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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin chen Ming-Hui Zeng Xue-Mei Tao Jia-xin Han Yue-Kui Wang Lian-xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-Yu Hu Yan-Mei Zeng Qian Ling Jie Zou cheng chen Liang-Qi He Xiao-Yu Wang Hong Wei Xu chen Yi-xin Wang Yi Shao Yao Yu Department of Ophthalmology Dahua HospitalShanghai 200237China Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

aiM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

Biomass-derived 2D Pb0/Pb^(2+) dual-center-site catalysts for efficient 5 hydroxymethylfurfural electroreduction

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Nano Research 2025年第2期18卷 101-110页

作者： Haoran Wu Haishan Xu Zhenbing Xie Runlu Yang xin Wang xinwei chen Liang Wu Chongyin Zhang Weixia Zhu Yiyong Mai School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Tangshan Normal UniversityTangshan 063000China Shanghai Aerospace Equipments Manufacturer Co. Ltd.Shanghai 200245China

Using natural resources to construct electrocatalysts for biomass conversion and elucidating their catalytic mechanisms are of great significance,but have remained ***,a series of two-dimensional(2D)biomass-based Pb/PbO@C nanoparticles catalysts with Pb/PbO anchored on carbon nanosheets were synthesized using natural-derived humate as the *** adjusting the carbonization temperature,an electron-deficient Pb0/Pb^(2+)dual-center-site catalyst can be *** optimized Pb/PbO@C catalyst showed an excellent performance for the electrochemical hydrogenation of 5 hydroxymethylfurfural(HMF)to high value-added 2,5 bis(hydroxymethyl)furan(BHMF),with high Faradaic efficiency(FE:91.9%)and selectivity(Sel:89.7%),achieving comparable performance to those of the reported noble metal-based *** study revealed that the electron-deficient Pb0/Pb^(2+)dual-center-site provided abundant Lewis acidic sites and promoted the dissociation of water to the active hydrogen(H^(*))species,thus enhancing the adsorption of HMF on Pb^(2+)sites and the coverage of H^(*)species on Pb0 *** high coverage of H*species and the synergistic effect of dual-center sites substantially promoted the binding of H*and HMF to form H-HMF^(*)and inhibited the recombination of H^(*)species,thereby accelerating the reaction kinetics of HMF reduction.

关键词： biomass conversion biomass-derived carbon materials electrocatalysis hydrogenation 5 hydroxymethylfurfural

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定窑遗址出土制瓷原料的科学分析

光谱学与光谱分析 2025年第1期45卷 72-81页

作者：陈殿崔剑锋秦大树黄信李鑫北京师范大学历史学院陶瓷考古与艺术研究中心北京100875 考古科学教育部重点实验室(北京大学) 北京100871 浙大城市学院考古学系浙江杭州310015 河北省文物考古研究院河北石家庄050031 中国社会科学院考古研究所北京100101

首次通过窑址发掘出土的制瓷原料,复原了定窑不同时代的胎釉配方。对2009年定窑作坊遗址考古发掘所出五代至宋金时期二十余种制瓷原料开展了ED-XRF成分分析和XRD结构分析等光谱学分析。ED-XRF成分分析显示,这些原料可能包括单一原料和... 详细信息

首次通过窑址发掘出土的制瓷原料,复原了定窑不同时代的胎釉配方。对2009年定窑作坊遗址考古发掘所出五代至宋金时期二十余种制瓷原料开展了ED-XRF成分分析和XRD结构分析等光谱学分析。ED-XRF成分分析显示,这些原料可能包括单一原料和混合原料两种。其中单一原料包括岩石、粘土以及草木灰。混合原料则包括胎料和釉料两种。XRD结构分析表明用于定窑白瓷生产高岭土类原料是含有蒙脱石和方解石的伴生石英的长石类矿物原料。高铁粘土类原料由于铁含量特别高,应当是用于配黑釉的粘土。钙质原料的分析与康葆强等学者对定窑配釉用的灰料可能使用了40%的白灰和60%的松木灰配制的结论相同。同时,还发现了釉灰,即草木煅烧石灰石后形成的混合灰料。在分析定窑白瓷釉时,认为五代的白瓷釉可能使用了釉灰配制,因此定窑釉灰的使用可能推早到五代,这是目前发现使用釉灰配釉最早的实例。对制胎原料XRD晶相分析的结果表明,除了石英和高岭石占主要比重外,还含有长石、蒙脱石、方解石等岩石类矿物。从对单一原料的X射线衍射的分析结果看,石英是粘土以及岩石这类单一原料中都含有的一类矿物,因此可能石英并非必须要添加的胎体原料。石英和高岭石是粘土原料中的主要成分,因此制胎原料应该主要以岩石类原料和粘土作为主要配料。定窑细白瓷胎料可能使用了粘土类原料配合第一类岩石类原料的配方,其配比在金代时大约为1∶1左右,北宋时期可能约为7∶3(粘土∶岩石),五代时大概为6∶4左右。对制釉原料分析结果表明,定窑配釉原料是岩石类原料与釉灰配合形成的,五代、北宋时岩石和灰的比例约为9∶1,金代时石:灰达到了9.5∶0.5。这使得我们对定窑鼎盛时期的白瓷胎釉配方有了更加清晰的了解,从而为开展定窑的复烧提供了确凿的依据。

