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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 226-230页

作者： xin-hua zhu Bing Liao Ke Liu Yue-Hui Liu Department of Otorhinolaryngology Head and Neck Surgery the Second Affiliated Hospital of Nanchang University Department of Head and Neck Surgery the Tumor Hospital of Jiangxi Province

Objective:To observe the clinical manifestations of allergic rhinitis mice and the expression changes of the eosinophils CCR3 and the granule protein rnRNA in the bone marrow,peripheral blood and nasal lavage ***:Twenty-four BALB/c mice were randomly divided into the control *** therapy *** therapy group and the CCR3 siRNA therapy group(n=6).Allergic rhinitis model were sensitized and stimulated by ovalbunfin,and CCR3 siKNA therapy group were administered with CCH3 transnasally before *** levels of the eosinophils *** and EPO in bone marrow,peripheral blood and nasal lavage fluid were detected by ***:Compared to the control group and CCR3 *** therapy group,the nasal mucosa of the PBS therapy group and siRNA therapy group developed *** cells hyperplasia,squamous epithelium metaplasia,epithelium necrosis,lamina propria and submucosa gland hyperplasia,vasodilatation,tissue edema,and the characterized eosinophil ***-PCR indicated that the CCR3 rnRNA,*** and EPC)expression in bone marrow,peripheral blood and nasal lavage fluid of the CCR3 siKNA therapy group was lower than the PBS therapy group and *** therapy group(P<0.05).Conclusions:The RNA interference therapy to CCR3 by local administration pernasal can suppress the process of the development,migration and invasion of the allergic rhinitis eosinophil,thus can reduce the effect of eosinophils and then reduce the inflammation effect of the allergic *** may be a new treatment for respiratory tract allergic inflammation.

关键词： Allergic rhinitis Eosinophil CCR3 RNA interfering

Effect of early enteral combined with parenteral nutrition in patients undergoing pancreaticoduodenectomy

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World Journal of Gastroenterology 2013年第35期19卷 5889-5896页

作者： xin-hua zhu Ya-Fu Wu Yu-Dong Qiu Chun-Ping Jiang Yi-Tao Ding Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School of Nanjing University

AIM:To investigate the effect of early enteral nutrition(EEN)combined with parenteral nutritional support in patients undergoing pancreaticoduodenectomy(PD).METHODS:From January 2006,all patients were given EEN combined with parenteral nutrition(PN)(EEN/PN group,n=107),while patients prior to this date were given total parenteral nutrition(TPN)(TPN group,n=67).Venous blood samples were obtained for a nutrition-associated assessment and liver function tests on the day before surgery and 6 d after *** assessment of clinical outcome was based on postoperative ***-up for infectious and noninfectious complications was carried out for 30 d after hospital *** within 30 d afterdischarge was also ***:Compared with the TPN group,a significant decrease in prealbumin(PAB)(P=0.023)was seen in the EEN/PN *** bilirubin(TB),direct bilirubin(DB)and lactate dehydrogenase(LDH)were significantly decreased on day 6 in the EEN/PN group(P=0.006,0.004 and 0.032,respectively).The rate of gradeⅠcomplications,gradeⅡcomplications and the length of postoperative hospital stay in the EEN/PN group were significantly decreased(P=0.036,0.028and 0.021,respectively),and no hospital mortality was observed in our *** with the TPN group(58.2%),the rate of infectious complications in the EEN/PN group(39.3%)was significantly decreased(P=0.042).Eleven cases of delayed gastric emptying were noted in the TPN group,and 6 cases in the EEN/PN *** rate of delayed gastric emptying and hyperglycemia was significantly reduced in the EEN/PN group(P=0.031 and P=0.040,respectively).CONCLUSION:Early enteral combined with PN can greatly improve liver function,reduce infectious complications and delayed gastric emptying,and shorten postoperative hospital stay in patients undergoing PD.

