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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian xin Hua Jianhong Dong Zheyu Fang Yuqing liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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3D atomic-scale growth characteristics of {10-12} twin in magnesium

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Journal of Magnesium and Alloys 2019年第3期7卷 474-486页

作者： xin Wan Jing Zhang Xueyan mo Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing 400044China

In this work,we carried out three-dimensional(3D)atomic-scale study on the growth characteristics of{10-12}twin in magnesium(Mg).The study was performed by MD simulations on Mg single crystals with an initial twin nucleus structures.A detailed atomistic analysis reveals that a stabilized 3D{10-12}twin nucleus is bounded by basal/prismatic(BP)interfaces,prismatic/basal(PB)interfaces,and{10-11}***,a{10-12}twin boundary(TB)occurs at the junction of the BP and PB interface with the growth of the twin *** this process,two twinning mechanisms are involved:a pure-shuffle mechanism in which{10-11}interface migration along the[11-20]direction is mediated by atomic shuffle,and a glide-shuffle mechanism in which BP/PB and{10-12}TB movements are realized by the migration of disconnections along the relevant *** addition,we systematically investigate the stress state associated with the activation of twinning,aiming to discover the intrinsic relationship of the elastic stress field to twin growth on an atomic *** results suggest that the elastic stress in the matrix is an important driving force for twin growth,much similar to what stress does for a *** addition,it is rather remarkable that the{10-11}interface has a greater ability to migrate than other interfaces,and this is thought to be a main factor for the rapid growth of a{10-12}twin.

关键词： molecular dynamics {10-12}twinning 3D growth Twin-related interfaces

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Discrepancies and error evaluation metrics for machine learning interatomic potentials

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npj Computational Materials 2023年第1期9卷 533-545页

作者： Yunsheng liu xingfeng He Yifei mo Department of Materials Science and Engineering University of MarylandCollege ParkMDUSA

Machine learning interatomic potentials(MLIPs)are a promising technique for atomic *** small errors are widely reported for MLIPs,an open concern is whether MLIPs can accurately reproduce atomistic dynamics and related physical properties in molecular dynamics(MD)*** this study,we examine the state-of-the-art MLIPs and uncover several discrepancies related to atom dynamics,defects,and rare events(REs),compared to ab initio *** find that low averaged errors by current MLIP testing are insufficient,and develop quantitative metrics that better indicate the accurate prediction of atomic dynamics by *** MLIPs optimized by the RE-based evaluation metrics are demonstrated to have improved prediction in multiple *** identified errors,the evaluation metrics,and the proposed process of developing such metrics are general to MLIPs,thus providing valuable guidance for future testing and improvements of accurate and reliable MLIPs for atomistic modeling.

关键词： properties methods testing

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Mesh migration into the sigmoid colon after inguinal hernia repair presenting as a colonic polyp:A case report and review of literature

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World Journal of Clinical Cases 2018年第12期6卷 564-569页

作者： Sha liu xin-xin Zhou Lin Li mo-Sang Yu Hong Zhang Wei-Xiang Zhong Feng Ji Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University

Mesh migration and penetration into abdominal visce-ra rarely occur after laparoscopic inguinal hernia repair. We present the first case of mesh migration into the sigmoid colon identified as a colonic polyp at initial co-lonoscopic examination. The patient complained of mild abdominal distention in the lower abdomen over the previous year without changes in bowel habits or stool appearance and without weight loss. By complement-ary endoscopic ultrasonography, a cavity--like structure beneath the suspected polyp was further confirmed. Enhanced abdominal computed tomography merely re-vealed local bowel wall thickening and inflammation of the colosigmoid junction. The migrating mesh, which was lodged in the sigmoid colon and caused intra--abdomi-nal adhesion in the lower abdominal cavity, was finally identified via exploratory surgery. The components of inflammatory granulation tissue around the mesh mate-rial were diagnosed based on histological examination of the surgical specimen after sigmoidectomy. In this patient, nonspecific endoscopic and imaging outcomes during clinical work--up led to the diagnostic dilemma of mesh migration. Therefore, the clinical, radiological and endoscopic challenges specific to this case as well as the underlying reasons for mesh migration are discussed in detail.

