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The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory

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Biomedical and Environmental Sciences 2015年第8期28卷 558-570页

作者： ZHAO Ya Li LI Ying Xian MA Hong Bo LI Dong LI Hai Liang JIANG Rui KAN Guang Han YANG Zhen Zhong huang Zeng xin Astronaut Research and Training Center of China Beijing Institute of Radiation Medicine Southern Medical University

Objective To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfunction. Methods Mice were exposed to whole body 2100 MHz microwaves with specific absorption rates (SARs) of 0.45 W/kg, 1.8 W/kg, and 3.6 W/kg for 1 hour daily for 8 weeks. Differentially expressing genes in the brains were screened using high-density oligonucleotide arrays, with genes showing more significant differences further confirmed by RT-PCR. Results The gene chip results demonstrated that 41 genes (0.45 W/kg group), 29 genes (1.8 W/kg group), and 219 genes (3.6 W/kg group) were differentially expressed. GO analysis revealed that these differentially expressed genes were primarily involved in metabolic processes, cellular metabolic processes, regulation of biological processes, macromolecular metabolic processes, biosynthetic processes, cellular protein metabolic processes, transport, developmental processes, cellular component organization, etc. KEGG pathway analysis showed that these genes are mainly involved in pathways related to ribosome, Alzheimer's disease, Parkinson's disease, long-term potentiation, Huntington's disease, and Neurotrophin signaling. Construction of a protein interaction network identified several important regulatory genes including synbindin (sbdn), Crystallin (CryaB), PPP1CA, Ywhaq, Psap, Psmb1, Pcbp2, etc., which play important roles in the processes of learning and memory. Conclusion Long-term, low-level microwave exposure may inhibit learning and memory by affecting protein and energy metabolic processes and signaling pathways relating to neurological functions or diseases.

关键词： Long-term Low-level Microwave Gene chip Learning and memory

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Wind characteristics near the ground during typhoon Meari

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第1期18卷 33-48页

作者： Xu WANG Peng huang Xian-feng YU xin-rong WANG Hai-ming LIU State Key Laboratory Breeding Base of Mountain Bridge and Tunnel Engineering Chongqing diaotong University Chongqing 400074 China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China State Key Laboratory of Subtropical Building Science South China University of Technology Guangzhou 510640 China

Wind speed and direction data during typhoon Meari were obtained from eight anemometers installed at heights of 10, 20, 30, and 40 m on a 40-m tower built in the Pudong area of Shanghai. Wind-turbulence characteristics, including wind-speed profile, turbulence integral scale, power spectra, correlations, and coherences were analyzed. Wind-speed profiles varied with time during the passage of Meari. Measured wind-speed profiles could be expressed well by both a power law and a log law. Turbulence integral scales for u, v, and w components all increased with wind speed. The ratios of the turbulence scales among the turbulence components averaged for all 10-min data were 1：0.69：0.08 at 10 m, 1：0.61：0.09 at 20 m, and 1：0.65：0.13 at 40 m. The turbulence integral scales for the u and v components increased with average gust time, but the turbulence integral scale for the w component remained almost constant when the gust duration was greater than 10 min. The decay factor of the coherence function increased slightly with wind speed, with average values for longitudinal and lateral dimensions of 14.3 and 11.3, respectively. The slope rates of the turbulence spectra in the inertial range were less than -5/3 at first, but gradually satisfied the Kolmogorov 5/3 law. The longitudinal wind-power fluctuation spectrum roughly fitted the von Karman spectrum, but slight deviations occurred in the high-frequency band for lateral and vertical wind-power fluctuation spectra.

