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Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

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World Journal of Diabetes 2024年第3期15卷 348-360页

作者： Jin Wang Ke Wan xin Chang Rui-Feng mao Department of Ultrasound Medicine Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Faculty of Medicine and Health The University of SydneyCamperdown NSW 2050Australia School of Life Science Huaiyin Normal UniversityHuai'an 223300Jiangsu ProvinceChina

As a common hyperglycemic disease,type 1 diabetes mellitus(T1DM)is a complicated disorder that requires a lifelong insulin supply due to the immunemediated destruction of pancreaticβcells.Although it is an organ-specific autoimmune disorder,T1DM is often associated with multiple other autoimmune disorders.The most prevalent concomitant autoimmune disorder occurring in T1DM is autoimmune thyroid disease(AITD),which mainly exhibits two extremes of phenotypes:hyperthyroidism[Graves'disease(GD)]and hypothyroidism[Hashimoto's thyroiditis,(HT)].However,the presence of comorbid AITD may negatively affect metabolic management in T1DM patients and thereby may increase the risk for potential diabetes-related complications.Thus,routine screening of thyroid function has been recommended when T1DM is diagnosed.Here,first,we summarize current knowledge regarding the etiology and pathogenesis mechanisms of both diseases.Subsequently,an updated review of the association between T1DM and AITD is offered.Finally,we provide a relatively detailed review focusing on the application of thyroid ultrasonography in diagnosing and managing HT and GD,suggesting its critical role in the timely and accurate diagnosis of AITD in T1DM.

关键词： Type 1 diabetes mellitus Autoimmunity Autoimmune thyroid disease Ultrasonography Diagnosis

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-xin Fu Feng Duan mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to efficacy.AIM To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable HCC.METHODS This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April 2022.Overall survival(OS)and progression-free survival(PFS)were determined.The objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid Tumors.Additionally,the prognostic factors affecting the clinical outcome were assessed.RESULTS One hundred and two patients were enrolled with a median follow-up duration of 12.63 months.The median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,respectively.The patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their counterparts.CONCLUSION This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable HCC.The patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

A framework of force of information influence and application for C4KISR system

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Journal of Systems Engineering and Electronics 2024年第2期35卷 430-443页

作者： mao Shaojie DIAO Lianwang SUN Yu WANG Heng YI Kan XU xin mao Xiaobin ZHANG Kecheng SHENG Long Science and Technology on Information Systems Engineering Laboratory The 28th Research Institute of China Electronics Technology Group CorporationNanjing 210007China Unit 94860 of the PLA Nanjing 210008China

The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.

关键词： information warfare command control communications computer kill intelligence surveillance reconnaissance(C4KISR)system information circulation force of information influence information entropy

Alkaline zinc-based flow battery: chemical stability, morphological evolution, and performance of zinc electrode with ionic liquid

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Frontiers of Materials Science 2024年第1期18卷 113-121页

作者： Tianyong mao Jing Dai Meiqing xin Deliang Zeng Zhipeng Xie Jiangxi Province Key Laboratory of Power Batteries and Materials Jiangxi University of Science and TechnologyGanzhou 341000China

Zinc-based flow battery is an energy storage technology with good application prospects because of its advantages of abundant raw materials,low cost,and environmental friendliness.The chemical stability of zinc electrodes exposed to electrolyte is a very important issue for zinc-based batteries.This paper reports on details of chemical stability of the zinc metal exposed to a series of solutions,as well as the relationship between the morphological evolution of zinc electrodes and their properties in an alkaline medium.Chemical corrosion of zinc electrodes by the electrolyte will change their surface morphology.However,we observed that chemical corrosion is not the main contributor to the evolution of zinc electrode surface morphology,but the main contributor is the Zn/Zn^(2+)electrode process.The morphological evolution of zinc electrodes was controlled by using ionic liquids,1-ethyl-3-methylimidazolium acetate(EMIA),and 1-propylsulfonic-3-methylimidazolium tosylate(PSMIT),and the electrode performance was recorded during the morphological evolution process.It was observed that the reversible change of zinc electrode morphology was accompanied by better electrode performance.

