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Adropin and glucagon-like peptide-2 are associated with glucose metabolism in obese children

World Journal of Pediatrics 2019年第6期15卷 565-571页

作者： Rui-Min chen xin Yuan Qian Ouyang Xiang-Quan Lin Zhuan-Zhuan ai Ying Zhang Xiao-Hong Yang Department of Endocrinology Fuzhou Children's Hospital of Fujian ProvinceFujian Medical University Teaching HospitalNo.145817 Middle RoadFuzhou 350005China

Background The interaction of adropin,glucagon-like peptide-2(GLP2),angiopoietin-like protein 4(ANGPTL4),and with childhood obesity and glucose metabolism is *** study is to evaluate the association of the three cytokines and glucose *** This was a cross-sectional study of children with obesity ranging from 5 to 14 years compared to age-and sex-matched children of normal *** plasma glucose(FPG),oral glucose tolerance test 2-hour plasma glucose(OGT-T2hPG),and insulin(INS)were measured,and serum adropin,GLP2,and ANGPTL41evels were measured by enzyme-linked immunosorbent *** body mass index(BMI),BMI-Z scores,waist-to-hip ratio(WHR),and homeostasis model assessment of insulin resistance(HOMA-IR)were *** Thirty-nine children(9.70±1.71 years,18 females)with obesity and 29 normal weight children(8.98±1.98 years,16 females)were *** levels of INS,HOMA-IR and GLP2 of the obesity group were significantly higher than the controls(P<0.05).Pearson correlation analysis showed that serum GLP2 was positively associated with WHR,FPG,and OGTT2hPG,and adropin was negatively associated with BMI,BMI-Z,WHR,INS,and HOMA-IR(all P<0.05).Further-more,GLP2 were negatively associated with adropin and ANGPTL4(both P<0.05).By binary logistic regression,adropin and GLP2 were found to be independent markers of *** linear regression showed that GLP2 was associated with OGTT2hPG,and adropin was associated with INS and HOMA-IR(all P<0.05).Conclusions Obese children had elevated GLP2 concentrations,and adropin and GLP2 associated with both childhood obesity and glucose ***,there may be a physiologic interplay between adropin and GLP2 in obese children.

关键词： Adropin Children Glucagon-like peptide-2 Glucose metabolism Obesity

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An Impedance-based Parameter Design Method for Active Damping of Load Converter Station in MTDC Distribution System

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1423-1436页

作者： Pengwei chen Wenmeng Zhao xin chen Wenwei Jiang IEEE Jiangsu Key Laboratory of New Energy Generation and Power Conversion College of Automation EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina

To achieve the efficient application of impedance analysis in the stability assessment and enhancement of multiterminal DC distribution systems, this paper proposes the DCside reduced-order impedance models with power control and AC voltage control, respectively, by taking the load converter station as the object. By using the DC-side current as the feedforward state, the active compensator applied to the load converter station with two control modes is also derived as well as the corresponding reduced-order impedance models. Combined with the reduced-order impedance models, a method based on damping factor sensitivity is further proposed to design the parameters of the derived active compensators. The verification results in the frequency domain and time domain demonstrate the accuracy of the reduced-order impedance and the effectiveness of the proposed compensator parameter design method.

关键词： Impedance modeling order reduction active compensator damping factor sensitivity

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iGMDR:Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 150-160页

作者： Xiang chen Yi Guo xin chen Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital Department of Radiation Oncology Zhejiang University School of MedicineHangzhou 310058China Department of Polymer Science and Engineering and Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang UniversityHangzhou 310027China Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhou 310058China

Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticancer *** some of these models are of crucial importance and have been used in clinical practice,these very valuable models have not been well adopted into cancer research to promote the development of cancer therapies due to the lack of integration and standards for the existing data of the pharmacogenetic *** this purpose,we built a resource investigating genetic model of drug response(iGMDR),which integrates the models from in vitro and in vivo pharmacogenetic studies with different omics data from a variety of technical *** this study,we introduced a standardized process for all integrations,and described how users can utilize these models to gain insights into *** is freely accessible at https://***.

