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锻压技术 2011年第3期36卷 131-135页

作者：郭安庶庄新村赵震董湘怀上海交通大学塑性成形工程系上海200030

为了研究不同剪挤成形工艺参数对成形零件质量的影响,本文使用Deform 2D有限元软件建立二维轴对称模型,采用Ludwik硬化流动应力模型和能够同时反映空穴损伤发展和空穴形状变化对损伤程度影响的韧性损伤模型,进行剪挤成形弹塑性有限元分... 详细信息

为了研究不同剪挤成形工艺参数对成形零件质量的影响,本文使用Deform 2D有限元软件建立二维轴对称模型,采用Ludwik硬化流动应力模型和能够同时反映空穴损伤发展和空穴形状变化对损伤程度影响的韧性损伤模型,进行剪挤成形弹塑性有限元分析。分析归纳出板厚、凸凹模间隙、凸模半径、压边力和反顶力等工艺参数对剪挤成形质量和成形力的影响规律,对工程应用具有参考价值。

关键词：剪挤成形有限元方法韧性断裂准则

Diagnosis and treatment of autoimmune pancreatitis: experience with 100 patients

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 642-648页

作者： Lei xin Yuan-xiang He Xiao-Fei Zhu Qun-hua Zhang Liang-Hao Hu Duo-Wu Zou zhen-Dong Jin Xue-Jiao Chang Jian-Ming zheng Changhai Hospital Second Military Medical University Chang-Jing Zuo Cheng-Wei Shao Gang Jin Zhuan Liao zhao-Shen Li Department of Gastroenterology Changhai Hospital Second Military Medical University Department of Surgical Oncology Chinese PLA General Hospital Department of General Surgery Huashan Hospital Fudan University Department of Pathology Changhai Hospital Second Military Medical University Department of Nuclear Medicine Changhai Hospital Second Military Medical University Department of Radiology Changhai Hospital Second Military Medical University Department of General Surgery Changhai Hospital Second Military Medical University

BACKGROUND： Autoimmune pancreatitis （ALP） is increasingly recognized as a unique subtype of pancreatitis. This study aimed to analyze the diagnosis and treatment of AIP patients from a tertiary care center in China. METHODS： One hundred patients with AIP who had been treated from January 2005 to December 2012 in our hospital were enrolled in this study. We retrospectively reviewed the data of clinical manifestations, laboratory tests, imaging examinations, pathological examinations, treatment and outcomes of the patients. RESULTS： The median age of the patients at onset was 57 years （range 23-82） with a male to female ratio of 8.1：1. The common manifestations of the patients included obstructive jaundice （49 patients, 49.0%）, abdominal pain （30, 30.0%）, and acute pancreatitis （11, 11.0%）. Biliary involvement was one of the most extrapancreatic manifestations （64, 64.0%）. Fifty-six （56.0%） and 43 （43.0%） patients were classified into focal- type and diffuse-type respectively according to the imaging examinations. The levels of serum IgG and IgG4 were elevated in 69.4% （43/62） and 92.0% （69/75） patients. Pathological analysis of specimens from 27 patients supported the diagnosis of lymphoplasmacytic sclerosing pancreatitis, and marked （〉10 ceUs/HPF） IgG4 positive cells were found in 20 （74.1%） *** treatment and surgery as the main initial treatments were given to 41 （41.0%） and 28 （28.0%） patients, respectively. The remission rate after the initial treatment was 85.0%. Steroid was given as the treatment after relapse in most of the patients and the total remission rate at the end of follow-up was 96.0%. CONCLUSIONS： Clinical manifestations, laboratory tests, imaging and pathology examinations in combination could increase the diagnostic accuracy of AIP. Steroid treatment with an initial dose of 30 or 40 mg prednisone is effective and safe in most patients with AIP.

