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Correlation of CT enhancement, tumor angiogenesis and pathologic grading of pancreatic carcinoma

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World Journal of Gastroenterology 2003年第9期9卷 2100-2104页

作者： Zhong-QiuWang Jie-ShouLi Guang-MingLu xin-huazhang Zi-QianChen KuiMeng DepartmentofMedicalImaging JinlingHospitalMedicalSch0olNanjingUniversityNanjing210002JiangsuProvinceChina DepartmentofGeneralSurgery JinlingHospitalMedicalSchool-NanjingUniversityNanjing210002JiangsuProvinceChina DepartmentofPathology JinlingHospitalMedicalSchoolNanjingUniversityNanjing210002JiangsuProvinceChina

AIM: To study the correlation between pancreatic phase CT enhancement, intratumor microvessel density (MVD) and pathologic grading of pancreatic carcinoma and to evaluate the relationship between the degrees of CT enhancement and malignancy of pancreatic ***: Thirty four patients with pancreatic carcinoma underwent CT scanning before resection. The enhancement degrees and forms of tumor were observed in pancreatic phase. The operative sample was stained with HE and CD34marked by immunohistochemistry. MVD and histopathological grades of pancreatic carcinoma were examined. CT enhancement of the tumor, MVD counting in hot spot areas of neoplastic parenchymal cells and pathological grades of pancreatic carcinoma were comparatively ***: Highly differentiated pancreatic adenocarcinoma was identified in 16 patients, moderately-differentiated tumor in 7 and poorly-differentiated in 11. Isodensity CT enhancement was demonstrated in 13 cases, slightly low density enhancement in 9, slightly low density enhancement with small cystic lesions in 9 and slightly low density enhancement with large cystic lesions in 3. The counting of MVD with CD34 marked by immunohistochemistry in hot spot areas of neoplastic parenchyma cells was small in 10cases, medium in 16 and large in 8. The pathological grades correlated well with CT enhancement of the tumor (r=0.7857,P＜0.001) and with vMVD counting of tumor (r=0.3613,P＜0.05). The CT enhancement of tumor correlated with MVD(r=0.6768, P＜0.001).CONCLUSION: There is an obvious and significant correlation between CT enhancement, pathological grades and MVD number in the hot spot areas of tumor. The extent of CT enhancement is inversely proportional to the malignant degree of pancreatic carcinoma, and to the MVD number in the hot spot areas of neoplastic parenchyma. The MVD in the hot spot areas of neoplastic parenchyma cells can also reflect the prognosis of the patients, and is directly proportional to the malignant deg

关键词：胰腺癌 CT检查血管生成病理学

Observation of DNA damage of human hepatoma cells irradiated by heavy ions using comet assay

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World Journal of Gastroenterology 2003年第7期9卷 1450-1454页

作者： Li-MeiQiu Wen-JianLi xin-Yue Qing-XiangGao YanFeng Li-BinZhou Gao-huazhang InstituteofModernPhysics.theChineseAcademyofSciences Lanzhou730000GansuProvinceChina SchoolofLifeScience LanzhouUniversityLanzhou730000GansuProvinceChina

