检索结果-南通市图书馆

Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics

引用

Nano Research 2020年第12期13卷 3377-3386页

作者： Zhike Li Xi Qiao Guihua He xin Sun Danhua Feng Liefeng Hu Hua Xu Hai-Bing Xu Shengqian ma Jian tian Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Hubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsSchool of Pharmaceutical SciencesWuhan UniversityWuhan430071China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei Collaborative Innovation Center for Advanced Organic Chemical MaterialsCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China Department of Chemistry University of North TexasDentonTX76201USA

The nanoplatforms based on upconversion nanoparticles(UCNPs)have shown great promise in amplified photodynamic therapy(PDT)triggered by near-infrared(NIR)***,their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence(UCL)by *** solve these defects,core-satellite metal-organic framework@UCNP superstructures,composed of a single metal-organic framework(MOF)NP as the core and Nd3+-sensitized UCNPs as the satellites,are designed and synthesized via a facile electrostatic self-assembly *** superstructures realize a high co-loading capacity of chlorin e6(Ce6)and rose bengal(RB)benefitted from the highly porous nature of MOF NPs,showing a strong spectral overlap between maximum absorption of photosensitizers and emission of *** in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal(magnetic resonance(MR)/UCL/fluorescence(FL))imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation,avoiding the laser irradiation-induced overheating *** study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics.

关键词： core-satellite structures upconversion nanoparticles(UCNPs) nanoscale metal-organic frameworks photodynamic therapy theranostics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three Types of Isocoumarins with Unusual Carbon Skeletons from Artemisia dubia var. subdigitata and Their Antihepatoma Activity

引用

Chinese Journal of Chemistry 2024年第16期42卷 1901-1912页

作者： Ke-xin Yang tian-Ze Li Yun-Bao ma Yong-Cui Wang Feng-Jiao Li Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia ***(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-methylcyclohexyl)propan-1-one moiety fused with isocoumarin core *** 4a/4b were characterized as an unexpected 2,5-dimethylcyclohexan-1-one scaffold,and compounds 5a/5b and 6a/6b were rare 1,*** structures and absolute configurations were elucidated through spectroscopic data,X-ray crystallography,ECD and NMR calculations with DP4+*** biosynthetic pathways were proposed from the naturally occurring *** pharmacological analysis suggested that the targets of compound 1 were significantly enriched in the cell cycle and Pl3K-Akt signaling *** molecular docking revealed that compound 1 had high binding affinity with CDK2(total score:6.8717).Furthermore,compounds 1 and 2 exhibited inhibitory activity on three human hepatoma cell lines,with inhibitory ratios of 85.1% and 84.5%(HepG2),88.2% and 87.3%(Huh7),and 69.2% and 69.1%(SK-Hep-1)at 200μmol·L^(-1),respectively.

关键词： Artemisia dubia var.subdigitata Isocoumarins Antihepatoma activity Cancer Natural products X-ray diffraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide

引用

Neuroscience Bulletin 2024年第10期40卷 1403-1420页

作者： Nan Zhang Xiaoying ma xinyu He Yaxin Zhang xin Guo Zhiyuan Shen Xiaosu Guo Danshen Zhang Shujuan tian Xiaowei ma Yuan xing Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease The First Hospital of Hebei Medical UniversityShijiazhuang050000China Neuromedical Technology Innovation Center of Hebei Province Department of NeurologyThe First Hospital of Hebei Medical UniversityShijiazhuang050000China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang050000China Department of Neurology Hebei HospitalXuanwu Hospital of Capital Medical UniversityShijiazhuang050000China

Excessive secretion of human islet amyloid polypeptide(hIAPP)is an important pathological basis of diabetic encephalopathy(DE).In this study,we aimed to investigate the potential implications of hIAPP in DE *** magnetic resonance imaging and cognitive scales were applied to evaluate white matter damage and cognitive *** found that the concentration of serum hIAPP was positively correlated with white matter damage but negatively correlated with cognitive scores in patients with type 2 diabetes *** vitro assays revealed that oligodendrocytes,compared with neurons,were more prone to acidosis under exogenous hIAPP ***,western blotting and co-immunoprecipitation indicated that hIAPP interfered with the binding process of monocarboxylate transporter(MCT)1 to its accessory protein CD147 but had no effect on the binding of MCT2 to its accessory protein *** differential analysis of proteins co-immunoprecipitated with CD147 in oligodendrocytes revealed Yeast Rab GTPase-Interacting protein 2(YIPF2,which modulates the transfer of CD147 to the cell membrane)as a significant ***,YIPF2 inhibition significantly improved hIAPP-induced acidosis in oligodendrocytes and alleviated cognitive dysfunction in DE model *** findings suggest that increased CD147 translocation by inhibition of YIPF2 optimizes MCT1 and CD147 binding,potentially ameliorating hIAPP-induced acidosis and the consequent DE-related demyelination.

