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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Optical Properties of Cirrus Transition Zones over China Detected by CALIOP

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Journal of Meteorological Research 2017年第3期31卷 576-585页

作者： Hongke cai Yunfei FU Quanliang CHEN xiao FENG xin TIE Ranting TAO Kepiao XU School of Atmospheric Science Chengdu University of Information Technology/Plateau Atmospheric and Environment Laboratory of Sichuan Province School of Earth and Space Sciences University of Science and Technology of China

A transition zone near cirrus lateral boundaries can be detected by CALIOP （cloud-aerosol lidar with orthogonal polarization）. In the present study, for such transition zones over China, a number of optical properties, such as the backscatter coefficient and depolarization ratio, showed transitional characteristics between cirrus and clear sky. The stepped horizontal profile showed sharp changes in particle number and morphology between cirrus clouds and clear sky. The color ratio, however, was unable to show cirrus transition features because of the low signal-to-noise ratio. Typical ice particles presented a color ratio of 0.55-1.25 and a depolarization ratio of greater than 0.12, which were significantly higher than those of clear sky. Therefore, optical properties in transition took the form of stepwise hori- zontal profiles. The proportion of typical-featured particles also demonstrated a stepped horizontal profile similar to the optical characteristics, but the relationship between the proportion and the optical characteristics was not uniform in the cirrus clouds, transition zone, and clear sky. Therefore, the optical changes in the transition zone were caused by not only the change in particle concentration, but also the change in the particles themselves. The probability dens- ity distribution of the transition-zone widths showed a positive skewness distribution, and transition zones with widths of 3-5 km occurred most frequently. Overall, transition-zone width decreased with increasing temperature and increased with increasing vertical and horizontal wind speeds. This trend demonstrated independence with the direc- tion of the vertical and horizontal winds. These observations implied that the transitional features were caused by ma- terial exchange, such as entrainment and turbulent transport, near the cirrus lateral boundaries, and by the phase trans- formation of particles, such as sublimation.

关键词： cirrus transition zone lidar temperature wind speed

Theoretical calculation of high-pressure CO_(2)jet in cases of composite rock-breaking based on span-wagner equation of state

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Journal of Hydrodynamics 2022年第5期34卷 948-964页

作者： Xian-peng Yang Can cai xiao-hua Chen Pei Zhang xin Zeng Chi Peng Yingfang Zhou Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan Province School of Mechanical EngineeringSouthwest Petroleum UniversityChengdu610500China School of Engineering University of AberdeenAberdeenUK Laboratory of High-pressure Jet Theory and Application Technology Southwest Petroleum UniversityChengdu610599China Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun130021China Southwest Pipeline Co. Ltd.National Pipe Network GroupChengdu610064China

Although several theoretical calculation methods for high-pressure jet are available,there is currently no theoretical model for the high-pressure CO_(2)jet based on the high-precision equation of state(EOS).To investigate the flow field of the high-pressure CO_(2)jet in cases of the composite rock-breaking under the high-pressure CO_(2)Jet and PDC cutter,a semi-analytical approach of the high-pressure CO_(2)jet is developed based on the Span-Wagner EOS and CO_(2)jet *** semi-analytical calculations and the physical property calculations under the action of the high-pressure CO_(2)jet are conducted with consideration of the jet pressure,the jet distance,the nozzle diameter and the jet *** results indicate that the distribution of the physical properties calculated by the semi-analytical approaches is similar to that obtained by experimental monitoring and numerical simulation,which indicates that the calculation method of the high-pressure CO_(2)jet presented in this paper is effective and *** properties of the CO_(2)jet obtained by the theoretical calculation see a significant difference between the initial region and the jet impact *** the temperature of 300 K,the increase of the initial pressure can effectively increase the impact force and the cooling ability of the *** proportion of the jet core lengths in the jet on the axis increases with the increase of the ratio of the nozzle diameter to the jet length,accompanied with the increase of the impact force of the *** increase of the jet angle can effectively increase the impacting force of the jet,but hampers the fluid *** study combines the theoretical calculation of the jet with the calculation of the physical properties of the high-pressure CO_(2),for comprehensively understanding the CO_(2)jet field in the composite rock-breaking under the action of the high-pressure CO_(2)jet and PDC *** theoretical calculation of the CO_(2)jet based on the high-precisio

关键词： CO_(2)jet hydraulic jet drill theoretical calculation equation of state(EOS) physical property

Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe Ying Hao Jiang Yan Wang Timing Fang You Zhang Bing Sun xiao Tang xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong Yang Haochen Shen xiaoming xiao Zhichao Li Qi Zhou Wei Yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting xing Peng Yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Characteristics and efficiency of a new vibrating screen with a swing trace

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Particuology 2013年第5期11卷 601-606页

作者： Jianzhang xiao xin Tong School of Mechanical Engineering and Automation Huaqiao University

A new vibration type and motion characteristics were proposed according to the principle of manual sie- ving. A mechanical model of the new motion was established and the characteristics of the new vibrating screen were analyzed to establish its equation of motion by using the vibration theory, to include as tech- nological parameters, amplitude, movement velocity, and throwing index through theoretical calculation. The efficiency of particle screening was studied at different values of frequency and swing declination angle. The discrete element method （DEM） was used to simulate the screening with the swing trace. The functional relationship between screening efficiency and the parameters was fitted with the least square method. The results show that high frequency and large swing angle are suitable for small particles, while small values are suitable for particles close to the aperture size. Compared to the linear vibration trace, both screening efficiency and processing capacity were effectively improved.

关键词： Motion characteristicSwing traceScreening efficiencySimulation

New Diterpenoids from Andrographis paniculata （Burm. f.） Nees

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Journal of Integrative Plant Biology 2006年第9期48卷 1122-1125页

作者： xiao-Qi Zhang Guo-cai Wang Wen-cai Ye Qian Li Guang-Xiong Zhou xin-Sheng Yao Institute of Traditional Chinese Medicine and Natural Products Jinan University Guangzhou 510632 China Department of Phytochemistry China Pharmaceutical University Nanjing 210009 China

To investigate diterpenoids from the aerial parts of Andrographis paniculata （Burm. f.） Nees, three new ent-labdane diterpenoids, namely 19-norandrographolides A-C （compounds 1-3）, were isolated from the ethanolic extract of A. paniculata. Their structures were established by HRESIMS and NMR spectral data in combination with X-ray crystallographic analysis.

关键词： Andrographis paniculata diterpenoid 19-norandrographolides A-C