AIM: Now many countries have developed cancer therapy with heavy ions, especially in GSI (Gesellschaft fur Schwerionenforschung mbH, Darmstadt, Germany),remarkable results have obtained, but due to the complexity of particle track structure, the basic theory still needs further researching. In this paper, the genotoxic effects of heavy ions irradiation on SMMC-7721 cells were measured using the single cell gel electrophoresis (comet assay). The information about the DNA damage made by other radiations such as X-ray, γ-ray, UV and fast neutron irradiation is very plentiful, while little work have been done on the heavy ions so far. Hereby we tried to detect the reaction of liver cancer cells to heavy ion using comet assay, meanwhile to establish a database for clinic therapy of cancer with the heavy ***: The human hepatoma cells were chosen as the test cell line irradiated by 80Mev/u 20Ne10+ on HIRFL (China), the radiation-doses were 0, 0.5, 1, 2, 4 and 8 Gy,and then comet assay was used immediately to detect the DNA damages, 100-150 cells per dose-sample (30-50 cells were randomly observed at constant depth of the gel). The tail length and the quantity of the cells with the tail were put down. EXCEL was used for statistical ***: We obtained clear images by comet assay and found that SMMC-7721 cells were all damaged apparently from the dose 0.5Gy to 8Gy (t-test: P＜0.001, vs control).The tail length and tail moment increased as the doses increased, and the number of cells with tails increased with increasing doses. When doses were higher than 2Gy, nearly 100 % cells were damaged. Furthermore, both tail length and tail moment, showed linear ***: From the clear comet assay images, our experiment proves comet assay can be used to measure DNA damages by heavy ions. Meanwhile DNA damages have a positive correlation with the dose changes of heavy ions and SMMC-7721 cells have a great radiosensitivity to 20Ne10+.Different reactions to th

关键词： DNA损伤肝细胞瘤重离子辐射彗星实验单细胞凝胶电泳

双层索系支承玻璃幕墙结构的抗震设计反应谱研究

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工业建筑 2007年第10期37卷 76-79页

作者：周华樟武岳李欣哈尔滨工业大学土木工程学院哈尔滨150090

广泛应用于大型公共建筑中的双层索系支承玻璃幕墙结构是一种新型结构形式。针对这种结构的研究,以往大多侧重于其抗风性能,而对于其抗震性能的研究较少。针对双层索系支承幕墙结构的特点,构造非线性单质点体系,利用多条最不利地震动记... 详细信息

广泛应用于大型公共建筑中的双层索系支承玻璃幕墙结构是一种新型结构形式。针对这种结构的研究,以往大多侧重于其抗风性能,而对于其抗震性能的研究较少。针对双层索系支承幕墙结构的特点,构造非线性单质点体系,利用多条最不利地震动记录,采用时程分析法计算该类结构在小震、中震和大震下的加速度反应谱。在此基础上,经过统计、平滑处理,得到适用于双层索系支承玻璃幕墙结构抗震设计的设计地震反应谱和地震影响系数。算例分析表明,采用该反应谱所得到的结构地震响应值与时程分析结果较为接近。

关键词：索桁架结构玻璃幕墙非线性反应谱抗震设计

E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2

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E3 ubiquitin ligase NEDD4L negatively regulates inflammation...

浙江省免疫学会第十三次学术大会

作者： Hui Li Ning Wang Yu Jiang Haofei Wang Zengfeng xin huazhang An Hao Pan Wangqian Ma Ting Zhang Xiaojian Wang Wenlong Lin Institute of Immunology and The Second Affiliated Hospital Zhejiang University School of Medicine Department of Medical Oncology the Cancer Hospital of the University of Chinese Academy of Sciences (ZhejiangCancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of Sciences Cancer Institute Institute of Translational MedicineSecond Military Medical University & Shanghai Key Laboratory of Cell Engineering Department of Urology The First Affiliated HospitalCollege of MedicineZhejiang University Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of Medicine Department of Radiation Oncology The Second Affiliated HospitalZhejiang University School of Medicine

