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Dramatic sediment load changes and sedimentation characteristics upstream of the Three Gorges Dam due to the large reservoirs construction

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Frontiers of Earth Science 2024年第3期18卷 565-578页

作者： Jie LIU Wenwu zhang ying SHEN xin WANG National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing 400074China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of River&Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Tianjin Research Institute for Water Transport Engineering Tianjin 300456China

After the construction of cascade reservoirs in the upper reaches of the Three Gorges Reservoir(TGR),the sediment load outflow of the upper Yangtze River Basin(YRB)has been significantly altered,decreasing from 491.8 Mt/yr(1956–2002)to 36.1 Mt/yr(2003–2017)at Yichang *** has widely affected river hydrology,suspended sediment grain size distribution,and channel *** study analyzed hydrological variations in water discharge and sediment load of the upper YRB over the past 62 years(1956–2017)by employing a double mass *** variations in the source areas of sediment yielding for the upper YRB were quantified,and field measurement data of the cross-channel profile were collected to investigate the sedimentation process in the TGR from 2003 to *** than 90%of the sediment load reduction in the upper YRB may be explained by human *** Jinshajiang River was no longer the largest sediment source area for the Zhutuo station(accounting for 5.23%)in the 2013–2017 time span,and the sediment rating rates for the inflow and outflow of the TGR shifted to negatively correlated.A longitudinal fining trend was revealed in the suspended sediment ***,the mean median grain size of suspended sediment in the TGR had an increasing trend in the 2013–2017 *** result may be closely related to sediment regulation in reservoirs and incoming sediment load *** in the TGR decreased sharply from 299.8 Mt/yr in 2003–2012 to 47.2 Mt/yr in 2013–2017,but the sedimentation rate of the TGR remained at>80%***,some cross sections in the fluctuating backwater zone experienced scouring.

关键词： cascade reservoirs sediment load sedimentation characteristics suspended sediment grain size Three Gorges Reservoir

Complement factor B polymorphism(rs641153) and susceptibility to age-related macular degeneration: evidence from published studies

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 861-867页

作者： xin Wang ying zhang Mao-Nian zhang Department of Ophthalmology Chinese People's Liberation Army General Hospital

AIM:To determine whether single nucleotide polymorphism(SNP)rs641153 is associated with the risk of age-related macular degeneration(AMD),we performed a systematic meta-analysis of 15 eligible *** in the complement factor B(CFB)gene is considered to have significant association with AMD susceptibility,but there is great discrepancy in these ***:The eligible studies were identified by searching the databases of PubMed,EMBASE,and Web of *** ratios(ORs)with 95%confidence intervals(CIs)were used to assess the *** data were analyzed using Stata ***:The association between rs641153 and AMD risk was statistically significant under the homozygous model(AA vs GG:OR=0.26,95%CI=0.15-0.45,P_h=0.973,/~2=0.0%,fixed effects),dominant model(AA+GA vsGG:OR=0.49,95%CI=0.40-0.59,P_h=0.004,/~2=56.4%,random effects)and recessive model(AA vs GA+GG:OR=0.30,95%CI=0.17-0.51,R_n=0.983,I^2=0.0%,fixed effects).The same results were also observed in the stratified analyses by ethnicity,source of control and sample ***:Our meta-analysis suggests that rs641153 in the CFB gene may play a protective role in AMD susceptibility,the late AMD in particular,both in Caucasians and in Asians.

关键词： complement factor B rs641153 age-related macular degeneration meta-analysis

Explosive eye injuries: characteristics, traumatic mechanisms, and prognostic factors for poor visual outcomes

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Military Medical Research 2023年第6期10卷 751-762页

作者： ying zhang xin Kang Qiong Wu Zhong Zheng Jun ying Mao-Nian zhang Senior Department of Ophthalmology the Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Ophthalmol‑ogy the First Medical Center of Chinese PLA General HospitalBeijing 100853China Medical Security Center Chinese PLA General HospitalBeijing 100853China Information Center Logistics Support DepartmentCentral Military CommissionBeijing 100842China Information Management Department Chinese PLA General HospitalBeijing 100853China

