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整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

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Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye Wan-Qiong li Mei-ling Chen Qian-Kun Shi Hua Wang xin-ling li Ying-He li Jie Yang Qiao-li Wang Fang Hu Yan-Feng Gao Shu-Wen liu Mu-Sheng Zeng Guo-Kai Feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide

Integrinα6:a potential target for cancer molecular imaging and targeting therapy

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Malignancy Spectrum 2024年第1期1卷 30-45页

作者： xin-ling li Zhuo-Lun Shen Qiao-li Wang Jia-Cong Ye Wen-Biao Zhang Ying-He li Guo-Kai Feng Mu-Sheng Zeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdongChina

As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor *** role of integrins in tumor cells and the tumor microenvironment has been extensively *** the integrin family,integrinαvβ3 is the most studied integrin in the past 20 *** of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and ***,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin ***α6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the *** studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising *** this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.

关键词： tumor imaging tumor therapy tumor microenvironment molecular imaging integrin

抗HPV生物蛋白敷料联合普罗雌烯乳膏治疗绝经后女性宫颈HPV感染的疗效

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中华医院感染学杂志 2024年第6期34卷 903-906页

作者：宋魏如辛玲丽张俊琴王丽蓉张鑫鑫侯庆香火箭军特色医学中心妇产科北京100088

目的探究抗人乳头瘤病毒(HPV)生物蛋白敷料联合普罗雌烯乳膏治疗绝经后女性宫颈HPV感染的治疗效果及安全性。方法回顾性分析2018年3月—2022年8月于火箭军特色医学中心就诊的228例绝经后高危型人乳头瘤病毒(HR-HPV)感染女性,其中抗HP... 详细信息

目的探究抗人乳头瘤病毒(HPV)生物蛋白敷料联合普罗雌烯乳膏治疗绝经后女性宫颈HPV感染的治疗效果及安全性。方法回顾性分析2018年3月—2022年8月于火箭军特色医学中心就诊的228例绝经后高危型人乳头瘤病毒(HR-HPV)感染女性,其中抗HPV生物蛋白敷料联合普罗雌烯乳膏治疗的患者为研究组共124例,保妇康栓治疗的患者为对照组共104例。采集患者一般资料,两组患者均治疗3个月,分别于治疗前及治疗3个月后检测患者液基细胞学技术(TCT)、HPV及阴道微生态指标。对比研究组及对照组治疗前后HPV转阴情况、阴道微生态指标及不良反应发生率。结果两组患者年龄、绝经时间及HR-HPV感染亚型数量比较无统计学差异,研究组患者治疗后阴道微生态异常率、pH值及Nugent评分下降(P<0.05),研究组患者治愈率及总有效率分别为34.7%、65.3%,高于对照组(P<0.05),两组间不良反应发生率比较无统计学差异。结论抗HPV生物蛋白敷料联合普罗雌烯乳膏可以改善阴道微生态从而促进绝经后女性HR-HPV转阴,其疗效确切、应用安全。

关键词：抗人乳头瘤病毒生物蛋白敷料普罗雌烯乳膏人乳头瘤病毒阴道微生态疗效

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大口径光学合成孔径系统研究进展

航天返回与遥感 2024年第3期45卷 7-18页

作者：张家福王小勇李梦旭陶鑫李凌王任远北京空间机电研究所北京100094

光学合成孔径技术是增大望远镜有效口径、提高望远镜分辨率、增强望远镜集光能力的有效途径,但是大口径光学合成孔径系统的技术难度随着子孔径离散程度的提高与自由度的释放呈指数级增长。文章比较了光学合成孔径系统的基本原理与结构形... 详细信息

光学合成孔径技术是增大望远镜有效口径、提高望远镜分辨率、增强望远镜集光能力的有效途径,但是大口径光学合成孔径系统的技术难度随着子孔径离散程度的提高与自由度的释放呈指数级增长。文章比较了光学合成孔径系统的基本原理与结构形式,回顾了以拼接式、稀疏孔径式和分布式为代表的大口径光学合成孔径系统的发展历程,分析了大口径光学合成孔径系统在主动光学、编队与控制、路径规划等关键技术领域面临的技术难题,并提出下一代大口径光学合成孔径系统的发展方向。

关键词：大口径望远镜光学合成孔径干涉成像 “觅音”计划

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Two thin middle-crust low-velocity zones imaged in the Chuan-Dian region of southeastern Tibetan Plateau and their tectonic implications

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Science China Earth Sciences 2024年第5期67卷 1675-1686页

作者： Long li xin WANG Guangbing HOU Yuan ling Yinshuang AI Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

Intracrustal low-velocity zones(LVZs)indicate a mechanically weak crust and are widely observed in the southeast margin of the Tibetan ***,their spatial distributions and formation mechanisms remain *** investigate their distribution and detailed morphology of the LVZs in the southeastern Tibetan Plateau,here we used teleseismic events and continuous waveform data recorded by 40 broadband seismic stations newly deployed in the Sichuan-Yunnan region from December 2018 to October 2020.A total of 12,924 high-quality P-wave receiver functions and 5–40 s fundamental Rayleigh surface wave phase velocity dispersion curves from ambient noise cross-correlation functions were *** Swave velocity model at a depth interval of 0–100 km in the study area was inverted by using the trans-dimensional Markov chain Monte Carlo strategy to jointly invert the complementary data of the receiver function waveform and Rayleigh surface wave phase velocity *** results show that there are two separate LVZs(~3.5 km/s)surrounding the rigid Daliangshan subblock at crustal depths of approximately 30–40 km,providing new constraints on the geometry of the LVZs in our study *** two LVZs obtained in this study may represent the middle crustal flow channels,through which the material in the center of the Tibetan Plateau extrudes to its southeast *** by the rigid Sichuan Basin and the spindle-like Daliangshan subblock,the material continues to flow southward through the mechanically weak middle crustal channels surrounding the Daliangshan *** addition,the existence of thin LVZs in the middle crust plays an important role in understanding the decoupling between the upper and lower crust in the study *** also provides new constraint on the complex tectonic deformation process of the southeastern margin of the Tibetan Plateau caused by the collision and compression of the Indian and the Eurasian plates.

