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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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DETERMINATION　OF　STATES　OF　STRESS　AND　STRAIN　AT　POLE　OF　HYDRAULIC　BULGE　ORTHOTROPIC　SHEET　SAMPLE

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中国有色金属学会会刊：英文版 1995年第3期5卷 84-87页

作者： zhou, Weixian zhou, xin Northwestern Polytechnical Univ Xi'an China

ＤＥＴＥＲＭＩＮＡＴＩＯＮＯＦＳＴＡＴＥＳＯＦＳＴＲＥＳＳＡＮＤＳＴＲＡＩＮＡＴＰＯＬＥＯＦＨＹＤＲＡＵＬＩＣＢＵＬＧＥＯＲＴＨＯＴＲＯＰＩＣＳＨＥＥＴＳＡＭＰＬＥ￥Ｚｈｏｕ，Ｗｅｉｘｉａｎ；Ｚｈｏｕ，Ｘｉｎ（Ｄｅｐ... 详细信息

ＤＥＴＥＲＭＩＮＡＴＩＯＮＯＦＳＴＡＴＥＳＯＦＳＴＲＥＳＳＡＮＤＳＴＲＡＩＮＡＴＰＯＬＥＯＦＨＹＤＲＡＵＬＩＣＢＵＬＧＥＯＲＴＨＯＴＲＯＰＩＣＳＨＥＥＴＳＡＭＰＬＥ￥Ｚｈｏｕ，Ｗｅｉｘｉａｎ；Ｚｈｏｕ，Ｘｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＡｅｒｏｎａｕｔ...

关键词： orthotropic sheet hydraulic bulge specimen pole stress state strain state

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Priority access for QoS support in distributed wireless networks

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Journal of Systems Engineering and Electronics 2019年第6期30卷 1202-1211页

作者： zhou xin ZHENG Changwen Institute of Software Chinese Academy of Sciences

Guaranteed quality of service(QoS) support has been an open issue of distributed wireless networks for years. The IEEE802.11 e provides a valuable method for this purpose. However, it could only provide service differentiation, rather than service guarantee, for multi-priority traffic. Many studies have tried to improve its QoS ability, but still leave some problems. This paper investigates these problems and proposes a scheme called the priority access based on busy tone(PABT) to improve the Qo S performance. To guarantee the priority channel access, this scheme uses an in-band busy tone to limit the transmission of lower-priority traffic when higher-priority traffic has packets to send. Based on that, it also optimizes the contention window tuning according to the flows number of each traffic type individually, in order to improve the throughput as well as the traffic capacity. Simulation results show that the proposed scheme significantly improves the real-time traffic capacity, throughput, delay, fairness and packet loss rate.

关键词： 802.11e quality of service(QoS) busy tone priority access traffic capacity contention window

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Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-xin zhou Xian Kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

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ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke: Highlights of the Phase 3 Clinical Trial on Nerinetide

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Neuroscience Bulletin 2021年第4期37卷 579-581页

作者： xin-Fu zhou Health and Biomedical Innovation Clinical and Health SciencesUniversity of South AustraliaAdelaideAustralia

Stroke is a leading disease for morbidity and the second leading cause of mortality following ischemic heart disease. The health burden for stroke ranks the fourth of all diseases as measured in disability-adjusted life years[1]. Worldwide annual new stroke incidence is approximately 16 million with the increasing trend of an epidemic due to the aging population [2].

关键词： protective mortality diseases

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First-principles investigation of β-Ge3N4 loaded with RuO2 cocatalyst for photocatalytic overall water splitting

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Journal of Energy Chemistry 2020年第5期29卷 24-32页

作者： Yanxia Ma Miaomiao Wang xin zhou College of Environment and Chemical Engineering Dalian UniversityDalian 116622LiaoningChina

β-Ge3N4 loaded with nanoparticulate RuO2 as a cocatalyst is the first successful non-oxide photocatalyst for overall water *** get an insight into the working mechanism of this particular photocatalytic system,we have calculated geometrical structures of low-index surfaces forβ-*** of surface energies indicates that the most preferentially exposed surface is(100).The band gap of surface is narrower than that of bulk due to the dangling *** water adsorption on(100)surface is thermodynamically *** adsorption behavior of(RuO2)n(n=2,3,and 4)clusters on theβ-Ge3N4(100)surface has been *** is found that all the clusters bind to(100)surface strongly by forming interfacial bonds so that the adsorptions are exothermic *** calculation on density of states forβ-Ge3N4(100)surface loaded with(RuO2)nclusters reveals that photo-induced electrons tend to accumulate on(RuO2)nclusters and holes tend to stay inβ-*** on the theoretical indication of Type-II staggered band alignment,we have proposed that in photocatalytic water splitting reaction,oxygen evolution reaction is inclined to occur on the surface ofβ-Ge3N4 while hydrogen evolution reaction is apt to occur on(RuO2)*** a word,loading RuO2 nanoparticles as a reduction cocatalyst benefits the charge separation inβ-***,attaching(RuO2)nclusters ontoβ-Ge3N4(100)surface results in the redshift of absorption edge and the increase of absorption *** calculations have reasonably explained the experimental observation on the decomposition of water into H2 and O2 after loading RuO2 cocatalyst inβ-Ge3N4 photocatalyst.

