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Distribution and changes in hepatitis C virus genotype in China from 2010 to 2020

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World Journal of Clinical Cases 2022年第14期10卷 4480-4493页

作者： Jia Yang hui-xin liu Ying-Ying Su Zhi-Sheng Liang hui-Ying Rao Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesPeking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthXiamen UniversityXiamen 361000Fujian ProvinceChina Department of Global Health School of Public HealthPeking UniversityBeijing 100044China

BACKGROUND Hepatitis C virus(HCV)causes a large number of infections worldwide.New infections seem to be increasing according to a report of the World Health Organization in 2015.Although direct-acting antivirals are quite effective for most genotypes of the HCV,some genotypes fail to respond.Therefore,the trend of genotype distribution is vital to better control the development of this infection.AIM To analyze the distribution and trends of the HCV genotype before and after the emergence of direct-acting antivirals in China.METHODS We searched all literature published in five electronic databases-China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese Journal Database,Chinese Biomedical Literature Service System,and PubMed-from January 1,2010 to December 31,2020.The search strategy combined medical subject headings and free-text terms,including“hepatitis C virus”or“HCV”and“genotype”or“subtype”and“China”or“Chinese”.Additional relevant articles were searched by manual selection.Data were extracted to build a database.All of the data were totaled according to regions,periods,routes of transmission,and sexes.The percentages in various stratifications were calculated.RESULTS There were 76110 samples from 30 provinces included in the study.Genotype 1(G1)accounted for 58.2%of cases nationwide,followed by G2,G6,G3b,G3a,unclassified and mixed infections(17.5%,7.8%,6.4%,4.9%,1.8%,and 1.2%,respectively).The constitution of genotype varied among different regions,with G6 and G3b being more common in the south and southwest,respectively(28.1%,15.4%).The past ten years have witnessed a decrease in G1 and G2 and an increase in G3 and G6 in almost all regions.The drug-use population had the most abundant genotypes,with G6 ranking first(33.3%),followed by G1 and G3b(23.4%,18.5%).CONCLUSION G3 and G6 pose a new challenge for HCV infection.This study revealed the distribution of HCV genotypes in China over the past 10 years,providing information for HCV management strategies.

关键词： Hepacivirus Genotype China Drug users Direct-acting antiviral Hepatitis C virus

Synergistic Optimization of Toughness and EMI Shielding Properties in Rigid Polyurethane Composites by Designing Ring Structures on the Surface of Carbon Fibers

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Chinese Journal of Polymer Science 2023年第12期41卷 1958-1968,I0010页

作者： Yi-Long Zhou Wei-Wei Li hui-xin liu Kai-Yuan Pei Shi-Ting Li School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

How to achieve both toughness and enhanced electromagnetic interference shielding effectiveness(EMI SE)of carbon fibers(CFs)reinforced rigid polyurethane(RPU)composites is a significative challenge at present.In this work,a ring-shaped zinc coating was deposited on the short CFs by electrodeposition technique.It is expected to improve the interfacial properties between the fibers and the resin matrix as well as enhance the EMI shielding properties of the composites by changing the surface morphology and roughness of the fibers.Results showed that the surface free energy of the ring-shaped zinc modified carbon fibers(RS-CFs)increased from 49.0 mJ/m^(2) to 53.2 mJ/m^(2),indicating that the surface roughness and wettability of the CFs were effectively improved.In comparison with the pristine short carbon fibers/rigid polyurethane(CFs/RPU)composites,tensile strength and tensile toughness of RS-CFs modified composites were increased by 27.1% and 121.4%,respectively.In addition,the bending and impact strengths of RS-CFs reinforced RPU composites were also improved.Notably,the electrical conductivity of RS-CFs/RPU composites reached 1.2×10^(-5) S/m,which was much higher than that of CFs/RPU composites at 1.4×10^(-10) S/m.Moreover,the EMI SE of the modified composites reached 22 dB,which was 152.9% higher than that of CFs/RPU composites.The enhanced electrical conductivity and EMI shielding properties of the composites could be attributed to the synergistic effect of the porous structure in the RPU matrix and the CFs modified by the metal coating.