关键词： Genetic model Pharmacogenetics Anticancer drug Cancer Drug response

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Carrier frequency disturbance distributions on GPS during equatorial ionospheric scintillation

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1308-1317页

作者： ZHU Xuefen LIN Mengying chen xin chen Xiyuan Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology of Ministry of Education School of Instrument Science and EngineeringSoutheast UniversityNanjing 210096China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In the equatorial region,deep amplitude fading in global positioning system(GPS)signals frequently occurs during the strong ionospheric scintillation,it can lead to the loss of lock in GPS carrier tracking loops,and result in increased positioning error and even navigation *** relationships between amplitude scintillation indices and detrended carrier frequency are investigated,based on GPS L1 C/A signals during the last peak of the solar cycle at the low latitude site of São Josédos Campos,Brazil(23.2S,45.9W)from 2013 to *** mathematic model of the probability distribution function is built for the first time to provide statistical analysis on the above *** results show that the standard carrier frequencies reveal an almost linear relation with the amplitude scintillation ***,the frequency widths of detrended frequency are proportional to levels of amplitude scintillation when the value of the peak probability is lower than the corresponding boundary.A conclusion can be drawn that different levels of amplitude scintillation will influence the fluctuation of the carrier *** analysis will provide useful guidance to set the receiver’s bandwidth with respect to the different scintillation levels and design the advanced tracking algorithms to improve the robustness and precision of the GPS receiver.

关键词： ionospheric scintillation carrier frequency disturbance probability distribution bandwidth

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Using BiLSTM with attention mechanism to automatically detect self-admitted technical debt

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Frontiers of Computer Science 2021年第4期15卷 49-60页

作者： Dongjin YU Lin WANG xin chen Jie chen School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou 310018China

Technical debt is a metaphor for seeking short-term gains at expense of long-term code *** studies have shown that self-admitted technical debt,which is introduced intentionally,has strong negative impacts on software development and incurs high maintenance *** help developers identify self-admitted technical debt,researchers have proposed many state-of-the-art ***,there is still room for improvement about the effectiveness of the current methods,as self-admitted technical debt comments have the characteristics of length variability,low proportion and style ***,in this paper,we propose a novel approach based on the bidirectional long short-term memory(BiLSTM)networks with the attention mechanism to automatically detect self-admitted technical debt by leveraging source code *** BiLSTM,we utilize a balanced cross entropy loss function to overcome the class unbalance *** experimentally investigate the performance of our approach on a public dataset including 62,566 code comments from ten open source *** results show that our approach achieves 81.75%in terms of precision,72.24%in terms of recall and 75.86%in terms of F1-score on average and outperforms the state-of-the-art text mining-based method by 8.14%,5.49%and 6.64%,respectively.

关键词： technical debt self-admitted technical debt long short-term memory attention mechanism natural language processing

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NUMERICAL SIMULATION OF VENTILATED CAVITATING FLOW AROUND A 2D FOIL

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Journal of Hydrodynamics 2005年第5期17卷 607-614页

作者： chen xin LU Chuan-jing Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China

By using a pressure-based method and the finite volume method in the framework of the time dependent Reynolds-averaged Navier-Stokes equations, the authors studied the unsteady process of ventilated cavities generated forcing air through an orifice in a 2D hydrofoil without natural cavitation physically. The computation was carried out with the Volume Of Fluid （VOF） technique to track the gas-liquid two-phase interface. The results of simulation indicate that the ventilation rate is an important parameter in determining the morphology of cavity. There exists a critical value to convert sheet cavity into supereavity. A high ventilation rate can induce a two phase interface fluctuation and enable the ventilated eavitating flow to present a characteristic of periodicity.