关键词：定窑制瓷原料光谱学分析

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Investigations of inelastic cross sections of H_(2)O molecule by He^(2+)and C^(6+)projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： Guo-Zhuang Li cheng-Ye Sun Rui cheng Yan-Shi Zhang Liang-Wen chen Sheng Zhang xin-Xia Li Lei Yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H_(2)O molecules using He^(2+)and C^(6+)projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were *** illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(0◦∼30◦)to large angles(60◦∼120◦),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Highly portable electrochemical oxygen removal device for microenvironmental low-oxygen control

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Nano Research 2025年第2期18卷 263-272页

作者： xin Wang xingen Lin Wanyu Shen Yimin Li Yi Tan Zihan Wang Peng Jiang Song Gong Kong chen Yu Zhang Yuen Wu Department of Endocrinology Institute of Endocrine and Metabolic DiseasesThe First Affiliated Hospital of University of Science and Technology of China(USTC)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Deep Space Exploration Laboratory University of Science and Technology of ChinaHefei 230026China Division of Endocrinology Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China

Low-oxygen(O_(2))environments are essential in various research and application fields,yet traditional methods like nitrogen flushing or chemical O_(2) absorbers face challenges in high equipment cost and low *** study introduces a novel electrochemical oxygen removal(EOR)controller,offering a lightweight,low-cost,and precise low-O_(2) control *** self-powered EOR controller uses a sacrificial anode to drive the cathodic oxygen reduction reaction(ORR),efficiently consuming environmental O_(2) to reduce its level,thus eliminating the requirements of external gas or power *** integrating a single-atom ORR catalyst and flexible design,the device achieves a substantial reduction in weight and *** incorporation of electronic components for the EOR controller,including a switch for reaching targeted O_(2) concentration and a fixed resistor for O_(2) removal rate regulation,enables multi-dimensional O_(2) removal *** system also realizes the O_(2) concentration estimation in real-time with±1%accuracy(within the 21%-1% range)by calculating electron *** EOR controller's effectiveness is validated in plant hypoxia stress experiments,demonstrating precise O_(2) level adjustments and its potential across various applications requiring controlled hypoxic conditions.

关键词： low-oxygen condition oxygen reduction reaction(ORR) oxygen level control for microenvironment electrochemical oxygen removal

Continuum estimation in low-resolution gamma-ray spectra based on deep learning

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Nuclear Science and Techniques 2025年第2期36卷 5-17页

作者： Ri Zhao Li-Ye Liu xin Liu Zhao-xing Liu Run-cheng Liang Ren-Jing Ling-Hu Jing Zhang Fa-Guo chen China Institute for Radiation Protection Taiyuan 030006China Shanxi Provincial Key Laboratory for Translational Nuclear Medicine and Precision Protection Taiyuan 030006China

In this study,an end-to-end deep learning method is proposed to improve the accuracy of continuum estimation in low-resolution gamma-ray spectra.A novel process for generating the theoretical continuum of a simulated spectrum is established,and a convolutional neural network consisting of 51 layers and more than 105 parameters is constructed to directly predict the entire continuum from the extracted global spectrum *** testing,an in-house Nai-type whole-body counter is used,and 106 training spectrum samples(20%of which are reserved for testing)are generated using Monte Carlo *** addition,the existing fitting,step-type,and peak erosion methods are selected for *** proposed method exhibits excellent performance,as evidenced by its activity error distribution and the smallest mean activity error of 1.5%among the evaluated ***,a validation experiment is performed using a whole-body counter to analyze a human physical phantom containing four *** largest activity error of the proposed method is−5.1%,which is considerably smaller than those of the comparative methods,confirming the test *** multiscale feature extraction and nonlinear relation modeling in the proposed method establish a novel approach for accurate and convenient continuum estimation in a low-resolution gamma-ray ***,the proposed method is promising for accurate quantitative radioactivity analysis in practical applications.

关键词： Gamma-ray spectrum Continuum estimation Deep learning Convolutional neural network End-to-end prediction