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Chinese Chemical Letters 2001年第2期12卷 157-160页

作者： Wei Min WANG xin miao liang Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116011

The adsorption and desorption coefficients of atrazine, methiocarb and simazine on a sandy loam soil were measured in this study with soil column liquid chromatographic (SCLC) technique. The adsorption and desorption data of all the three pesticides followed Freundlich isotherms revealing the existence of hysteresis. In comparing with other methods, SCLC method showed some characteristics such as rapidity, online and accuracy.

关键词： Adsorption desorption pesticides soil column

A New Rapid Determination Method of Soil Organic Carbon Adsorption Coefficients of Pesticides with Soil Column Liquid Chromatography

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Chinese Chemical Letters 2001年第3期12卷 261-264页

作者： Wei Min WANG xin miao liang Qing ZHANG Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116011

Soil column liquid chromatography (SCLC) was developed to determine soil organic carbon adsorption coefficients (E-oc) for chemicals. The uptake by soil of pesticides from water can be conveniently calculated from the related breakthrough curves (BTC). The nine pesticides chosen for determination in this study are soluble ones, with their water solubility ranging from 62 mg/L to Z mg/L. In comparing with existing methods of K-oc, SCLC possesses rapid, online and accurate characteristics.

关键词： Soil organic carbon adsorption coefficients (Koc) determination soil column

Synthesis of Novel Monophosphoramidite Ligands Derived from L-Proline for Rh-catalyzed Asymmetric Hydrogenation of α-Dehydroamino Acid Esters

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Chinese Chemical Letters 2005年第10期16卷 1321-1323页

作者： Qing Heng ZENG Xiang Ping HU xin miao liang Zhuo ZHENG Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Graduate School of Chinese Academy of Sciences Beijing 100039

Two novel monophosphoramidites were synthesized through a five-step transformation from commercially available L-proline. In the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives, ligand （Sc,... 详细信息

关键词： Monophosphoramidite L-proline Rh-catalyzed asymmetric hydrogenation α-dehydroamino acid.

Synthesis of Novel C_(2)-Symmetrical Bidentate Phosphoramidite Ligands for Rh-catalyzed Asymmetric Hydrogenation of β-(Acylamino)acrylates

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Chinese Chemical Letters 2006年第6期17卷 711-713页

作者： Qing Heng ZHNG Xiang Ping HU xin miao liang Zhuo ZHENG Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023 Graduate School of Chinese Academy of Sciences Beijing 100039

Two new C2-symmetrical bidentate phosphoramidite ligands were synthesized and employed in the Rh-catalyzed asymmetric hydrogenation of β-（acylamino）acrylates, up to 89% ee with full conversions was obtained.

关键词： β-Aminoacid phosphoramidite 1,2-diphenylethylenediamine Rh-catalyzed asymmetric hydrogenation,β-(acylamino)acrylates.

The Study on the Noncovalent Complexes of Silver Ion with Xanthone Diglycosides by Electrospray Ionization with Tandem Mass Spectrometry

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Chinese Chemical Letters 2006年第3期17卷 391-394页

作者： Yan Guo SUN Xi ZHANG Hong Bin XIAO xin miao liang Dalian Institute of Chemical Physics Chinese Academy of Science Dalian 116023

The silver ionic complexes of xanthone glycosides were studied by ESI-MS/MS in the positive ion mode. The fragmentation pathways of silver ionic complexes under collisioninduced dissociation （CID） were investigated and the differences in MS/MS spectra of different silver ionic complexes of xanthones were correlated to the characterization of saccharide and the coordination pattern of silver ion with xanthones, including the glycosilation position and linkage type of disaccharide （1-2 and 1-6 linkages）.

关键词： Electrospray ionization MS/MS xanthone glycosides silver ionic complexes

Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis

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Chinese Chemical Letters 2005年第9期16卷 1233-1236页

作者： Shao Ping FU Xiao Zhe ZHANG Feng ZHANG Qing XU Hong Bin XIAO xin miao liang Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023

The protein binding constant, binding sites of the Strychnos alkaloid-strychnine and bovine serum albumin （BSA） was determined by capillary electrophoretic frontal analysis （CE-FA） for the first time. The experiment was carried out in a polyacrylamide-coated fused silica capillary （48.4 cm×50 μm i.d., 38.1 cm effective length） with 20 mmol/L citrate/MES buffer （pH 6.0, ionic strength 0.17）. The applied voltage was 12 kV and detection wavelength was set at 257 nm. The plateau height of the peak was employed to determine the unbound concentration of drug in BSA equilibrated sample solution based on the external drug standard in the absence of protein. The present method provides a convenient, accurate technique for the early stage of drug screening.