关键词： Carbon fiber Surface decoration Rigid polyurethane Mechanical properties EMI shielding

PVP-Supported Palladium-Cadmium Bimetallic Catalyst for the Hydrogen Transfer Dechlorination of Aryl Chlorides

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Chinese Chemical Letters 1999年第7期10卷 607-610页

作者： Ru Hong KANG Jiang Hua MA xin hui liu Shu Mei HE(Chemistry Department of Flebei Normal University. Shijiazhuang 050016)(Experimental Center of Hebei Normal University. Shijiazhuang 050016) Chemistry Department Hebei Normal University Shijiazhuang 050016 China Experimental Center Hebei Normal University Shijiazhuang 050016 China

PVP-supported bimetallic catalyst, PVP-PdCl2-CdCl2, exhibits extremely high catalytic activity for the hydrogen transfer dechlorination of aryl chlorides in neutral environment. The yields of dechlorination products a... 详细信息

关键词： bimetallic catalyst aryl chlorides hydrogen transfer dechlorination

Special electromyographic features in a child with paramyotonia congenita: A case report and review of literature

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World Journal of Clinical Cases 2024年第3期12卷 587-595页

作者： hui Yi Chen-Xiang liu Shu-xin Ye Yu-Lin liu Department of Neuroelectrophysiology Qilu Children’s Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Neuroelectrophysiology University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266000Shandong ProvinceChina

BACKGROUND Paramyotonia congenita(PMC)stands as a rare sodium channelopaty of skeletal muscle,initially identified by Eulenburg.The identification of PMC often relies on electromyography(EMG),a diagnostic technique.The child’s needle EMG unveiled trains of myotonic discharges with notably giant amplitudes,alongside irregular wave trains of myotonic discharges.This distinctive observation had not surfaced in earlier studies.CASE SUMMARY We report the case of a 3-year-old female child with PMC,who exhibited la-ryngeal stridor,muffled speech,myotonia from birth.Cold,exposure to cool water,crying,and physical activity exacerbated the myotonia,which was relieved in warmth,yet never normalized.Percussion myotonia was observable in bilateral biceps.Myotonia symptoms remained unchanged after potassium-rich food consumption like bananas.Hyperkalemic periodic paralysis was excluded.Cranial magnetic resonance imaging yielded normal results.Blood potassium remained within normal range,while creatine kinase showed slight elevation.Exome-wide genetic testing pinpointed a heterozygous mutation on chromosome SCN4A:c.3917G>A(p.G1306E).After a six-month mexiletine regimen,symptoms alleviated.CONCLUSION In this case revealed the two types of myotonic discharges,and had not been documented in other studies.We underscore two distinctive features:Giant-amplitude potentials and irregular waves.

关键词： Paramyotonia congenita Channelopathy Electromyography Child Case report

Knockout of C6orf120 in Rats Alleviates Concanavalin A-induced Autoimmune Hepatitis by Regulating Macrophage Polarization

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Biomedical and Environmental Sciences 2024年第6期37卷 594-606页

作者： xin Wang Yuqi Wang hui liu Yingying Lin Peng Wang Yunyun Yi xin Li Department of Center of Integrated Traditional Chinese and Western Medicine Peking University Ditan Teaching HospitalBeijing 100015China Department of Center of Integrated Traditional Chinese and Western Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Center of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective The effect of the functionally unknown gene C6orf120 on autoimmune hepatitis was investigated on C6orf120 knockout rats(C6orf120^(-/-))and THP-1 cells.Method Six–eight-week-old C6orf120^(-/-)and wild-type(WT)SD rats were injected with Con A(16 mg/kg),and euthanized after 24 h.The sera,livers,and spleens were collected.THP-1 cells and the recombinant protein(rC6ORF120)were used to explore the mechanism in vitro.The frequency of M1 and M2 macrophages was analyzed using flow cytometry.Western blotting and PCR were used to detect macrophage polarization-associated factors.Results C6orf120 knockout attenuated Con A-induced autoimmune hepatitis.Flow cytometry indicated that the proportion of CD68^(+)CD86^(+)M1 macrophages from the liver and spleen in the C6orf120^(-/-)rats decreased.C6orf120 knockout induced downregulation of CD86 protein and the mRNA levels of related inflammatory factors TNF-α,IL-1β,and IL-6 in the liver.C6orf120 knockout did not affect the polarization of THP-1 cells.However,rC6ORF120 promoted the THP-1 cells toward CD68^(+)CD80^(+)M1 macrophages and inhibited the CD68^(+)CD206^(+)M2 phenotype.Conclusion C6orf120 knockout alleviates Con A-induced autoimmune hepatitis by inhibiting macrophage polarization toward M1 macrophages and reducing the expression of related inflammatory factors in C6orf120^(-/-)rats.

