检索结果-南通市图书馆

The relationship between the distribution of HBcAg in liver cells and the pathological manifestations of the liver in 429 HBeAg-positive chronic HBV-infected individuals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology & Hepatology Research 2024年第3期6卷 10-15页

作者： Fan Nie Chang-chun Zeng Guang-Dong Tong Mu-Min Shao Xiao-Hua Le xin deng Da-Qiao Zhou National Clinical Research Center for Infectious Diseases Shenzhen 518112China Central Laboratory of Shenzhen Longhua District Central Hospital Shenzhen 518112China Hepatology Department of Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518112China Pathology Department of Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518112China Pathology Department of Shenzhen Third People's Hospital Shenzhen 518112China Traditional Chinese Medicine Department of Shenzhen Third People's Hospital Shenzhen 518112China

Background:The natural history of chronic HBV infection is typically characterized by four stages:the immune tolerance period,the immune clearance period,the immune control period,and the immune escape *** stages are associated with the distribution of HBcAg in liver cells;however,this relationship remains a topic of broad debate within the field of liver *** objectively and quantitatively measure the intracellular distribution of HBcAg,this paper aims to design a method referred to as the“layered evaluation method”and to examine its ***:The distribution of HBcAg in liver cells is assessed using Image Pro Plus image processing software,along with calculations of cytoplasmic and nuclear positive staining ***:The findings indicate that the highest proportion of patients exhibited a positive cytoplasmic expression rate ranging from 0-2.5%.More than 40% of the total sample was categorized within the 0-2.5% positive nuclear expression *** HBcAg cytoplasmic positive staining rates were classified into five levels:a cytoplasmic HBcAg positive staining rate of less than 0.05% is designated as level 0,indicating negative expression;a staining rate between 0.05% and 5% is classified as level 1;a rate from 5% to less than 10% is classified as level 2;a rate from 10% to less than 20% is classified as level 3;and a nuclear positivity rate exceeding 20% is classified as level ***:The inflammatory activity grade in these patients was positively correlated with the cytoplasmic distribution of ***,the nuclear distribution rate of HBcAg was significantly higher in the G3 group compared to the other groups.

关键词： distribution of HBcAg pathological manifestations of the liver positive staining rate

N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 72-91页

作者： Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li xin deng Qin Peng Zigang Li Hongsheng Wang Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Department of Biomedical Sciences City University of Hong Kong Institute of Systems and Physical Biology Shenzhen Bay Laboratory

Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer（CRC） cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione（GSH） via the upregulation of RRM2B——a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3 UTR of RRM2B increased its m RNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence（CDS） of OPA1——an essential GTPase protein for mitochondrial inner membrane fusion——also increased m RNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.

关键词： m6A mitochondrial fusion glutathione OPA1 colorectal cancer

六氟化铀及氟化物汽液相平衡数据预测及精馏过程模拟

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

化工学报 2024年第2期75卷 463-474页

作者：杨同王欢邓春中国石油大学(北京)化学工程与环境学院重质油全国重点实验室北京102249 中核第七研究设计院有限公司山西太原030012

精馏技术提纯六氟化铀是铀转化工艺的重要环节,该精馏工艺的模拟可为工艺设计及操作优化提供关键支撑。然而,由于六氟化铀及氟化物汽液相平衡数据及物性数据的缺乏,六氟化铀提纯精馏工艺的建模和模拟难以开展。为此,利用COSMOtherm和Tur... 详细信息

精馏技术提纯六氟化铀是铀转化工艺的重要环节,该精馏工艺的模拟可为工艺设计及操作优化提供关键支撑。然而,由于六氟化铀及氟化物汽液相平衡数据及物性数据的缺乏,六氟化铀提纯精馏工艺的建模和模拟难以开展。为此,利用COSMOtherm和Turbomole软件,预测UF_(6)与TiF_(4)二元体系汽液相平衡数据。通过预测已知的WF_(6)-UF_(6)二元体系汽液相平衡实验数据以间接验证COSMO-RS模型预测的准确性。利用Aspen Plus软件的物性常数估算系统(property constant estimation system),估算出缺失的无限稀释水溶液Gibbs生成能等物性参数。文献中UF_(6)饱和蒸气压实验数据与模拟值进行对比,相对误差在1.76%以内。根据文献中的实验数据和预测的汽液相平衡数据,利用Aspen Plus软件回归NRTL模型的二元交互作用参数。针对六氟化铀及氟化物的分离,设计直接分离序列和间接分离序列提纯UF_(6)的两种方案。设定UF_(6)产品纯度,以总年度费用(TAC)最小化为目标,采用灵敏度分析对塔板数、进料位置和回流比的关键参数进行优化,结果表明,间接分离序列提纯UF_(6)方案的TAC更低。