关键词： Strychnine binding constant capillary electrophoretic frontal analysis bovine serumalbumin

Updated clinical and glycomic features of mannosyl-oligosaccharide glucosidase deficiency:Two case reports

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World Journal of Clinical Cases 2022年第21期10卷 7397-7408页

作者： Kuerbanjiang Abuduxikuer Lei Wang Lin Zou Cui-Yan Cao Long Yu Hong-Mei Guo xin-miao liang Jian-She Wang Li Chen Department of Hepatology Children's Hospital of Fudan UniversityShanghai 201102China Department of Research and Development SysDiagno BiomedtechNanjing 211800Jiangsu ProvinceChina Department of Medical Microbiology Key Laboratory of Medical Molecular Virology of Ministries of Education and HealthSchool of Basic Medical SciencesFudan UniversityShanghai 200032China Dalian Institute of Chemical Physics Chinese Academy of ScienceDalian 116023Liaoning ProvinceChina Department of Gastroenterology Children's Hospital Affiliated to Nanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND Mannosyl-oligosaccharide glucosidase(MOGS)deficiency is an extremely rare type of congenital disorder of glycosylation(CDG),with only 12 reported *** clinical,genetic,and glycomic features are still *** aim is to update the novel clinical and glycosylation features of 2 previously reported patients with *** SUMMARY We collected comprehensive clinical information,and conducted the immunoglobulin G1 glycosylation assay using nano-electrospray ionization source quadruple time-of-flight mass *** dysmorphic features included an enlarged tongue,forwardly rotated earlobes,a birth mark,overlapped toes,and abnormal fat *** imaging findings included pericardial effusion,a deep interarytenoid groove,mild congenital subglottic stenosis,and *** laboratory findings included peripheral leukocytosis with neutrophil predominance,elevated C-reactive protein and creatine kinase,dyslipidemia,coagulopathy,complement 3 and complement 4 deficiencies,decreased proportions of T lymphocytes and natural killer cells,and increased serum interleukin *** studies showed a significant increase of hypermannosylated glycopeptides(Glc3Man7GlcNAc2/N2H10 and Man5GlcNAc2/N2H5)and hypersialylated glycopeptides.A compensatory glycosylation pathway leading to an increase in Man5GlcNAc2/N2H5 was indicated with the glycosylation *** We confirmed abnormal glycomics in 1 patient,expanding the clinical and glycomic spectrum of *** also postulated a compensatory glycosylation pathway,leading to a possible serum biomarker for future diagnosis.

关键词： Mannosyl-oligosaccharide glucosidase MOGS-CDG Congenital disorder of glycosylation type IIb Mannosyl-oligosaccharide glucosidase gene Glycomics of IgG1 Case report

Comprehensive Quality Evaluation of ShuXueNing Injection Employing Quantitative High-Performance Liquid Chromatography Fingerprint and Chemometrics

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 54-62页

作者： Yu Zhang xin Xu Hua-Wen Qi Yu-Cheng Liu Jia-Tao Dong Gui-Cai Xi Hong-Li Jin Yan-Fang Liu xin-miao liang Chinese Medicine Science Center Key Laboratory of Separation Science for Analytical ChemistryDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 TCM Standardization Technology Research Group DICP‑CMC Innovation Institute of MedicineTaizhou 225300 HeiLongJiang ZBD Pharmaceutical Co. LtdHeilongjian158400China

Objective:In this study,a comprehensive and effective quality method for evaluating the efficacy of ShuXueNing injection(SXNI)was *** and Methods:Quantitative high-performance liquid chromatography fingerprint,the quantitative analysis of multicomponents by a single marker(QAMS)method,hierarchical cluster analysis(HCA),and orthogonal partial least squares discrimination analysis(OPLS-DA)were used to distinguish 53 batches of SXNI samples from 7 ***:A total of 53 batches of samples were analyzed to establish antithesis fingerprint of SXNI,and 12 peaks of the common model were collected and used for the similarity ***,six index flavonoid components were determined by the QAMS method,using rutin as internal reference *** accuracy of the QAMS method was confirmed by investigating the relative deviation between the QAMS method and the traditional external standard *** results demonstrated that there was no significant difference(RE<1%),suggesting that QAMS was a reliable and convenient method for the content determination of multiple *** HCA and OPLS-DA methods drew a similar *** 53 batches of SXNI samples from 7 manufacturers were categorized into five groups,indicating that chemometrics could reveal the quality differences of SXNI between the ***:The method established herein was efficient and successful in assessing the quality of SXNI,and that it may be potentially employed in the quality control of related products composed of Ginkgo biloba extract.

