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Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yun ZHU Qing SUN Xiao-chuan JIAng Rong-cai yAO Zhi-gang WAng Lei DAng yan-wei LIU De-zhong LIU y.ng FAng Wen-hua WAng Fang-yu LIN yuan-xiang WAng An-xin WAng Deng-liang KAng De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 120 patients were enrolled and randomly assigned between March 30, 2018 and April 15, 2020. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), Py outcomes showed no statistical significance between two groups, either in FAS or per-protocol set(P>0.05). Furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo Dihan Duan yi Zhang xin Chen y.ngjiu Li Zheng Tu Lei Feng Lei Chen Xiyun yan Lizeng Gao Minmin Liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

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EPEG型聚羧酸保坍剂的制备及性能研究

四川建材 2024年第6期50卷 13-15页

作者：汪咏梅赵明敏倪涛宋欣 Serina ng 石家庄市长安育才建材有限公司河北石家庄051430 河北省混凝土用功能性材料工程技术研究中心河北石家庄051430

以乙二醇单乙烯基聚乙二醇醚(EPEG)、丙烯酸羟丙酯(HPA)、丙烯酸(AA)为主要原料,在常温条件下通过自由基聚合合成聚羧酸保坍剂。通过试验考察了釜底浓度、反应温度、引发剂、链转移剂用量及酸醚比对产品性能的影响。最佳反应条件:HPA∶A... 详细信息

以乙二醇单乙烯基聚乙二醇醚(EPEG)、丙烯酸羟丙酯(HPA)、丙烯酸(AA)为主要原料,在常温条件下通过自由基聚合合成聚羧酸保坍剂。通过试验考察了釜底浓度、反应温度、引发剂、链转移剂用量及酸醚比对产品性能的影响。最佳反应条件:HPA∶AA∶EPEG=3.5∶1.5∶1.0,引发剂占单体质量百分比为1.2%,滴加时间为60 min,保温30 min,反应结束。通过对EPEG和TPEG大单体核磁对比分析,以及EPGE与TPEG型保坍剂进行凝胶渗透色谱(GPC)、总有机碳分析仪(TOC)微观分析,证实了EPEG型保坍剂具有更优性能的微观原因。在达到相同保坍性能条件下,EPEG型保坍剂只占TPEG型保坍剂用量的80%,大幅降低了保坍剂用量,显著节约成本,大幅提高市场竞争力,同时EPEG型保坍剂常温、短时间、高效率的生产特点,使其具有良好的经济价值及广泛的应用前景。

关键词： EPEG 保坍剂常温合成微观分析保坍性能

Unraveling magnetic properties and martensitic transformation in Mn-rich Ni-Mn-Sn alloys:first-principles calculations and experiments

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Rare Metals 2024年第4期43卷 1769-1785页

作者： yu Zhang Jing Bai Ke-Liang Guo Jia-xin Xu Jiang-Long Gu Nicola Morley Qui-Zhi Gao yu-Dong Zhang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao066004China Department of Material Science and Engineering University of SheffieldSheffieldS13JDUK State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China Laboratoire d’Étude des Microstructures Et de Mécanique des Matériaux University of Lorraine57045MetzFrance

We have investigated the phase stability,magnetic properties,and martensitic transformation thermodynamics/kinetics of the Ni_(24-x)Mn_(18+x+y)Sn_(6-y)(x,y=0,1,2)system by combining the first-principles calculations and *** calculation results show that the optimized lattice parameters are consistent with the experimental ***,we obtain the relation equation for the austenite formation energy(E_(form-A))and Mn content(X_(Mn)):E_(form-A)=507.358X_(Mn)-274.126,as well as for the six-layer modulated(6M)martensite formation energy(E_(form-6M))and Ni content(X_(Ni)):E_(form-6M)=-728.484X_(Ni)+*** ternary phase diagram of the total magnetic moment was *** excess Mn will reduce the total magnetic moment of 6M(Mag6M)and non-modulated(NM)(MagNM)martensites,with the following equations relating the total magnetic moment and Mn content:Mag_(6M)=-15.905X_(Mn)+7.902and Mag_(NM)=-14.781X_(Mn)+7.411,while the effect on austenite is *** variation of total magnetic moment is mainly dominated by the Mn atomic magnetic *** 3d electrons of Mn_(Sn)(Mn at Sn sublattice)play an important role in magnetic properties from the perspective of the electronic density of *** on the thermodynamics of martensitic transformation,the alloys will likely undergo austenite?6M?NM transformation *** the thermodynamic and kinetic results,the martensitic transformation temperature decreases with x increasing and increases with y *** results are expected to provide reference for predicting the phase stability and magnetic properties of NiMn-Sn alloys.