关键词： Typhoon Meari Field measurement Turbulence integral scale Decay factor Power spectra

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Extract of Ginkgo biloba promotes neuronal regeneration in the hippocampus after exposure to acrylamide

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Neural Regeneration Research 2017年第8期12卷 1287-1293页

作者： Wei-ling huang Yu-xin Ma Yu-bao Fan Sheng-min Lai Hong-qing Liu Jing Liu Li Luo Guo-ying Li Su-min Tian Department of Anatomy School of Basic Medicine Guangdong Pharmaceutical University Guangzhou Guangdong Province China Department of Physiology School of Basic Medicine Guangdong Pharmaceutical University Guangzhou Guangdong Province China

Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba. To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin（DCX）, brain-derived neurotrophic factor, and growth associated protein-43（GAP-43） in the hippocampus. Simultaneously, DCX-and GAP-43-immunoreactive cells increased. These findings suggest that extract of Ginkgo biloba can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal regeneration in the hippocampus of acrylamide-treated mice.

关键词： nerve regeneration brain injury extrat of Ginkgo biloba acrylamide doublecortin brain-derived neurotrophic factor growthassociated protein-43 neurons damage hippocampus mice neural regeneration

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Inhibitory effects of sunitinib on ovalbumin-induced chronic experimental asthma in mice

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Chinese Medical Journal 2009年第9期122卷 1061-1066页

作者： huang Mao LIU Xuan DU Qiang YAO xin YIN Kai-sheng Department of Respiratory Medicine First Affiliated HospitalNanjing Medical University Nanjing Jiangsu 210029 China Department of Respiratory Medicine First People's Hospital ofChangshu City Changshu Jiangsu 215500 China

Background Tyrosine kinase signaling cascades play a critical role in the pathogenesis of allergic airway inflammation. Sunitinib, a multitargeted receptor tyrosine kinase inhibitor, has been reported to exert potent immunoregulatory, anti-inflammatory and anti-fibrosis effects. We investigated whether sunitinib could suppress the progression of airway inflammation, airway hyperresponsiveness （AHR）, and airway remodeling in a murine model of chronic asthma. Methods Ovalbumin （OVA）-sensitized mice were chronically challenged with aerosolized OVA for 8 weeks. Some mice were intragastrically administered with sunitinib （40 mg/kg） daily during the period of OVA challenge. Twelve hours after the last OVA challenge, mice were evaluated for the development of airway inflammation, AHR and airway remodeling. The levels of total serum immunoglobulin E （IgE） and Th2 cytokines （interleukin （IL）-4 and IL-13） in bronchoalveolar lavage fluid （BALF） were measured by ELISA. The expression of phosphorylated c-kit protein in the lungs was detected by immunoprecipitation/Western blotting （IP/WB） analysis. Results Sunitinib significantly inhibited eosinophilic airway inflammation, persistent AHR and airway remodeling in chronic experimental asthma. It reduced levels of total serum IgE and BALF Th2 cytokines and also lowered the expression of phosphorylated c-kit protein in remodelled airways. Conclusions Sunitinib may inhibit the development of airway inflammation, AHR and airway remodeling. It is potentially beneficial to the prevention or treatment of asthma.

关键词： asthma airway remodeling tyrosine kinase inhibitor sunitinib

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Longer conserved alpine forests ecosystem exhibits higher stability to climate change on the Tibetan Plateau

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Journal of Plant Ecology 2019年第4期12卷 645-652页

作者： Jian Li Nan Cong Jiaxing Zu Yuqin xin Ke huang Quan Zhou Yaojie Liu Lin Zhou Li Wang Yang Liu Ge Zhang Southwest Branch of State Grid Corporation of China Chengdu 610094China Lhasa Plateau Ecosystem Research Station Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100090China Xizang xinhe Supervision and Consulting Limited Company Lhasa 850000China International Institute for Earth System Science Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Peking University Shenzhen Graduate School Shenzhen 518055China State Grid Sichuan Electric Power Company Chengdu 610094China School of Urban and Environment Liaoning Normal UniversityDalian 116029China Heilongjiang University of Science and Technology Harbin 150001China

