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基于尺寸效应的钛合金二维超声辅助精密切削特性研究

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河南理工大学学报（自然科学版） 2025年第1期44卷 117-123页

作者：王鑫刘建慧焦锋新乡航空工业(集团)有限公司河南新乡453000 河南理工大学机械与动力工程学院河南焦作454000

目的为了减少尺寸效应对精密加工的影响,提高钛合金微尺度切削的加工精度与表面质量,方法将特种加工理论和精密切削方法相结合,提出二维超声辅助精密切削方法。首先,基于ABAQUS力-热耦合模型分析二维超声辅助精密切削钛合金的切削过程,... 详细信息

目的为了减少尺寸效应对精密加工的影响,提高钛合金微尺度切削的加工精度与表面质量,方法将特种加工理论和精密切削方法相结合,提出二维超声辅助精密切削方法。首先,基于ABAQUS力-热耦合模型分析二维超声辅助精密切削钛合金的切削过程,探究精密切削与二维超声辅助精密切削的切削力学特性;其次,通过试验以超声振幅、切削深度与刃口半径的比值(a_(p)/r_(n))为因素,分析尺寸效应作用下超声振动切削中切削力及单位切削力的变化规律;最后,对比分析精密切削与二维超声辅助精密切削在不同切削深度与刃口半径的比值(a_(p)/r_(n))下的表面形貌特征。结果结果表明,随着切削深度与刃口半径的比值(a_(p)/r_(n))增大,精密切削钛合金表面形貌出现黏结、凹坑、耕犁现象,而二维超声辅助精密切削加工表面则出现均匀、完整的网状表面纹理特征。另外,二维超声辅助精密切削加工单位切削力远小于精密切削加工的,且随着振幅增大,单位切削力的增长比值由57.7%降至45.2%。结论二维超声辅助精密切削能够显著改善尺寸效应中产生的负前角效应和犁切现象,降低单位切削力,提高切削过程的稳定性,在提高钛合金微尺度切屑加工精度和表面质量方面具有重要应用价值。

关键词：二维超声辅助切削尺寸效应刃口半径切削力

N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis

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Genes & Diseases 2023年第2期10卷 554-567页

作者： Wan-xin Peng Fei liu Jia-Hong Jiang Hang Yuan Ziqiang Zhang liu Yang Yin-Yuan mo Department of Surgical Oncology The Children's HospitalZhejiang University School of MedicineNational Research Center for Child HealthHangzhouZhejiang 310052China Cancer Center and Research Institute University of Mississippi Medical CenterJacksonMS 39216USA Department of Nephrology The Children's HospitalZhejiang University School of MedicineNational Research Center for Child HealthHangzhouZhejiang 310052China Department of Medical Oncology Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Colorectal Surgery Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Pulmonary Medicine Tongji HospitalTongji UniversityShanghai 200065China Key Laboratory of Tumor molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Pharmacology/Toxicology University of Mississippi Medical CenterJacksonMS 39216USA

Accumulating evidence indicates that RNA methylation at N6-methyladenosine(m6A)plays an important regulatory role in gene expression and aberrant mRNA m6A modification is often associated with a variety of ***,little is known whether and how m6A-modification impacts long non-coding RNA(lncRNA)and lncRNA-mediated tumorigenesis,particularly in pancreatic ductal adenocarcinoma(PDAC).In the present study,we report that a previously uncharacterized lncRNA,LINC00901,promotes pancreatic cancer cell growth and invasion and moreover,LINC00901 is subject to m6A modification which regulates its *** this regard,YTHDF1 serves as a reader for the m6A modified LINC00901 and downregulates the LINC00901 ***,two conserved m6A sites in LINC00901 are critical to the recognition of LINC00901 by ***,RNA sequencing(RNA-seq)and gene function analysis revealed that LINC00901 positively regulates MYC through upregulation of IGF2BP2,a known RNA binding protein that can enhance MYC mRNA ***,our results suggest that there is a LINC00901-IGF2BP2-MYC axis through which LINC00901 promotes PDAC progression in an m6A dependent manner.