Background: Explosions can produce blast waves, high-speed medium, thermal radiation, and chemical spatter,leading to complex and compound eye injuries. However, few studies have comprehensively investigated the clinical features of different eye injury types or possible risk factors for poor ***: We retrospectively reviewed all consecutive records of explosive eye injuries(1449 eyes in 1115 inpatients)in 14 tertiary referral hospitals in China over 12 years(between January 1, 2008 and December 31, 2019). Data on demographics, eye injury types, ocular findings, treatments, and factors affecting visual prognosis were extracted from a standardized database of eye injuries and statistically ***: Mechanical ocular trauma accounted for 94.00% of explosion-related eye injuries, among which intraocular foreign bodies(IOFBs) resulted in 55.17% of open globe injuries(OGIs) and contusion caused 60.22% of close globe injuries(CGIs). Proliferative vitreous retinopathy(PVR) was more common in perforating(47.06%) and IOFB(26.84%)than in penetrating(8.79%) injuries, and more common with laceration(24.25%) than rupture(9.22%, P<0.01).However, no difference was observed between rupture and contusion. Ultimately, 9.59% of eyes were removed and the final vision was ≤4/200 in 45.82% of patients. Poor presenting vision [odds ratio(OR)=5.789], full-thickness laceration of the eyeball ≥5 mm(OR=3.665), vitreous hemorrhage(OR=3.474), IOFB(OR=3.510), non-mechanical eye injury(NMEI, OR=2.622), rupture(OR=2.362), traumatic optic neuropathy(OR=2.102), retinal detachment(RD,OR=2.033), endophthalmitis(OR=3.281), contusion(OR=1.679), ciliary body detachment(OR=6.592), zone Ⅲ OGI(OR=1.940), and PVR(OR=1.615) were significant negative predictors for poor visual outcomes(P<0.05).Conclusions: Explosion ocular trauma has complex mechanisms, with multiple eyes involved and poor prognosis. In lethal level Ⅰ explosion injuries, eyeball rupture is a serious condition, whereas con

关键词： Explosion-related eye injury Mechanical ocular trauma Visual outcome Risk factor

From nanoparticles to single atoms for Pt/CeO2:Synthetic strategies,characterizations and applications

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Journal of Rare Earths 2020年第8期38卷 850-862,I0002页

作者： ying xin Nana zhang Yanan Lv Jin Wang Qian Li Zhaoliang zhang Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

Pt/CeO2 catalysts with unitary Pt species,nanoparticles,clusters or single atoms,often exhibit excellent activity and unique selectivity in many catalytic reactions benefiting from their small size,abundant unsaturated active sites,and unique electro nic *** recent years,a tre mendous number of related articles have provided great inspiration to future research and development of Pt/CeO2 *** this review,the state-of-the-art evolution of Pt nanoparticles to Pt single atoms on CeO2 is reviewed with the emphasis on synthetic strategies,advanced characterization techniques(allowing one to clarify the single atoms from clusters),the catalytic applications and mechanisms from the viewpoint of theoretical ***,the critical outlooks and the challenges faced in developing the single-atom Pt/CeO2 catalysts are highlighted.

关键词： Pt/CeO2 Single atoms Cluster Synthetic strategy Characterization Application

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

腺病毒介导shRNA干扰绵羊MSTN基因效果及对生肌调节因子和干扰素反应基因表达的影响

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畜牧兽医学报 2017年第10期48卷 1833-1842页

作者：王红娜孙洪新张英杰刘月琴谷振慧王苏瑶河北农业大学动物科技学院保定071000 河北省畜牧兽医研究所保定071000

旨在进一步揭示MSTN在绵羊成肌细胞中的调控机制,制备可有效失活MSTN基因的工具,为通过RNA干扰技术提高绵羊产肉量提供方法和理论依据。本研究以绵羊成肌细胞为试验材料,构建特异靶向绵羊MSTN基因的shRNA干扰质粒载体,将干扰效果好的质... 详细信息

旨在进一步揭示MSTN在绵羊成肌细胞中的调控机制,制备可有效失活MSTN基因的工具,为通过RNA干扰技术提高绵羊产肉量提供方法和理论依据。本研究以绵羊成肌细胞为试验材料,构建特异靶向绵羊MSTN基因的shRNA干扰质粒载体,将干扰效果好的质粒进一步包装为重组腺病毒,转染细胞后采用qRT-PCR和Western blot检测MSTN基因以及生肌调节因子和干扰素反应基因的表达。结果表明,质粒ShR218和ShR511干扰MSTN基因效率分别达到35%和48%,双元干扰质粒ShR3+4干扰效率最高达到85%。成功包装shRNA重组腺病毒载体Sh511和Sh3+4,病毒滴度达到1×10~8 pfu·mL^(-1),对成肌细胞的感染效率达到90%以上。Sh511和Sh3+4对MSTN基因mRNA的表达抑制分别达到53%和76%,对蛋白表达抑制分别达到55%和64%。MSTN基因沉默后,伴随着Myf5、MyoD、MyoG、Myf6基因mRNA水平的极显著性下调(P<0.01),但只引起MyoG蛋白水平极显著升高(P<0.01),未引起Myf5、MyoD、Myf6蛋白水平的显著变化;腺病毒感染成肌细胞未引起OAS1基因mRNA水平的显著变化,但引起IFNGR1基因mRNA水平的极显著升高(P<0.01),对二者蛋白水平均无显著影响。本研究成功构建靶向MSTN基因的shRNA腺病毒载体,能有效抑制成肌细胞MSTN的mRNA和蛋白表达,并影响生肌调节因子Myf5、MyoD、MyoG、Myf6基因和干扰素受体基因IFNGR1表达。

