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Tungsten 2025年第1期 183-194页

作者： xin-ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang Shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

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国内外养老照护评估现状及对我国养老照护分级的启发

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中国全科医学 2017年第30期20卷 3719-3724页

作者：孙欣然孙金海第二军医大学军队健康管理学教研室上海市200433

对老年人进行养老照护评估并进行分级照护是保障养老资源公平分配的基础,然而我国养老照护评估指标与体系尚需完善。本文回顾了国内外养老照护评估现状,从自理能力、认知功能、疾病及健康指标、营养状态及需求、心理精神状态及需求5个... 详细信息

对老年人进行养老照护评估并进行分级照护是保障养老资源公平分配的基础,然而我国养老照护评估指标与体系尚需完善。本文回顾了国内外养老照护评估现状,从自理能力、认知功能、疾病及健康指标、营养状态及需求、心理精神状态及需求5个方面进行分类讨论,提出构建基于基本能力的评估指标体系进而保障公平性、研究匹配评估结果与照护分级的科学方法、引入第三方评估机制等建议,并认为可以从上述五方面构建养老照护评估指标体系,推动养老照护分级的制定和实践。

关键词：老年人养老照护评估分级

Study on graphene oxide and its derivatives as drug carriers in cancer therapy

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Journal of Hainan Medical University 2020年第3期26卷 76-80页

作者： xin-ran sun xin Li Jing Zhang School of Life Sciences Bengbu Medical CollegeAnhui 233030China

Graphene oxide and its derivatives,which carry abundant functional groups,have large surface area,excellent aqueous dispersity,biocompatibility and high drug-loaded rate *** become a kind of safe,efficient and optional targeting drug vectors in tumor *** oxide and its derivatives can load various of natural and artificial antineoplastic drugs and gene drugs,as well as treat tumor with *** report attempts to review the applications of Graphene oxide in tumor therapy.

关键词： Graphene oxide and derivatives Frug carrier Anti-tumor

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi ran sun Lianfei Ding Mukun He Jiaming Li Hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen sun Liang Xue Wenyao Zhang Pan Xiong xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

层状云微物理属性垂直分布的季节变化——以新疆地区为例

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干旱区地理 2017年第4期40卷 754-761页

作者：光莹邓军英陈勇航辛渝孙冉王旭杨莲梅刘岩张瑞东华大学环境科学与工程学院上海201620 中国气象局乌鲁木齐沙漠气象研究所新疆乌鲁木齐830002 新疆气象局人工影响天气办公室新疆乌鲁木齐830002

利用CloudSat卫星资料2B-CLDCLASS和2B-CWC-RVOD数据集,分别揭示了层云与层积云的云粒子等效半径、数浓度及含水量等微物理属性的垂直分布特征及其季节变化规律。结果表明:层云所在的云层高度比层积云高,特别是春季,层云可以延伸到11.0... 详细信息

利用CloudSat卫星资料2B-CLDCLASS和2B-CWC-RVOD数据集,分别揭示了层云与层积云的云粒子等效半径、数浓度及含水量等微物理属性的垂直分布特征及其季节变化规律。结果表明:层云所在的云层高度比层积云高,特别是春季,层云可以延伸到11.0 km处,而层积云云层所在高度最高出现在夏季,最高延伸到8.5 km处。层云中的冰水分布在1.0~11.0 km,液态水分布在0~9.0 km,而层积云的冰水和液态水均分布在0~9.0 km。层云与层积云的冰粒子等效半径、水云粒子数浓度、液态水含量呈现随云层高度的增加而减小的趋势,冰粒子数浓度随云层高度增加呈增大趋势,冰水含量呈峰值分布,峰值出现在6~10 km范围内。各季节层积云粒子等效半径、粒子数浓度及水含量的最大值均大于层云的对应值,从这方面看,层积云更适合作人工增水对象。

关键词： CloudSat卫星层状云微物理属性垂直分布季节变化

Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe sun, xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian Tang Jiaying He Huihang sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

Sub-Atmospheric Pressure Coupled with Width Effect on Downward Flame Spread over Energy Conservation Material Polyurethane Foam

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Journal of Thermal Science 2020年第1期29卷 115-121页

作者： MA xin TU ran CHENG Xudong ZHU Shuguang sun Qiang FANG Tingyong College of Environment and Energy Engineering Anhui Jianzhu UniversityHefei 230022China College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

Rigid polyurethane(PUR)foam,a sustainable thermosetting building facade porous polymer material,has been widely applied in the construction industry for energy *** knowledge of the fire safety performance of PUR foam at different altitudes and sample widths is *** lab-scale experiments were conducted in the Lhasa plateau(66.5 kPa)and the Hefei plain(99.8 kPa)in *** propagation characteristics(average flame spread rate and flame height)were measured at different widths and atmospheric pressures of the test *** results show that the dependence of dimensionless flame heights on sample width shows negative power law relationships with index of−w/5.4 to−w/*** flame height and flame spread rate were lower under low ambient pressure conditions as H fP0.26~0.33 and VfP0.057~*** spread rate decreased with increasing sample width in the convection regime before a critical width of 4 cm–8 cm,after which the flame spread rate increased in the radiation *** of this study contribute to the science of combustion,fire safety and energy conservation,and provide a basis for fire safety protocols for historical heritage buildings in the Lhasa plateau.

关键词： rigid polyurethane low air pressure building facade energy conservation heat transfer