-photothrombotic ischemia mouse model and retrovirus expressing green fluorescent protein labeling,we observed maturation of locally generated new ***,fate tracing analyses using PDGFRα-,GFAP-,and Sox2-Cre^(ER) mice showed a transient wave of neuroblast generation in mild ischemic cortex and identified that Sox2-positive astrocytes were the major neurogenic cells in adult *** addition,a similar upregulation of Sox2 and appearance of neuroblasts were observed in the focal ischemic cortex of Macaca *** findings demonstrated a transient neurogenic response of Sox2-positive astrocytes in ischemic cortex,which suggests the possibility of inducing neuronal regeneration by amplifying this intrinsic response in the future.

关键词： adult astrocyte cortex fate-mapping ischemia local neurogenesis neural stem cells Sox2

Visuospatial properties of caudal area 7b in Macaca fascicularis

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Zoological Research 2013年第2期34卷 50-61页

作者： hui-hui JIANG Ying-Zhou hu Jian-Hong WANG Yuan-Ye MA xin-tian hu Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

To proceed from sensation to movement,integration and transformation of information from different senses and reference frames are *** brain areas are involved in this transformation process,but previous neuroanatomical and neurophysiological studies have implicated the caudal area 7b as one particular component of this transformation *** this study,we present the first quantitative report on the spatial coding properties of caudal area *** results showed that neurons in this area had intermediate component characteristics in the transformation system;the area contained bimodal neurons,and neurons in this area encode spatial information using a hybrid reference *** results provide evidence that caudal area 7b may belong to the reference frame transformation system,thus contributing to our general understanding of the transformation system.

关键词： Reference frame Spatial coding Receptive field Area 7b

Low color temperature artificial lighting can slow myopia development: Long-term study using juvenile monkeys

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Zoological Research 2022年第2期43卷 229-233页

作者： Ying-Zhou hu hua Yang Hao Li Long-Bao Lv Jing Wu Zhu Zhu Yu-hua Zhang Fang-Fang Yan Shu-Han Fan Shu-Xiao Wang Jian-Ping Zhao Qiang Qi Chang-Bing huang xin-tian hu Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-human Primates Kunming Primate Research Centerand National Research Facility for Phenotypic and Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China China Academy of Building Research Beijing 100013China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Center for the 3rd Generation Semiconductor Materials and Application Beijing 100083China

The incidence of myopia has increased rapidly in recent decades, suggesting that environmental factors, such as light,may be an important cause. Correlated color temperature(CCT) is a commonly used index to quantify the spectral composition of light. Here, we used 32 juvenile monkeys(16 females and 16 males) and selected four kinds of light with typical but different CCTs to study the relationship between CCT and ocular axial elongation.

关键词： artificial lighting myopia

Meeting report:the 4^(th) symposium on animal models of non-human primates in Kunming,Yunnan,China

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Zoological Research 2016年第6期37卷 361-365页

作者： Jia-Li LI Yong-Tang ZHENG Xu-Dong ZHAO xin-tian hu Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of Sciences

From 2 to 4 November, 2016, the 4th Symposium on Animal Models of Non-human Primates （NHP） was held in Kunming, Yunnan, China. This meeting was organized by the Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences （CAS）＆ Yunnan Province Kunming Primate Research Center （KPRC）, Zoological Research, and Kunming Institute of Zoology （KIZ）, CAS.

关键词： Meeting report symposium on animal models of non-human primates in Kunming,Yunnan,China th

The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria

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Science Bulletin 2017年第12期62卷 820-830页

作者： Ling-Qun Ye hui Zhao He-JiangZhou Xiao-Die Ren Lin-Lin Liu Newton O.Otecko Zheng-boWang Min-Min Yang Lin Zeng xin-tian hu Yong-Gang Yao Ya-Ping Zhang Dong-Dong Wu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan UniversityKunming 650091China Key Laboratory of Animal Models and human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Kunming 650223China Kunming College of Life Science University of Chinese Academy of Scienceskunming 650204China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

RNA editing was first discovered in mitochondrial RNA molecular. However, whether adenosine-toinosine(A-to-I) RNA editing has functions in nuclear genes involved in mitochondria remains ***, we retrieved 707,246 A-to-I RNA editing sites in Macaca mulatta leveraging massive transcriptomes of 30 different tissues and genomes of nine tissues, together with the reported data, and found that A-to-I RNA editing occurred frequently in nuclear genes that have functions in mitochondria. The mitochondrial structure, the level of ATP production, and the expression of some key genes involved in mitochondrial function were dysregulated after knocking down the expression of ADAR1 and ADAR2, the key genes encoding the enzyme responsible for RNA editing. When investigating dynamic changes of RNA editing during brain development, an amino-acid-changing RNA editing site(I234/V) in MFN1, a mediator of mitochondrial fusion, was identified to be significantly correlated with age, and could influence the function of MFN1. When studying transcriptomes of brain disorder, we found that dysregulated RNA editing sites in autism were also enriched within genes having mitochondrial functions. These data indicated that RNA editing had a significant function in mitochondria via their influence on nuclear genes.

关键词：线粒体RNA RNA编辑酶猕猴特性编辑位点核基因体功能动态变化