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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue XIAO Yan-wei MA jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and migration.Methods:HaCaT cells were treated with HSYA.Cell proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration assay.The mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,respectively.Circ_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with HSYA.The expression of circ_0084443 was detected by qRT-PCR.Results:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative regulator circ_0084443.

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Coexistence of liver abscess, hepatic cystic echinococcosis and hepatocellular carcinoma: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2404-2411页

作者： Ya-Wen Hu Yi-Lin Zhao jing-xin Yan Cun-Kai Ma Department of Interventional Therapy The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina West China Hospital Sichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND Human cystic echinococcosis(CE)is a life-threatening zoonosis caused by the Echinococcus granulosus(sensu lato).Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality in the world.The coexistence of CE and HCC is exceedingly rare,and only several well-documented cases have been reported.In addition to this coexistence,there is no report of the coexistence of CE,HCC,and liver abscess to date.Herein,we aimed to report a case of coexistence of liver abscess,hepatic CE,and HCC.CASE SUMMARY A 65-year-old herdsman presented to the department of interventional therapy with jaundice,right upper abdominal distension and pain for 10 d.Laboratory test showed that he had positive results for HBsAg,HBeAb,HBcAb,and echino-coccosis IgG antibody.The test also showed an increased level of alpha fetopro-tein of 3400 ng/mL.An abdominal computed tomography(CT)scan revealed an uneven enhanced lesion of the liver at the arterial phase with enhancement and was located S4/8 segment of the liver.In addition,CT scan also revealed a mass in the S6 segment of the liver with a thick calcified wall and according to current guideline and medical images,the diagnoses of hepatic CE(CE4 subtype)and HCC were established.Initially,transarterial chemoembolization was performed for HCC.In the follow-up,liver abscess occurred in addition to CE and HCC;thus,percutaneous liver puncture drainage was performed.In the next follow-up,CE and HCC were stable.The liver abscess was completely resolved,and the patient was discharged with no evidence of recurrence.CONCLUSION This is the first reported case on the coexistence of liver abscess,hepatic CE,and HCC.Individualized treatment and multidisciplinary discussions should be performed in this setting.Therefore,treatment and diagnosis should be based on the characteristics of liver abscess,hepatic CE,and HCC,and in future clinical work,it is necessary to be aware of the possibility of this complex composition of liver diseases.

关键词： Cystic echinococcosis Hepatocellular carcinoma Liver abscess Multidisciplinary discussions Case report

Effect of magnetic resonance imaging in liver metastases

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World Journal of Gastroenterology 2024年第1期30卷 112-114页

作者： xing-Liang Huang Xiao-Dong Wang Zhao-Miao Gong Yan-Feng Zheng jing-xin Mao Department of Science and Education Dianjiang People's Hospital of ChongqingChongqing 408399China Department of Science and Industry Chongqing Medical and Pharmaceutical CollegeChongqing 400030China

This letter to the editor is a commentary on a study titled"Liver metastases:The role of magnetic resonance imaging."Exploring a noninvasive imaging evaluation system for the biological behavior of hepatocellular carcinoma(HCC)is the key to achieving precise diagnosis and treatment and improving prognosis.This review summarizes the role of magnetic resonance imaging in the detection and evaluation of liver metastases,describes its main imaging features,and focuses on the added value of the latest imaging tools(such as T1 weighted in phase imaging,T1 weighted out of phase imaging;diffusion-weighted imaging,T2 weighted imaging).In this study,I investigated the necessity and benefits of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid for HCC diagnostic testing and prognostic evaluation.

关键词： Liver metastases Magnetic resonance imaging Liver-specific contrast agents Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Hepatocellular carcinoma Hepatobiliary contrast agents

Dangling Ligand Enables an Iron Hexa-Coordinated Molecular Catalyst for Water Oxidation by Photocatalysis

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CCS Chemistry 2024年第3期6卷 623-630页

作者： Bing Yang Qi Liu Xiang-Zhu Wei Tao Lei Qing-Qing Yang Xu-Zhe Wang jing-xin Jian xin Jiang Chen-Ho Tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials New Cornerstone Science LaboratoryTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal catalysts.In this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic condition.Herein,we describe a unique hexa-coordinated catalyst 1[Fe^(II)(Py_(3)tacn)Cl_(2)]and its reference 2[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,respectively.We anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst 1.To our delight,the“open form”of catalyst 1 provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and robustness.The turnover number and turnover frequency values of 2332 and 60 s^(−1)are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.