关键词： autoimmune pancreatitis immunoglobulin G4 steroid treatment

Double contrast-enhanced ultrasonography of a small intestinal neuroendocrine tumor:a case report of a recommendable imaging modality

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Precision Clinical Medicine 2020年第2期3卷 147-152页

作者： Jie-ying zhao hua zhuang Yuan Luo Ming-gang Su Mo-li Xiong Yu-ting Wu Department of Ultrasound West China Hospital of Sichuan University37#Guo Xue XiangChengduSichuan 610041China Department of Nuclear Medicine Imaging West China Hospital of Sichuan University37#Guo Xue XiangChengduSichuan 610041China Department of Pathology West China Hospital of Sichuan University37#Guo Xue XiangChengduSichuan 610041China

A 57-year-old male presenting with spontaneously relieved abdominal cramp and distension was admitted to theWest China *** diagnosis remained unclear after colonoscopy and computed *** contrast-enhanced ultrasonography was then performed and a neoplasm in the small intestine was suspected,supported by a thin-section computed tomography and positron emission tomography/computed *** was confirmed pathologically after surgery to be a small intestinal G1 neuroendocrine *** was performed to remove approximately 25 cm of small bowel and a 3-cm solid mass located in the *** patient had a complete recovery and was tumor-free at the final *** intestinal tumors including neuroendocrine tumors have always posed a diagnostic *** case indicated that double contrastenhanced ultrasonography is feasible in detection of small intestinal neuroendocrine tumors,and it may be an advisable approach assisting diagnosis of small intestinal tumors.

关键词： double contrast-enhanced ultrasonography neuroendocrine tumor small intestinal tumor carcinoid

本征正交分解技术及其在预测屋盖风压场中的应用

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振动工程学报 2007年第1期20卷 1-8页

作者：倪振华江棹荣谢壮宁汕头大学土木工程系广东汕头515063

本征正交分解(POD)是以能量表述的随机场的最优分解,采用瑞利商概念及其极值性质推导了POD原理。根据风洞试验同步采集的风压数据利用POD技术预测了圆拱顶屋盖未布置测压点位置的风压时间序列。对预测风压包括均值、均方根值、极值在内... 详细信息

本征正交分解(POD)是以能量表述的随机场的最优分解,采用瑞利商概念及其极值性质推导了POD原理。根据风洞试验同步采集的风压数据利用POD技术预测了圆拱顶屋盖未布置测压点位置的风压时间序列。对预测风压包括均值、均方根值、极值在内的统计特性,时程曲线以及功率谱与实测风压作了比较。通过采用完全二次型组合法计算屋盖风致响应对所提预测方法的有效性进行了检查。

关键词：本征正交分解瑞利商风压场预测圆拱顶屋盖风致响应

Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4914-4926页

作者： Qianyun Liu Haiyan zhao Zhiqiang Li zhen Zhang Rui huang Mengxue Gu Ke zhuang Qing Xiong Xianying Chen Weiyi Yu Shengnan Qian Yuzhen Zhang Xue Tan Muyi Zhang Feiyang Yu Ming Guo Zhixiang huang xin Wang Wenjie xiang Bihao Wu Fanghua Mei Kun Cai Limin Zhou Li Zhou Ying Wu huan Yan heng Cao Ke Lan Yu Chen State Key Laboratory of Virology Instute for Vaccine ResearchCollege of Life SciencesWuhan UniversityWuhan 430072China Department of Thoracic Surgery Renmin HospitalWuhan UniversityWuhanChina CAS Key Laboratory of Special Pathogens Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430o71P.R.China Animal Biosafety Level-ll Laboratory/lnstitute for Vaccine Research Wuhan UniversityWuhanChina State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology Institute of Medical VirologyTaikang Medical SchoolWuhan UniversityWuhan 430072China Hubei Center for Disease Control and Prevention Wuhan 430079China Maternal and Child Health Hospital of Hubei Province Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Coronavirus disease 2019(COviD-19)was first reported three years ago,when a group of individuals were infected with the original SARS-CoV-2 strain,based on which vaccines were ***,we develop six human monoclonal antibodies(mAbs)from two elite convalescents in Wuhan and show that these mAbs recognize diverse epitopes on the receptor binding domain(RBD)and can inhibit the infection of SARS-CoV-2 original strain and variants of concern(VOCs)to varying degrees,including Omicron strains XBB and XBB.