关键词： Enteral nutrition Parenteral nutrition Pancreaticoduodenectomy Complications Metabolism

Establishment of a rat liver transplantation model with prolonged biliary warm ischemia time

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World Journal of Gastroenterology 2012年第48期18卷 7194-7200页

作者： xin-hua zhu Jun-Ping Pan Ya-Fu Wu Yi-Tao Ding Department of Hepatobiliary SurgeryAffiliated Drum Tower HospitalMedical School of Nanjing University

AIM:To investigate the impact of different time points of secondary warm ischemia on bile duct in a rat autologous liver transplantation model with external bile ***:One hundred and thirty-six male inbred SD rats were randomly assigned to one of four groups(Ⅰ-Ⅳ) according to the secondary warm ischemia time of 0,10,20 and 40 min.A rat model of autologous liver transplantation with continuous external biliary drainage under ether anesthesia was *** rats in each group were used to evaluate the one-week survival *** 6 h,24 h,3 d and 7 d after reperfusion of the hepatic artery,6 rats were killed in each group to collect the blood sample via the infrahepatic vena cava and the median lobe of liver for *** ischemia time of liver,cold perfusion time,anhepaticphase,operative duration for biliary external drainage and survival rates in the four groups were analyzed for the establishment of ***:No significant difference was shown in warm ischemia time,anhepatic phase and operative duration for biliary external drainage among the four *** of the 40 rats in this study evaluated for the one-week survival rate died,including three deaths of severe pulmonary infection in group Ⅳ.A significant decrease of one-week survival rate in group Ⅳ was noted compared with the other three *** the prolongation of the biliary warm ischemia time,the indexes of the liver function assessment were significantly elevated,and biliary epithelial cell apoptosis index also *** examinations showed significantly aggravated inflammation in the portal area and bile duct epithelial cell injury with the prolonged secondary warm ischemia *** were found in the micrangium around the biliary tract in some sections from groups Ⅲ and Ⅳ.CONCLUSION:The relationship between secondary warm ischemia time and the bile duct injury degree is time-dependent,and 20 min of secondary warm ischemia time is feasible for the study of bi

关键词： Bile duct Liver Transplantation Warm ischemia Rat

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沿空留巷综合支护技术研究

岩土力学 2006年第12期27卷 2225-2228页

作者：华心祝赵少华朱昊胡华君安徽理工大学资源开发与管理工程系淮北矿业集团岱河煤矿淮北235046

用沿空留巷技术保留的巷道要经历掘进和两次强烈的采动影响,对所需留巷的巷道,应该从掘进期间的支护设计与施工到留巷期间的巷旁支护方式选择,及下个工作面回采期间的加强支护均应统筹考虑,这样才能保证沿空留巷技术的成功实施,故沿空... 详细信息

用沿空留巷技术保留的巷道要经历掘进和两次强烈的采动影响,对所需留巷的巷道,应该从掘进期间的支护设计与施工到留巷期间的巷旁支护方式选择,及下个工作面回采期间的加强支护均应统筹考虑,这样才能保证沿空留巷技术的成功实施,故沿空留巷技术是一项系统工程。据此,在淮北岱河矿Ⅲ3215工作面机巷进行了沿空留巷实践,巷内采用了锚网索支护,巷旁采用了工字钢密集支柱及矸石(碎煤)带联合支护,并在矿压观测的基础上,得出了所留巷道矿压显现规律,工业试验和应用实践表明,取得了良好的技术、经济效果。

关键词：沿空留巷巷旁支护锚网索支护综合支护

Effects of warm ischemia time on biliary injury in rat liver transplantation

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World Journal of Gastroenterology 2012年第43期18卷 6308-6314页

作者： xin-hua zhu Jun-Ping Pan Ya-Fu Wu Yi-Tao Ding Department of Hepatobiliary Surgery Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina

AIM:To investigate the effect of different secondary warm ischemia time (SWIT) on bile duct injury in livertransplanted rats. METHODS:Forty-eight male inbred Sprague-Dawley rats were randomly assigned into four groups:a shamoperation group and three groups with secondary biliary warm ischemia time of 0 min, 10 min and 20 min. A rat model of autologous liver transplantation under ether anesthesia was established, and six rats were killed in each group and blood samples and the median lobe of the liver were collected for assay at 6 h and 24 h after hepatic arterial reperfusion. RESULTS:With prolongation of biliary warm ischemia time, the level of vascular endothelial growth factor-A was significantly decreased, and the value at 24 h was higher than that at 6 h after hepatic arterial reperfusion, but with no significant difference. The extended biliary SWIT led to a significant increase in bile duct epithelial cell apoptosis, and a decrease in the number of blood vessels, the bile duct surrounding the blood vessels and bile duct epithelial cell proliferation in the early postoperative portal area. Pathologic examinations showed that inflammation of the rat portal area was aggravated, and biliary epithelial cell injury was significantly worsened. CONCLUSION:A prolonged biliary warm ischemia time results in aggravated injury of the bile duct and the surrounding vascular plexus in rat autologous orthotopic liver transplantation.