关键词： Diabetic encephalopathy Human islet amyloid polypeptide Oligodendrocytes:Yeast Rab GTPase-interacting protein 2-Monocarboxylate transporters CD147

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Understanding on the Memory Effect of Crystallized iPP

引用

Chinese Journal of Polymer Science 2014年第9期32卷 1224-1233页

作者： Xiang-yang Li Zhe ma Feng-mei Su Nan tian You-xin Ji Jie Lu Zhen Wang 李良彬 National Synchrotron Radiation Laboratory College of Nuclear Science and Technology University of Science and Technology of China Department of Mechanical Engineering Eindhoven University of Technology P.O. Box 513 5600MB Eindhoven The Netherlands Department of Polymer Science and Engineering CAS Key Lab of Soft Matter Chemistry University of Science and Technology of China

In this study, recovery processes of isotactic polypropylene （iPP） melted spherulites at 135 ℃ after melting at higher temperatures （170 ℃-176 ℃） were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.

关键词： Memory effect Isotactic polypropylene Conformational ordering Topological connectivity Aggregate.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MoS_(2)core-shell nanoparticles prepared through liquid-phase ablation and light exfoliation of femtosecond laser for chemical sensing

引用

Science China(Technological Sciences) 2023年第3期66卷 853-862页

作者： ZUO Pei JIANG Lan LI xin tian MengYao YUAN YongJiu HAN WeiNa ma Le HU LiFei HE ZhiCong LI Fang School of Mechanical and Electrical Engineering Hubei Key Laboratory of Optical Information and Pattern RecognitionSchool of Optical Information and Energy EngineeringWuhan Institute of TechnologyWuhan 430073China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Molybdenum disulfide(MoS_(2))-based nanostructures are highly desirable for applications such as chemical and biological sensing,photo/electrochemical catalysis,and energy storage due to their unique physical and chemical *** this work,MoS_(2)core-shell nanoparticles were first prepared through the liquid-phase processing of bulk MoS2by a femtosecond *** core of prepared nanoparticles was incompletely and weakly crystalline MoS_(2);the shell of prepared nanoparticles was highly crystalline MoS_(2),which wrapped around the core layer by *** femtosecond laser simultaneously achieved liquid-phase ablation and light *** formation mechanism of the core-shell nanoparticles is to prepare the nanonuclei first by laser liquid-phase ablation and then the nanosheets by light exfoliation;the nanosheets will wrap the nanonuclei layer by layer through van der Waals forces to form core-shell *** MoS_(2)core-shell nanoparticles,because of Mo-S bond breakage and recombination,have high chemical activity for chemical ***,the nanoparticles were used as a reducing agent to directly prepare three-dimensional(3D)Au-MoS_(2)micro/nanostructures,which were applied as surface-enhanced Raman spectroscopy(SERS)substrates to explore chemical sensing *** ultrahigh enhancement factor(1.06×10^(11)),ultralow detection limit(10-13M),and good SERS adaptability demonstrate highly sensitive SERS activity,great ability of ultralow concentration detection,and ability to detect diverse analytes,*** work reveals the tremendous potential of 3D Au-MoS_(2)composite structures as excellent SERS substrates for chemical and biological sensing.

关键词： MoS_(2)core-shell nanoparticle femtosecond laser liquid-phase ablation light exfoliation 3D Au-MoS_(2)composite structure chemical sensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cloning and functional analysis of a novel ascorbate peroxidase(APX) gene from Anthurium andraeanum

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1110-1120页

作者： Hui-chun LIU Dan-qing tian Jian-xin LIU Guang-ying ma Qing-cheng ZOU Zhu-jun ZHU College of Agriculture & Biotechnology Zhejiang University Research & Development Center of Flower Zhejiang Academy of Agricultural Sciences School of Agricultural and Food Science Zhejiang A&F University