关键词： C6orf120 Autoimmune hepatitis Macrophage polarization M1 macrophages

Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-hui liu Xiao-Peng Zhang Gang liu Wen-Dan Tan xin-Dan Zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was proposed.The digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional area.Each of these three parts was separately modeled.Using the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using VHDL-AMS.In the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area models.Furthermore,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital IC.TID experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose point.This confirms the practicality and accuracy of the proposed modeling method.The TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

Growth and development of children in China:achievements,problems and prospects

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World Journal of Pediatrics 2024年第2期20卷 97-104页

作者： xin-Nan Zong hui Li Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.

关键词： mother statement children

Jurassic integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1195-1228页

作者： Jianguo LI xin RAO Lin MU Xiaohui CUI xin LI hui LUO Peixue liu Center for Excellence in Life and Paleoenvironment Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Nanjing College University of Chinese Academy of SciencesNanjing 211135China

The Qinghai-Tibetan Plateau experienced a unique geological evolution during the Jurassic,driven by the termination of the Palaeotethys and the reduction of the Neotethys.The Indian Plate separated from the northern margin of Gondwana and drifted northward from the Southern Hemisphere.Given that the timing of strata serves as the basis for reconstructing geological history,the present work aimed to develop a new multiple stratigraphic and chronologic framework for the Jurassic strata of the Qinghai-Tibetan Plateau region via a synthesis of the material on lithostratigraphy,palaeontology,iso-radiometric dating,magnetostratigraphy,and other techniques with an emphasis on recent progress and findings.The new framework included the Jurassic System from the four major subdivisions of the plateau:the Baryan Har,Qiangtang,Lhasa-Gandise,and Southern Xizang(Himalaya).Ultimately,a more complete,refined biostratigraphic sequence was proposed,comprising the most common fossils in the plateau and those that are stratigraphically significant for the Jurassic stratigraphy,including ammonites,bivalves,brachiopods,foraminifera,radiolarians,and dinoflagellate cysts for the marine strata,and pollen and spores,and charophytes for the terrestrial sediments.This biostratigraphic framework was correlated with the Jurassic international standard zonation of the Geological Time Scale 2020 via standard or representative species or genera of ammonites.Based on this framework,we constructed a lateral correlation of the Jurassic strata between different basins of the plateau.The palaeontologic correlation in the present work shows that the Lhasa-Gandise Block had a closer relationship with the Qiangtang Block than with the Southern Xizang Himalaya during the Jurassic Period.Meanwhile,the Lhasa-Gandise Block and Qiangtang Block shared similar marine fauna features of the north marginal East Tethys.This contrasts the opinion suggesting that the Yarlung Zangbo Tethys was a small back-arc basin.A combination of stratigraphical,palaeontological,a

关键词： Biostratigraphy Chronostratigraphy Correlation Yarlung Zangbo suture Bangong Co-Nujiang suture Tethys

Principal components of nuclear mass models

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 65-71页

作者： xin-hui Wu Pengwei Zhao Department of Physics Fuzhou UniversityFuzhou 350108China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Principal component analysis(PCA)is employed to extract the principal components(PCs)present in nuclear mass models for the first time.The effects from different nuclear mass models are reintegrated and reorganized in the extracted PCs.These PCs are recombined to build new mass models,which achieve better accuracy than the original theoretical mass models.This comparison indicates that using the PCA approach,the effects contained in different mass models can be collaborated to improve nuclear mass predictions.

关键词： nuclear mass principal component analysis nuclear models statistical methods