关键词： Bile duct Liver Transplantation Warm ischemia Rat

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沿空留巷底板变形力学分析及底臌防控

煤炭学报 2016年第7期41卷 1624-1631页

作者：华心祝李迎富安徽理工大学煤矿安全高效开采省部共建教育部重点实验室安徽淮南232001 安徽理工大学矿业工程博士后流动站安徽淮南232001

上覆岩层垮落产生的动载荷通过巷帮煤体、巷内支护体以及巷旁支护体传递给底板,造成工作面后方一段距离的沿空留巷底臌变形加剧。为了控制上覆岩层垮落引起的底臌变形,在分析沿空留巷力学环境的基础上,建立底板力学模型,计算出沿空留巷... 详细信息

上覆岩层垮落产生的动载荷通过巷帮煤体、巷内支护体以及巷旁支护体传递给底板,造成工作面后方一段距离的沿空留巷底臌变形加剧。为了控制上覆岩层垮落引起的底臌变形,在分析沿空留巷力学环境的基础上,建立底板力学模型,计算出沿空留巷煤帮弹性压缩区、塑性区、破裂区的宽度,以及煤帮对底板的作用力。应用关键层理论,确定顶板硬岩层位置及其破断顺序,以及垮断极限层的层位;采用顶板载荷条带分割法,计算出巷旁支护体对底板的作用力,并引入等效载荷的概念,构建底板等效载荷分布力学模型,将沿空留巷底臌与上覆岩层垮落紧密联系起来,分析上覆岩层垮落对底板的受力及变形影响,推导出底臌变形计算式。研究结果表明:上覆岩层垮落引起的底臌主要是由于塑性区煤体和巷旁支护体下方底板岩层高应力压剪破坏,以及巷道底板和采空区底板在强卸荷条件的拉伸破坏共同影响造成的。基于此,提出了降低塑性区煤体和巷旁支护体传递给底板的作用力,提高采空区冒落矸石对底板的作用力,防止巷道底板岩层拉伸破坏,巷旁支护体宽度、刚度与底板岩层强度相匹配等底臌防控措施,并应用于工程实践。

关键词：沿空留巷底板变形垮断极限层顶板载荷条带分割法底臌防控措施

沿空留巷上覆岩层关键块稳定性力学分析及巷旁充填体宽度确定

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岩土力学 2012年第4期33卷 1134-1140页

作者：李迎富华心祝安徽理工大学能源与安全学院安徽淮南232001

由于沿空留巷服务时间较长,巷道围岩变形较大,合理地计算巷旁充填体宽度至关重要。根据沿空留巷上覆岩层的活动规律,建立了关键块和直接顶的力学模型,分析了关键块与沿空留巷围岩相互作用机制,推导出巷旁支护阻力的计算公式,并引入了关... 详细信息

由于沿空留巷服务时间较长,巷道围岩变形较大,合理地计算巷旁充填体宽度至关重要。根据沿空留巷上覆岩层的活动规律,建立了关键块和直接顶的力学模型,分析了关键块与沿空留巷围岩相互作用机制,推导出巷旁支护阻力的计算公式,并引入了关键块稳定性系数K1、K2及其稳定性影响因素的敏感度。研究结果表明,当K1>1时,关键块发生挤压变形失稳;当K2>1时,关键块发生滑落失稳。以淮南谢一矿512(5)工作面为工程背景,确定了合理的巷旁充填体宽度,计算出关键块稳定性系数,获得了各影响因素对关键块稳定性的敏感度。实例分析表明,采高对关键块的稳定性影响较大,在大采高工作面中进行沿空留巷较为困难。

关键词：沿空留巷关键块稳定性力学分析充填体宽度稳定性系数影响因素的敏感度

Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation

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World Journal of Gastroenterology 2012年第42期18卷 6141-6147页

作者： xin-hua zhu Ya-Fu Wu Yu-Dong Qiu Chun-Ping Jiang Yi-Tao Ding Department of Hepatobiliary Surgery AffiliatedDrum Tower Hospital Medical School of Nanjing UniversityNanjing 210008 Jiangsu Province China

