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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang xin shuai Min Chen Yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

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一类具有转点的右端不连续奇摄动边值问题

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应用数学和力学 2024年第4期45卷 470-489页

作者：帅欣倪明康华东师范大学数学科学学院上海200241

研究了一类具有转点的右端不连续二阶半线性奇摄动边值问题解的渐近性.首先,在间断处将原问题分为左右两个问题,通过修正左问题退化问题的正则化方程,提高了左问题渐近解的精度,并利用Nagumo定理证明了左问题光滑解的存在性.其次,证明... 详细信息

研究了一类具有转点的右端不连续二阶半线性奇摄动边值问题解的渐近性.首先,在间断处将原问题分为左右两个问题,通过修正左问题退化问题的正则化方程,提高了左问题渐近解的精度,并利用Nagumo定理证明了左问题光滑解的存在性.其次,证明了右问题具有空间对照结构的解,并通过在间断点的光滑缝接,得到了原问题的渐近解.最后,通过一个算例验证了结果的正确性.

关键词：奇摄动边值问题转点右端不连续空间对照渐近解

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郑州市冬夏季污染过程中大气VOCs污染特征、来源解析及活性分析

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环境科学 2024年第2期45卷 689-699页

作者：赖梦洁张栋于世杰宋鑫帅李晓张瑞芹郑州大学生态与环境学院郑州450001 郑州大学化学学院郑州450001

为了研究挥发性有机物(VOCs)的污染特征,于2021年6月和12月在郑州市对两个污染过程中的VOCs进行了连续监测.结合气象条件,对比分析了VOCs冬夏季污染过程的污染特征、来源贡献和活性差异.结果显示,两个污染过程φ(VOCs)分别为(27.92±12.... 详细信息

为了研究挥发性有机物(VOCs)的污染特征,于2021年6月和12月在郑州市对两个污染过程中的VOCs进行了连续监测.结合气象条件,对比分析了VOCs冬夏季污染过程的污染特征、来源贡献和活性差异.结果显示,两个污染过程φ(VOCs)分别为(27.92±12.68)×10^(-9)和(24.30±5.93)×10^(-9).冬季雾-霾污染过程相较于夏季O3污染过程,VOCs体积分数变化范围更大.冬季污染过程源解析结果:工业源(27.0%)、机动车源(22.5%)、燃烧源(20.1%)、溶剂使用源(16.3%)和油气挥发源(14.1%);夏季污染过程源解析结果:机动车源(24.8%)、工业源(24.1%)、溶剂使用源(17.4%)、油气挥发源(14.2%)、燃烧源(11.2%)和植物源(8.4%).光化学烟雾产量模型结果显示,两个污染过程中夏季臭氧生成处于VOCs控制区的天数占比(66.7%)小于冬季(100.0%).二次反应活性结果显示,冬季和夏季污染过程·OH自由基反应活性(L·OH)均值分别为4.12 s^(-1)和4.76 s^(-1).夏季污染过程臭氧生成潜势(OFP)均值108.36μg·m^(-3),L·OH和OFP贡献率排名前10名物种夏季污染过程以烯烃为主.郑州市冬季污染过程的总二次有机气溶胶生成潜势(SOAFP)为54.38μg·m^(-3),冬季污染过程SOAFP贡献率前10名物种中芳香烃占9个.

关键词：挥发性有机物(VOCs) 源解析光化学烟雾产量模型二次反应活性郑州

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三教改革背景下高职体育课程教学的桎梏与突破

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当代体育科技 2024年第12期14卷 61-64页

作者：施淏亮辛帅江苏商贸职业学院江苏南通226011

三教改革是指要进行教材、教师和教法的三项改革。在三教改革背景下,高职体育教学面临着许多问题与挑战。为了促进三教改革背景下高职体育课程教学的发展,该文采用文献资料法等研究方法,对高职体育课程教学的桎梏与突破展开研究。首先... 详细信息

三教改革是指要进行教材、教师和教法的三项改革。在三教改革背景下,高职体育教学面临着许多问题与挑战。为了促进三教改革背景下高职体育课程教学的发展,该文采用文献资料法等研究方法,对高职体育课程教学的桎梏与突破展开研究。首先对三教改革进行了概述,分析了三教改革背景下高职体育课程教学中的桎梏,提出了三教改革背景下高职体育课程教学的突破方案,以期为能高职体育课程教学的创新与发展提供有力的支持。

关键词：三教改革高职体育课程教学

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Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： shuai-Bin Hua Tian Jin xin Guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

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颅脑损伤合并肺部感染miRNA表达谱与MASP-2位点rs72550870突变的关联

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中华医院感染学杂志 2024年第4期34卷 522-526页