关键词： Ni-Mn-Sn First-principles calculations Martensitic transformation Magnetic property Kinetics

Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： Qiang-Qiang Fu Le Ma Xiao-Min Niu Hua-xin Zhao Xu-Hua Ge Hua Jin De-Hua yu Sen y.ng Department of General Practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai General Practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

Immune Regulatory Networks and Therapy of yδT Cells in Liver Cancer:Recent Trends and Advancements

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 287-297页

作者： Kun-Li yin Kai-Jian Chu Ming Li yu-xin Duan yan-Xi yu Mei-Qing Kang Da Fu Rui Liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Biliary Surgical Department I the Eastern Hepatobiliary Surgical HospitalNaval Medical UniversityShanghaiChina General Surgery Institute of Pancreatic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

The roles of γδ T cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research *** re-view briefly describes the basic characteristics of γδ T cells,focusing on their diverse effects on liver *** particular,different subtypes of γδ T cells have diverse or even opposite effects on liver *** provide a detailed description of the immune regulatory network of γδ T cells in liver can-cer from two aspects:immune components and nonimmune *** interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ T cells in liver *** also integrate the current knowledge of γδ T-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.

关键词： Liver cancer γδT cells Immunotherapy Tumor microenvironment

The AaBBX21–AaHy5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu Wu Qing Miao xinyi Hu xin yan Hangyu Wen yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science Center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underly.ng regulatory mechanism remains *** this study,we demonstrate that ELOngATED HyPOCOTyL5(Hy5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHy5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHy5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMyB108,and AaORA,encoding positive regulators of artemisinin ***,AaHy5 and AaBBX21 physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELy PHOTOMORPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHy5 and AaBBX21 and repressed the activation of genes downstream of the AaHy5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHy5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

Filamentous morphology engineering of bacteria by iron metabolism modulation through MagR expression

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Synthetic and Systems Biotechnology 2024年第3期9卷 522-530页

作者： Mengke Wei Cheny.ng Han Xiujuan Zhou Tiany.ng Tong Jing Zhang xinmiao Ji Peng Zhang yanqi Zhang yan Liu xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui230032China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang310027China

The morphology is the consequence of evolution and *** coli is rod-shaped bacillus with regular dimension of about 1.5μm long and 0.5μm *** shape-related genes have been identified and used in morphology engineering of this ***,little is known about if specific metabolism and metal irons could modulate bacteria *** in this study,we discovered filamentous shape change of *** cells overexpressing pigeon MagR,a putative magnetoreceptor and extremely conserved iron-sulfur *** transcriptomic analysis strongly suggested that the iron metabolism change and iron accumulation due to the overproduction of MagR was the key to the morphological *** model was further validated,and filamentous morphological change was also achieved by supplement *** cells with iron in culture medium or by increase the iron uptake genes such as entB and *** study extended our understanding of morphology regulation of bacteria,and may also serves as a prototype of morphology engineering by modulating the iron metabolism.

关键词： Morphology regulation Iron accumulation Filamentous bacteria MagR overexpression

Compressive properties of a novel slurry-infiltrated fiber concrete reinforced with arc-shaped steel fibers

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第6期24卷 543-556页

作者： Hedong LI yabiao LI yunfeng PAN P.L.ng Christopher K.y.LEUng xin ZHAO School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Civil Engineering The University of Hong KongHong Kong 999077China Faculty of Civil Engineering Vilnius Gediminas Technical UniversityVilnius LT-10223Lithuania Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China

Slurry-infiltrated fiber concrete(SIFCON)is a sort of strain hardening cement-based composite material,typically made with 5%–20%steel *** study focused on a novel type of SIFCON in which hooked-end steel fibers were replaced by arc-shaped steel *** quasi-static compressive properties of the SIFCON were first *** results suggested that using arc-shaped steel fibers in lieu of hooked-end steel fibers increased the quasi-static compressive strength by 47.1%and the strain at peak stress by 56.3%.We attribute these improvements to new crack-resisting mechanisms,namely“fiber crosslock”,“dual bridging”,and“confinement loops”,when the arc-shaped steel fibers are introduced into *** high impact resistance is a special property of SIFCON that is of practical significance,the dynamic compressive properties of arc-shaped steel fiber SIFCON were studied by using an 80-mm-diameter split Hopkinson pressure bar(SHPB).The results showed that the dynamic compressive strength,dynamic increase factor(DIF),and dynamic toughness of SIFCON all increased with the strain *** SIFCON incorporating arc-shaped steel fibers proved to have significant advantages in structural applications requiring high impact resistance.

关键词： Slurry-infiltrated fiber concrete(SIFCON) Arc-shaped steel fiber Quasi-static compressive properties Spilt Hopkinson pressure bar(SHPB) Dynamic compressive properties