An 888-bp ful-length ascorbate peroxidase （APX） complementary DNA （cDNA） gene was cloned from Anthurium andraeanum, and designated as AnAPX. It contains a 110-bp 5′-noncoding region, a 28-bp 3′-noncoding region, and a 750-bp open reading frame （ORF）. This protein is hydrophilic with an aliphatic index of 81.64 and its structure consisting ofα-helixes,β-turns, and random coils. The AnAPX protein showed 93%, 87%, 87%, 87%, and 86% similarities to the APX homologs from Zantedeschia aethiopica, Vitis pseudoreticulata, Gossypium hirsutum, Elaeis guineensis, and Zea mays, respectively. AnAPX gene transcript was measured non-significantly in roots, stems, leaves, spathes, and spadices by real-time polymerase chain reaction （RT-PCR） analysis. Interestingly, this gene expression was remarkably up-regulated in response to a cold stress under 6 °C, implying that AnAPX might play an important role in A. andraeanum tolerance to cold stress. To confirm this function we overexpressed AnAPX in tobacco plants by transformation with an AnAPX expression construct driven by CaMV 35S promoter. The transformed tobacco seedlings under 4 °C showed less electrolyte leakage （EL） and malondialdehyde （MDA） content than the control. The content of MDA was correlated with chilling tolerance in these transgenic plants. These results show that AnAPX can prevent the chilling challenged plant from cellmembrane damage and ultimately enhance the plant cold tolerance.

关键词： AnAPX Gene expression Cold stress Anthurium andraeanum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Residue management induced changes in soil organic carbon and total nitrogen under different tillage practices in the North China Plain

引用

Journal of Integrative Agriculture 2019年第6期18卷 1337-1347页

作者： PU Chao KAN Zheng-rong LIU Peng ma Shou-tian QI Jian-ying ZHAO xin ZHANG Hai-lin College of Agronomy and Biotechnology China Agricultural University/Key Laboratory of Farming SystemMinistry of Agriculture

Crop residue retention has been considered a practicable strategy to improve soil organic carbon(SOC)and total nitrogen(TN),but the effectiveness of residue retention might be different under varied tillage *** evaluate the effects of residue management on the distribution and stocks of SOC and TN under different tillage practices,a bifactorial experiment with three levels for tillage practices(no-tillage,rotary tillage,and conventional tillage)and two levels for residue managements(residue retention and residue removal)was conducted in the North China Plain(NCP).Results showed that after a short experimental duration(3–4 years),concentrations of SOC and TN in the 0–10 cm layer were higher under no-tillage than under conventional tillage,no matter whether crop residues were retained or *** retention increased SOC and TN concentrations in the upper layers of soil to some degree for all tillage practices,as compared with residue removal,with the greatest increment of SOC concentration occurred in the 0–10 cm layer under rotary tillage,but in the 10–30 cm layer under conventional *** stocks of SOC in the 0–50 cm depth increased from 49.89 Mg ha–1 with residue removal to 53.03 Mg ha–1 with residue ***,no-tillage did not increase SOC stock to a depth of 50 cm relative to conventional tillage,and increased only by 5.35%as compared with rotary ***,residue retention may contribute more towards SOC sequestration than ***,the combination between residue retention and no-tillage has the greatest advantage in enhancing SOC and TN in the NCP region.

关键词： no-tillage residue retention residue removal stratification ratio SOC stock total nitrogen stock

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Parametric study on controllable growth of SrZrS_(3)thin films with good conductivity for photodetectors

引用

Nano Research 2023年第5期16卷 7867-7873页

作者： Yurun Liang Yuewen Zhang Jie Xu Jingli ma Huifang Jiang xin Li Baolin Zhang Xu Chen Yongtao tian Yanbing Han Zhifeng Shi Key Laboratory of materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityDaxue Road 75Zhengzhou 450052China

SrZrS_(3)is a promising chalcogenide perovskite with unique advantages including high abundance of consisting elements,high chemical stability,strong light absorption above its direct band gap,excellent carrier transport *** unfortunately,due to the lack of breakthroughs in its thin film synthesis technique,its optoelectronic properties are not fully investigated,not to mention the device *** this work,large-area and uniform SrZrS_(3)thin film(5 cm×5 cm)was prepared by facile sputtering method,followed by a post-annealing treatment at a high temperature of 1000℃for 2–12 h under CS_(2)*** SrZrS_(3)samples prepared adopt distorted orthorhombic structure with pnma space group and have high *** addition,the band gap of SrZrS_(3)thin film is measured to be 2.29 eV,higher than that of the powder form(2.06 eV).Importantly,the light absorption coefficient of SrZrS_(3)thin film reaches over 105 cm^(−1),the carrier mobility is as high as 106 cm^(2)/(V∙s).The above advantages allow us to use the SrZrS_(3)thin film as photoactive layer for photodetector ***,a symmetrically structured photoconductive detector was fabricated,performing a high responsivity of 8 A/W(405 nm light excitation).These inspiring results promise the glorious application potential of SrZrS_(3)thin film in photodetectors,solar cells,other optoelectronic devices.