关键词： antibodies monoclonal neutral

Downregulating IGF-1R alleviates β-amyloid deposition in cortex induced by chronic sleep restriction

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Downregulating IGF-1R alleviates β-amyloid deposition in co...

Downregulating IGF-1R alleviates β-amyloid deposition in cortex induced by chronic sleep restriction

第八届中国睡眠医学论坛暨中国睡眠研究会睡眠障碍专业委员会学术年会

作者： Hong-Yi zhao Hui-Juan Wu Jia-Lin He Jian-hua zhuang zhen-Yu Liu Liu-Qing huang Zhong-xin zhao Department of Neurology Changzheng HospitalSecond Military Medical University Academy of Clinical Medicine Second Military Medical University

Aim In chronic sleep restriction(CSR) mice model,we have showed the Aβaccumulation in frontal cortex in adult wildtype(WT) *** study aims to explore whether down regulate the IGF-1 R signal pathway would alleviate β-amyloid(Aβ) metabolism and deposition in cortical in IGF-1 R+/-*** Mice(8 months old) were divided into four groups:IGF-1 R+/-CSR(MUSR),IGF-1 R+/-control(MUCO),WT CSR(C57 SR) and WT control(C57 CO).CSR was achieved by application of a slowly rotating drum for 2 *** compared weight,Lee’s index and IGF-1 level in peripheral blood among four *** and western blotting were used to detect Aβ accumulation,APP,BACE1 and *** Plasma IGF-1 decreased after CSR in WT mice,but not in MUCO *** cortical Ap concentration was increased in C57 SR,but not significant changed in MUSR,MUCO,and C57 CO ***,the expression amount of APP,BACE1 protein and C99 protein were higher in C57 SR group,but not increased significantly in MUSR,MUC,C57 CO *** CSR decreased serum IGF-1,change the metabolism,and induce A βdeposition in WT *** study indicates that down-regulating IGF-1 R signal pathway could inhibited BACE1 protein expression and activity,thereby inhibitedβ-cleaving of APP,and finally decreased CSR caused mice frontal cortical Aβ protein abnormal deposition.

关键词： IGF-1R signal pathway Chronic sleep restriction BACE1 Aβ metabolism

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Downregulating IGF-1R alleviates β-amyloid deposition in co...

Evaluating patients' perception of service quality at hospitals in nine Chinese cities by use of the ServQual scale

中国睡眠研究会第十届全国学术年会

Aim In chronic sleep restriction（CSR） mice model,we have showed the Aβaccumulation in frontal cortex in adult wildtype（WT） *** study aims to explore whether down regulate the IGF-1 R signal pathway would alleviate β-amyloid（Aβ）metabolism and deposition in cortical in IGF-1 R+/-*** Mice（8 months old） were divided into four groups: IGF-1 R+/-CSR（MUSR）,IGF-1 R+/-control（MUCO）,WT CSR（C57 SR） and WT control（C57 CO）.CSR was achieved by application of a slowly rotating drum for 2 *** compared weight,Lee’s index and IGF-1 level in peripheral blood among four *** and western blotting were used to detect Aβ accumulation,APP,BACE1 and *** Plasma IGF-1 decreased after CSR in WT mice,but not in MUCO *** cortical Aβ concentration was increased in C57 SR,but not significant changed in MUSR,MUCO,and C57 CO ***,the expression amount of APP,BACE1 protein and C99 protein were higher in C57 SR group,but not increased significantly in MUSR,MUC,C57 CO *** CSR decreased serum IGF-1,change the metabolism,and induce Aβdeposition in WT *** study indicates that down-regulating IGF-1 R signal pathway could inhibited BACE1 protein expression and activity,thereby inhibitedβ-cleaving of APP,and finally decreased CSR caused mice frontal cortical Aβ protein abnormal deposition.

