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Science Bulletin 2024年第4期69卷 526-534页

作者：田原武依戚敏杰宋莉娟陈伯望王椿淇路甲鹏杨阳张小艳崔建兰许巍杨皓贺文彦张岩郑昕张海波郭远林李希 National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Henan Provincial Center for Disease Control and Prevention Zhengzhou 450000China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Shenzhen Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 501800China Central China Sub-Center of the National Center for Cardiovascular Diseases Zhengzhou 450000China

The health significance of triglyceride-rich lipoproteins,also known as remnant cholesterol,has been increasingly ***,evidence of their associations with cause-specific mortality in the general population was previously *** explore these associations and their heterogeneities across subgroups,a prospective cohort study was conducted including 3,403,414 community-based participants from China HEART,an ongoing government-funded public health program throughout China,from November 2014 through December *** study assessed mortality risk of all-cause mortality,cardiovascular disease(CVD)mortality(including mortality from ischemic heart diseases(IHD),ischemic stroke(IS),and hemorrhagic stroke(HS),separately),and cancer mortality(including lung cancer,stomach cancer,and liver cancer,separately).During the 4-year follow-up,23,646 individuals died from CVD(including 8807 from IHD,3067 from IS,and 5190 from HS),and 20,318 from cancer(including 6208 from lung cancer,3013 from liver cancer,and 2174 from stomach cancer).Compared with individuals with remnant cholesterol<17.9 mg/d L,multivariable-adjusted mortality hazard ratios(HRs)for individuals with remnant cholesterol≥27.7 mg/d L were 1.03(1.00–1.05)for all-cause mortality,1.17(1.12–1.21)for CVD(1.19(1.12–1.27)for IHD mortality,and 1.22(1.09–1.36)for IS mortality),and 0.90(0.87–0.94)for allcancer mortality(0.94(0.87–1.02)for lung cancer,0.59(0.53–0.66)for liver cancer,and 0.73(0.64–0.83)for stomach cancer).In summary,this study revealed a correlation between increased remnant cholesterol levels and an elevated risk of cardiovascular disease mortality,as well as a reduced risk of mortality for certain types of cancer.

关键词： Remnant cholesterol Mortality Cardiovascular disease Cancer

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有机物料投入对滨海盐碱地土壤理化性状和夏玉米产量形成的影响

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作物学报 2024年第9期50卷 2323-2334页

作者：张贵芹王洪章郭新送朱福军高涵张吉旺赵斌任佰朝刘鹏任昊黄淮海区域玉米技术创新中心/山东农业大学农学院山东泰安271018 山东农大肥业科技股份有限公司山东肥城271600

探究不同有机物料投入对滨海盐碱地土壤理化性质及玉米生长发育的调控作用,为滨海盐碱地夏玉米生产提供理论依据。试验于2021-2022年夏玉米生长季在山东省滨州市无棣县滨海盐碱型农田进行。有机物料类型及用量分别为腐植酸(3000 kg hm^(... 详细信息

探究不同有机物料投入对滨海盐碱地土壤理化性质及玉米生长发育的调控作用,为滨海盐碱地夏玉米生产提供理论依据。试验于2021-2022年夏玉米生长季在山东省滨州市无棣县滨海盐碱型农田进行。有机物料类型及用量分别为腐植酸(3000 kg hm^(–2), HA)、生物炭(15,000 kg hm^(–2), BC)、生物有机肥(15,000 kg hm^(–2), BO),以不添加有机物料为对照(CK),探究0~40 cm土层土壤容重、总孔隙度、田间持水量、pH值、电导率及总有机碳含量的变化,分析不同有机物料投入对玉米地上部干物质积累和产量形成的影响。结果表明,腐植酸、生物炭和生物有机肥的施用均可在一定程度上改善盐碱土理化性质。3种有机物料连续处理能有效降低表层土壤容重,增加土壤总孔隙度和田间持水量;可显著降低0~10cm土层pH,分别平均降低0.17、0.08和0.20。连续施用2年后,腐植酸显著降低0~40cm土层电导率,平均降低32.74%;3种有机物料显著增加0~20 cm土层中总有机碳的含量,其中生物炭处理能显著增加57.99%。腐植酸和生物有机肥处理显著增加夏玉米地上部干物质积累量和产量;连续使用2年后腐植酸处理产量显著增加了11.01%,表现较好。综上所述,本试验条件下腐植酸施用后能改善土壤物理结构、降低0~10 cm土层pH、提高土壤中有机碳含量、显著降低土壤电导率,促进夏玉米地上部干物质积累、提高籽粒产量,且连续施用2年后较CK增加纯收益。故而腐植酸可作为改良滨海盐碱地土壤理化性状、促进夏玉米生长发育的有机物料。生物有机肥的施用可改善土壤理化性状,但仍需进行定位试验以验证其长期经济效应。