关键词： β-Ge3N4 RuO2 Cocatalyst Photocatalytic water splitting Density functional theory

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Advances, Problems and Prospects of Modern Geodesy Applied in Tibetan Geodynamic Changes

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Acta Geologica Sinica(English Edition) 2013年第2期87卷 318-332页

作者： SUN Wenke zhou xin Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences University of Chinese Academy of Sciences

Modern geodetic techniques have developed rapidly in recent years, providing reliable observation data and new effective approaches, and greatly enhancing studies of the Tibetan geodynamics. For instance, the well-known GPS technique has been employed to measure seismic slips for many faults in the Tibetan Plateau. GPS data agree well with the hypothesis of a thickening crust and eastward mass flow. Moreover, absolute gravimetric data have been applied to interpret geophysical phenomena such as crust movement, co-seismic gravity change, GIA, and ground water change. The satellite gravity mission GRACE launched in 2002 provided global gravity models with unprecedentedly high precision and high spatial resolution. It has been used in implementing temporal gravity changes and improving our knowledge of the Earth＇s interior, including lithosphere dynamics, mantle viscosity and rheology, plateau uplift, and subduction processing. It is noteworthy that gravity presents unique advantages for the study of Tibetan geodynamics because of its sensitivity to mass migration and dynamic redistribution. To date, great advances have been made in applying modern geodetic data in studying dynamic changes of Tibetan plateau. For instance, the horizontal displacement field from GPS data revealed dynamical characteristics of the present-day Tibetan plateau. The combination of gravity anomalies and topographic data describe the tectonic characteristics of Tibetan plateau. The combination of gravity data and GPS data show present properties of the Tibetan plateau such as crust thickening, Moho＇s subsidence, and plateau uplift. GRACE data were used to estimate the distribution of ice/snow melting. These results demonstrate that mere application of integrated geodetic data as well as geophysical methods and numerical simulations can enhance our knowledge of Tibetan plateau dynamics. It must be pointed out that GRACE data include various geophysical signals such as crust vertical movement, d

关键词： modern geodesy gravity GPS gravity satellite geodynamics Tibetan plateau

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Fault diagnosis based on measurement reconstruction of HPT exit pressure for turbofan engine

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Chinese Journal of Aeronautics 2019年第5期32卷 1156-1170页

作者： xin zhou Feng LU Jinquan HUANG College of Energy and Power Engineering Jiangsu Province Key Laboratory of Aerospace Power System Nanjing University of Aeronautics and Astronautics

Aero-engine gas path health monitoring plays a critical role in Engine Health Management(EHM). To achieve unbiased estimation, traditional filtering methods have strict requirements on measurement parameters which sometimes cannot be measured in engineering. The most typical one is the High-Pressure Turbine(HPT) exit pressure, which is vital to distinguishing failure modes between different turbines. For the case of an abrupt failure occurring in a single turbine component, a model-based sensor measurement reconstruction method is proposed in this paper. First,to estimate the missing measurements, the forward algorithm and the backward algorithm are developed based on corresponding component models according to the failure hypotheses. Then,a new fault diagnosis logic is designed and the traditional nonlinear filter is improved by adding the measurement estimation module and the health parameter correction module, which uses the reconstructed measurement to complete the health parameters estimation. Simulation results show that the proposed method can well restore the desired measurement and the estimated measurement can be used in the turbofan engine gas path diagnosis. Compared with the diagnosis under the condition of missing sensors, this method can distinguish between different failure modes, quantify the variations of health parameters, and achieve good performance at multiple operating points in the flight envelope.

关键词： Component-level model Condition monitoring Fault diagnosis Measurement reconstruction Turbofan engines Unscented Kalman filter

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Find slow dynamic modes via analyzing molecular dynamics simulation trajectories

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Chinese Physics B 2020年第10期29卷 33-39页

作者： Chuanbiao Zhang xin zhou College of Physics and Electronic Engineering Heze UniversityHeze 274015China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

It is a central issue to find the slow dynamic modes of biological macromolecules via analyzing the large-scale data of molecular dynamics simulation (MD). While the MD data are high-dimensional time-successive series involving all-atomic details and sub-picosecond time resolution, a few collective variables which characterizing the motions in longer than nanoseconds are needed to be chosen for an intuitive understanding of the dynamics of the system. The trajectory map (TM) was presented in our previous works to provide an efficient method to find the low-dimensional slow dynamic collective-motion modes from high-dimensional time series. In this paper, we present a more straight understanding about the principle of TM via the slow-mode linear space of the conformational probability distribution functions of MD trajectories and more clearly discuss the relation between the TM and the current other similar methods in finding slow modes.

关键词： molecular dynamics simulation slow modes trajectory map

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Full-feedback contention window adaption for IEEE 802.11 WLANs

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Journal of Systems Engineering and Electronics 2016年第1期27卷 90-98页

作者： xin zhou Changwen Zheng Mingxue Liao Institute of Software Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

Backoff mechanism is a key component of contention-based medium access control（MAC） layer *** has been shown that the backoff mechanism of IEEE 802.11 standard may be very inefficient especially when the network is *** of methods have been proposed to tune the contention window（CW） with the aim to achieve the optimal throughput in IEEE 802.11 ***,the mechanisms do not specifically address proper settings for the variable packet length influence and CW diverging *** paper proposes a novel four-way handshaking full-feedback backoff algorithm named adoptive contention window backoff（ACWB） to overcome these *** performance of the proposed algorithm is investigated through analysis and *** results demonstrate that the ACWB algorithm provides a remarkable performance improvement in terms of short-term fairness,packet delay and delay jitter,while maintaining an optimal throughput close to the theoretical throughput limit of the IEEE 802.11 distributed coordination function（DCF） access scheme.

关键词： 802.11 contention window backoff model feedback

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