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Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： yu-xin zhu Zi-Ling Tang Lu Lu Zuo-Cheng Qiu Dabo Pan Yang yu Hui-Hui Xiao Man-Sau Wong State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

A PARTIALLY-AVERAGED NAVIER-STOKES MODEL FOR HILL AND CURVED DUCT FLOW

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Journal of Hydrodynamics 2011年第4期23卷 466-475页

作者： MA Jia-mei WANG Fu-jun yu xin LIU zhu-qing College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

Turbulent flows past hill and curved ducts exist in many engineering applications. Simulations of the turbulent flow arc carried out based on a newly developed technique, the Partially-Averaged Navier-Stokes （PANS） model, including separation, recirculation, reattachment, turbulent vortex mechanism. The focus is on how to accurately predict typical separating, reattaching and secondary motion at a reasonable computational expense. The effect of the parameter, the unresolved-to-total ratio of kinetic energy （ fk ）, is examined with a given unresolved-to-total ratio of dissipation （ fE ） for the hill flow with a much coarser grid system than required by the LES. An optimal value of fk can be obtained to predict the separation and reattachment locations and for more accurate simulation of the resolved turbulence. In addition, the turbulent secondary motions are captured by a smaller fi as compared with the RANS method with the same grid.

关键词： Partially-Averaged Navier-Stokes (PANS) flow separation recirculation reattachment resolved turbulence

THREE-DIMENSIONAL NUMERICAL MODELLING OF SUBMERGED DIKE ALIGNMENT IN CURVED ESTUARINE CHANNEL

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Journal of Hydrodynamics 2005年第5期17卷 601-606页

作者： ZHENG Jin-hai LIU Ying-qi YAN Yi-xin zhu yu-liang Research Institute of Coastal and Ocean Engineering Hohai University Nanjing 210098 China

Submerged dikes were frequently built in curved estuarine channels to improve navigational conditions. A three-dimensional numerical model of tidal motions was developed to simulate flows through the submerged dike alignment in curved estuarine reach of complex bathymetry on the basis of satisfactory calibrations. Through the analysis of the morphological characteristics of the curved channel of the Huangpu River mouth in the Yangtze River Delta, a submerged dike alignment project was examined. The effect of the navigation channel improvement project and its influence on the flow regimes, the navigational conditions, the flood control and the operating conditions of harbours within the adjacent water area were evaluated, and the technical feasibility of the navigation channel improvement scheme was demonstrated.

关键词： submerged dike alignment three-dimensional numerical model curved estuarine channel morphological analysis

Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution,lignin biosynthesis regulation,and stress tolerance

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Science China(Life Sciences) 2024年第6期67卷 1266-1279页

作者： Wanwan Li xin Chen Jianing yu yuxian zhu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China The State Key Laboratory of Protein and Gene Research College of Life SciencesPeking UniversityBeijing 100871China The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

Durian(Durio zibethinus)is a tropical fruit that has a unique flavor and *** occupies a significant phylogenetic position within the Malvaceae *** core-eudicot plants are reported to share seven ancestral karyotypes that have undergone reshuffling,resulting in an abundant genomic ***,the ancestral karyotypes of the Malvaceae family,as well as the evolution trajectory leading to the28 chromosomes in durian,remain poorly ***,we report the high-quality assembly of the durian genome with comprehensive comparative genomic *** analyzing the collinear blocks between cacao and durian,we inferred 11 Malvaceae ancestral *** blocks were present in a single-copy form in cacao and mainly in triplicates in durian,possibly resulting from a recent whole genome triplication(WGT)event that led to hexaploidization of the durian genome around 20(17–24)million years ago.A large proportion of the duplicated genes in durian,such as those involved in the lignin biosynthesis module for phenylpropane biosynthesis,are derived directly from whole genome duplication,which makes it an important force in reshaping its genomic *** studies have revealed that genes involved in feruloyl-Co A formations were highly preferentially expressed in fruit peels,indicating that the thorns produced on durian fruit may comprise guaiacyl and syringyl *** all the analyzed transcription factors(TFs),members of the heat shock factor family(HSF)were the most significantly upregulated under heat *** subfamilies of genes encoding heat shock proteins(HSPs)in the durian genome appear to have undergone *** potential interactions between HSF Dzi05.397 and HSPs were examined and experimentally *** study provides a high-quality durian genome and reveals the reshuffling mechanism of ancestral Malvaceae chromosomes to produce the durian *** also provide insights into the mechanism underlying lignin bi