关键词： alkaline medium morphological evolution zinc-based flow battery new energy

Experimental and numerical study on protective effect of RC blast wall against air shock wave

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Defence Technology（防务技术） 2024年第1期31卷 567-579页

作者： xin-zhe Nian Quan-min Xie xin-li Kong Ying-kang Yao Kui Huang State Key Laboratory of Precision Blasting Jianghan UniversityWuhan430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan430056China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan430056China College of Defense Engineering Army Engineering University of PLANanjing210007China Institute of Defense Engineering AMSPLALuoyang471023China

Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in different regions.The above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP program.The results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP waveform.Through dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was obtained.According to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are set.The above results can provide a reference for the design and construction of the reinforced concrete blast wall.

关键词： Blast wall Shock wave Diffraction Overpressure Protection

Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells

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World Journal of Stem Cells 2024年第2期16卷 58-63页

作者： xin-xing Wan Xi-min Hu Kun Xiong Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013Hunan ProvinceChina

In this editorial,we offer our perspective on the groundbreaking study entitled“Hypoxia and inflammatory factor preconditioning enhances the immunosup-pressive properties of human umbilical cord mesenchymal stem cells”,recently published in World Journal of Stem Cells.Despite over three decades of research on the clinical application of mesenchymal stem cells(MSCs),only a few therapeutic products have made it to clinical use,due to multiple preclinical and clinical challenges yet to be addressed.The study proved the hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their biological characteristics,which revealed the combination of inflammatory factors and hypoxic preconditioning offers a promising approach to enhance the function of MSCs.As we delve deeper into the intricacies of pretreat-ment methodologies,we anticipate a transformative shift in the landscape of MSC-based therapies,ultimately contributing to improved patient outcomes and advancing the field as a whole.

关键词： Mesenchymal stem cells Inflammatory factor Hypoxia Pretreatment

Floating plants reduced methane fluxes from wetlands by creating a habitat conducive to methane oxidation

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Journal of Environmental Sciences 2024年第1期135卷 149-160页

作者： Fuwei Wang Songhe Zhang Xiuren Hu xin Lv min Liu Yu Ma Benjamin Manirakiza Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationHohai UniversityNanjing 210098China College of Environment Hohai UniversityNanjing 210098China China Machinery International Engineering Desigh and Research Institute co. Ltd.East China Regional CenterNanjing 210008China

Wetlands are one of the important natural sources of atmospheric methane (CH_4),as an important part of wetlands,floating plants can be expected to affect methane release.However,the effects of floating plants on methane release are limited.In this study,methane fluxes,physiochemical properties of the overlying water,methane oxidation potential and rhizospheric bacterial community were investigated in simulated wetlands with floating plants Eichhornia crassipes,Hydrocharis dubia,and Trapa natans.We found that E.crassipes,H.dubia,and T.natans plants could inhibit 84.31%-97.31%,4.98%-88.91%and 43.62%-92.51%of methane fluxes at interface of water-atmosphere compared to Control,respectively.Methane fluxes were negatively related to nutrients concentration in water column but positively related to the aerenchyma proportions of roots,stems,and leaves.At the same biomass,root of E.crassipes (36.44%) had the highest methane oxidation potential,followed by H.dubia (12.99%) and T.natans (11.23%).Forty-five bacterial phyla in total were identified on roots of three plants and 7 bacterial genera (2.10%-3.33%) were known methanotrophs.Type I methanotrophs accounted for 95.07%of total methanotrophs.The pmoA gene abundances ranged from 1.90×10^(16)to 2.30×10^(18)copies/g fresh weight of root biofilms.Abundances of pmoA gene was significantly positively correlated with environmental parameters.Methylotrophy (5.40%) and methanotrophy (3.75%) function were closely related to methane oxidation.This study highlights that floating plant restoration can purify water and promote carbon neutrality partially by reducing methane fluxes through methane oxidation in wetlands.