关键词：绵羊 MSTN 成肌细胞 RNA干扰

加味补肾活血方治疗各型狼疮肾炎患者疗效观察及免疫功能影响

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天津中医药大学学报 2016年第6期35卷 380-384页

作者：岳颖纪岩文阮颖欣张勉之刘维陈敬天津中医药大学天津300193 天津市公安医院天津300042 天津医科大学总医院天津300052 天津中医药大学第一附属医院天津300193

[目的]探讨加味补肾活血方对红斑狼疮肾炎(LN)患者治疗效果及对免疫功能影响。[方法]102例LN患者随机分为基础治疗组(51例)及联合治疗组(51例),两组均应用甲基泼尼松及环磷酰胺(CTX)或甲基泼尼松及吗替麦考酚酯(MMF)治疗,联合治疗组同... 详细信息

[目的]探讨加味补肾活血方对红斑狼疮肾炎(LN)患者治疗效果及对免疫功能影响。[方法]102例LN患者随机分为基础治疗组(51例)及联合治疗组(51例),两组均应用甲基泼尼松及环磷酰胺(CTX)或甲基泼尼松及吗替麦考酚酯(MMF)治疗,联合治疗组同时应用加味补肾活血方治疗,4个月后观察两组患者系统性红斑狼疮(SLE)疾病活动指数(SLEDAI)、补体C3、C4、24 h尿蛋白定量、内生肌酐清除率(Ccr)水平,同时运用流式细胞术检测CD3+、CD4+、CD8+水平。[结果]联合治疗组患者的Ccr水平升高,CD8+水平下调,与基础治疗组比较有统计学差异(P<0.05)。增殖型LN经联合治疗后,24 h尿蛋白定量下降、Ccr,与基础治疗组相比,差异有统计学意义(P<0.05)。混合型LN经联合治疗后,Ccr,与基础治疗组相比,差异有统计学意义(P<0.05)。[结论]加味补肾活血方能够改善LN患者肾滤过功能,对增值型及混合型LN疗效明显,能有效减少糖皮质激素及免疫抑制剂应用剂量,并可在一定程度上纠正免疫功能紊乱。

关键词：加味补肾活血方狼疮肾炎免疫学

Testing long memory based on a discretely observed process

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Applied Mathematics(A Journal of Chinese Universities) 2016年第3期31卷 253-268页

作者： LIU Guang-ying zhang xin-sheng zhang Shi-bin Department of Statistics Nanjing Audit University School of Mathematical Sciences Zhejiang University Department of Statistics Fudan University Department of Mathematics Shanghai Maritime University

In this paper we consider the problem of testing long memory for a continuous time process based on high frequency data. We provide two test statistics to distinguish between a semimartingale and a fractional integral process with jumps, where the integral is driven by a fractional Brownian motion with long memory. The small-sample performances of the statistics are evidenced by means of simulation studies. The real data analysis shows that the fractional integral process with jumps can capture the long memory of some financial data.

关键词： long memory jump fractional Brownian motion semimartingale high frequency data power variation

谱系1和8重组猪繁殖与呼吸综合征病毒的分离鉴定与遗传进化分析

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动物医学进展 2025年第1期46卷 29-37页

作者：邹舟黎颖韦莹莹刘惠僮韦祖樟广西大学动物科学技术学院动物传染病与分子免疫学实验室广西南宁530005 广西壮族自治区兽用生物制品工程研究中心广西南宁530005 广西畜禽繁育与疾病防控重点实验室广西南宁530004

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产... 详细信息

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产生明显的细胞病变;该毒株全基因组长度为15019个核苷酸(nt),与基因2型PRRSV谱系1 NADC30-like毒株的同源性最高,为94.0%,与基因1型PRRSV代表毒株Lelystad virus同源性最低,仅为60.0%;通过Nsp2氨基酸序列比对,结果发现GXWZ20230831存在NADC30-like典型的131(111+1+19)个氨基酸的不连续缺失模式;与美洲型代表株VR2332相比,GXWZ20230831的GP5蛋白在非中和抗原表位发生了V27A、V185A以及R191K 3处突变,同时在GP5蛋白中存在4个潜在的N-糖基化位点;构建的全基因组序列、nsp2基因、ORF5基因遗传进化树均显示该毒株处于谱系1的分支;重组分析表明,GXWZ20230831是1株以谱系1经典毒株NADC30为骨架,谱系8毒株提供重组片段的重组毒株,重组断点位于基因组的nsp1(458-1821 nt)和Nsp4(5405-8179 nt)中。研究结果可为掌握广西地区的PRRSV遗传变异规律提供参考,为制定防控措施提供科学依据。

关键词：猪繁殖与呼吸综合征病毒分离鉴定重组遗传进化分析