关键词：滨海盐碱地有机物料土壤理化性状产量

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脑卒中患者社会参与的纵向研究进展

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护理学杂志 2024年第11期39卷 126-128,F0003页

作者：郭鑫石红英朱杉杉王帅有李丁丁潘勤贾琳婧张会敏新乡医学院护理学院河南新乡453003 河南省肿瘤医院新乡医学院第三附属医院

从脑卒中患者社会参与相关概念、纵向研究现状(定量研究、定性研究、时间点选取)、变化趋势(前6个月社会参与改善最大,以后改善幅度趋于稳定)、面临的挑战(重复多次收集资料,耗时长、成本高、失访率高,无法确定最佳研究时间点)等方面进... 详细信息

从脑卒中患者社会参与相关概念、纵向研究现状(定量研究、定性研究、时间点选取)、变化趋势(前6个月社会参与改善最大,以后改善幅度趋于稳定)、面临的挑战(重复多次收集资料,耗时长、成本高、失访率高,无法确定最佳研究时间点)等方面进行综述,旨在为开展更高质量的脑卒中患者社会参与纵向研究和针对性干预提供参考。

关键词：脑卒中社会参与社会活动社会隔离纵向研究综述文献

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Impact of environmental change on runoff in a transitional basin:Tao River Basin from the Tibetan Plateau to the Loess Plateau,China

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Advances in Climate Change Research 2019年第4期10卷 214-224页

作者： SUN Long WANG Yue-Yang ZHANG Jian-Yun YANG qin-Li BAO Zhen-xin GUAN Xiao-Xiang GUAN Tie-Sheng CHEN xin WANG guo-qing State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing210029China Institute of Hydrology and Water Resources Hohai UniversityNanjing210098China Hydrology Bureau Ministry of Water ResourcesBeijing100053China College of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing210044China Research Center fo r Climate Change Ministry of Water ResourcesNanjing210029China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu611731China

Quantification of the impacts of environmental changes on runoff in the transitional area from the Tibetan Plateau to the Loess Plateau is of critical importance for regional water resources *** and abrupt change points of the hydro-climatic variables in the Tao River Basin were investigated during *** also quantitatively separates the impacts of climate change and human activities on runoff change in the Tao River by using RCC-WBM *** indicate that temperature presented a significant rising trend(0.2℃per decade)while precipitation exhibited an insignificant decreasing trend(3.8 mm per decade)during *** runoff in the Tao River decreased significantly with a magnitude of-13.7 mm per decade and abrupt changes in 1968 and 1986 were *** to the baseline period(1956-1968),runoff in the two anthropogenic disturbed periods of 1969-1986 and 1987-2015 decreased by 27.8 mm and 76.5 mm,respectively,which can be attributed to human activities(accounting for 69%)and climate change(accounting for 31%).Human activities are the principal drivers of runoff reduction in the Tao River ***,the absolute influences on runoff reductions by the both drivers tend to increase,from 7.7 mm in 1969-1986 to 24.4 mm in 1987-2015 by climate change and from 20.2 mm to 52.2 mm by human activities.

关键词： Climate change Human activity Runoff change RCCC-WBM model Runoff naturalization Attribution analysis Tao River Basin

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基于SSR荧光标记的121份野生枸杞种质遗传结构解析

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湖北农业科学 2024年第5期63卷 207-214页

作者：戴国礼刘娜秦垦张波尹跃米佳何昕孺宁夏农林科学院枸杞科学研究所银川740002

以采集的121份野生枸杞(Lycium barbarum L.)种质为材料,用9对SSR引物进行扩增,采用GeneALEX、Power Marker软件进行多态性分析,利用NTSYS、STRUC-TURE软件进行遗传多样性分析、聚类分析和主成分分析。结果表明,9对SSR引物共检测到108... 详细信息

以采集的121份野生枸杞(Lycium barbarum L.)种质为材料,用9对SSR引物进行扩增,采用GeneALEX、Power Marker软件进行多态性分析,利用NTSYS、STRUC-TURE软件进行遗传多样性分析、聚类分析和主成分分析。结果表明,9对SSR引物共检测到108个等位基因,等位基因数(Na)、有效等位基因数(Ne)、观测杂合度(Ho)、期望杂合度(He)、多态信息含量(PIC)、Shannon’s信息指数分别为12个、4.620个、0.678、0.651、0.629、1.568;聚类结果显示121份野生枸杞种质可划分为5个亚群,群体遗传结构表明当K=5时,121个种质划分为5个亚群,来自宁夏的NXGY-02、NXGY-032个种质与来自内蒙古的6个种质之间的遗传距离最远,亲缘关系较远,来自青海省、新疆、甘肃省及内蒙古的其余野生枸杞种质之间存在广泛的基因交流现象;宁夏、内蒙古的野生枸杞种质具有独立起源进化的可能,而新疆、甘肃省、青海省的种质与宁夏种质亲缘关系较近,很可能属于同一起源。