关键词： ventilated cavity re entrant jet interface fluctuation Volume Of Fluid (VOF) techinique

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A general two-phase mixture model for sediment-laden flow in open channel

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Journal of Hydrodynamics 2022年第2期34卷 286-298页

作者： Jia-xing Li xin chen Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing100083China

This work extends the sediment-laden mixture model with consideration of the turbulence damping and particle wake effects under the framework of improved efficiency and *** mixture model consists of the continuity and momentum equations for the sediment-laden mixture,and the continuity equation for the sediment.A theoretical formula is derived for the relative velocity between the water and sediment phases,with consideration of the effects of the pressure gradient,the shear stress and the lift force.A modified expression of the particle wake effect,inducing the local turbulence enhancement around the sediment particle,is employed to improve the turbulent diffusion of the coarse *** k_(m)-ε_(m) model is proposed to close the mixture turbulence,with the turbulence damping effect due to the high sediment concentration expressed by the density-stratification term without an empirical *** k_(m)-ε_(m) turbulence model requires smaller computational work and offers better results than an empirical density-stratification turbulence model in high sediment concentration ***,with the proposed mixture model,the sediment transport in the open channel under a wide range of sediment sizes and concentrations can be revealed with the results in good agreement with experimental data for the velocity,the sediment concentration and the turbulent kinetic energy.

关键词： Sediment-laden flow two-phase mixture model particle wake effect turbulence damping effect density stratification

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THE EIGENVALUE PERTURBATION BOUND FOR ARBITRARY MATRICES

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Journal of Computational Mathematics 2006年第2期24卷 141-148页

作者： Wen Li Jian-xin chen School of Mathematical Sciences South China Normal University Guangzhou 510631 China College of Applied Mathematics Guangdong University of Technology Guangzhou 510090 China

In this paper we present some new absolute and relative perturbation bounds for the eigenvalue for arbitrary matrices, which improves some recent results. The eigenvalue inclusion region is also discussed.

关键词： Eigenvalue perturbation bound Jordan canonical form Frobenius norm Spectral norm Inclusion region.

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Dynamic Task Offloading for Mobile Edge Computing with Hybrid Energy Supply

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Tsinghua Science and Technology 2023年第3期28卷 421-432页

作者： Ying chen Fengjun Zhao Yangguang Lu xin chen Computer School Beijing Information Science and Technology UniversityBeijing 100101China

Mobile edge computing(MEC),as a new distributed computing model,satisfies the low energy consumption and low latency requirements of computation-intensive *** task offloading of MEC has become an important research hotspot,as it solves the problems of insufficient computing capability and battery capacity of Internet of things(IoT)*** study investigates task offloading scheduling in a dynamic MEC *** integrating energy harvesting technology into IoT devices,we propose a hybrid energy supply *** jointly optimize local computing,offloading duration,and edge computing decisions to minimize system *** the basis of stochastic optimization theory,we design an online dynamic task offloading algorithm for MEC with a hybrid energy supply called *** can make task offloading decisions by weighing system cost and queue *** quote dynamic programming theory to obtain the optimal task offloading *** results verify the effectiveness of DTOME,and show that DTOME entails lower system cost than two baseline task offloading strategies.

关键词： mobile edge computing Internet of Things dynamic offloading hybrid energy supply stochastic optimization

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Human PRV Infection in China: An Alarm to Accelerate Eradication of PRV in Domestic Pigs

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Virologica Sinica 2021年第4期36卷 823-828页

作者： Zhenhua Guo xin-xin chen Gaiping Zhang Key Laboratory of Animal Immunology of the Ministry of Agriculture Henan Provincial Key Laboratory of Animal ImmunologyHenan Academy of Agricultural SciencesZhengzhou 450002China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China

Pseudorabies,also known as Aujeszky's disease,is one of the most economically important viral diseases in pigs and is lethal to other susceptible animals(Ren et al.2020).The causative agent,pseudorabies virus(PRV),is an enveloped virus with a large double-stranded DNA genome encoding at least 70 proteins(Wong et al.2019).PRV belongs to the family Herpesviridae,subfamily Alphaherpesvirinae,genus Varicellovirus and infects multiple animals,such as pigs,dogs,cats,rabbits,cattle,sheep,goats,minks.

关键词： PRV belongs Human

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