Aims Vegetation dynamics are simultaneously regulated by climate change and anthropogenic *** the 1980s,climate has been warming on the Tibetan Plateau(TP)at a rate higher than North Hemisphere *** activities,including grazing,farming,and urbanization,are also influencing the alpine ecosystem on the ***,an ensemble of large engineering projects,such as power transported from west to east by State Grid,has been in operation on the *** studies disentangling effects of climate and anthropogenic activities interference are still lacking for the forest ecosystems on the *** overarching objectives of this study were to separate effects of natural climates and human interferences on forest ecosystem dynamics on the *** We compared vegetation activities of two typical natural reserves(Gongbu natural reserve,GNR,and Yarlung zangbo river grand canyon natural reserve,YNR)and their surroundings in southeastern Tibet(outside of the natural reserves,ONR)using long-term satel-lite normalized difference vegetation index(NDVI)*** regression and partial correlation analyses were constructed for the relationship between vegetation activity and climates to evaluate the distinct climate effects on the two natural *** Findings The two natural reserves were established at different time,which were related to anthropogenic activities impact *** results showed that the annual mean NDVI fluctuated between 0.5 and 0.6 in the relatively longer reserved YNR,which was re-markably higher than those in other regions(with NDVI lower than 0.45).The vegetation vigor in the YNR showed neither a sig-nificant temporal trend nor significant relationship with ***,vegetation vigor exhibited a significant increasing trend during the last three decades(0.012/decade)at the *** inter-decadal analysis turned out positive relationships between vegetation vigor and annual temperature since late 1990s u

关键词： climate change human interference natural reserves vegetation activity Southeastern Tibet

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盐的多领域应用研究

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云南化工 2024年第7期51卷 21-25页

作者：庄小峰陈潇川严欣黄明华卢玉栋陈庆华要要股份有限公司福建泉州362801 福建师范大学环境与资源学院碳中和现代产业学院福建福州350117 福建师范大学化学与材料学院福建福州350117

系统整理了盐在日化领域、食品领域、医学领域、建筑领域上的应用研究,可为盐的应用研究提供参考。

关键词：盐氯化钠多种领域应用

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A 9-year-old Chinese boy with Alagille syndrome

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Chinese Medical Journal 2007年第10期120卷 941-942页

作者： huang Xiao-lei CHEN Jie MA Ming WANG Pei-xin Department of Gastroenterology Children＇s Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Alagille syndrome （AGS, OMIM#118450） is a multi-system, autosomal dominant disorder with variable clinical manifestation, which primarily affects the liver, heart, eyes, face, and skeleton. The estimated incidence of AGS is 1 in 70000 births of all races worldwide; however it has been rarely reported in Chinese children. We treated a Chinese boy presenting with jaundice, pruritus and gowth failure finally who had been diagnosed as having AGS. Informed consent was obtained from the legal guardian of the child before reporting.

关键词： Alagille syndrome cholestasis growth

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Synthetic and structural chemistry of hexacobalt cluster compounds——Ⅱ. Preparation and structure of Co_6(μ_3-S)_8(Ph_2PCH_2P(O)Ph_2)_6

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Chinese Journal of Chemistry 1991年第5期9卷 425-429页

作者： HONG Mao-Chun huang Zhi-Ying LEI xin-Jian KANG Bei-Sheng JIANG Fei-Long LIU Han-Qin Fuzhou Laboratory of Structural Chemistry and Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFuijan 350002

Co_6(μ_3-S)_8(Ph_2PCH_2P(O)Ph_2)_6, MW=3012.5, space group R, has the hexagonal parameters, a=26.764(10), c=16.979 (10), V=10532.8~3, Z=3. Mo Kα radiation, λ= 0.71069, Dc=1.425 g/cm^3, μ=9.94 cm^(-3), F(000)=4650, R=0.073 and Rw=0.077 for 1965 observed unique reflections with I>3σ(I). The molecular structure consists of a distorted octahed- ral Co_6-core. The Co-Co and Co-S distances fall in the range of 2.805-2.838 and 2.213-2.253, respectively.