关键词： Durio zibethinus whole genome duplication whole genome triplication Malvaceae ancestral karyotypes chromosome reshuffling lignin biosynthesis heat stress

Probabilistic outlier detection for sparse multivariate geotechnical site investigation data using Bayesian learning

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Geoscience Frontiers 2021年第1期12卷 425-439页

作者： Shuo Zheng yu-xin zhu Dian-Qing Li Zi-Jun Cao Qin-Xuan Deng Kok-Kwang Phoon State Key Laboratory of Water Resources and Hydropower Engineering Science Institute of Engineering Risk and Disaster PreventionWuhan University299 Bayi RoadWuhan 430072China Department of Civil and Environmental Engineering National University of SingaporeBlk E1A#07-031 Engineering Drive 2Singapore 117576Singapore

Various uncertainties arising during acquisition process of geoscience data may result in anomalous data instances(i.e.,outliers)that do not conform with the expected pattern of regular data *** sparse multivariate data obtained from geotechnical site investigation,it is impossible to identify outliers with certainty due to the distortion of statistics of geotechnical parameters caused by outliers and their associated statistical uncertainty resulted from data *** paper develops a probabilistic outlier detection method for sparse multivariate data obtained from geotechnical site *** proposed approach quantifies the outlying probability of each data instance based on Mahalanobis distance and determines outliers as those data instances with outlying probabilities greater than *** tackles the distortion issue of statistics estimated from the dataset with outliers by a re-sampling technique and accounts,rationally,for the statistical uncertainty by Bayesian machine ***,the proposed approach also suggests an exclusive method to determine outlying components of each *** proposed approach is illustrated and verified using simulated and real-life *** showed that the proposed approach properly identifies outliers among sparse multivariate data and their corresponding outlying components in a probabilistic *** can significantly reduce the masking effect(i.e.,missing some actual outliers due to the distortion of statistics by the outliers and statistical uncertainty).It also found that outliers among sparse multivariate data instances affect significantly the construction of multivariate distribution of geotechnical parameters for uncertainty *** emphasizes the necessity of data cleaning process(e.g.,outlier detection)for uncertainty quantification based on geoscience data.

关键词： Outlier detection Site investigation Sparse multivariate data Mahalanobis distance Resampling by half-means Bayesian machine learning

Optimization of Gas Production from Hydrate-Bearing Sediments with Fluctuation Characteristics

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Journal of Ocean University of China 2024年第3期23卷 618-632页

作者： LI Yaobin XU Tianfu xin xin yu Han yuAN Yilong zhu Huixing Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Water Resources and Environment Jilin UniversityChangchun 130021China

As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption *** the hydrate industry in the South China Sea is important to achieving‘carbon peak and carbon neutrality’goals as soon as ***-water areas subjected to the action of long-term stress and tectonic movement have developed complex and volatile terrains,and as such,the morphologies of hydrate-bearing sediments(HBSs)fluctuate *** key to numerically simulating HBS morphologies is the establishment of the conceptual model,which represents the objective and real description of the actual geological ***,current numerical simulation models have characterized HBSs into horizontal strata without considering the fluctuation *** representing the HBS as a horizontal element reduces simulation ***,the commonly used horizontal HBS model and a model considering the HBS’s fluctuation characteristics with the data of the SH2 site in the Shenhu Sea area were first constructed in this ***,their production behaviors were compared,and the huge impact of the fluctuation characteristics on HBS production was *** this basis,the key parameters affecting the depressurization production of the fluctuating HBSs were studied and *** research results show that the fluctuation characteristics have an obvious influence on the hydrate production of HBSs by affecting their temperatures and pressure distributions,as well as the transmission of the pressure drop and methane gas ***,the results show that the gas productivity of fluctuating HBSs was about 5%less than that of horizontal *** optimizing the depressurization amplitude,well length,and layout location of vertical wells,the productivity of fluctuating HBSs increased by about 56.6%.