关键词：氟化物物性估算汽液平衡精馏

A vibration isolator with a controllable quasi-zero stiffness region based on nonlinear force design

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1279-1294页

作者： xinyu LIAN Bing LIU Huaxia deng xinglong GONG CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

To achieve stability optimization in low-frequency vibration control for precision instruments,this paper presents a quasi-zero stiffness(QZS)vibration isolator with adjustable nonlinear ***,the stress-magnetism coupling model is established through meticulous theoretical *** controllable QZS interval is constructed via parameter design and magnetic control,effectively segregating the high static stiffness bearing section from the QZS vibration isolation ***,a displacement control scheme utilizing a magnetic force is proposed to regulate entry into the QZS working range for the vibration isolation *** results demonstrate that the operation within this QZS region reduces the peak-to-peak acceleration signal by approximately 66.7%compared with the operation outside this region,thereby significantly improving the low frequency performance of the QZS vibration isolator.

关键词： low frequency nonlinear vibration isolator quasi-zero stiffness(QzS)

Nonlinear robust adaptive control for bidirectional stabilization system of all-electric tank with unknown actuator backlash compensation and disturbance estimation

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 144-158页

作者： Shusen Yuan Wenxiang deng Jianyong Yao Guolai Yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

Since backlash nonlinearity is inevitably existing in actuators for bidirectional stabilization system of allelectric tank,it behaves more drastically in high maneuvering *** this work,the accurate tracking control for bidirectional stabilization system of moving all-electric tank with actuator backlash and unmodeled disturbance is *** utilizing the smooth adaptive backlash inverse model,a nonlinear robust adaptive feedback control scheme is *** unknown parameters and unmodelled disturbance are addressed separately through the derived parametric adaptive function and the continuous nonlinear robust *** the unknown backlash parameters are updated via adaptive function and the backlash effect can be suppressed successfully by inverse operation,which ensures the system ***,the system disturbance in the high maneuverable environment can be estimated with the constructed adaptive law online improving the engineering ***,Lyapunov-based analysis proves that the developed controller can ensure the tracking error asymptotically converges to zero even with unmodeled disturbance and unknown actuator *** co-simulations and experiments illustrate the advantages of the proposed approach.

关键词： Bidirectional stabilization system Robust control Adaptive control Backlash inverse Disturbance estimation

Synthesis of multifunctional additives for solid propellants:Structure,properties and mechanism

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 308-316页

作者： Pingan Zhang Lina Sun Jianmin Yuan Jianru deng College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082PR China College of Material Science and Engineering Hunan UniversityChangsha 410082PR China Hu Bei Sanjiang Aerospace Jianghe Chemical Technology Co. LtdYichang 444200PR China

To simplify the composite propellant formulation and address the current issue of the single-functionality present in existing additives,the multi-cyano,amine-based polybutadiene(AEHTPB-CN)was prepared based on AEHTPB by adopting appropriate synthesis *** replacing 10% of HTPB binder in the propellant formulation,it can effectively enhance the interfacial bond strength between the propellant binder matrix and solid fillers(AP(ammonium perchlorate)and RDX(cyclotrimethylene-trinitramine)),the mechanical properties of the HTPB/AP/RDX/Al propellant were superior to blank control propellant with an improvement of 35.4% in tensile strength,62.0% enhancement in elongation at break,and reduce the propellant burn rate by 10.7% with any energy *** function mechanism of AEHTPB-CN was systematically elucidated through experiments and computer simulation *** results show that the tertiary amine group in AEHTPB-CN can react with AP to form ammonium ionic bonds,and the hydroxyl and cyano groups can form hydrogen bonding interactions with AP,which enables AEHTPB-CN to be firmly adsorbed on the AP surface through chemical and physical *** RDX,the interfacial bonding effect of AEHTPB-CN is attributed to their ability to form C-H···N≡C weak hydrogen bonding interaction between the cyano group and RDX methylene group.