关键词： chalcogenide perovskite thin film SrZrS_(3) sputter photodetector

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-polyphenol oxidase mechanism of oligomeric procyanidins and its application on browning control of“Baiyu”loquat during storage

引用

Food Bioscience 2022年第4期48卷 398-405页

作者： Gui-Li Huang tian-tian Liu Jia-Jia ma Ling-Xiang Sun Si-Yao Sui xin-Yao Quan Yu-Ning Wang Agricultural Product Storage and Processing Laboratory Suzhou Academy of Agricultural SciencesSuzhou215105China Key Laboratory of Carbohydrate Chemistry and Biotechnology Science Center for Future FoodsJiangnan UniversityWuxi214122China Jiangsu Key Laboratory for Biomass Energy and material Institute of Chemical Industry of Forest Products CAFNanjing210042China

The harvested loquat fruits are prone to browning,leading to a decline in fruit *** activity of polyphenol oxidase(PPO)is an important way to prevent *** this study,we evaluated the inhibitory impact of oligomeric procyanidins(OPC)on hydroxylation of monophenol and oxidation of o-diphenol catalyzed by PPO and effect of OPC on loquat fruits *** obtained results revealed that OPC could attenuate the activity of monophenolase and *** monophenolase activity,the inhibition rate was observed to be dose-dependent with an IC50 of 11.6±3.4μg/mL for the steady-state *** diphenolase activity,OPC inhibited PPO activity(IC50=15.75±2.1μg/mL)with a reversible and competitive mechanism and quenched fluorescence of PPO by forming OPC-PPO complex with one binding site in a static *** addition,the data obtained from storage assays revealed that OPC could enhance the quality of harvested loquat fruits by attenuating the PPO activity,augmenting the content of total phenolics and flavonoids,and simultaneously delaying the browning of *** this research,we identified a potent PPO inhibitor and expanded its potential as a food preservative.

关键词： Polyphenol oxidase Oligomeric procyanidins Inhibitory mechanism Fluorescence quenching Storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis

引用

World Journal of Diabetes 2024年第5期15卷 977-987页

作者： Hong-Dong ma Lei Shi Hai-tian Li xin-Dong Wang mao-Wei Yang Department of Orthopedics The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Orthopedics The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Recently,type 2 diabetic osteoporosis(T2DOP)has become a research hotspot for the complications of diabetes,but the specific mechanism of its occurrence and development remains *** caused by iron overload is con-sidered an important cause of *** RNA-binding protein 1(PCBP1),an iron ion chaperone,is considered a protector of *** To investigate the existence of ferroptosis and specific role of PCBP1 in the development of type 2 *** A cell counting kit-8 assay was used to detect changes in osteoblast viability under high glucose(HG)and/or ferroptosis inhibitors at different concentrations and *** electron microscopy was used to examine the morpho-logical changes in the mitochondria of osteoblasts under HG,and western blotting was used to detect the expression levels of PCBP1,ferritin,and the ferroptosis-related protein glutathione peroxidase 4(GPX4).A lentivirus silenced and overex-pressed *** blotting was used to detect the expression levels of the osteoblast functional proteins osteoprotegerin(OPG)and osteocalcin(OCN),whereas flow cytometry was used to detect changes in reactive oxygen species(ROS)levels in each *** Under HG,the viability of osteoblasts was considerably decreased,the number of mitochondria undergoing atrophy was considerably increased,PCBP1 and ferritin expression levels were increased,and GPX4 expression was *** blotting results demonstrated that infection with lentivirus overexpressing PCBP1,increased the expression levels of ferritin,GPX4,OPG,and OCN,compared with the HG *** cytometry results showed a reduction in ROS,and an opposite result was obtained after silencing *** PCBP1 may protect osteoblasts and reduce the harm caused by ferroptosis by promoting ferritin expression under a HG ***,PCBP1 may be a potential therapeutic target for T2DOP.

关键词： Polycytosine RNA-binding protein 1 Ferroptosis Reactive oxygen species Ferritin Osteoblast Type 2 diabetic osteoporosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：