Background:Inflammation represents an adaptive and dynamic host response against pathogens,physical/chemical injuries,toxins,or *** stimulant triggers leukocyte infiltration,cytokines,and chemokines expression,and eventual subsiding of proinflammatory *** or prolonged inflammation has been closely related to a variety of human diseases such as autoimmune diseases,cancer,cardiovascular disease,and metabolic ***,immune-regulatory and negative feedback mechanisms are critically required to harness inflammation and prevent excessive immunopathology ***:Neural precursor cell expressed developmentally down-regulated gene 4-like（NEDD4 L） is a highly conserved HECT type E3 *** recent data demonstrate that NEDD4 L promotes Lys-29-linked ubiquitination of TRAF3,and thus positively regulates antivirus innate *** also showed in a previous study that NEDD4 L negatively regulates keratinocyte hyperplasia by promoting Lys-27-linked ubiquitination of GP130 and proteasomal degradation in ***,the physiologic role of NEDD4 L in autoimmune diseases remains largely *** and methods:Male age-matched Nedd4 l and Nedd41 littermates were treated with IL-17 or MOG to induce IL-17-associated inflammation or *** vitro,pull-down assay,ubiquitination assay,and co-immunoprecipitation assay were employed for mechanism ***:Here we identify neural precursor cell expressed developmentally down-regulated gene 4-like（NEDD4 L）,a HECT type E3 ligase,as a common negative regulator of signaling induced by TNF-α,IL-1,and ***4 L modulates the degradation of mitogen-activated protein kinase kinase kinase 2（MEKK2） via constitutively and directly binding to MEKK2 and promotes its *** interleukin-17 receptor（IL-17 R） signaling,Nedd41 knockdown or deficiency enhances IL-17-induced p38 and NF-κB activation and the production of proinflammatory cytokines and chemok

关键词： NEDD4L MEKK2 IL-17R signaling ubiquitination inflammation

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不同工艺条件下CO甲烷化催化剂的稳定性

化学反应工程与工艺 2015年第5期31卷 459-468页

作者：魏雪梅唐浩东李鑫刘化章浙江工业大学工业催化研究所浙江杭州310014

为开发性能较优的合成气甲烷化催化剂,采用固相混合法制备了20%Ni/Al2O3催化剂,通过H2程序升温还原(H2-TPR)和X射线衍射(XRD)表征发现,简单固相混合法制备的催化剂具有较好的分散性和还原性能。考察了压力、温度、空速和进料比(H2与CO... 详细信息

为开发性能较优的合成气甲烷化催化剂,采用固相混合法制备了20%Ni/Al2O3催化剂,通过H2程序升温还原(H2-TPR)和X射线衍射(XRD)表征发现,简单固相混合法制备的催化剂具有较好的分散性和还原性能。考察了压力、温度、空速和进料比(H2与CO的体积比)等不同操作条件下该CO甲烷化催化剂的稳定性,结果表明:在CO甲烷化反应体系中随着温度、压力和进料比的增大,催化剂稳定性增强;空速增大,催化剂稳定性降低。采用XRD和H2程序升温表面反应(H2-TPSR)技术对催化剂失活原因进行了探讨,发现催化剂由于表面沉积无定形胶质碳(Cβ)而失活,升高温度和压力会使催化剂表面活性碳物种(Cα)向更稳定的蠕虫状碳(Cv)和石墨型碳(Cc)沉积,从而催化剂稳定性增强。

关键词：一氧化碳甲烷化催化剂催化稳定性

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情境的心理学内涵探微

山东师范大学学报（人文社会科学版） 2003年第5期48卷 99-102页

作者：谷传华张文新北京师范大学发展心理研究所北京100000 山东师范大学教育科学学院山东济南250014

　情境是众多学科领域涉及的问题。心理学的情境有其独特内涵。应在个体行为活动系统发生的意义上界定情境。心理学的情境具有以下基本特点:整体性、连续性、生态性、不确定性。

关键词：情境心理学情境内涵

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医院管理人员职业化的必要性及可行性研究

卫生经济研究 2002年第10期19卷 3-7页

作者：王昕吴华章中国医科大学社会科学部辽宁沈阳110001

由于医院管理人员水平与医院科学管理、医疗服务领域进一步扩大开放的需要不相适应 ,医院管理人员职业化有其必要性 ;同时 ,建立职业化医院管理队伍的政策基础、认识基础、体制基础、物质基础、人才基础及国际国内环境基础已基本具备 ,... 详细信息