关键词： Co Ph2PCH2P O)Ph2 Preparation and structure of Co6 Synthetic and structural chemistry of hexacobalt cluster compounds PCH

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FABRICATION AND AFM/FFM STUDIES OF C_(60)-CONTAINING POLYELECTROLYTE SELF-ASSEMBLED FILMS

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Chinese Journal of Polymer Science 2002年第3期20卷 197-203页

作者： Lan huang Xiao-rong Hou Yuan-kang He Xiao-liang Zheng Fang Wei xin-sheng Zhao Wei-xiao Cao College of Chemistry & Molecular Engineering Peking University Beijing 100871, China College of Chemistry & Molecular Engineering Peking University 北京 100871

An initial investigation on the roughness and frictional properties of the self-assembled thin films from polyelectrolytes is presented. Star-shaped C-60-Poly(styrene-maleic anhydride) was successful prepared. The multilayer thin films have been fabricated on mica with diazoresin as the cationic polyelectrolyte and hydrolyzed star-shaped C-60-poly(styrene-maleic anhydride) as the anionic polyelectrolyte via self-assembly technique. The crosslinking structure of the films is formed from the conversion of ionic bond to covalent bond after UV irradiation. AFM/FFM investigations provide insights into the roughness and frictional properties on a microscale. The roughness depends strongly on the number of film layers in the case of C-60-containing films. The frictional forces of the films exhibited a well behaved non-linear relationship in response to the change of applied load. It supports the prediction of enhanced load-bearing property Of C60-containing thin films.

关键词： star-shaped C-60-poly(styrene-maleic anhydride) self-assembly film AFM/FFM roughness frictional properties

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Self-compassion and resilience mediate the relationship between childhood exposure to domestic violence and posttraumatic growth/stress disorder during COVID-19 pandemic

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World Journal of Psychiatry 2021年第11期11卷 1106-1115页

作者： xin-Li Chi Qiao-Min huang Xiao-Feng Liu Liu-Yue huang Meng-Jian Hu Zhi-Jing Chen Can Jiao Brendon Stubbs M Mahbub Hossain Li-Ye Zou Institute of KEEP Collaborative Innovation School of PsychologyShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Guangdong Polytechnic Foshan 528041Guangdong ProvinceChina Longhua No.2 Experimental School Affiliated Hongchuang Kindergarten Shenzhen 518100Guangdong ProvinceChina Physiotherapy Department South London&Maudsley NHS Fdn TrustLondon WC2R 2LSUnited Kingdom Institute of Psychiatry Psychology and NeuroscienceKing's College LondonLondon WC2R 2LSUnited Kingdom School of Public Health Texas A&M UniversityTexasTX 77843United States Exercise Psychophysiology Laboratory Institute of KEEP Collaborative InnovationSchool of PsychologyShenzhen UniversityShenzhen 518060Guangdong ProvinceChina

BACKGROUND Studies have indicated that childhood exposure to domestic violence is a common factor in posttraumatic growth(PTG)and posttraumatic stress disorder(PTSD),but it is unclear whether PTG and PTSD share a common/different underlying *** To explore the common/different underlying mechanism of PTG and *** Between February 12 and 17,2020,a nationwide cross-sectional online survey was conducted in China among 2038 university students,and a self-administered questionnaire was used for the data *** data included demographic characteristics,such as age,gender,and subjective social economic status,and childhood exposure to domestic violence scale that was selected from the Chinese version of revised Adverse Childhood Experiences Question,Self-compassion Scale,Connor–Davidson Resilience Scale,Posttraumatic Growth Inventory,and the Abbreviated PTSD Checklist-Civilian version.A structural equation model was used to test the *** Exposure to domestic violence was significantly associated with PTG and PTSD via a 1-step indirect path of self-compassion(PTG:β=-0.023,95%CI:-0.44 to-0.007;PTSD:β=0.008,95%CI:0.002,0.014)and via a 2-step indirect path from self-compassion to resilience(PTG:β=-0.008,95%CI:-0.018 to-0.002;PTSD:β=0.013,95%CI:0.004-0.024).However,resilience did not mediate the relationship between exposure to domestic violence and PTG and *** PTG and PTSD are common results of childhood exposure to domestic violence,which may be influenced by self-compassion and resilience.

关键词： Self-compassion Resilience Domestic violence Posttraumatic growth Posttraumatic stress disorder COVID-19

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