关键词： natural gas hydrate numerical simulation fluctuation characteristics depressurization production production well optimization

Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： xin-yu Liu Liang zhu Su-yun Jie Bo-Geng Li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL

Discovery of two rotational modulation periods from a young hierarchical triple system

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中国科学:物理学、力学、天文学英文版 2023年第9期66卷 179-189页

作者： yu-Tao Chen Hai-Jun Tian Min Fang Xiao-Xiong Zuo Sarah ABird Di Liu xin-yu zhu Peng Zhang Gao-Chao Liu Sheng Cui Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443002China School of Science HangZhou Dianzi UniversityHangZhou 310018China Space Information Research Institute Hangzhou Dianzi UniversityHangZhou 310018China School of Physics and Astronomy China West Normal UniversityNanChong 637002China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

GW Ori is a young hierarchical triple system located in λ Orionis, consisting of a binary(GW Ori A and B), a tertiary star(GW Ori C) and a rare circumtriple disk. Due to the limited data with poor accuracy, several short-period signals were detected in this system, but the values from diferent studies are not fully consistent. As one of the most successful transiting surveys, the transiting exoplanet survey satellite(TESS) provides an unprecedented opportunity to make a comprehensive periodic analysis of GW Ori. In this work we discover two significant modulation signals by analyzing the light curves of GW Ori's four observations from TESS, i.e.,(3.02 ± 0.15) and(1.92 ± 0.06) d, which are very likely to be the rotational periods caused by starspot modulation on the primary and secondary components, respectively. We calculate the inclinations of GW Ori A and B according to the two rotational periods. The results suggest that the rotational plane of GW Ori A and B and the orbital plane of the binary are almost coplanar. We also discuss the aperiodic features in the light curves;these may be related to unstable accretion. The light curves of GW Ori also include a third(possible) modulation signal with a period of(2.51±0.09) d, but the third is neither quite stable nor statistically significant.

关键词： GW Ori pre-main sequence fundamental parameters triple stars

Hazard evaluation of ignition sensitivity and explosion severity for three typical MH_(2) (M=Mg,Ti,Zr)of energetic materials

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Defence Technology（防务技术） 2021年第4期17卷 1262-1268页

作者： xing-liang Wu Sen Xu Ai-min Pang Wei-guo Cao Da-bin Liu xin-yu zhu Fei-yang Xu Xu Wang School of Chemical Engineering Nanjing University of Science and TechnologyNanjingJiangsu210094PR China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang441003PR China School of Environmental and Safety Engineering North University of ChinaTaiyuan030051ShanxiPR China

MgH_(2),TiH_(2),and ZrH_(2) are three typical metal hydrides that have been gradually applied to composite explosives and propellants as additives in recent *** evaluate ignition sensitivity and explosion severity,the Hartmann device and spherical pressure vessel were used to test ignition energy and explosion pressure,*** results showed that the ignition sensitivity of ZrH_(2),TiH_(2) and MgH_(2) gradually *** the concentration of MgH_(2) is 83.0 g/m^(3) in Hartmann device,the ignition energy attained a minimum of 10.0 *** explosion pressure of MgH_(2) were 1.44 times and 1.76 times that of TiH_(2) and ZrH_(2),respectively,and the explosion pressure rising rate were 3.97 times and 9.96 times that of TiH_(2) and ZrH_(2),respectively,through the spherical pressure *** indicated that the reaction reactivity and reaction rate of MgH_(2) were higher than that of TiH_(2) and ZrH_(2).In addition,to conduct in edepth theoretical analysis of ignition sensitivity and explosion severity,gas production and combustion heat per unit mass of ZrH_(2),TiH_(2) and MgH_(2) were tested by mercury manometer and oxygen bomb *** experimental results revealed that MgH_(2) had a relatively high gas production per unit mass(5.15 mL/g),while TiH_(2) and ZrH_(2) both had a gas production of less than 2.0 mL/*** thermal stability gradually increased,leading to a gradual increase in ignition ***,compared with theoretical combustion heat,the combustion ratio of MgH_(2),TiH_(2) and ZrH_(2) was more than 96.0%,with combustion heat value of 29.96,20.94 and 12.22 MJ/kg,respectively,which was consistent with the explosion pressure and explosion severity test results.

关键词： Ignition energy Explosion pressure Reaction activity Combustion heat