关键词： Floating plants Methane fluxes Aerenchyma Methanotrophs

Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer

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Genes & Diseases 2024年第3期11卷 338-350页

作者： xin Xu Yuan Fang Somaira Nowsheen Ye-Xiong Li Zhenkun Lou min Deng State Key Laboratory of Molecular Oncology and Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Dermatology University of California San DiegoSan DiegoCA 92093USA Department of Oncology Mayo ClinicRochesterMN 55905USA

The adenosine monophosphate(AMP)-activated protein kinase(AMPK)sits at a cen-tral node in the regulation of energy metabolism and tumor progression.AMPK is best known to sense high cellular ADP or AMP levels,which indicate the depletion of energy stores.Previous studies have shown that the low expression of phosphorylated AMPK is associated with a poor prognosis of pancreatic cancer.In this study,we report that AMPK is also highly sensitive to extracellular matrix(ECM)stiffness.We found that AMPK is activated in cells when cultured under low ECM stiffness conditions and is functionally required for the metabolic switch induced by ECM stiffness.This regulation of AMPK requires the Hippo kinases but not LKB1/CaMKKp.Hippo kinases directly phosphorylate AMPKa at Thr172 to activate AMPK at low ECM stiffness.Furthermore,we found AMPK activity is inhibited in patients with pancreatic ductal adenocarcinoma(PDAC)with high ECM stiffness and is associated with a poor survival outcome.The activation of Hippo kinases by ROCK inhibitor Y-27632 in combination with the mitochondrial inhibitor metformin synergistically activates AMPK and dramatically inhibits PDAC growth.Together,these findings establish a novel model for AMPK regulation by the mechanical properties of ECMs and provide a rationale for simultaneously targeting the ECM stiffness-Hippo kinases-AMPK signaling and low glucose-LKB1-AMPK signaling pathways as an effective therapeutic strategy against PDAC.

关键词： AMPKactivity Cellularmetabolic switch ECM stiffness Hippokinase signaling Pancreaticductal adenocarcinoma

Software Defect Prediction Method Based on Stable Learning

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Computers, Materials & Continua 2024年第1期78卷 65-84页

作者： xin Fan Jingen mao Liangjue Lian Li Yu Wei Zheng Yun Ge College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing210012China School of Software Nanchang Hangkong UniversityNanchang330029China Software Testing and Evaluation Center Nanchang Hangkong UniversityNanchang330029China

The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and labor.In previous software defect prediction studies,transfer learning was effective in solving the problem of inconsistent project data distribution.However,target projects often lack sufficient data,which affects the performance of the transfer learning model.In addition,the presence of uncorrelated features between projects can decrease the prediction accuracy of the transfer learning model.To address these problems,this article propose a software defect prediction method based on stable learning(SDP-SL)that combines code visualization techniques and residual networks.This method first transforms code files into code images using code visualization techniques and then constructs a defect prediction model based on these code images.During the model training process,target project data are not required as prior knowledge.Following the principles of stable learning,this paper dynamically adjusted the weights of source project samples to eliminate dependencies between features,thereby capturing the“invariance mechanism”within the data.This approach explores the genuine relationship between code defect features and labels,thereby enhancing defect prediction performance.To evaluate the performance of SDP-SL,this article conducted comparative experiments on 10 open-source projects in the PROMISE dataset.The experimental results demonstrated that in terms of the F-measure,the proposed SDP-SL method outperformed other within-project defect prediction methods by 2.11%-44.03%.In cross-project defect prediction,the SDP-SL method provided an improvement of 5.89%-25.46% in prediction performance compared to other cross-project defect prediction methods.Therefore,SDP-SL can effectively enhance within-and cross-project defect predictions.

关键词： Software defect prediction code visualization stable learning sample reweight residual network