AIM:To investigate the liver-protecting effect of parenteral nutrition(PN) support with omega-3 fatty acids in a randomized controlled clinical ***:Sixty-six patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma were admitted to the Affiliated Drum Tower Hospital,Nanjing University,China for orthotopic liver *** patients were randomly divided into two groups:PN group(n = 33) and polyunsaturated fatty acid(PUFA) group(n = 33).All patients received isocaloric and isonitrogenous PN for seven days after surgery,and in PUFA group omega-3 fish oil lipid emulsion replaced part of the standard lipid *** function was tested on days 2 and 9 after *** examination was performed after reperfusion of the donor liver and on day *** outcome was assessed based on the post-transplant investigations,including:(1) post-transplant mechanical ventilation;(2) total hospital stay;(3) infectious morbidities;(4) acute and chronic rejection;and(5) mortality(intensive care unit mortality,hospital mortality,28-d mortality,and survival at a one-year post-transplant surveillance period).RESULTS:On days 2 and 9 after operation,a significant decrease of alanine aminotransferase(299.16 U/L ± 189.17 U/L vs 246.16 U/L ± 175.21 U/L,P = 0.024) and prothrombin time(5.64 s ± 2.06 svs 2.54 s ± 1.15 s,P = 0.035) was seen in PUFA group compared with PN *** pathological results showed that omega-3 fatty acid supplement improved the injury of hepatic *** with PN group,there was a significant decrease of post-transplant hospital stay in PUFA group(18.7 d ± 4.0 d vs 20.6 d ± 4.6 d,P = 0.041).Complications of infection occurred in 6 cases of PN group(2 cases of pneumonia,3 cases of intra-abdominal abscess and 1 case of urinary tract infection),and in 3 cases of PUFA group(2 cases of pneumonia and 1 case of intra-abdominal abscess).No acute or chronic rejection and hospital mortality were found in both grou

关键词： Fish oil lipid Liver Transplantation Parenteral nutrition Metabolism

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我国沿空留巷支护技术发展现状及改进建议

煤炭科学技术 2006年第12期34卷 78-81页

作者：华心祝安徽理工大学资源开发与管理工程系安徽淮南232001

介绍了我国沿空留巷巷内和巷旁支护形式及其理论研究现状,分析了沿空留巷的适用条件,指出了我国沿空留巷目前所存在的主要问题是支护设计思路不合理、巷内支护多属于被动支护、巷旁支护存在力学性能与沿空留巷围岩变形不适应、对沿空留... 详细信息

介绍了我国沿空留巷巷内和巷旁支护形式及其理论研究现状,分析了沿空留巷的适用条件,指出了我国沿空留巷目前所存在的主要问题是支护设计思路不合理、巷内支护多属于被动支护、巷旁支护存在力学性能与沿空留巷围岩变形不适应、对沿空留巷围岩控制机理研究不够深入。并提出了将沿空留巷技术视为一项系统工程、采用锚网索支护作为沿空留巷内基本支护等发展沿空留巷技术的建议。

关键词：沿空留巷巷内支护巷旁支护巷旁充填锚网索支护

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开采速度对综放面围岩力学特征影响研究

岩土工程学报 2007年第7期29卷 963-967页

作者：谢广祥常聚才华心祝安徽理工大学资源开发与管理工程系安徽淮南232001

以谢桥矿#13煤层综放工作面工程地质和开采技术条件为背景,应用计算机数值模拟和实验室相似材料模拟,对不同推进速度下综放面围岩应力、位移、破坏情况进行了深入分析,研究了工作面推进速度对综放开采安全生产的影响。研究结果表明:随... 详细信息

以谢桥矿#13煤层综放工作面工程地质和开采技术条件为背景,应用计算机数值模拟和实验室相似材料模拟,对不同推进速度下综放面围岩应力、位移、破坏情况进行了深入分析,研究了工作面推进速度对综放开采安全生产的影响。研究结果表明:随着工作面推进速度增加,工作面低应力区和周围煤岩体破坏区的范围以及位移都相应减小,而前方支承压力峰值位置向工作面煤壁靠近,峰值应力增大。现场生产实践适当加快工作面推进速度,有利于保持巷道的稳定性和改善巷道维护状态,但是应做好监测工作,防止岩爆等动力灾害的发生,确保井下安全生产的正常进行。

关键词：综放面推进速度围岩力学特征