关键词： Hydroxyl-terminated polybutadiene(HTPB) HTPB propellant Chemical modification Bonding agent Mechanism

Precision motion control for electro-hydraulic axis systems under unknown time-variant parameters and disturbances

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第1期37卷 463-471页

作者： Xiaowei YANG Yaowen GE Wenxiang deng Jianyong YAO School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

This article focuses on asymptotic precision motion control for electro-hydraulic axis systems under unknown time-variant parameters,mismatched and matched *** from the traditional adaptive results that are applied to dispose of unknown constant parameters only,the unique feature is that an adaptive-gain nonlinear term is introduced into the control design to handle unknown time-variant *** both mismatched and matched disturbances existing in electro-hydraulic axis systems can also be addressed in this *** skillful integration of the backstepping technique and the adaptive control,a synthesized controller framework is successfully developed for electro-hydraulic axis systems,in which the coupled interaction between parameter estimation and disturbance estimation is ***,this designed controller has the capacity of low-computation costs and simpler parameter tuning when compared to the other ones that integrate the adaptive control and observer/estimator-based technique to dividually handle parameter uncertainties and ***,a nonlinear filter is designed to eliminate the“explosion of complexity”issue existing in the classical back-stepping *** stability analysis uncovers that all the closed-loop signals are bounded and the asymptotic tracking performance is also ***,contrastive experiment results validate the superiority of the developed method as well.

关键词： Adaptive control Asymptotic convergence Electro-hydraulic axis system Precision motion control Unknown time-variant parameters and disturbances

Disinfection Byproducts and Their Precursors in Drinking Water Sources:Origins,Influencing Factors,and Environmental Insights

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第5期36卷 36-50页

作者： Rong Xiao Yang deng Zuxin Xu Wenhai Chu State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Ministry of Education Key Laboratory of the Yangtze River Water Environment Tongji UniversityShanghai 200092China Department of Earth and Environmental Studies Montclair State UniversityMontclairNJ 07043USA

Tracing the contamination origins in water sources and identifying the impacts of natural and human processes are essential for ecological safety and public ***,current analysis approaches are not ideal,as they tend to be laborious,time-consuming,or technically *** byproducts(DBPs)are a family of well-known secondary pollutants formed by the reactions of chemical disinfectants with DBP precursors during water disinfection *** DBP precursors have various origins(e.g.,natural,domestic,industrial,and agricultural sources),and since the formation of DBPs from different precursors in the presence of specific disinfectants is distinctive,we argue that DBPs and DBP precursors can serve as alternative indicators to assess the contamination in water sources and identify pollution *** providing a retrospective of the origins of DBPs and DBP precursors,as well as the specific formation patterns of DBPs from different precursors,this article presents an overview of the impacts of various natural and anthropogenic factors on DBPs and DBP precursors in drinking water *** practice,the DBPs(i.e.,their concentration and speciation)originally present in source water and the DBP precursors determined using DBP formation potential tests—in which water samples are dosed with a stoichiometric excess of specific disinfectants in order to maximize DBP formation under certain reaction conditions—can be considered as alternative *** jointly used with other water quality parameters(e.g.,dissolved organic carbon,dissolved organic nitrogen,fluorescence,and molecular weight distribution)and specific contaminants of emerging concern(e.g.,certain pharmaceuticals and personal care products),DBPs and DBP precursors in drinking water sources can provide a more comprehensive picture of water pollution for better managing water resources and ensuring human health.

关键词： Disinfection byproducts Disinfection byproduct precursors Drinking water sources Contamination indicator Natural factors Human factors

A new centrality measure based on neighbor loop structure for network dismantling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 472-480页

作者： Qingxia Liu Bang Wang Jiming Qi Xianjun deng School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan430074China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Nearly all real-world networks are complex networks and usually are in danger of ***,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network *** dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive *** overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation *** addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and ***,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation *** results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack ***,the insights gained from this study may be of assistance to future practical research into real-world networks.

关键词： Complex networks Network dismantling Centrality measure