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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin zeng Le Wang Wenwu Zhang Gang Li xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi zeng Chunyan Wang Li Yang cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

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A systematic review of morphological models of salt marshes

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Water Science and Engineering 2023年第4期16卷 313-323页

作者： xin-chen Wang Pei xin zeng Zhou Fu-xin Zhang College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology–Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China Jiangsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai UniversityNanjing 210098China

Salt marshes are among the most important coastal wetlands and provide critical ecological services,including climate regulation,biodiversity maintenance,and blue carbon ***,most salt marshes worldwide are shrinking,owing to the effects of natural and human factors,such as climate change and artificial ***,it is essential to understand the decline in the morphological processes of salt marshes,and accordingly,the likely evolution of these marshes,in order to enable measures to be taken to mitigate this *** this end,this study presented an extensive systematic review of the current state of morphological models and their application to salt *** emergence of process-based(PB)and data-driven(DD)models has contributed to the development of morphological *** morphodynamic simulations in PB models,multiple physical and biological factors(e.g.,the hydrodynamics of water bodies,sediment erosion,sediment deposition,and vegetation type)have been *** systematic review revealed that PB models have been extended to a broader interdisciplinary ***,most DD models are based on remote sensing database for the prediction of morphological characteristics with latent *** to DD models,PB models are more transparent but can be complex and require a lot of computational ***,to make up for the shortcomings of each model,future studies could couple PB with DD models that consider vegetation,microorganisms,and benthic animals together to simulate or predict the biogeomorphology of salt marsh ***,this review found that there is a lack of unified metrics to evaluate model performance,so it is important to define clear objectives,use multiple metrics,compare multiple models,incorporate uncertainty,and involve experts in the field to provide guidance in the further study.

关键词： Morphology Salt marsh Predictive modeling Tidal creek Tidal flat

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Numerical investigation of the South China Sea deep circulation

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Acta Oceanologica Sinica 2022年第5期41卷 1-11页

作者： Shengquan Tang Xueen chen Zhi zeng xin Liu College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao266100China Shandong Computer Science Center(National Supercomputer Center in Jinan) Qilu University of Technology(Shandong Academy of Sciences)Jinan250014China College of Meteorology and Oceanography National University of Defense TechnologyChangsha410073China

Based on a two-level nested model from the global ocean to the western Pacific and then to the South China Sea(SCS),the high-resolution SCS deep circulation is numerically *** SCS deep circulation shows a basin-scale cyclonic structure with a strong southward western boundary current in summer(July),a northeast-southwest through-flow pattern across the deep basin without a western boundary current in winter(January),and a transitional pattern in spring and *** sensitivity model experiments illustrate that the Luzon Strait deep overflow is the main factor controlling the seasonal variation in the SCS deep *** SCS surface wind can significantly influence the SCS deep circulation in *** Luzon Strait deep overflow transport from the Pacific into the SCS ranges from 0.68×10^(6) m^(3)/s to 1.83×10^(6) m^(3)/s,reaching its maximum in summer(July,up to 1.83×10^(6) m^(3)/s),less in autumn and winter,and the minimum in spring(May,0.68×10^(6) m^(3)/s).In summer,the strong Luzon Strait deep overflow dominates the SCS deep circulation when the role of the SCS surface wind is *** winter,the weaker Luzon Strait deep overflow and SCS surface wind jointly drive the SCS deep circulation into a northeast-southwest through-flow *** potential vorticity(PV)dissipation in the SCS deep basin reaches its maximum(−0.122 m^(2)/s^(2))in May and its minimum(−0.380 m^(2)/s^(2))in July.

关键词： South China Sea deep sea circulation deep overflow surface wind potential vorticity

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Engineering graphene oxide and hydrogel coatings on fabrics for smart Janus textiles with superior thermal regulation

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Chinese Journal of Chemical Engineering 2024年第10期74卷 1-12页

作者： Weidong Wu Yukun zeng chen Zhou xin Zhou Shengyang Yang Department of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Veterinary Medicine Yangzhou UniversityYangzhou 225009China Department of Physical Sciences University of Central MissouriWarrensburgMO 64093USA

Fabric multifunctionality offers resource savings and enhanced human *** study innovatively integrates cooling,heating,and antimicrobial properties within a Janus fabric,surpassing previous research focused solely on cooling or *** effects are achieved by applying distinct coatings to each side of the *** graphene oxide(GO)coating exhibits exceptional light-to-heat conversion,absorbing and transforming light energy into heat,thereby elevating fabric temperature by 15.4℃,22.7℃,and 43.7℃ under 0.2,0.5,and 1 sun irradiation,***,a hydrogel coating on one side absorbs water,facilitating heat dissipation through evaporation upon light exposure,reducing fabric temperature by 5.9℃,8.4℃,and 7.1℃ in 0.2,0.5,and 1 sun irradiation,***,both sides of Janus fabric exhibit potent antimicrobial properties,ensuring fabric *** work presents a feasible solution to address crucial challenges in fabric thermal regulation,providing a smart approach for intelligent adjustment of body comfort in both summer and *** integrating heating and cooling capabilities along with antimicrobial properties,this study promotes sustainable development in textile techniques.

