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Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin Chen yu-xin Xu yuan-Shuo Wang Jian-Liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

Green carbonization of waste coffee grounds into porous C/Fe hybrids for broadband and high-efficiency microwave absorption

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Journal of Materials Science & Technology 2024年第3期170卷 1-10页

作者： xin Wen Cui Li Hui Liu Guohua Fan Yanan Tang Chuncheng Hao Lili Ma Pingan song Institute of Advanced Electrical Materials College of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China Center for Future Materials University of Southern QueenslandSpringfieldQLD 4300Australia School of Agriculture and Environmental Science University of Southern QueenslandSpringfieldQLD 4300Australia

Recently great effort s have been focused on designing high-performance microwave absorbers using sustainable biomass resources,but there remains a lack of green and efficient fabrication ***,inspired by natural porous character of biomass waste,we demonstrated a green one-step route to convert waste coffee grounds into porous C/Fe hybrids,and further explored their potential applications for broadband and high-efficiency microwave *** this design,the WCG-20-750(incorporated 20 wt%Fe(C_(5)H_(7)O_(2))_(3)catalyst and carbonized at 750℃)exhibited porous microstructure with the highest char yield of 55.45 wt%.Furthermore,the as-prepared C/Fe hybrids from WCG-20-750 displayed excellent microwave absorption ***,the minimum reflection loss(RL_(min))reached to-52.86 dB and the widest effective absorption bandwidth(EAB)was 6.40 GHz at the thickness of 3.0 *** work provides an economically viable and environmentally friendly strategy to convert biomass wastes into value-added microwave absorbers,ultimately making contributions to the upcycling of renewable biomass resources and the fostering of sustainable environment.

关键词： Waste recycling Microwave absorption Green carbonization Porous carbon Biomass

Coping strategy of independent directors for job-fulfillment risk under different ownership types and enforced legal environments

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China Journal of Accounting Research 2024年第4期17卷 112-142页

作者： yu xin Ying xin xinyi Huang Liping Xu School of Business Sun Yat-sen UniversityGuangzhouChina School of Accounting Guangdong University of Foreign StudiesGuangzhouChina

Ownership type,legal system evolution and their interaction significantly affect the incentives and behaviors of independent *** use the 2019 Securities Law revision as an exogenous shock to examine how state-owned enterprises(SOEs)versus non-SOEs and their independent directors respond to variations in regulatory compliance *** the revision,SOEs are more likely to purchase directors’and officers’liability insurance to provide job security for independent ***-SOEs are more likely to compensate for independent directors’fulfillment risk by increasing salaries and their independent directors are more likely to resign to avoid litigation *** coping strategies for SOEs,non-SOEs and independent directors are dynamic under different compliance risk stages and are affected by firm-level and director-level characteristics.

关键词： New Securities Law Ownership type Regulatory compliance risk Independent directors Job-fulfillment risk

Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min ZHANG yu Lan ZHANG Kai Li LI Ping Ping Lyu yu Han LIANG Ya xin yu yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

Double-layered skeleton of Li alloy anchored on 3D metal foam enabling ultralong lifespan of Li anode under high rate

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Chinese Chemical Letters 2024年第3期35卷 479-485页

作者： Chaohui Wei Zeyu Yao Jin Ruan Zhicui song Aijun Zhou Yingze song Donghuang Wang Jicheng Jiang xin Wang Jingze Li Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313000China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Environmental-Friendly Energy Materials Tianfu Institute of Research and InnovationSchool of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China

The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed ***,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of *** three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'***,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal ***,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling *** to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional ***,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.

关键词： Double-layered skeleton Li alloy 3D Metal foam Ultralong lifespan Lithium metal batteries High rate

Spherical Polyelectrolyte Brush Nanoreactor:Preparation of Hollow TiO_(2) Nanospheres and Characterization by Small Angle X-Ray Scattering

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Chinese Journal of Polymer Science 2024年第9期42卷 1393-1400,I0009页

作者： yu-Hua Zhang Zi-yu Zhang xin Liu En-Guang Ma Jiang-Tao Guo Li Li Xu-Hong Guo State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou253023China Institute of Bast Fiber Crops&Center of Southern Economic Crops Chinese Academy of Agricultural SciencesChangsha410205China

Titanium dioxide(TiO_(2))hollow nanoparticles present significant potential for photocatalytic applications while their straightforward preparation with precise structure control is still *** work reports the approach to preparing tunable hollow TiO_(2) nanospheres by utilization of spherical polyelectrolyte brushes(SPB)as nanoreactors and *** the preparation,the evolution of the structure was characterized by small angle X-ray scattering(SAXS),and in combination with dynamic light scattering and transmission electron *** formation of TiO_(2) shell within the brush(SPB@TiO_(2))is confirmed by the significant increase of the electron density,and its internal structure has been analyzed by fitting SAXS data,which can be influenced by Titanium precursors and ammonia *** calcining SPB@TiO_(2) in a muffle furnace,hollow TiO_(2) nanospheres are produced,and their transition to the anatase crystal form is triggered,as confirmed by X-ray diffraction *** the advantages of their hollow structure,these TiO_(2) nanospheres exhibit exceptional catalytic degradation efficiency of methylene blue(MB),tetracycline(TC),and 2,4-dichlorophenoxyacetic acid(2,4-D),and also demonstrate excellent recyclability.

