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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu li-Yun Zhou Xiao Huang xin-Yue li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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重组人Endostatin在甲醇酵母Pichia Pastoris中的分泌表达

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四川大学学报（自然科学版） 2002年第S1期39卷 -页

作者：吴纬陈静娴宋宁焦丽华中国协和医科大学.中国医学科学院输血研究所生物技术室成都610081

为了获得高效表达分泌型重组人Endostatin菌株 ,利用基因工程技术 ,将目的基因连接到Pichia表达载体 pPIC9K中 ,将该重组质粒转入GS115菌株后筛选His阳性菌株 ,并用G4 18筛选高拷贝阳性克隆菌 .重组表达的Endostatin经SDS PAGE电泳 ,可... 详细信息

为了获得高效表达分泌型重组人Endostatin菌株 ,利用基因工程技术 ,将目的基因连接到Pichia表达载体 pPIC9K中 ,将该重组质粒转入GS115菌株后筛选His阳性菌株 ,并用G4 18筛选高拷贝阳性克隆菌 .重组表达的Endostatin经SDS PAGE电泳 ,可在分子量 2 2kD处见到单一目标带 .经体外生物学活性检测 ,Pichia菌株表达的Endostatin能有效地抑制培养的ECV30 4细胞及P6 1细胞的生长 .

关键词： Pichia Pastoris rh-Endostatin 分泌表达

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手性流动相添加剂法拆分苯磺酸氨氯地平对映体

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沈阳药科大学学报 2010年第2期27卷 131-134页

作者：陈静姚鑫宁林丽娜郭兴杰沈阳药科大学药学院辽宁沈阳110016

目的用磺丁基醚-β-环糊精(SBE-β-CD)作为手性选择剂,建立RP-HPLC法分离苯磺酸氨氯地平对映体。方法使用Hypersil BDS C8色谱柱(150 mm×4.6 mm,5μm),流动相为25 mmol.L-1SBE-β-CD水溶液(pH值2.5)-甲醇(体积比55∶45),流速0.8 ***-1... 详细信息

目的用磺丁基醚-β-环糊精(SBE-β-CD)作为手性选择剂,建立RP-HPLC法分离苯磺酸氨氯地平对映体。方法使用Hypersil BDS C8色谱柱(150 mm×4.6 mm,5μm),流动相为25 mmol.L-1SBE-β-CD水溶液(pH值2.5)-甲醇(体积比55∶45),流速0.8 ***-1,检测波长为238 nm,进样量为20μL,柱温20℃。考察了环糊精种类、SBE-β-CD浓度、有机改性剂的种类和浓度、水相pH值、柱温、流速等因素对对映体分离的影响。结果在优化的色谱条件下,苯磺酸氨氯地平对映体达到完全分离,分离度R为1.6,分离因子α为1.1。结论方法简单、经济,为苯磺酸氨氯地平对映体的拆分提供了新的方法。

关键词：手性流动相添加剂磺丁基醚-β-环糊精苯磺酸氨氯地平对映体分离

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几种因素对重组大肠杆菌目标蛋白表达的影响

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四川大学学报（自然科学版） 2002年第S1期39卷 149-151页

作者：吴纬陈静娴宋宁焦丽华中国协和医科大学.中国医学科学院输血研究所生物技术室成都610081

应用基因工程技术 ,获得能表达蛋白B的重组大肠杆菌 .在摇床条件下 ,研究了几种因素———IPTG浓度、接种不同初始浓度的菌种及培养温度对目标蛋白表达的影响 .结果表明 ,IPTG浓度在常规用量 1mmol/L的基础上降低至 0 .2mmol/L时 ,目标... 详细信息

应用基因工程技术 ,获得能表达蛋白B的重组大肠杆菌 .在摇床条件下 ,研究了几种因素———IPTG浓度、接种不同初始浓度的菌种及培养温度对目标蛋白表达的影响 .结果表明 ,IPTG浓度在常规用量 1mmol/L的基础上降低至 0 .2mmol/L时 ,目标蛋白的表达量无显著差异 ;菌种初始浓度并非越大越好 ,结合表达量 ,作者认为 ,在 1∶80时较适宜 ;培养温度为 37℃对菌株目标蛋白的表达明显好于 30℃ .