关键词： Janus fabric Heat transfer Membranes Gels Evaporation Bacterial resistance

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Substance flow analysis for an urban drainage system of a representative hypothetical city in China

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Frontiers of Environmental Science & Engineering 2013年第5期7卷 746-755页

作者： Hua BAI Siyu zeng xin DONG Jining chen School of Environment Tsinghua University Beijing 100084 China

This paper discusses the use of substance flow analysis （SFA） as a tool to support quantified research on urban drainage systems. Based on the principle of mass balance, a static substance flow model is established to describe and examine the routes and intensities of water, chemical oxygen demand （COD）, total nitrogen （TN） and total phosphorus （TP） for a representative hypothetical city （RH city） in China, which is a devised and scaled city using statistical characteristics of urban circumstances at the national level. It is estimated that the annual flux of water, COD, TN and TP through the urban drainage system in 2010 was 55.1 million m3, 16037.3 t, 1649.5 t and 209.7 t, respectively. The effluent of wastewater treatment plant （WWTP） was identified as the most important pathway for pollutant emissions, which con- tributed approximately 60% of COD, 65% of TN and 50% of TP to receiving water. During the wastewater treatment process, 1.0 million m3, 7042.5 t, 584.2 t and 161.4 t of the four studied substances had been transmitted into sludge, meanwhile 3813.0 t of COD and 394.0 t of TN were converted and emitted to the atmosphere. Compared with the representative hypothetical city of 2000, urban population and the area of urban built districts had expanded by approximately 90% and 80% respectively during the decade, resulting in a more than threefold increase in the input of substances into the urban drainage system. Thanks to the development of urban drainage systems, the total loads of the city were maintained at a similar level.

关键词： substance flow analysis (SFA) urban drainage system representative hypothetical city (RH city) waterpollution control

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An integrated model for structure optimization and technology screening of urban wastewater systems

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Frontiers of Environmental Science & Engineering 2015年第6期9卷 1036-1048页

作者： Yue HUANG xin DONG Siyu zeng Jining chen School of Environment Tsinghua University Beijing 100084 China

The conventional approach to wastewater system design and planning considers each component separately and does not provide the optimum performance of the entire system. However, the growing concern for environmental protection, economic efficiency, and sus- tainability of urban wastewater systems requires an integrated modeling of subsystems and a synthetic evaluation of multiple objectives. In this study, a multi- objective optimization model of an integrated urban wastewater system was developed. The model encom- passes subsystems, such as a sewer system, stormwater management, municipal wastewater treatment, and a wastewater reclamation system. The non-dominated sort- ing genetic algorithm （NSGA-II） was used to generate a range of system design possibilities to optimize conflicting environmental and economic objectives. Information from a knowledge base, which included rules for generating treatment trains as well as the performance characteristics of commonly used water pollution control measures, was utilized. The trade-off relationships between the objec- tives, total water pollution loads to the environment, and life cycle costs （which consist of investment as well as operation and maintenance costs）, can be illustrated using Pareto charts. The developed model can be used to assist decision makers in the preliminary planning of system structure. A benchmark city was constructed to illustrate the methods of multi-objective controls, highlight cost- effective water pollution control measures, and identify the main pressures on urban water environment.

关键词： urban wastewater system integrated model-ing multi-objective optimization non-dominated sortinggenetic algorithm (NSGA-I1)

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Toxicity assessment of metals in sediment from the lower reaches of the Haihe River Basin in China

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International Journal of Sediment Research 2013年第2期28卷 172-181页

作者： Si-yu zeng xin DONG Ji-ning chen School of Environment Tsinghua University

The aqueous environmental quality of the Haihe River Basin is crucial for the ecological health of local catchments and the Bohai *** the routine management neglected sediment tests and no legitimate tool supported the toxicity evaluation yet,one supplementary monitoring was implemented to examine the occurrence and toxic level of sediment metals in the lower reaches of the Haihe River Basin in *** world-widely used consensus-based sediment quality guidelines and China's environmental quality standard for soils(EQSS) were used as assessment ***,Zn, As,Hg,Cd,and Pb were detected in all 24 samples,while Cr was detected in 18 *** results showed 9 samples were toxic and the most dominant toxic element was *** the river water quality is getting better, sediment metals have accumulated over thirty years due to continuous industrial development,with toxicity far beyond safety *** highest toxicity levels were encountered in Binhai New Area,suggesting three rivers should be given priority for *** is found that EQSS is also applicable for sediment toxicity assessment until a dedicated tool for Haihe River Basin is available,except for that EQSS is too conservative for Pb.

关键词： Sediment toxicity assessment Metal Consensus-based sediment quality guidelines Soil environmental quality standards Haihe River Basin

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