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Detection and characteristics analysis of the western subarctic front using the high-resolution SST product

Acta Oceanologica Sinica 2023年第6期42卷 24-32页

作者： Changyuan chen chen Wang Huimin Li Denghui Hu Gang Li xin chen Yijun He School of Marine Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China

Oceanic front plays a significant role in the ocean vertical mixing and the regulation of air-sea interaction,among others.The western branch of the subarctic front(WSAF)located in the Northwest Pacific has attained lots of attention given its strong intensity and widespread influence on this region.In this study,we take advantage of the merged sea surface temperature(SST)at a high spatial resolution of 0.05°to investigate the characteristics of WSAF.The front detection algorithm that combines the Sobel operator and histogram analysis is adopted.It is advantageous in both preserving the front intensity represented by the SST gradient as well as reducing the detection noise level.We systematically applied this algorithm to the daily SST products for front detection,based on which the WSAF characteristics including its intensity,occurrence of frequency,latitudinal position and coverage area are then extracted.WSAF is mostly located within a small latitude range between 40°N and 41°N with a clear seasonal trend in its intensity that peaks in the winter and troughs in the summer.The seasonal variation of WSAF intensity is almost consistent throughout the temporal period of interest from 2010 to 2018.Similar seasonality is observed for its occurrence of frequency with the winter-summer contrast reaching up to5%.The findings presented here shall help better interpret the WSAF characteristics in the long-term run as well as their impact on the regional weather and climate patterns at high spatial resolution.

关键词： sea surface temperature western subarctic front front detection characteristics analysis

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Risk factors and outcomes of postoperative stroke in surgical treatment for giant intracranial aneurysms

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Chinese Neurosurgical Journal 2023年第2期9卷 105-113页

作者： Hao Wang Junlin Lu xin chen Qiang Hao Department of Neurosurgery Fengtai DistrictBeijing Tiantan HospitalCapital Medical UniversityNo.119 South Fourth Ring Rd WestBeijing 100070China Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina

Background:Giant intracranial aneurysms(GIAs)are challenges for surgical treatment.Risk factors of postoperative stroke remain unclear.This study aims to investigate the predictors of postoperative stroke in GIAs and the impact of stroke on outcomes.Methods:We performed a retrospective medical record review of patients with GIAs who received microsurgery at our institution between 2011 and 2018.Multivariate logistic regression analyses were carried out to identify risk factors for postoperative stroke.The clinical and angiographic outcomes were compared between patients with and without stroke.Results:A total of 97 patients were included in this study.Surgical modalities included direct aneurysm neck clipping in 85 patients(87.7%),trapping with the bypass in 8(8.2%),proximal artery ligation in 1(1%),and bypass alone in 3(3.1%).Postoperative stroke was found in 26 patients(26.8%).Independent factors that affect postoperative stroke were recurrent aneurysm(OR,10.982;95%CI,1.976-61.045;P=0.006)and size≥3.5 cm(OR,3.420;95%CI,1.133-10.327;P=0.029).Combined perioperative mortality and morbidity was 26.8%.Follow-up was achieved from 89 patients(91.8%),with a mean follow-up period of 39 months(range 19 to 94 months).Good outcomes were observed in 75 patients(84.3%)and poor outcomes were observed in 14 patients(15.7%).Conclusions:Postoperative stroke was significantly associated with clinical outcome.Favorable outcomes can be achieved in most patients with GIAs after appropriate microsurgical modality.Recurrent aneurysm and size≥3.5 cm are risk factors of postoperative stroke.

关键词： Giant intracranial aneurysms Microsurgery Outcome Stroke Complication

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Systematic bio‑fabrication of aptamers and their applications in engineering biology

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Systems Microbiology and Biomanufacturing 2023年第2期3卷 223-245页

作者： Rongfeng Cai xin chen Yuting Zhang Xiaoli Wang Nandi Zhou The Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Aptamers are single-stranded DNA or RNA molecules that have high affinity and selectivity to bind to specific targets.Compared to antibodies,aptamers are easy to in vitro synthesize with low cost,and exhibit excellent thermal stability and programmability.With these features,aptamers have been widely used in biology and medicine-related fields.In the meantime,a variety of systematic evolution of ligands by exponential enrichment(SELEX)technologies have been developed to screen aptamers for various targets.According to the characteristics of targets,customizing appropriate SELEX technology and post-SELEX optimization helps to obtain ideal aptamers with high affinity and specificity.In this review,we first summarize the latest research on the systematic bio-fabrication of aptamers,including various SELEX technologies,post-SELEX optimization,and aptamer modification technology.These procedures not only help to gain the aptamer sequences but also provide insights into the relationship between structure and function of the aptamers.The latter provides a new perspective for the systems bio-fabrication of aptamers.Furthermore,on this basis,we review the applications of aptamers,particularly in the fields of engineering biology,including industrial biotechnology,medical and health engineering,and environmental and food safety monitoring.And the encountered challenges and prospects are discussed,providing an outlook for the future development of aptamers.