关键词： water oxidation photocatalysis homogeneous catalysis iron complexes dangling ligand intermediates characterization

Insights into ionic association boosting water oxidation activity and dynamic stability

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Journal of Energy Chemistry 2024年第2期89卷 99-109,I0004页

作者： Zanling Huang Shuqi Zhu Yuan Duan Chaoran Pi Xuming Zhang Abebe Reda Woldu jing-xin Jian Paul K.Chu Qing-Xiao Tong Liangsheng Hu Xiangdong Yao Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063GuangdongChina Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063GuangdongChina State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina School of Advanced Energy Sun Yat-sen University(Shenzhen)Shenzhen 518107GuangdongChina

There have been reports about Fe ions boosting oxygen evolution reaction(OER)activity of Ni-based catalysts in alkaline conditions,while the origin and reason for the enhancement remains elusive.Herein,we attempt to identify the activity improvement and discover that Ni sites act as a host to attract Fe(Ⅲ)to form Fe(Ni)(Ⅲ)binary centres,which serve as the dynamic sites to promote OER activity and stability by cyclical formation of intermediates(Fe(Ⅲ)→Fe(Ni)(Ⅲ)→Fe(Ni)-OH→Fe(Ni)-O→Fe(Ni)OOH→Fe(Ⅲ))at the electrode/electrolyte interface to emit O_(2).Additionally,some ions(Co(Ⅱ),Ni(Ⅱ),and Cr(Ⅲ))can also be the active sites to catalyze the OER process on a variety of electrodes.The Fe(Ⅲ)-catalyzed overall water-splitting electrolyzer comprising bare Ni foam as the anode and Pt/Ni-Mo as the cathode demonstrates robust stability for 1600 h at 1000 mA cm^(-2)@~1.75 V.The results provide insights into the ioncatalyzed effects boosting OER performance.

关键词： Oxygen evolution reaction Fe(Ⅲ)-catalysis Ni-Fe binary active centers Ion-catalyzed effects Robust stability

Soil salinization increases the stability of fungal not bacterial communities in the Taklamakan desert

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Soil Ecology Letters 2023年第4期5卷 111-123页

作者： Litao Lin Zhiyong Ruan xin jing Yugang Wang Wenting Feng State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China the Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Grassland Agro-Ecosystems and College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730000China State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Fukang Station of Desert Ecology Chinese Academy of SciencesFukang 831505China University of Chinese Academy of Sciences Beijing 100049China

●Bacterial richness declined but fungal richness increased under salinization.●Bacteria did not become interactively compact or facilitative under salinization.●Fungi exhibited more compartmentalized and competitive patterns under salinization.●Fungal stability showed steeper increases under salinization than bacterial stability.Soil salinization is a typical environmental challenge in arid regions worldwide.Salinity stress increases plant convergent adaptations and facilitative interactions and thus destabilizes communities.Soil bacteria and fungi have smaller body mass than plants and are often efficient against soil salinization,but how the stability of bacterial and fungal communities change with a wide range of soil salinity gradient remains unclear.Here,we assessed the interactions within both bacterial and fungal communities along a soil salinity gradient in the Taklamakan desert to examine(i)whether the stability of bacterial and fungal communities decreased with soil salinity,and(ii)the stability of which community decreased more with soil salinity,bacteria or fungi.Our results showed that the species richness of soil fungi increased but that of soil bacteria decreased with increasing salinity in topsoils.Fungal communities became more stable under soil salinization,with increasing compartmentalization(i.e.,modularity)and proportion of competitions(i.e.,negative:positive cohesion)as salinity increased.Bacterial communities exhibited no changes in modularity with increasing salinity and smaller increases in negative:positive cohesion under soil salinization compared to fungal communities.Our results suggest that,by altering interspecific interactions,soil salinization increases the stability of fungal not bacterial communities in extreme environments.

关键词： community stability soil salinization diversity fungi modularity desert ecosystem

基于视觉传达技术的舰船航行图像去雾增强方法

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舰船科学技术 2024年第7期46卷 163-166页

作者：井新新郑州科技学院河南郑州450064

大雾天气对舰船在海上航行的安全造成极大干扰,同时也对雾天舰船的作战能力产生影响。大雾天气下获取的图像会存在舰船特征信息丢失、对比度失真等情况,本文提出基于视觉传达技术的舰船航行图像去雾增强方法,研究雾天的图像衰减模型,在... 详细信息

大雾天气对舰船在海上航行的安全造成极大干扰,同时也对雾天舰船的作战能力产生影响。大雾天气下获取的图像会存在舰船特征信息丢失、对比度失真等情况,本文提出基于视觉传达技术的舰船航行图像去雾增强方法,研究雾天的图像衰减模型,在此基础上研究直方图均衡法和多源目标融合图像去雾算法,并对比不同算法的图像去雾效果。提出基于视觉传达的船舶特征提取方法,实现视觉传达的雾天舰船航行图像监控系统,通过对图像的去雾及增强,改善了雾天下图像的视觉效果,提升了舰船航行的安全性。