关键词： IGF2BP2 LINC00901 MYC N6-methyladenosine modification(m6A) PDAC YTHDF1

Electrospun polypyrrole-coated polycaprolactone nanoyarn nerve guidance conduits for nerve tissue engineering

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Frontiers of Materials Science 2018年第4期12卷 438-446页

作者： xin PAN Binbin SUN Xiumei mo Department of Orthopaedics Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine Shanghai 200011China Sunna Technologies (Shanghai)Co. Ltd.Shanghai 201203China State Key Laboratory for modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

Nerve guidance conduits (NGCs) can provide suitable microenvironment for nerve repair and promote the proliferation and migration of Schwann cells (SCs). Thus, we developed nerve guidance conduits (NGCs) with polypyrrole-coated polycaprolactone nanoyarns (PPy-PCL-NYs) as fillers in this study. PCL-NYs with the oriented structure were prepared with a double-needle electrospinning system and then PPy was coated on PCL-NYs via the in situ chemical polymerization. Subsequently, PCL nanofibers were collected around nanoyarns by the conventional electrospinning process as the outer layer to obtain PPy-PCL-NY nerve guidance conduits (PPy-PCLNY NGCs). PPy-PCL-NYs were analyzed by SEM, FTIR and XPS. Results showed that PPy was homogeneously and uniformly deposited on the surface of PCL-NY. Strain-stress curves and the Young’s modulus of PPy-PCL-NYs were investigated compared with those of non-coated PCL-NYs. Studies on biocompatibility with SCs indicated that PPy-PCL-NY NGCs were more conducive to the proliferation of SCs than PCL-NY NGCs. In summary, PPy-PCL-NY NGCs show the promising potential for nerve tissue engineering repair and regeneration.

关键词： electrospinning Schwann cell (SC) polypyrrole (PPy) polycaprolactone nanoyarn (PCL-NY) nerve guidance conduit (NGC)

Leveraging core capabilities and environmental dynamism for food traceability and firm performance in a food supply chain: A moderated mediation model

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Journal of Integrative Agriculture 2019年第8期18卷 1820-1837页

作者： SONG mo-xi YANG morgan xin Department of Management College of Economics and Management China Agricultural University Beijing 100083 P.R.China Department of Marketing School of Business The Hang Seng University of Hong Kong Hong Kong P.R.China

This paper develops a moderated mediation model in which the interactive effects of food traceability and environmental dynamism on firm performance are mediated by the core capabilities(operating capabilities and marketing capabilities)in food supply chain context, by invoking the indirect view of organizational learning theory. Our hypotheses were tested using hierarchical regression and bootstrapping methods with a sample of 216 food manufacturing firms in China, and a survey-based, two-informant design was used to collect data. The results revealed that operating and marketing capabilities fully mediate the food traceability-performance link. In addition, environmental dynamism positively moderates the food traceability-core capabilities link. moreover, it is found that operating and marketing capabilities transform the interactive impacts of environmental dynamism and food traceability into firm performance. Our study offers a fine-grained picture of the essential food traceability-performance link by revealing for the first time that there is an interactive impacts of food traceability and environmental dynamism on firm performance via core capabilities.

关键词： food traceability operating capabilities marketing capabilities organizational learning environmental dynamism food firm performance China

Seasonal variations and spatial distribution of particulate matter emissions from a ventilated laying hen house in Northeast China

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International Journal of Agricultural and Biological Engineering 2020年第3期13卷 57-63页

作者： Li Guo Dongsen Zhao Bo Zhao Shuli Ma Xiaolin liu mo Li xin liu College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China Key Laboratory of Bionic Engineering Ministry of Education of ChinaJilin UniversityChangchun 130022China China Architecture Design Group Beijing 100044China

With the development of concentrated animal feeding operations in China,the air pollution problem has drawn widespread public *** living near farms are suffering from the emissions of particulate matter(PM)and ***,scientific data on the characteristics of these emissions are limited to the establishment and evaluation of mitigation strategies in *** study was conducted to provide fundamental information on the concentrations of PM inside and outside a typical ventilated laying hen house in northeastern *** results showed that outdoor PM concentrations of this laying hen house did not meet the requirements of the environmental quality standard of China’s livestock and poultry farms in the two days out of six sampling days in summer,while indoor PM concentrations met the environmental requirements during this *** indoor and outdoor PM concentrations were highly correlated in summer,and over 60%of particles indoor were emitted outside via mechanical *** were more fine particles dominated both inside and outside of the laying hen ***,twelve and nine elements were measured from the PM sources inside and outside laying hen house,*** control strategies may be adjusted based on the status of exhaust fans,the ages of laying hens,atmospheric conditions,and routine house management to well reduce PM emissions and improve control efficiency.

