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2-(2-Benzofuranyl)-2-imidazoline treatment within 5 hours after cerebral ischemia/reperfusion protects the brain

Neural Regeneration Research 2018年第12期13卷 2111-2118页

作者： Zheng Zhang Jin-Long Yang lin-Lei Zhang Zhen-Zhen Chen Jia-Ou Chen Yun-Gang Cao Man Qu xin-da lin Xun-Ming Ji Zhao Han Department of Neurology the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Department of Neurology the First Affiliated Hospital of Wenzhou Medical University Department of Neurosurgery Xuanwu Hospital Capital Medical University Department of Neurology Shan Xian Central Hospital Department of Children Rehabilitation the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University China-America Institute of Neuroscience Xuanwu Hospital Capital Medical University

We previously demonstrated that administering 2-（2-benzofuranyl）-2-imidazolin（2-BFI）, an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI（3 mg/kg） through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion. Neurological function was assessed using the Longa＇s method. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride assay. Morphological changes in the cortical penumbra were observed by hematoxylin-eosin staining under transmission electron microscopy. The apoptosis levels in the ipsilateral cortex were examined with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling（TUNEL） assay. The protein expression of Bcl-2 and BAX was detected using immunohistochemistry. We found the following： Treatment with 2-BFI within 5 hours after reperfusion obviously improved neurological function. Administering 2-BFI within 9 hours after ischemia/reperfusion decreased infarct volume and alleviated apoptosis. 2-BFI administration at different time points after reperfusion alleviated the pathological damage of the ischemic penumbra and reduced the number of apoptotic neurons, but the protective effect was more obvious when administered within 5 hours. Administration of 2-BFI within 5 hours after reperfusion remarkably increased Bcl-2 expression and decreased BAX expression. To conclude, 2-BFI shows potent neuroprotective effects when administered within 5 hours after reperfusion, seemingly by up-regulating Bcl-2 and down-regulating BAX expression. The time window provided clinical potential for ischemic stroke by 2-BFI.

关键词： nerve regeneration ischemia/reperfusion 2-(2-benzofuranyl)-2-imidazoline neuroprotection time window apoptosis Bcl-2 BAX neural regeneration

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Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： xin Tang Hongsheng Jiang Zhengliang lin Xuan Wang Wenliang Wang Guoqiang Li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

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Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu xin Li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

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Overexpression of PrLZ elevates the expression of androgen receptor in LNCaP cell lines

Overexpression of PrLZ elevates the expression of androgen r...

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第十五届全国泌尿外科学术会议

作者： ZHANG Dong,LI Lei, ZHANG lin-lin, XUE Yan, WU Kai-jie, WANG xin-yang, HE da-lin (Deparment of Urology,the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi , China 710061)

Objective: To investigate the effect of PrLZ overexpression on the expression of androgen receptor in prostate cancer LNCaP cells. Methods: Reconstructive expression vector pEGFP-C1/PrLZ was transfected into LNCaP cel...

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辐射等效人工骨功能材料的设计及其实现

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四川大学学报（自然科学版） 2002年第2期39卷 294-298页

作者：李立新林大全任成君四川大学化学学院成都610064 四川大学制造学院成都610065

作者从X射线和γ光子与物质相互作用出发 ,根据骨组织的成分分布和辐射衰减特性 ,提出了射线能量与质量衰减系数之间的相关数学模型 .该模型不仅为辐射等效人工骨材料的设计提供了依据。

关键词：辐射等效人工骨材料材料设计功能材料骨组织辐射衰减成分分布配方设计

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Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie Weijie Yang xin Wang Xiang Li Lele Wei Xiaolin Bai lin Liu Feng Fu Jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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支气管哮喘的血流动力学变化

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中华结核和呼吸杂志 1993年第S1期16卷 62-63页

作者：邹霞英辛达临秦伟毅李志斌广州军区广州总医院呼吸内科

对病情中等以上的缓解期哮喘患者50例,进行血流动力学观察。其中24例为哮喘合并肺动脉高压、PāP为3.34±0.9kPa、PVR为723.6±298.1kPa(L·s)、PaO2为7.44±1.46kPa。另26例为哮喘未合并肺动脉高压,PāP为2.2±0.27kPa、PVR为405.8±15... 详细信息

对病情中等以上的缓解期哮喘患者50例,进行血流动力学观察。其中24例为哮喘合并肺动脉高压、PāP为3.34±0.9kPa、PVR为723.6±298.1kPa(L·s)、PaO2为7.44±1.46kPa。另26例为哮喘未合并肺动脉高压,PāP为2.2±0.27kPa、PVR为405.8±154.1kPa/(L·s)、PaO210.36±1.17kPa。经5年随访,哮喘合并肺动脉高压组死亡5例,4例死于呼吸衰竭,1例死于呼吸衰竭合并心衰。

关键词：哮喘高血压,肺性

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen lin Zhong Luji Huang F U Cheng xindan Sheng xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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慢性阻塞性肺病患者氧动力学变化及意义

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第三军医大学学报 2007年第19期29卷 1902-1905页

作者：张德明邹霞英辛达临邓青南曹淑芳广州军区广州总医院老年呼吸内科广州510010

目的观察慢性阻塞性肺病(COPD)不同病情下氧动力学的变化,探讨其临床意义。方法对166例COPD患者进行20年跟踪随访,并运用右心漂浮导管结合血气分析,检测其血流与氧动力学的变化,对其中COPD和并发肺动脉高压(PH)、COPD和并发呼吸衰竭、C... 详细信息

目的观察慢性阻塞性肺病(COPD)不同病情下氧动力学的变化,探讨其临床意义。方法对166例COPD患者进行20年跟踪随访,并运用右心漂浮导管结合血气分析,检测其血流与氧动力学的变化,对其中COPD和并发肺动脉高压(PH)、COPD和并发呼吸衰竭、COPD死亡和生存、COPD急性和缓解期进行对比研究,并对40例COPD并PH用消心痛进行干预。结果116例死亡,总病死率69.9%。单纯COPD、COPD稳定期、COPD存活者平均肺动脉压(mPAP)、心脏指数(CI)、总肺血管阻力(TPR)、氧供(DO2)尚保持在相对正常水平,氧耗(VO2)及氧摄取率(O2-ER)呈低水平;COPD并PH、呼衰、COPD急性期及死亡者首诊时的CI、DO2、VO2、O2-ER显著低于单纯COPD、COPD稳定期、COPD存活者,而mPAP、TPR显著增高(P<0.05,P<0.01);消心痛干预后CI、DO2、O2-ER显著上升,mPAP、TPR显著降低(P<0.05,P<0.01)。结论单纯COPD、COPD稳定期、COPD存活者,呈现低氧性非氧供依赖;COPD如急性加重或并发PH、呼衰、或死亡者,出现病理性氧供依赖;消心痛干预可增加氧供;氧供与氧耗严重降低可能是COPD死亡的危险因素。

关键词：肺疾病,慢性阻塞性氧供给氧消耗

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