关键词：野生枸杞(Lycium barbarum L.) 种质 SSR荧光标记遗传结构

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The complete mitogenome of Lamproptera curia （Lepidoptera： Papilionidae） and phylogenetic analyses of Lepidoptera

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Frontiers in Biology 2015年第5期10卷 458-472页

作者： xin-Min qin qing-xin Guan Hui-Min Li Yu Zhang Yu-Ji Liu Dan-Ni guo Guangxi Key Laboratory of Rare and Endangered Animal Ecology College of Life Science Guangxi Normal University Guilin 541004China

The complete mitochondrial genome sequence of Lamproptera curia was determined in the present study. Our findings showed that the mtDNA of L. curia had a typical organization of insect mitochrondrial DNA - being 15277 base pairs in length, it contained 13 protein-coding genes （PCGs）, 2 rRNA genes, 22 tRNA genes, and a control region （CR）. The newly determined sequence was used for phylogenetic analyses, together with those of 45 species of Lepidoptera published elsewhere, including sequences of three species of Diptera as outgroups. The phylogenetic trees were constructed using the concatenated amino acid and nucleotide sequences of the 13 protein-coding genes （PCGs） based on the maximum likelihood （ML） and Bayesian inference （BI） methods. Both BI and ML trees revealed a similar topology structure：（（（（（Bombycoidea ＋ Geometroidea）＋ Noctuoide）＋ Pyraloidea）＋（Papilionoidea ＋ Hesperioidea））＋ Tortricoidea）. Furthermore, the phylogenetic analyses demonstrated that each of the 16 families belonged to a monophyletic group respectively. The results of molecular phylogeny from the present study were congruent with traditional classification based on morphology but failed to demonstrate the monophyly of Hesperiidae.

关键词： Lamproptera curia phylogeny mitochondrial genome

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高放固体废物桶γ无损检测装置的研究与改进

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电工技术 2024年第13期 139-145页

作者：秦川李亚丽郭建锋魏田田辛桂利中核四0四有限公司甘肃兰州732850

高放固体废物桶γ无损检测装置主要用于高放固体废物γ核素的测量,通过对装置的软件、算法、结构等方面进行改造升级,解决了高放废物测量过载、传输辊道卡滞、测量与动力系统同一路供电等问题,提升了该装置的工作效率,减少了人员的受照... 详细信息

高放固体废物桶γ无损检测装置主要用于高放固体废物γ核素的测量,通过对装置的软件、算法、结构等方面进行改造升级,解决了高放废物测量过载、传输辊道卡滞、测量与动力系统同一路供电等问题,提升了该装置的工作效率,减少了人员的受照剂量,保障了人员的辐射安全,对加快推进核设施退役和放射性三废治理进程,保障核安全具有重要意义。

关键词：高放固体废物无损测量超量程

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Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang,China

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Biomedical and Environmental Sciences 2010年第5期23卷 363-370页

作者： YUN WANG xin LI WEN-LI ZHU JIN-ZHEN guo XIAO-MING SONG SHU-qin LI YONG LI Department of Nutrition and Food Hygiene School of Public HealthPeking University Health Science CentreBeijing 100191China Beijing Institute of Genomics Chinese Academy of Sciences Sheng-Jing Hospital of China Medical University China

Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate （NSCL/P） in Northern Chinese people in Shenyang by using genomewide and interaction linkage *** Two multiplex families in Shenyang from North China were ascertained through probands with NSCL/*** of every member was drawn for DNA extraction and *** were available for 382 autosomal short tandem repeat （STR） markers from the ABI Prism Linkage Mapping Set version *** between markers and NSCL/P was assessed by 2-point parametric LOD scores,multipoint heterogeneity parametric LOD scores （HLODs）,and multipoint nonparametric linkage score （NPL）.Results The initial scan suggested linkage on Chromosomes 1,2,and *** subsequent fine mapping,1q32-q42 showed a maximum multipoint LOD score of 1.9（empirical P=0.013） and an NPL score of 2.35 （empirical P=0.053）.For 2p24-p25,the multipoint NPL increased to 2.94 （empirical P=0.007）.2-locus interaction analysis obtained a maximum NPL score of 3.73 （P=0.00078） and a maximum LOD score of 3 for Chromosome 1 （at 221 cM） and Chromosome 2 （at 29 cM）.Conclusion Both parametric and nonparametric linkage scores greatly increased over the initial linkage scores on 1q32-q42,suggesting a susceptibility locus in this *** linkage gave a strong evidence for a candidate region on chromosome *** superiority of 2-locus linkage scores compared to single-locus scores gave additional evidence for linkage on 1q32-q42 and 2p24-p25,and suggested that certain genes in the two regions may contribute to NCSL/P risks with interaction.