由于医院管理人员水平与医院科学管理、医疗服务领域进一步扩大开放的需要不相适应 ,医院管理人员职业化有其必要性 ;同时 ,建立职业化医院管理队伍的政策基础、认识基础、体制基础、物质基础、人才基础及国际国内环境基础已基本具备 ,建立职业化医院管理队伍已具有可行性。因此 ,各级卫生行政主管部门应转变观念 ,提高认识 ,加快卫生管理人才的培养 ,建立完善的职业管理者评价体系。

关键词：医院管理管理人员职业化规范化培训继续教育

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高性能灌浆料置换加固混凝土柱的受力性能

建筑科学 2015年第11期31卷 1-7页

作者：熊进刚谈歆林悦慈胡华章南昌大学建筑工程学院江西南昌330031 江西省商业建筑设计院江西南昌330002

对采用高性能灌浆料置换加固的混凝土框架柱的轴压受力性能进行了全过程分析,讨论了加固前混凝土初始应力对置换截面（组合截面）高性能灌浆料强度发挥程度的影响。结果表明,对于加固时不能卸载的柱,高性能灌浆料与混凝土之间存在应变... 详细信息

对采用高性能灌浆料置换加固的混凝土框架柱的轴压受力性能进行了全过程分析,讨论了加固前混凝土初始应力对置换截面（组合截面）高性能灌浆料强度发挥程度的影响。结果表明,对于加固时不能卸载的柱,高性能灌浆料与混凝土之间存在应变滞后现象,混凝土与高性能灌浆料不能同时达到其抗压强度。加固前,柱的初始应力越高,高性能灌浆料的强度发挥程度越低。混凝土初始应力在（0.2~0.6）fc时,高性能灌浆料的强度发挥程度为（69~87）%。在此基础上,提出了高性能灌浆料置换加固柱折算混凝土强度和轴心受压承载力的计算方法。

关键词：钢筋混凝土柱高性能灌浆料置换加固轴心受压性能全过程分析

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岩体节理体积频率的计算方法及工程应用

工程地质学报 2012年第4期20卷 585-590页

作者：章广成李华章林叶向欣朱志明中国地质大学(武汉)工程学院武汉430074 北京航天勘察设计研究院北京100070 中国长江三峡集团公司北京100038

利用Monte-Carlo原理进行三维结构面网络模拟是研究岩体内节理面发育规律最常用的技术手段,节理体积频率(λv)则是影响结构面网络模拟正确与否的关键参数之一,需要根据野外实测节理线频率(λ)进行换算。利用三维结构面网络模拟程序,提... 详细信息

利用Monte-Carlo原理进行三维结构面网络模拟是研究岩体内节理面发育规律最常用的技术手段,节理体积频率(λv)则是影响结构面网络模拟正确与否的关键参数之一,需要根据野外实测节理线频率(λ)进行换算。利用三维结构面网络模拟程序,提出了基于线频率反演节理体积频率的新思路。首先赋给某组节理一个初始体积频率,利用三维结构面网络模拟程序,生成只包含该组节理的三维网络模型样本,计算此模型中该组节理在测线方向上的线频率,不同体积频率(λv)对应不同线频率(λ),进而可建立两者的函数关系,最后将测线方向上该组节理的线频率带入该函数即可确定其体积频率。以贵州省息烽县鱼简河水库坝址区岩体为例,按照上述思路根据测线法统计数据计算了节理体积频率,结果表明λv与λ之间呈现出高度的线性关系。当节理圆盘半径服从对数正态分布时,λv与λmax的比值约为0.4～1.0,而当节理圆盘半径服从负指数分布时,λv与λmax的比值约为1.3～3.5。最后依据《工程岩体分级标准(GB50218-94)》表3.3.1、表3.4.3和表3.4.4,分别基于线频率和体积频率对鱼简河水库坝肩岩体完整性进行了评价,结果表明,后者评价结果的可信度比前者高。

关键词：节理岩体体积频率线频率三维结构面网络模拟岩体完整性