关键词：视觉传达技术图像去雾舰船图像融合特征提取

投资者关注、ESG信息披露与企业绿色技术创新

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经济问题 2024年第6期 115-122页

作者：韩玲景昕山西财经大学会计学院山西太原030006

绿色技术创新是实施国家创新战略的核心动力、实现“双碳”目标的重要支撑。利用网络爬虫技术,爬取深交所“互动易”平台2011—2021年管理层与投资者问答记录数据,探究投资者关注对企业绿色技术创新的影响及作用机理。研究发现,投资者... 详细信息

绿色技术创新是实施国家创新战略的核心动力、实现“双碳”目标的重要支撑。利用网络爬虫技术,爬取深交所“互动易”平台2011—2021年管理层与投资者问答记录数据,探究投资者关注对企业绿色技术创新的影响及作用机理。研究发现,投资者关注明显促进了企业绿色技术创新,且能够通过提升企业ESG信息披露水平进而推动企业绿色技术创新。进一步研究发现,在市场化程度高、行业竞争程度高、低碳试点城市的企业,投资者关注对绿色技术创新的激励作用更明显,更易推动企业进行绿色发明创新。同时,政府补助对投资者关注与企业绿色技术创新的关系有正向调节作用。研究结论可以为推动我国企业绿色技术创新、绿色低碳转型以及改善企业环境绩效提供理论支持和政策建议。

关键词：投资者关注 ESG信息披露绿色技术创新

季节性生态旅游地的旅游化过程与机制及其启示——基于新疆赛里木湖案例

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自然资源学报 2024年第7期39卷 1626-1642页

作者：梁增贤李新静中山大学旅游学院珠海519082 新疆历史文化旅游可持续发展重点实验室乌鲁木齐830046

如何平衡保护与开发、淡季与旺季问题是促进生态旅游地高质量发展的关键,而旅游化是生态地区常用的平衡途径。然而,现有旅游化研究缺乏有效的分析工具和解释机制,难以厘清旅游地历时态的阶段性特征、因果机制及其时空影响。拓展旅游化... 详细信息

如何平衡保护与开发、淡季与旺季问题是促进生态旅游地高质量发展的关键,而旅游化是生态地区常用的平衡途径。然而,现有旅游化研究缺乏有效的分析工具和解释机制,难以厘清旅游地历时态的阶段性特征、因果机制及其时空影响。拓展旅游化理论的应用情境,构建包含时空维度的旅游化模型,并开展案例研究,采用观察法、访谈法和收集二手数据等方式获得多源数据,解释与厘清新疆赛里木湖景区由生态牧场到成熟生态旅游地20多年的旅游化过程及其内在机制。研究表明:赛里木湖的旅游化经历政府主导的内部空间旅游化、政府主导的外部空间旅游化、企业主导的深度时空旅游化、政企主导的淡季时间旅游化四个阶段,总体上呈现先内部旅游化、再外部旅游化及先旺季和白天的旅游化、再夜间和淡季旅游化等特征。赛里木湖旅游化的各阶段互有交叉,解决的关键问题和旅游化的驱动力均不同。其中,内部旅游化是构建吸引力的重点,外部旅游化是发挥吸引力的关键,二者应相互协调。本文提出的旅游化模型为理解旅游化的演进规律和各阶段的因果关系及其影响提供了分析工具,为生态旅游地平衡保护与开发、破解淡旺季供需矛盾、促进高质量发展提供路径指引和案例借鉴。

关键词：生态旅游旅游化季节性旅游目的地赛里木湖

多尺度人口空间大数据聚合模型在地图可视化中的研究与应用

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测绘通报 2024年第3期 145-150页

作者：李亚云忻静丛婧上海市测绘院上海200063 自然资源部超大城市自然资源时空大数据分析应用重点实验室上海200063

为解决海量人口和建筑物数据导致的地图渲染时间长、页面卡顿无响应等技术问题,本文提出了一种多尺度人口空间大数据聚合模型,通过研究海量数据逐级嵌套的树型逻辑架构和可视域内的空间关系,实现了超大城市多尺度行政区域的人口空间数... 详细信息

为解决海量人口和建筑物数据导致的地图渲染时间长、页面卡顿无响应等技术问题,本文提出了一种多尺度人口空间大数据聚合模型,通过研究海量数据逐级嵌套的树型逻辑架构和可视域内的空间关系,实现了超大城市多尺度行政区域的人口空间数据统计分析与可视化,并在多源异构属性融合方面得到了较好的应用,更好地满足了超大城市精细化管理需求。

关键词：人口普查海量数据地理信息系统多尺度空间