关键词： Aptamer SELEX Engineering biology Biosensors

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平均降采样多周期微分均值的旋转部件故障特征增强方法

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振动工程学报 2024年第2期37卷 346-355页

作者：陈鑫郭瑜昆明理工大学机电工程学院云南昆明650500

为解决编码器的瞬时角速度(Instantaneous Angular Speed,IAS)信号中旋转部件故障特征微弱的难题,本文提出一种平均降采样多周期微分均值(Average Down⁃Sampling Multi⁃period Differential Means,ADSMPDM)的故障特征增强方法。基于IAS信号的估计特性,开展了IAS信号的平均降采样研究,验证了平均降采样具有抑制随机噪声的特性;基于平均降采样抑制随机噪声特性、降低计算成本和减小存储空间的优势,结合多周期微分均值的累积特性,提出一种ADSMPDM算法对原始IAS信号中的旋转部件故障分量进行增强处理;通过阶次谱分析揭示故障特征。采用仿真数据和实验数据进行验证分析,并与快速谱峭度、可调整多点优化最小熵反卷积、离散随机分离和谱幅值调制算法进行对比,验证了ADSMPDM算法增强旋转部件故障特征的有效性和优势。

关键词：故障诊断平均降采样多周期微分均值编码器信号瞬时角速度特征提取

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Grating‐like anechoic layer for broadband underwater sound absorption

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International Journal of Mechanical System Dynamics 2022年第3期2卷 265-277页

作者： chenlei Yu Mingyu Duan Wei He xin chen Fengxian xin Tian J.Lu State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong UniversityXi'anChina MOE Key Laboratory for Multifunctional Materials and Structures School of Aerospace EngineeringXi'an Jiaotong UniversityXi'anChina Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijingChina Xi'an Modern Chemistry Research Institute Xi'anChina State Key Laboratory for Mechanics and Control of Mechanical Structures College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina

To address the challenging task of effective sound absorption in the low and broad frequency band for underwater structures,we propose a novel grating‐like anechoic layer by filling rubber blocks and an air backing layer into metallic grating.The metallic gratings are incorporated into the anechoic layer as a skeleton for enhanced viscoelastic dissipation by promoting shear deformation between rubber and metal plates.The introduction of an air backing layer releases the bottom constraint of the rubber,thus intensifying its deformation under acoustic excitation.Based on the homogenization method and the transfer matrix method,a theoretical model is developed to evaluate the sound absorption performance of the proposed anechoic layer,which is validated against finite element simulation results.It is demonstrated that a sound absorption coefficient of the grating‐like anechoic layer of 0.8 can be achieved in the frequency range of 1294-10000 Hz.Given the importance of sound absorption at varying frequencies,the weighted average method is subsequently used to comprehensively evaluate the performance of the anechoic layer.Then,with structural density taken into consideration,an integrated index is proposed to further evaluate the acoustic properties of the proposed anechoic layer.Finally,the backing conditions and the boundary conditions of finite‐size structures are discussed.The results provide helpful theoretical guidance for designing novel acoustic metamaterials with broadband low‐frequency underwater sound absorption.

关键词： underwater sound absorption broadband transfer matrix method rubber coating

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Surface modification of metal-organic frameworks under sublimated iron-atmosphere by controlled carbonization for boosted oxygen evolution reaction

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Nano Research 2022年第7期15卷 5884-5894页

作者： Katam Srinivas xin chen Dawei Liu Fei Ma Xiaojuan Zhang Wanli Zhang Hua Lin Yuanfu chen School of Electronic Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Materials and Energy Southwest UniversityChongqing 400715China College of Science and Institute of Oxygen SupplyTibet UniversityLhasa 850000China

Development of cost-effective,efficient,and durable electrocatalysts for oxygen evolution reaction(OER)with fast kinetic reaction is highly significant,considering the elevated thermodynamic energy barrier involved in water electrolysis.To overcome such challenges,an innovative vapor phased iron-doping strategy is employed on carbon nanotubes(CNT)-interlinked metalorganic framework(MOF)nanosheets(Ni-MOF@CNT)to obtain mixed metal oxide and metal heteronanoparticles superficially implanted partially(semi)-decomposed MOF nanosheets(Ni-M@C-400).These semi-MOF nanosheets attain the structural privileges related to MOF-nanostructure,mixed metal nanoparticles synergism,interconnected-CNT assisted high conductivity,and mechanical strength.As a result,Ni-M@C-400 exhibits exceptional OER activity with overpotential as low as 229 mV to reach the benchmark current density of 10 mA/cm^(2)(η10)and exhibits greatly reduced thermodynamic barrier(Tafel slopes of 40.51 mV/dec)along with significant durability for~60 h.More importantly,this sublimated iron-doped semi-MOF(Ni-M@C-400)displays significantly better OER performance over the corresponding annealed bimetallic MOF(NiFe-M@C-400:270 mV atη10).Moreover,the successful incorporation of vapor phased iron into variety of MOFs(Cr,Mn,Co,Ni,and Cu)approved its uniqueness and the universality.This work provides an innovative vapor phased heteroatom-doping strategy to develop costeffective and efficient electrocatalysts for water electrolysis.