关键词：重组蛋白 TPTG浓度温度

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区域性医院药品监管体系的研究与思考

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华南国防医学杂志 2016年第12期30卷 809-812页

作者：李健姜志辉陈新万宁邬力祥中南大学公共卫生学院湖南长沙410078 广州军区广州总医院广州军区广州总医院药剂科

目的研究基于信息化平台的区域性医院药品监管体系,打破医院间信息孤岛,形成整体信息共享,促进医药资源优化。方法成立专门的监管部门,加强各级管理部门信息化建设的顶层设计,加快医药信息标准化,形成政府、行业、患者三位一体的对医院... 详细信息

目的研究基于信息化平台的区域性医院药品监管体系,打破医院间信息孤岛,形成整体信息共享,促进医药资源优化。方法成立专门的监管部门,加强各级管理部门信息化建设的顶层设计,加快医药信息标准化,形成政府、行业、患者三位一体的对医院的监管体系网络。结果建立了区域性医院药品监管体系的理论基础,为实现医药资源共享及合理用药监管提供了新模式。结论区域性医院药品监管体系的建立有利于促进医疗质量建设,降低区域内医疗资源不合理使用、将有限的资源合理服务于广大人民群众。

关键词：区域性信息孤岛药品监管体制资源共享标准化

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-xin li Shi-Xian Cao li-Bin Fu Meng-Meng liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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Surface characterization of metal oxides-supported activated carbon fiber catalysts for simultaneous catalytic hydrolysis of carbonyl sulfide and carbon disulfide

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Journal of Environmental Sciences 2020年第10期32卷 44-54页

作者： Kunlin li Chi Wang Ping ning Kai li xin Sun xin Song Yi Mei Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming 650500China

The sol–gel method was used to synthesize a series of metal oxides-supported activated carbon fiber (ACF) and the simultaneous catalytic hydrolysis activity of carbonyl sulfide (COS)and carbon disulfide (CS2) at relatively low temperatures of 60°C was *** effects of preparation conditions on the catalyst properties were investigated,including the kinds and amount of metal oxides and calcination *** activity tests indicated that catalysts with 5 wt.%Ni after calcining at 400°C (Ni(5)/ACF(400)) had the best performance for the simultaneous catalytic hydrolysis of COS and *** surface and structure properties of prepared ACF were characterized by scanning electron microscope-energy disperse spectroscopy (SEM-EDS),Brunauer–Emmett–Teller (BET),X-ray diffraction (XRD),carbon dioxidetemperature programmed desorption (CO2-TPD) and diffuse reflectance Fourier transform infrared reflection (DRFTIR).And the metal cation defects were researched by electron paramagnetic resonance (EPR) *** characterization results showed that the supporting of Ni on the ACF made the ACF catalyst show alkaline and increased the specific surface area and the number of micropores,then improved catalytic hydrolysis *** DRFTIR results revealed that-OH species could facilitate the hydrolysis of COS and CS2;-COO and-C–O species could facilitate the oxidation of catalytic hydrolysate *** the EPR results showed that high calcination temperature conditions provide more active reaction center for the COS and CS2 adsorption.

关键词： Simultaneous catalytic hydrolysis Carbonyl sulfide Carbon disulfide Ni(5)/ACF(400) Surface characterization Electron paramagnetic resonance

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Halide-Anion Water Clusters in Cucurbit[6]uril Supramolecular Systems

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Chinese Journal of Chemistry 2016年第11期34卷 1114-1120页

作者： Bo li xin li Xuzhuo Sun ning Wang College of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou Henan 450001 China College of Chemistry and Materials Science Northwest University Xi'an Shaanxi 710069 China

Three types of dihalide water clusters [X2（H20）8]2 （X=Cl, Br） and [I2（H20）10]^2- have been observed in cucurbit[6]uril supramolecular systems with same guest. According to the single crystal data and the quantitative theory computation, with the increase of electronegativity of halide ions, dihalide water clusters become more stable. A further comparison of three kinds of guests with different molecule length but the same anions, [p-phenylenediamine salt, hexamethylenediamine salt and N,N＇-hexamethylenebis（pyrazinylbromide）], gives the result that the dihalide water clusters collapse from 2D to 1D with the increase of the lengths.

关键词： cucurbituril dihalide water clusters halogen ions lengths of guests

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