作者：秦帅鑫高磊磊翟娟曹卫青甄朝建王军邢台市人民医院神经外科河北邢台054000 石家庄金域医学检测实验室河北石家庄050035

目的探讨颅脑损伤合并肺部感染miRNA表达图谱及凝集素相关丝氨酸蛋白酶2(MASP-2)位点rs72550870突变的关联.方法前瞻性纳入2019年3月—2020年8月邢台市人民医院急诊收治的95例颅脑损伤患者为研究对象,根据其术后是否发生肺部感染分为... 详细信息

目的探讨颅脑损伤合并肺部感染miRNA表达图谱及凝集素相关丝氨酸蛋白酶2(MASP-2)位点rs72550870突变的关联.方法前瞻性纳入2019年3月—2020年8月邢台市人民医院急诊收治的95例颅脑损伤患者为研究对象,根据其术后是否发生肺部感染分为感染组23例和非感染组72例;收集两组患者临床资料,检测其外周血中单个核细胞miRNAs表达谱,MASP-2基因多态性及MASP-2基因位点rs72550870检测,并利用Logistic回归模型进行相关性分析.结果两组患者入院时格拉斯哥昏迷(GCS)评分≥8分、术后卧床时间≥4周、术前血清白蛋白水平及外周血单个核细胞miRNAs表达水平对比,均存在统计学差异(P<0.05);改变倍数≥2倍的miRNA总数为42,其中24个表达下调、18个表达上调;感染组患者外周血miR-146a、miR-155、miR-125b及miR-22-3p水平均高于未感染组(P<0.05);miR-146a、miR-155、miR-125b及miR-22-3p水平检测的曲线下面积(AUC)分别为0.759、0.866、0.746、0.784(P<0.05);感染组MASP-2基因位点rs72550870基因型AA分布频率及等位基因A分布频率均较非感染组偏高(P<0.05);MASP-2基因位点rs72550870的等位基因A及基因型AA与颅脑损伤患者术后并发肺部感染相关(P<0.05).结论检测颅脑损伤患者的miRNA表达图谱可辅助临床评估其继发颅脑损伤的风险,其中MASP-2的位点rs72550870等位基因A和基因型AA突变是高危因素.

关键词：颅脑损伤肺部感染 miRNA表达图谱凝集素相关丝氨酸蛋白酶2 rs72550870突变评估价值

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Data Driven Vibration Control:A

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1898-1917页

作者： Weiyi Yang shuai Li xin Luo Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714 Chongqing School University of Chinese Academy of SciencesChongqing 400714China Faculty of Information Technology and Electrical Engineering University of OuluOulu 90570 VTT-Technology Research Center of Finland Oulu 90570Finlan College of Computer and Information Science Southwest UniversityChongqing 400715China

With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic *** shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC *** convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration *** on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of *** doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue.

关键词： Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration

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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying Liu shuai Ye xin-Ni Li Wei-Guang Li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

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Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient Tumor Targeted siRNA Delivery

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Chinese Journal of Polymer Science 2022年第9期40卷 1071-1079页

作者： Rong-Ze Wang Si Huang Qiao-Yun Zhang xing-Su Yu Ke-Ze Hong Jian-Rong Cao Hong Xiao Yong Wang xin-Tao shuai College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Nanomedicine Research Center The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Reproductive Medical Center Guangdong Women and Children HospitalGuangzhou 511400China

RNA interference(RNAi),known for the highly efficient targeted gene silencing,has been demonstrated to be a promising means for cancer ***,an effective approach for siRNA delivery is urgently needed to meet the needs for its clinical ***,we constructed a polymeric vector labeled with superparamagnetic iron oxide(SPIO)for magnetic resonance imaging(MRI)visible siRNA *** antibody was also modified to the surface of nanodrug to enhance the delivery *** results showed that the vector exhibited great siRNA complexation ability and mediated an increased endocytosis of siRNA without obvious ***,both in vitro and in vivo studies evidenced the vector could effectively deliver siRNA into tumor cells,exert highly interfering effect,and show potent MR imaging *** study provides a promising MRI-visible and EGFR targeting delivery system to improve RNAi efficacy for cancer therapy.

关键词： Polymeric vector siRNA delivery Magnetic resonance imaging visible Tumor targeting

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Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade

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Chinese Chemical Letters 2024年第6期35卷 331-336页

作者： Jing-Qi Tao shuai Liu Tian-Yu Zhang Hong xin Xu Yang xin-Hua Duan Li-Na Guo Department of Chemistry School of ChemistryXi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an 710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China

A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is *** adjusting the structure of alkoxyl radical precursors,functionalized lactones and ketoamides were synthesized with good yields and excellent functional group tolerance under redox-neutral ***,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.

关键词： Copper catalysis Ring-expansion Aminocarbonylatioin Macrolactones Keto-amides

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