关键词： Nonsyndromic cleft lip with or without cleft palate Parametric linkage Nonparametric linkage Interaction

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Interaction between insulin-like growth factor binding protein-related protein 1 and transforming growth factor beta 1 in primary hepatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 395-404页

作者： Xiu-qing Li Qian-Qian Zhang Hai-Yan Zhang Xiao-Hong guo Hui-qin Fan Li-xin Liu Department of Gastroenterology and Hepatology The First Clinical Hospital of Shanxi Medical University Experimental Center of Science and Research The First Clinical Hospital of Shanxi Medical University Key Laboratory of Cell Physiology Provincial Department of the Ministry of EducationShanxi Medical UniversityTaiyuan 030001China

BACKGROUND: We previously showed that insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) is a novel mediator in liver fibrosis. Transforming growth factor beta 1 (TGF beta 1) is known as the strongest effector of liver fibrosis. Therefore, we aimed to investigate the detailed interaction between IGFBPrP1 and TGF beta 1 in primary hepatic stellate cells (HSCs). METHODS: We overexpressed TGF beta 1 or IGFBPrP1 and inhibited TGF beta 1 expression in primary HSCs for 6, 12, 24, 48, 72, and 96 hours to investigate their interaction and observe the accompanying expressions of a-smooth muscle actin (alpha-SMA), collagen I, fibronectin, and phosphorylated-mothers against decapentaplegic homolog 2/3 (p-Smad2/3). RESULTS: We found that the adenovirus vector encoding the TGF beta 1 gene (AdTGF beta 1) induced IGFBPrP1 expression while that of alpha-SMA, collagen I, fibronectin, and TGF beta 1 increased gradually. Concomitantly, AdIGFBPrP1 upregulated TGF beta 1, alpha-SMA, collagen I, fibronectin, and p-Smad2/3 in a time-dependent manner while IGFBPrP1 expression was decreased at 96 hours. Inhibition of TGF beta 1 expression reduced the IGFBPrP1-stimulated expression of alpha-SMA, collagen I, fibronectin, and p-Smad2/3. CONCLUSIONS: These findings for the first time suggest the existence of a possible mutually regulation between IGFBPrP1 and TGF beta 1, which likely accelerates liver fibrosis progression. Furthermore, IGFBPrP1 likely participates in liver fibrosis in a TGF beta 1-depedent manner, and may act as an upstream regulatory factor of TGF beta 1 in the Smad pathway.

关键词： insulin-like growth factor binding protein related protein 1 transforming growth factor in primary hepatic stellate cells alpha-smooth muscle actin extracellular matrix Smad pathway

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高强度超声聚焦消融术在ⅡB型子宫瘢痕妊娠治疗中的疗效分析

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中国现代医生 2024年第8期62卷 51-54页

作者：郭欣秦贞立沈承承徐延华徐明玥济南市妇幼保健院妇科山东济南2500021

目的探究高强度超声聚焦消融术在ⅡB型子宫瘢痕妊娠治疗中的疗效分析。方法收集笔者医院2019年1月至2021年12月期间ⅡB型剖宫产瘢痕部位妊娠患者365例,分为高强度超声聚焦消融术预处理的实验组(186例)及未经处理的对照组(179例),比较两... 详细信息

目的探究高强度超声聚焦消融术在ⅡB型子宫瘢痕妊娠治疗中的疗效分析。方法收集笔者医院2019年1月至2021年12月期间ⅡB型剖宫产瘢痕部位妊娠患者365例,分为高强度超声聚焦消融术预处理的实验组(186例)及未经处理的对照组(179例),比较两组术中出血量、术后阴道流血时间、术后血人绒毛膜促性腺激素(humanchorionic gonadotropin,HCG)下降率及手术成功率等指标。结果实验组术中出血量、术后阴道流血时间均少于对照组(P0.05),但对照组月经期延长,两组术后并发症的发病率差异无统计学意义。结论高强度超声聚焦消融术可有效减少ⅡB型瘢痕妊娠患者术中出血量,减少腹腔镜等有创方式应用,可作为ⅡB型瘢痕妊娠的预处理方式推广。

关键词：子宫瘢痕妊娠高强度超声聚焦消融术宫腔镜手术

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