关键词： Southeastern Tibetan Plateau Joint inversion Intracrustal low-velocity zone Mid-crustal channel flow

Constructing S-scheme charge separation in cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4) heterojunction with enhanced photothermal-assisted photocatalytic H_(2) evolution

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Rare Metals 2024年第1期43卷 198-211页

作者： Wei-Long Shi Zheng Xu Yu-xing Shi ling-ling li Jia-lin Lu xin-Hai Sun xin Du Feng Guo Chang-Yu Lu School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Water Resource and Environment Hebei Province Key Laboratory of Sustained Utilization and Development of Water RecourseHebei Center for Ecological and Environmental Geology ResearchHebei Geo UniversityShijiazhuang 050031China

Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific ***,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) *** multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through *** addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme *** optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,*** work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.

关键词： Photothermal Photocatalytic H_(2)evolution Cobalt phthalocyanine Oxygen-doped g-C_(3)N_(4) Sscheme heterojunction

Learning to Branch in Combinatorial Optimization With Graph Pointer Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 157-169页

作者： Rui Wang Zhiming Zhou Kaiwen li Tao Zhang ling Wang xin Xu Xiangke liao IEEE the Xiangjiang Laboratory and the College of Systems Engineering National University of Defense TechnologyChangsha 410073China the Institute of Automation Chinese Academy of SciencesBeijing 100190China the College of Systems Engineering National University of Defense TechnologyChangsha 410073 the Hunan Key Laboratory of Multi-Energy System Intelligent Interconnection Technology Changsha 410073China the Department of Automation Tsinghua UniversityBeijing 100084China the College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China the College of Computer Science and Technology National University of Defense TechnologyChangsha 410073China

Traditional expert-designed branching rules in branch-and-bound(B&B) are static, often failing to adapt to diverse and evolving problem instances. Crafting these rules is labor-intensive, and may not scale well with complex *** the frequent need to solve varied combinatorial optimization problems, leveraging statistical learning to auto-tune B&B algorithms for specific problem classes becomes attractive. This paper proposes a graph pointer network model to learn the branch rules. Graph features, global features and historical features are designated to represent the solver state. The graph neural network processes graph features, while the pointer mechanism assimilates the global and historical features to finally determine the variable on which to branch. The model is trained to imitate the expert strong branching rule by a tailored top-k Kullback-Leibler divergence loss function. Experiments on a series of benchmark problems demonstrate that the proposed approach significantly outperforms the widely used expert-designed branching rules. It also outperforms state-of-the-art machine-learning-based branch-and-bound methods in terms of solving speed and search tree size on all the test instances. In addition, the model can generalize to unseen instances and scale to larger instances.

关键词： Branch-and-bound(B&B) combinatorial optimization deep learning graph neural network imitation learning

Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-ling li Hua Zhang Bao-Jun Suo Yu-xin Zhang xin-Lu Ren Yu-xin Wang Chang-Min Mi ling-ling Ma li-Ya Zhou Xue-li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

D-band center coordination modulated enzyme-like activity in Fe-Cu dual-metal single-atom nanozymes

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Nano Research 2024年第7期17卷 5872-5883页

作者： ling liu Shaofang Zhang Guo li Yadong Zhe Jiamin liu xinxu Zhang Jiahao Wei xin Sun Yonghui li Xiao-Dong Zhang Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of SciencesTianjin UniversityTianjin 300350China

After explorations in a diversity of single-atom nanozymes(SAzymes),developing dual-centered SAzymes becomes a promising approach for superior catalytic *** confusing mechanisms including atomic coordination,spatial configuration,and metal–metal atom interaction hinder the development and design of ***,a dual-centered Fe-Cu-N_(x)SAzyme exhibits excellent peroxidase(POD)-and catalase(CAT)-like activities with d-band center(ε_(d))coordination of Fe and Cu in multiple reaction stages,which plays a critical role in the adsorption of H_(2)O_(2)molecule and H_(2)O and O_(2)***,the dband center coordination,which can be represented byε_(d)(Fe)–ε_(d)(Cu)shifts,leads to the competition between one-side and bilateral adsorption,which determines the favorable reaction path with lower energy *** on experimental statistics,simulated formation energies,and reaction barriers,3 configurations,Fe-Cu-N6-I,Fe-Cu-N_(8)-II,and Fe-Cu-N_(8)-III,are modeled and ***,configuration-dependent catalytic selectivity and the competition between one-side and bilateral adsorption can be unveiled by d-band center coordination paradigm *** simulations suggest that the unsymmetrical charge distribution over the three Fe-Cu configurations could tune the adsorption strength compared with the counterparts FeN_(4)and CuN_(4).The present work provides a potential route for optimizing enzyme-like catalysis by designing the dual-or even triple-metal SAzymes,which demonstrates the large space to modulate the metal atomic configuration and interaction.

关键词： single-atom catalysis Fe-Cu dual-metal d-band center coordination enzyme mimicking competitive adsorption mechanisms