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Identification of potential key molecules and signaling pathways for psoriasis based on weighted gene co-expression network analysis

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World Journal of Clinical Cases 2022年第18期10卷 5965-5983页

作者： xin Shu Xiao-Xia Chen xin-dan kang Min Ran You-Lin Wang Zhen-Kai Zhao Cheng-xin Li Department of Dermatology The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Chinese PLA Medical School Beijing 100853China Department of Radiology The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Comprehensive Surgical The Second Medical Center of Chinese PLA General HospitalBeijing 100089China Department of Endocrine The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Dermatology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Psoriasis is a chronic inflammatory skin disease,the pathogenesis of which is more complicated and often requires long-term *** particular,moderate to severe psoriasis usually requires systemic *** is also associated with many diseases,such as cardiometabolic diseases,malignant tumors,infections,and mood *** can appear at any age,and lead to a substantial burden for individuals and *** present,psoriasis is still a treatable,but incurable,*** studies have found that micro RNAs(mi RNAs)play an important regulatory role in the progression of various ***,mi RNAs studies in psoriasis and dermatology are relatively ***,the identification of key mi RNAs in psoriasis is helpful to elucidate the molecular mechanism of *** To identify key molecular markers and signaling pathways to provide potential basis for the treatment and management of *** The mi RNA and m RNA data were obtained from the Gene Expression Omnibus ***,differentially expressed m RNAs(DEm RNAs)and differentially expressed mi RNAs(DEmi RNAs)were screened out by limma R ***,DEm RNAs were analyzed for Gene Ontology and Kyoto Encyclopedia of Genes and Genomics functional ***“WGCNA”R package was used to analyze the co-expression network of all mi *** addition,we constructed mi RNA-m RNA regulatory networks based on identified hub mi ***,in vitro validation was *** experimental procedures were approved by the ethics committee of Chinese PLA General Hospital(S2021-012-01).RESULTS A total of 639 DEm RNAs and 84 DEmi RNAs were *** RNAs screening criteria were adjusted P(adj.P)value*** RNAs screening criteria were adj.P value*** functional analysis demonstrated that DEm RNAs were significantly enriched in immune-related biological functions,for example,tolllike recepto

关键词： Psoriasis MicroRNAs Weighted gene co-expression network analysis Functional enrichment MicroRNA-mRNA regulatory network

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： dan Hu Yue Li Hua Zhang Lian-Lian Wang Wen-Wen Liu xin Yang Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Patient,Diagnosis,and Treatment Delays Among Tuberculosis Patients Before and During COVID-19 Epidemic—China,2018-2022

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China CDC weekly 2023年第12期5卷 259-265页

作者： Tao Li xin Du Jiaojie kang dan Luo Xiaoqiu Liu Yanlin Zhao National Center for Tuberculosis Control and Prevention China CDCBeijingChina School of Public Health Peking UniversityBeijingChina Department of Public Health Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina

Summary What is already known about this topic?The coronavirus disease(COVID-19)pandemic could have a damaging impact on access to tuberculosis(TB)diagnosis and *** is added by this report?The overall delay experienced by TB patients during the COVID-19 pandemic has shown a modest decrease in comparison to the period before the ***,higher patient delays were observed among agricultural workers and those identified through passive case-finding ***,the patient delay in eastern regions was shorter compared to western and central regions.

关键词： diagnosis Patients delay

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Influence of Fe on Microstructure and Mechanical Properties in Pdoped Ni–Cr–Fe Alloys

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 771-779页

作者： xin-Tong Lian Wen-Ru Sun xin xin Fang Liu dan-dan Zheng Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

The influence of Fe on the microstructure and mechanical properties of P-doped Ni–Cr–Fe alloys has been *** showed that increasing Fe content refined the dendrite microstructure and enhanced the solubility of P in as-cast *** change of microhardness in different dendrite regions was attributed to the segregation of P atoms in solid solution state,which had strengthening *** Fe contents from 15.2 to 60.7 wt%reduced the yield strength and tensile strength but had little influence on the elongation of *** stress rupture life of alloys after heat treatment decreased with the increment of Fe contents,and the failure fracture modes transferred from transgranular to intergranular fracture *** change of fracture modes was due to the weakness of grain boundaries caused by the increment of *** addition,the precipitation of M23C6 was believed to be related to the segregation of P toward grain boundaries,which led to the fluctuation of carbon and chromium atoms near the grain boundaries in alloys with low Fe ***,the increment of Fe decreased the strength of matrix and changed the existence of P atoms and the precipitates at grain boundaries.

关键词： Fe P Segregation Precipitate Mechanical properties

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Effects of Phosphorus and Iron on Microstructures and Mechanical Properties in NiCrFe-Based Alloys

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 659-667页

作者： xin-Tong Lian Wen-Ru Sun Fang Liu dan-dan Zheng xin xin Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

The microstructures and mechanical properties, especially creep properties, of the NiCrFe-based alloys with various contents of phosphorus and iron were investigated. The results showed that the tensile yield strength decreased with increasing iron contents while had no obvious change with the addition of phosphorus. For creep properties, the alloy with15.8 wt% iron and 0.09 wt% phosphorus possessed the longest creep life(679 h) among all alloys. Only M_(23)C_6 was formed in the alloys with low phosphorus contents, while both intergranular M_3P and M_(23)C_6 precipitated with the increment of phosphorus, which enhanced the strength of grain boundary by hindering the movements of dislocations during creep tests. The reasons for the enhancement of creep life were mainly related to the solid solution strengthening effect of phosphorus and optimization of grain boundary precipitations by phosphorus.