关键词： Colonoscopy Surgical mesh Hernia repair Sigmoid colon Colonic polyps Computed tomography Foreign bodies

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Poisson Stable Solutions for Stochastic Differential Equations with Lévy Noise

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Acta Mathematica Sinica,English Series 2022年第1期38卷 22-54页

作者： xin liu Zhen xin LI School of Mathematical Sciences Dalian University of TechnologyDalian 116024P.R.China

In this paper,we use a unified framework to study Poisson stable(including stationary,periodic,quasi-periodic,almost periodic,almost automorphic,Birkhoff recurrent,almost recurrent in the sense of Bebutov,Levitan almost periodic,pseudo-periodic,pseudo-recurrent and Poisson stable)solutions for semilinear stochastic differential equations driven by infinite dimensional L′evy noise with large *** suitable conditions on drift,diffusion and jump coefficients,we prove that there exist solutions which inherit the Poisson stability of *** we show that these solutions are globally asymptotically stable in square-mean ***,we illustrate our theoretical results by several examples.

关键词： Stochastic differential equation Lévy noise periodic solution quasi-periodic solution almost periodic solution Levitan almost periodic solution almost automorphic solution Birkhoff recurrent solution Poisson stable solution asymptotic stability

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Consensus problems on networks with free protocol

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Chinese Physics B 2021年第7期30卷 171-177页

作者： Xiaodong liu Lipo mo School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China Key Laboratory of Power Big Data of Guizhou Province Guizhou Institute of TechnologyGuiyang 550003China

In the real world,rule makers can only restrict,not completely control the behavior of the governed,while the governed can only choose their behavior patterns under these *** this paper,we design a new control protocol called free protocol to describe this ***,we calculate consensus probabilities based on the information of the interaction ***,sufficient conditions are obtained for all agents converging to a same value with probability ***,numerical simulation results are given to verify the above results.

关键词： multi-agent systems random protocol consensus with probability one

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Livability assessment of 101,630 communities in China's major cities: A remote sensing perspective

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Science China Earth Sciences 2022年第6期65卷 1073-1087页

作者： xin HUANG Yue liu School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

Some of China's major cities have entered the middle and late stages of urbanization, and the development focus of these cities has gradually shifted from outward expansion to inward renewal. The community, as the basic unit of a city, is undoubtedly the main object of urban renewal. In order to efficiently and effectively address the problems in current community construction, it is necessary to conduct a large-scale in-depth assessment of the community livability, which can directly imply the satisfaction of residents with their quality of life. This study achieved the first comprehensive livability assessment at the individual community scale for 42 major cities of China from the perspective of remotely sensed and crowd-sourced geographic information. Specifically, we produced abundant fine-grained datasets for 42 cities, including high-resolution land cover maps interpreted from Ziyuan-3 satellites(ZY-3, 2.1 m), building height, point-of-interest, and boundaries of 101,630 *** designed in our proposed framework, the community livability was evaluated by 5 level-1 indicators, 27 level-2 indicators and an integrated community livability index(CLI). A number of interesting findings were obtained from this assessment:(1)According to the expert questionnaires, living comfort was considered as the most important livability factor for residents with the highest weight, while the building environment was rated the least. The negative factors(e.g., the factories around the community) impacted more on livability than the positive ones.(2) most communities in major Chinese cities were characterized by dense buildings and sparse green spaces.(3) In these cities, community security construction was severely insufficient,particularly in less developed regions.(4) Imbalanced community livability development was prevalent across cities, and simultaneously, the CLI distribution within cities also exhibited significant spatial aggregation and heterogeneity. This resear

关键词： Community Livability Living comfort Building environment Security Remote sensing

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Radial point collocation method (RPCM) for solving convection-diffusion problems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第6期7卷 1061-1067页

作者： liu xin Department of Mechanics Zhejiang University Hangzhou 310027 China

In this paper, Radial point collocation method （RPCM）, a kind of meshfree method, is applied to solve convectiondiffusion problem. The main feature of this approach is to use the interpolation schemes in local supported domains based on radial basis functions. As a result, this method is local and hence the system matrix is banded which is very attractive for practical engineering problems. In the numerical examination, RPCM is applied to solve non-linear convection-diffusion 2D Burgers equations. The results obtained by RPCM demonstrate the accuracy and efficiency of the proposed method for solving transient fluid dynamic problems. A fictitious point scheme is adopted to improve the solution accuracy while Neumann boundary conditions exist. The meshfree feature of the nresent method is verv attractive in solving comnutational fluid nroblems.