关键词： Spherical polyelectrolyte brush Nanoreactor Hollow titanium dioxide X-ray scattering

Climate warming is significantly influenced by rising summer maximum temperatures: insights from tree-ring evidence of the Western Tianshan Mountains, China

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Journal of Forestry Research 2024年第5期35卷 47-59页

作者： Meng Ren yu Liu Qiufang Cai Qiang Li Huiming song Changfeng Sun The State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061People’s Republic of China Xi’an Institute for Innovative Earth Environment Research Xi’an 710061People’s Republic of China Institute of Desert Meteorology China Meteorological AdministrationÜrümqi 830002People’s Republic of China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061People’s Republic of China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237People’s Republic of China

As one of the regions most affected by global cli-mate warming,the Tianshan mountains has experienced sev-eral ecological crises,including retreating glaciers and water *** warming in these mountains is considered mainly to be caused by increases in minimum temperatures and winter temperatures,while the influence of maximum temperatures is *** this study,a 300-year tree-ring chronology developed from the Western Tianshan Moun-tains was used to reconstruct the summer(June-August)maximum temperature(T_(max6-8))variations from 1718 to *** reconstruction explained 53.1% of the variance in the observed T_(max6-8).Over the past 300 years,the T_(max6-8)reconstruction showed clear interannual and decadal *** was a significant warming trend(0.18°C/decade)after the 1950s,which was close to the increasing rates of the minimum and mean *** increase in maximum temperature was also present over the whole Tianshan mountains and its impact on climate warming has *** T_(max6-8) variations in the Western Tianshan mountains were influenced by frequent volcanic eruptions combined with the influence of solar activity and the sum-mer North Atlantic *** study reveals that cli-mate warming is significantly influenced by the increase in maximum temperatures and clarifies possible driving mech-anisms of temperature variations in the Western Tianshan mountains which should aid climate predictions.

关键词： Tree rings Western Tianshan mountains Temperature change Climate warming

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Steam disinfection enhances bioaccessibility of metallic nanoparticles in nano-enabled silicone-rubber baby bottle teats,pacifiers,and teethers

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Journal of Environmental Sciences 2024年第2期136卷 161-171页

作者： yu Su BinWang xin Tong Shuchuan Peng Sijin Liu Baoshan xing Rong Ji State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Stockbridge School of Agriculture University of MassachusettsAmherstMA 01003USA

Nano-enabled silicone-rubber articles for feeding or chewing could be a source of metallic nanoparticles(NPs)directly exposed to infants and young ***,the impact of steam disinfection on release of NPs and the related potential risks to children's health are ***,we investigated contents and form of Ag and Zn in 57 nano-enabled silicone-rubber baby bottle teats,pacifiers,and teethers of seven countries and examined the impacts of steam disinfection on in vitro bioaccessibility(IVBA)of Ag and Zn in the *** 89%articles had a mixture of Ag-and Zn-containing NPs and the teethers had relatively high Ag and Zn contents(up to 501 and 254μg/g,respectively).Steam disinfection caused rubber decomposition into micro(nano)plastics(0.54-15.7μm)and NP release from the interior of bulk rubber and micro-sized plastics,thus enhancing the IVBA of Ag and Zn by up to 5.5 *** findings provide insights into mechanisms for NP release by steam *** oral exposure risk assessment suggested low health concerns on individual metal release,our study points out the need to assess the potential health risks of child co-exposure to metallic NPs and micro(nano)plastics.

关键词： Silicone rubber Metallic nanoparticles Micro(nano)plastics Bioaccessibility Children's health

Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets

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动物营养学报 2024年第1期16卷 409-421页

作者： xin Lai Aimin Wu Bing yu Hui Yan Junqiu Luo Ping Zheng Jie yu Daiwen Chen Institute of Animal Nutrition Sichuan Agricultural University Chengdu China Key Laboratory for Animal Disease-resistance Nutrition of China Ministry of Education Sichuan Agricultural University Chengdu China

Rotaviruses (RV) are a major cause of severe gastroenteritis, particularly in neonatal piglets. Despite the availability of effective vaccines, the development of antiviral therapies for RV remains an ongoing challenge. Retinoic acid (RA), a metabolite of vitamin A, has been shown to have anti-oxidative and antiviral properties. However, the mechanism by which RA exerts its intestinal-protective and antiviral effects on RV infection is not fully understood. The study investigates the effects of RA supplementation in Duroc × Landrace × Yorkshire (DLY) piglets challenged with RV. Thirty-six DLY piglets were assigned into six treatments, including a control group, RA treatment group with two concentration gradients (5 and 15 mg/d), RV treatment group, and RV treatment group with the addition of different concentration gradients of RA (5 and 15 mg/d). Our study revealed that RV infection led to extensive intestinal architecture damage, which was mitigated by RA treatment at lower concentrations by increasing the villus height and villus height/crypt depth ratio ( P P P View The PDF

关键词： Rotavirus Piglet Retinoic acid Intestinal barrier Redox hemostasis Autophagic flux