关键词： IGF-1R signal pathway Chronic sleep restriction BACE1 Aβ metabolism

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 494-500页

作者： Min Li Douglas Bruce Lowrie Cheng-Yu huang xiang-Chan Lu Ying-Chu Zhu xing-hua Wu Mayila Shayiti Qiong-zhen Tan hua-Ling Yang Si-Yuan Chen Pan zhao Sheng-hua He Xiu-Rong Wang Hong-Zhou Lu Shanghai Public Health Clinical Center Fudan University Chongqing Infectious Disease Medical Center The Fourth People's Hospital of Nanning City Guangxi Zhuang Autonomous Region Public Health Clinical Center of Chengdu Infectious Disease Hospital of Honghezhou of Yunnan Province The People's Hospital of xinjiang Uygur Autonomous Region The People's Hospital of Laibin City the Guangxi zhuang Autonomous Region Affiliated Hospital of Guilin Medical College The Second People's Hospital of Zhongshan City of Guangdong Province huashan Hospital affiliated with Fudan University Shanghai Medical College Fudan University

Objective: To investigate patients' perception of service quality at hospitals in nine Chinese cities and propose some measures for improvement. Methods: The ServQ ual scale method was used in a survey involving patients at out-patient and in-patient facilities in Shanghai, Chongqing, Chengdu, Nanning, Guilin and Laibin of Guangxi, Honghezhou of Yunnan, Wulumuqi of xinjiang and Zhongshan of Guangdong. The data collected were entered and analyzed using SPSS 20.0. Statistical analyses included descriptive statistics, factor analyses, reliability analyses, product-moment correlations, independent-sample t-tests, One-way ANOVA and regression analyses. Results: The Kaiser-Meyer-Olkin value for the factor analysis of the scale was 0.979. The Cronbach's α for the reliability analysis was 0.978. All the Pearson correlation coei cients were positive and statistically signii cant. Visitors to out-patient facilities reported more positive perception tacilities on tangibles(t = 4.168, P(t = 1.979, P

关键词： China City hospital Patients Service Quality Evaluation

National Nutrition and Health Systematic Survey for Children 0–17 Years of Age in China

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Biomedical and Environmental Sciences 2021年第11期34卷 891-899页

作者： YANG zhen Yu ZHANG Qian ZHAI Yi XU Tao WANG Yu Ying CHEN Bo Wen TANG Xue Jun YUAN Xiao Lin FANG Hong Yun ZHU Yan PANG Xue Hong WANG Shuo XU Juan LI Rui Li SI xiang zhao Wen hua National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Chinese Center for Disease Control and Prevention Beijing 102206China National Center for Women and Children's Health Chinese Center for Disease Control and PreventionBeijing 100081China Capital Institute of Pediatrics Beijing 100020China National Center for Statistics and Information National Health CommissionBeijing 100044China

The main purpose of the National Nutrition and Health Systematic Survey for children 0-17 years of age in China(CNHSC)was to collect basic data on the nutrition,development,and health status for children in different regions across China using evidence-based,reliable,and cost-effective *** and their parents or guardians from seven regions(south,southwest,north,northwest,eastern,central,and northeast China)in China were recruited.A multi-stage stratified randomized sampling method was *** provinces were randomly sampled from each of the seven regions,from which one urban district and one rural country were also randomly sampled,resulting in a total of 28 survey counties/*** surveys,health examinations,laboratory testing,and questionnaires were used to collect dietary intake,nutritional status,child development,and health status ***,health,and lifestyle assessment of children and their parents was determined using the Knowledge Attitude Practice(KAP)*** than 100,000 children(38,000 children<6 years of age and 66,000 children6-17 years of age)completed the *** survey provided comprehensive data on child nutrition and health status for future studies and will serve as the basis for an integrated nutrition and health improvement strategies proposal for children in China.

关键词： Children 0-17 years of age Nutritional status Health status Study protocol