关键词： NiCrFe-based alloys Phosphorus Iron Microstructures Creep properties

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The inflammation influence on corneal surface after frontalis suspension surgery

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1489-1495页

作者： kang Li xin-Chun Zhang Xian-Xian Cai Ya-dan Quan Rong Lu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceZhongshan Ophthalmic CenterSun Yat-sen University Department of Prosthodontics Hospital of StomatologyGuangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen University

AIM： To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory ***： A prospective, observational case series. Thirty-one eyes of 25 patients with severe congenital blepharoptosis who underwent frontalis muscle flap suspension surgery with at least 6 mo of follow-up were included in the study. The main outcome measures were margin reflex distance 1（MRD_1）, degree of lagophthalmos, ocular surface disease index（OSDI）, fluorescein staining（Fl）, tear break-up time（BUT）, Schirmer I test, and inflammatory cytokine ***： The degrees of lagophthalmos significantly increased after surgery. The OSDI scores significantly increased 1wk postoperatively and then decreased 4wk after operation. The Fl scores reflected corneal epithelial defects in sixteen patients at early stage postoperatively. The BUT and Schirmer I test values remained stable and did not show change compared to those before surgery. The inflammatory cytokines in conjunctival epithelial cells（including IL-1β, IL-6, IL-8, TNF-α, and IL-17A） significantly increased 1wk after the surgery（P〈0.001）, then returned to the normal level at 24wk postoperatively. The levels of inflammatory cytokine IL-1β, IL-6, IL-8, TNF-α, and IL-17A elevated significantly and were positively correlated with OSDI and Fl ***： Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage.

关键词： congenital blepharoptosis frontalis muscle flap suspension corneal epithelial defects inflammation

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Surface effect induced phase transformation by Mn removal during annealing and its textures in cold-rolled high manganese transformation-induced plasticity steel

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Journal of Iron and Steel Research International 2022年第3期29卷 494-502页

作者： Li-ying Liu Ping Yang dan-dan Ma xin-fu Gu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

The surface effect induced transformation texture during vacuum annealing of cold-rolled high manganese transformation-induced plasticity(TRIP)steels was *** to Mn removal occurring at the surface layer,γ→δdiffusional phase transformation leads to the formation of hard pancake-shaped ferrite grains due to solution strengthening at the surface and the centre layer remains as austenite+martensite after *** the case of slow heating,{112}/{111}textures for the surface ferrite were strengthened with the increase in temperature and holding time,indicating an inheritance of rolling *** increasing the heating rate of annealing,the rotated cube texture was developed in surface *** kind of multiphase sandwich structure with hard ferrite surface layer and tough austenite dominant centre can increase tensile strength and should also improve deep drawing properties,therefore providing new possibility of controlling properties for the application of high manganese TRIP steel.

关键词： High manganese transformation-induced plasticity steel Surface effect Texture Microstructure Vacuum annealing

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On-line Separation and Detection of Peptides by Capillary Electrophoresis / Electrospray FT-ICR-MS

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Chinese Chemical Letters 2003年第2期14卷 191-194页

作者： Bin xin dan PU 等 BeijingMassSpectrometryCenter CenterforMolccularScienceInstituteofChemistryChineseAcademyofSciencesBeijing100080 BeijingMassSpectrometryCenter CenterforMolccularScienceInstitute

The coupling of capillary electrophoresis to electrospray Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was presented for the on-line separation and detection of mixture of peptides. With the ultra-high resolution and unmatchable mass measurement accuracy FT-ICR-MS provides, the separation and identification of angiotensin III, octreotide and elastin chemotactic were successfully achieved using this fabricated device, which showed its great application potential in detection and structural identification for multicomponent sample.

关键词： Capillary electrophoresis FT-ICR-MS peptide.

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上海市结核病防治综合管理信息系统的建设、应用与展望

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中国防痨杂志 2025年第1期47卷 18-21页

作者：饶立歆吴哲渊陈静毛丹刘星航沈鑫陈昕上海市疾病预防控制中心结核病与艾滋病防治所结核病防治科上海201107 上海市疾病预防控制中心科研管理处上海201107 上海市疾病预防控制中心疾病预防控制信息所标准和项目管理科上海201107 上海市疾病预防控制中心结核病与艾滋病防治所上海201107 上海市疾病预防控制中心上海201107

随着信息技术的迅猛发展和互联网的广泛普及,信息化建设在传染病防控过程中发挥着越来越重要的作用。上海市结核病管理信息系统自2010年起筹备,于2015年正式投入使用并与国家系统进行数据对接。作者首次总结了上海市在结核病信息化建设... 详细信息

随着信息技术的迅猛发展和互联网的广泛普及,信息化建设在传染病防控过程中发挥着越来越重要的作用。上海市结核病管理信息系统自2010年起筹备,于2015年正式投入使用并与国家系统进行数据对接。作者首次总结了上海市在结核病信息化建设方面的宝贵经验,全面介绍了上海市结核病管理信息系统的总体规划,回顾了十多年来的系统建设、改造和应用情况,并对系统后续的功能扩展、智能化应用等进行展望。

关键词：结核传染病控制管理信息系统

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