关键词： Chemometrics quantitative analysis of multicomponents by a single marker quantitative high-performance liquid chromatography fingerprint ShuXueNing injection

Double Off-line Two-dimensional Liquid Chromatography for Separation and Identification of Compounds in Salvia Miltiorrhiza(Danshen)

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World Journal of Traditional Chinese Medicine 2015年第3期1卷 27-39页

作者： Ji-xia Wang Xiu-li Zhang Fan Yang Hong-li Jin Li-ying Shi Wei-jia Zhou Yan-fang Liu xin-miao liang Key Lab of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of Sciences Institute of Materia Medica Dalian University

Background: Danshen is an important traditional Chinese medicine(TCM) used for the treatment of cardiovascular and cerebrovascular diseases. Separation and analysis of its components have been widely investigated. However, the systematical two dimensional liquid chromatography(2D-LC) methods have not been developed to comprehensively separate and characterize its ***: In this work, double off-line 2D-LC methods were aimed to develop for the systematical separation of compounds from ***: Using solid phase extraction(SPE), the Danshen extract was divided into a medium-polar fraction(Sample I) and a weak-polar fraction(Sample Ⅱ) according to their polarities. Based on reversed-phase liquid chromatography(RPLC) and hydrophilic interaction liquid chromatography(HILIC) modes, a 2D-HILIC × RPLC system and a 2D-RPLC × RPLC system were designed for the separation of Sample Ⅰ and Sample Ⅱ, respectively. According to reversed-phase and HILIC columns selectivities characterized in our previous reports, ZIC-HILIC and XTerra C18 were employed to build the 2D-HILIC × RPLC system and Click TE-CD and XTerra C18 for the 2D-RPLC × RPLC system,***: The 2D-HILIC × RPLC and 2D-RPLC × RPLC systems exhibited excellent orthogonality for the separation of Sample Ⅰ and Sample Ⅱ,respectively. Their orthogonalities were 88.42% and 63.24%. Based on these double 2D-LC systems combined with mass spectrometry, at least 200 compounds were found and 33 compounds of them were identified, including 16 phenolic acids and 17 diterpenoid ***: These results suggest that these two off-line 2D-LC methods are effective for the separation and characterization of components in Danshen.

关键词： two-dimensional liquid chromatography separation identification Danshen

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可信执行环境访问控制建模与安全性分析

软件学报 2023年第8期34卷 3637-3658页

作者：苗新亮常瑞潘少平赵永望蒋烈辉数学工程与先进计算国家重点实验室(战略支援部队信息工程大学) 河南郑州450002 浙江大学计算机科学与技术学院浙江杭州310027 浙江省区块链与网络空间治理重点实验室浙江杭州310027

可信执行环境(TEE)的安全问题一直受到国内外学者的关注.利用内存标签技术可以在可信执行环境中实现更细粒度的内存隔离和访问控制机制,但已有方案往往依赖于测试或者经验分析表明其有效性,缺乏严格的正确性和安全性保证.针对内存标签... 详细信息

可信执行环境(TEE)的安全问题一直受到国内外学者的关注.利用内存标签技术可以在可信执行环境中实现更细粒度的内存隔离和访问控制机制,但已有方案往往依赖于测试或者经验分析表明其有效性,缺乏严格的正确性和安全性保证.针对内存标签实现的访问控制提出通用的形式化模型框架,并提出一种基于模型检测的访问控制安全性分析方法.首先,利用形式化方法构建基于内存标签的可信执行环境访问控制通用模型框架,给出访问控制实体的形式化定义,定义的规则包括访问控制规则和标签更新规则;然后利用形式化语言B以递增的方式设计并实现该框架的抽象机模型,通过不变式约束形式化描述模型的基本性质;再次以可信执行环境的一个具体实现TIMBER-V为应用实例,通过实例化抽象机模型构建TIMBER-V访问控制模型,添加安全性质规约并运用模型检测验证模型的功能正确性和安全性;最后模拟具体攻击场景并实现攻击检测,评估结果表明提出的安全性分析方法的有效性.

关键词：内存标签可信执行环境访问控制模型检测安全性分析

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