关键词： metal-organic frameworks(MOFs) semi-MOFs controlled carbonization heteronanoparticles oxygen evolution reaction

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Research Progress in Function and Regulation of E3 Ubiquitin Ligase SMURF1

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Current Medical Science 2023年第5期43卷 855-868页

作者： Ji-xi WAN Yu-qi WANG Si-na LAN Liu chen Ming-qian FENG xin chen College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China College of Biomedicine and Health Huazhong Agricultural UniversityWuhan 430070China

Smad ubiquitylation regulatory factor 1(Smurf1)is an important homologous member of E6-AP C-terminus type E3 ubiquitin ligase.Initially,Smurf1 was reportedly involved in the negative regulation of the bone morphogenesis protein(BMP)pathway.After further research,several studies have confirmed that Smurf1 is widely involved in various biological processes,such as bone homeostasis regulation,cell migration,apoptosis,and planar cell polarity.At the same time,recent studies have provided a deeper understanding of the regulatory mechanisms of Smurf1’s expression,activity,and substrate selectivity.In our review,a brief summary of recent important biological functions and regulatory mechanisms of E3 ubiquitin ligase Smurf1 is proposed.

关键词： Smad ubiquitination regulator 1 bone morphogenesis protein signaling E3 ubiquitin ligase cancer bone homeostasis nerve cell development

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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-xin chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei chen Xiao-Dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer development.Circular RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still lacking.Processing bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and RNA.Previous evidence suggests a connection between PBs dynamics and cancer progression.Despite the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in CRC.Herein,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient survival.Elevated MEX3A accelerates malignance and inhibits autophagy of CRC cells.Importantly,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the cytoplasm.Specifically,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs proteins.The MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC cells.Clinically,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall survival.Our findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

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Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu Pan-Pan Zhou Xue-Zhang Xiao Jia-cheng Qi Jia-Peng Bi Tiao Ying xing-Wen Feng Yan Shi Wen-Hua Luo Li-xin chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable way.In this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation melting.Fundamental performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 MPa.Interestingly,unique phase transition behaviors were presented in Zr_(2)Co-H system.Specifically,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and hydrogen.Among the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free energy.Furthermore,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism

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A novel responsive stabilizing Janus nanosilica as a nanoplugging agent in water-based drilling fluids for exploiting hostile shale environments

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Petroleum Science 2024年第2期21卷 1190-1210页

作者： Alain Pierre Tchameni Lv-Yan Zhuo Lesly Dasilva Wandji Djouonkep Robert Dery Nagre Lu-xin chen Lin Zhao Chao Ma Bin-Qiang Xie College of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Key Laboratory of Drilling and Production Engineering for Oil and Gas HubeiChina Lost Circulation Control Laboratory National Engineering Laboratory for Petroleum Drilling EngineeringYangtze UniversityWuhan430100HubeiChina College of Petroleum Engineering Shandong Institute of Petroleum and Chemical TechnologyDongying257061ShandongChina Petroleum Engineer Research Institute of Petrochina Dagang Oilfield Tianjin300280China Department of Chemical Engineering Kumasi Technical UniversityP.O.Box 854KumasiGhana

Thermo-responsive nanocomposites have recently emerged as potential nanoplugging agents for shale stabilization in high-temperature water-based drilling fluids(WBDFs). However, their inhibitory properties have not been very effective in high-temperature drilling operations. Thermo-responsive Janus nanocomposites are expected to strongly interact with clay particles from the inward hemisphere of nanomaterials, which drive the establishment of a tighter hydrophobic membrane over the shale surface at the outward hemisphere under geothermal conditions for shale stabilization. This work combines the synergistic benefits of thermo-responsive and zwitterionic nanomaterials to synchronously enhance the chemical inhibitions and plugging performances in shale under harsh conditions. A novel thermoresponsive Janus nanosilica(TRJS) exhibiting zwitterionic character was synthesized, characterized,and assessed as shale stabilizer for WBDFs at high temperatures. Compared to pristine nanosilica(Si NP)and symmetrical thermo-responsive nanosilica(TRS), TRJS exhibited anti-polyelectrolyte behaviour, in which electrolyte ions screened the electrostatic attraction between the charged particles, potentially stabilizing nanomaterial in hostile shaly environments(i.e., up to saturated brine or API brine). Macroscopically, TRJS exhibited higher chemical inhibition than Si NP and TRS in brine, prompting a better capability to control pressure penetration. TRJS adsorbed onto the clay surface via chemisorption and hydrogen bonding, and the interactions became substantial in brine, according to the results of electrophoretic mobility, surface wettability, and X-ray diffraction. Thus, contributing to the firm trapping of TRJS into the nanopore structure of the shale, triggering the formation of a tight hydrophobic membrane over the shale surface from the outward hemisphere. The addition of TRJS into WBDF had no deleterious effect on fluid properties after hot-treatment at 190℃, implying that TRJS could find potential use as a shale stabilizer

关键词： Janus nanosilica Thermo-responsive copolymer Anti-polyelectrolyte effect Shale stabilizer Inhibition Plugging Drilling fluid

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