关键词： Radial basis functions Radial point collocation method (RPCM) Collocation Meshfree Convection-diffusion

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Expression and Function of Zinc-α2-Glycoprotein

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Neuroscience Bulletin 2019年第3期35卷 540-550页

作者： xin Wei Xi liu Changhong Tan Lijuan mo Hui Wang Xi Peng Fen Deng Lifen Chen Department of Neurology The Second Affiliated Hospital of Chongqing Medical University

Zinc-α2-glycoprotein(ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Only a few studies have investigated ZAG in the brain. It has been found in the brains of patients with Krabbe disease and epilepsy, and in the cerebrospinal fluid of patients with Alzheimer disease, frontotemporal lobe dementia, and amyotrophic lateral sclerosis. Both ZAG protein and AZGP1 m RNA are decreased in epilepsy patients and animal models, while overexpression of ZAG suppresses seizure and epileptic discharges in animal models of epilepsy, but knowledge of the specific mechanism of ZAG in epilepsy is limited. In this review, we summarize the known roles and molecular mechanisms of ZAG in lipid metabolism and glucose metabolism, and in the regulation of insulin sensitivity, and discuss the possible mechanisms by which it suppresses epilepsy.

关键词： Zinc-α2-glycoprotein Metabolism Glucose Lipid Insulin sensitivity Neuron

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青少年抑郁障碍患者非自杀性自伤行为与25羟维生素D_(3)和血脂水平的相关性研究

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中国全科医学 2025年第5期28卷 612-618页

作者：凡豪杰刘乐伟夏磊田英汉杨铖郝明茹赵鑫申晴晴莫大明耿峰刘寰忠安徽医科大学精神卫生与心理科学学院安徽省合肥市238000 安徽医科大学附属巢湖医院精神科安徽省合肥市238000 安徽省精神医学中心安徽省合肥市238000 安徽省合肥市第四人民医院 238000 安徽医科大学第二附属医院心理与睡眠医学科安徽省合肥市238000 脑库构建及资源利用安徽省重点实验室安徽省合肥市238000

背景抑郁障碍(MDD)在青少年人群中的发病率逐年增高,非自杀性自伤(NSSI)行为也是其常见的临床表现。有研究结果显示维生素D和血脂水平与MDD有关,但是其是否与NSSI有关尚不明确。目的比较伴或不伴有NSSI行为青少年MDD患者的25羟维生素D_(... 详细信息

背景抑郁障碍(MDD)在青少年人群中的发病率逐年增高,非自杀性自伤(NSSI)行为也是其常见的临床表现。有研究结果显示维生素D和血脂水平与MDD有关,但是其是否与NSSI有关尚不明确。目的比较伴或不伴有NSSI行为青少年MDD患者的25羟维生素D_(3)[25(OH)D_(3)]和血脂水平,并探索其对NSSI的诊断价值。方法选取2020年10月-2022年3月在安徽医科大学附属巢湖医院精神科和合肥市第四人民医院就诊的青少年MDD患者129例,参考《精神障碍诊断与统计手册》第5版(DSM-5)中NSSI的诊断标准将其分为NSSI组(77例)和非NSSI组(52例)。采用青少年自杀意念量表(PANSI)、失眠严重指数(ISI)、流调用抑郁量表(CES-D)评估患者的临床症状。采集空腹静脉血,检测样本中25(OH)D_(3)和血脂水平,并进行两两比较。进一步采用多因素Logistic回归分析探究青少年MDD患者发生NSSI行为的影响因素,并绘制受试者工作特征(ROC)曲线评估25(OH)D_(3)和血脂水平对NSSI行为的诊断价值。结果NSSI组的年龄低于非NSSI组,而PANSI总分、ISI总分、CES-D总分高于非NSSI组(Pmol/L、19.15μg/L;LDL-C联合25(OH)D_(3)水平[ln(p/1-p)=1.364X1-0.143X2-0.161,其中X1、X2分别为LDL-C、25(OH)D_(3)]预测青少年MDD患者NSSI行为的AUC为0.77(95%CI=0.69~0.85,P<0.001),灵敏度为77.92%、特异度为67.31%。结论伴有NSSI行为的青少年MDD患者存在一定水平的25(OH)D_(3)和血脂水平紊乱,且LDL-C联合25(OH)D_(3)水平对评估青少年MDD患者NSSI行为的发生有一定的参考价值,临床应定期检测其动态变化并对症处理。

关键词：抑郁抑郁障碍青少年非自杀性自伤 25羟维生素D_(3) 血脂异常

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