关键词： particulate matter ventilated laying hen house air emission animal feeding operation

Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis

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Bone Research 2017年第3期5卷 177-194页

作者： xin Xu Xiaoyue Jia Longyi mo Chengcheng liu Liwei Zheng Quan Yuan Xuedong Zhou State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Department of Periodontics West China Hospital of Stomatology Sichuan University Department of Pediatric Dentistry West China Hospital of Stomatology Sichuan University Department of Dental Implantology West China Hospital of Stomatology Sichuan University

Postmenopausal osteoporosis （Pmo） is a prevalent metabolic bone disease characterized by bone loss and structural destruction, which increases the risk of fracture in postmenopausal women. Owing to the high morbidity and serious complications of Pmo, many efforts have been devoted to its prophylaxis and treatment. The intestinal microbiota is the complex community of microorganisms colonizing the gastrointestinal tract. Probiotics, which are dietary or medical supplements consisting of beneficial intestinal bacteria, work in concert with endogenous intestinal microorganisms to maintain host health. Recent studies have revealed that bone loss in Pmo is closely related to host immunity, which is influenced by the intestinal microbiota. The curative effects of probiotics on metabolic bone diseases have also been demonstrated. The effects of the intestinal microbiota on bone metabolism suggest a promising target for Pmo management. This review seeks to summarize the critical effects of the intestinal microbiota and probiotics on Pmo, with a focus on the molecular mechanisms underlying the pathogenic relationship between bacteria and host, and to define the possible treatment options.

关键词： Pmo

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基于版权认证的文本匹配模型研究

天津理工大学学报 2025年第1期41卷 90-96页

作者：刘晓飞莫秀良天津理工大学计算机科学与工程学院天津市智能计算及软件新技术重点实验室

面对网络中日益增多的数字作品以及人们版权意识的增强，确认数字作品版权归属非常重要，对于数字作品原创性检测问题，文本匹配技术能够很好地解决这一问题。文本匹配技术通过算法来判断句子之间的语义是否相近。最近几年，深度学习迅... 详细信息

面对网络中日益增多的数字作品以及人们版权意识的增强，确认数字作品版权归属非常重要，对于数字作品原创性检测问题，文本匹配技术能够很好地解决这一问题。文本匹配技术通过算法来判断句子之间的语义是否相近。最近几年，深度学习迅速发展，解决文本匹配任务的方法也得到了很好的发展。在已有的基于核的文档排序神经模型(a kernel based neural model for document ranking, KNRM)上进一步地研究和创新，提出融合KNRM和轻量级梯度提升机(light gradient boosting machine, LightGBM)算法的文本匹配模型，在交互矩阵转化的直方图上采用kernel-pooling的方式来提取相关局部特征信息，引入K个不同大小的核函数，来捕捉不同细粒度的相关匹配信号，获取高斯核特征，将LightGBM算法作为分类器，进行分类处理工作，预测最后的匹配结果。通过多个数据集验证模型效果，实验表明，融合模型KNRM-LightGBM在准确率方面优于原模型KNRM,能够达到更好的文本匹配效果。

关键词：文本匹配基于核的文档排序神经模型轻量级梯度提升机数字版权

2022 Multiple-country monkeypox Outbreak and Its Importation Risk into China:An Assessment Based on the Risk Matrix Method

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Biomedical and Environmental Sciences 2022年第10期35卷 878-887页

作者： DU Min ZHANG Shi mo SHANG Wei Jing YAN Wen xin liu Qiao QIN Chen Yuan liu Min liu Jue Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing 100871China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China

Objective To analyze the 2022 multiple-country monkeypox outbreak and assess its importation risk into *** Data was from United States Centers for Disease Control and *** described the global epidemic and calculated concentration index to measure economic-related *** risk into China was evaluated and ranked by using risk matrix method and Borda count method,*** As of July 29,2022,of 79 countries or territories,39(49.37%,39/79),17(21.52%,17/79),6(7.59%,6/79),12(15.19%,12/79),and 5(6.33%,5/79)country or territories identified cases1,*** were economic-related health disparities exist in the distribution of cases(the concentration index=0.42,P=0.027),and the inequality disadvantageous to the rich(pro-poor).There were 12(15.38%,12/78),15(19.23%,15/78),6(7.69%,6/78),and 45(57.69%,45/78)countries or territories with extremely high,high,moderate,and low importation *** States and France ranked first with the highest Borda points of 156,and counts of *** Of 78 countries or territories,the key attention need be paid to the United States and France,*** the epidemic progresses,preparing prevention and control measures to further reduce importation risk was crucial.

关键词： monkeypox Importation risk China Risk matrix method

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian xin Hua Jianhong Dong Zheyu Fang Yuqing liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin