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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li xin-Ran song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Binding Affinity of Novel Cyclodextrin Dimers to Ethyl Orange

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Chinese Chemical Letters 2002年第10期13卷 1005-1006页

作者： Le xin song Department of Chemistry University of Science and Technology of ChinaHefei 230026

The interaction between ethyl orange (Eto, guest) and beta-cyclodextrin dimers (1asimilar tod, host) bridged with 2-t-butoxycarbonyl(Boc)-amino diacid was investigated. A remarkable synergic complexation of two caviti... 详细信息

关键词： beta-cyclodextrin inclusion compound amino acid

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IMPROVED OXYGEN PERMEABILITY AND MECHANICAL STRENGTH OF SILICONE HYDROGELS WITH INTERPENETRATING NETWORK STRUCTURE

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Chinese Journal of Polymer Science 2010年第6期28卷 849-857页

作者： Jing-jing Wang xin-song Li Biomaterials and Drug Delivery Laboratories School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

The interpenetrating polymer network(IPN) silicone hydrogels with improved oxygen permeability and mechanical strength were prepared by UV-initiated polymerization of monomers including methacryloxypropyl tris(trimethylsiloxy)silane(TRIS),2-hydroxyethylmethacrylate(HEMA) and N-vinyl pyrrolidone(NVP) in the presence of free radical photoinitiator and cationic *** polymerization mechanism was investigated by the formation of gel *** structure of IPN hydrogels was characterized by Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry(DSC) and transmission electron microscopy(TEM).The results showed that the IPN hydrogels exhibited a heterogeneous *** mechanical properties,surface wettability and oxygen permeability were examined by using a tensile tester,a contact angle goniometer and an oxygen transmission tester,*** equilibrium water content of the hydrogels was measured by the gravimetric *** results revealed that the IPN hydrogels possessed hydrophilic surface and high water *** exhibited improved oxygen permeability and mechanical strength because of the incorporation of TRIS.

关键词： Interpenetrating polymer network Silicone hydrogel Photopolymerization Oxygen permeability Mechanical strength

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Resource allocation optimization for SWIPT full-duplex relaying networks with practical energy harvester

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The Journal of China Universities of Posts and Telecommunications 2023年第1期30卷 39-46页

作者： Xu Siyang song xin Zhu Jiahui School of Computer and Communication Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

In this paper,the resource allocation optimization for the simultaneous wireless information and power transfer(SWIPT)full-duplex(FD)relaying networks is investigated,in which the power-constrained relay scavenges energy from the source signal and assists information transmission by FD *** into account non-linear energy harvesting(EH)hardware circuit characteristics of the relay,the information rate maximization problem is developed by jointly optimizing the time-switching(TS)factor and transmission powers of the source in two different ***,the formulated optimization is highly non-convex and difficult to *** cope with this problem,the primary problem is decomposed into two sub-problems with respect to the TS factor and transmission *** solving these two sub-problems,the final sub-optimal solutions can be obtained by alternating *** results prove that the optimization of both TS factor and transmission powers can effectively enhance the information rate for the considered networks.

关键词： resource allocation optimization full-duplex relaying networks energy harvesting information rate

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Ad hoc distributed mutual exclusion algorithm based on token-asking

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Journal of Systems Engineering and Electronics 2007年第2期18卷 398-406页

作者： Wang Zheng Liu xin'song Li Mei'an School of Economic Information Engineering Southwestern Univ. of Finance and Economics Chengdu 610074 P.R.China 8010 R&D Computer Science and Engineering College Univ. of Electronic Science and Technology Chengdu 610054 P.R.China

The solution of distributed mutual exclusion is difficult in Ad hoc networks owing to dynamic topologies and mobility. Based on the analysis of the properties of Ad hoc networks and the disadvantages of the traditional algorithms, an improved Ad hoc system model was given and a novel algorithm was presented as AHDME （Ad Hoc Distributed Mutual Exclusion）; it was based on the token-asking algorithms. It utilized broadcast to search for the token and to decrease the message complexity of multi-hop Ad hoc networks. Lamport＇s timestamp was improved to ensure the time sequence and to prevent nodes from starvation. When compared to traditional algorithms, AHDME does not require the fixed size of request queues and the global system information, which adapts itself to the frequent arrival/departures and the limited computing capability of nodes in Ad hoc networks. Performance analysis and simulation results show that the AHDME algorithm has low message complexity, small space complexity, and short response delay.

关键词： Ad hoc Distributed mutual exclusion Token-asking Logical timestamp.

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Sludge reduction with Tubificidae and the impact on the performance of the wastewater treatment process

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Journal of Environmental Sciences 2007年第3期19卷 257-263页

作者： GUO Xue-song LIU Jun-xin WEI Yuan-song LI Lin Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

To reduce excess sludge, a Tubificidae reactor was combined with an integrated oxidation ditch with vertical circle （IODVC）, and a new integrated system was developed for wastewater treatment, A pilot-scale of this integrated system was tested to investigate the sludge reduction with Tubificidae and the impact on effluent quality and sludge production. The dominant worm was Branchnria Sowerbyi in the Tubificidae reactor after inoculation of Branchnria Sowerbyi and Limnodrilns sp., and the maximal volume density of wet Tubificidae in vessels of the Tubificidae reactor was 17600 g/m^3. Two operational modes, treating the excess sludge （first mode） and the returned sludge （second mode） of IODVC by the Tubificidae reactor, were used in this experiment. The results showed that the excess sludge reduction rate was 46.4% in the first mode, and the average sludge yield of the integrated system was 6.19× 10^-5 kg SS/kg COD in the second mode. Though the sludge returned to IODVC via the Tubificidae reactor, it had little impact on the effluent quality and the sludge characteristics of the IODVC. No new type of recalcitrant substance in the supernatant was discharged into the environment when the sludge was treated by Tubificidae. The experimental results also indicated that no significant changes occurred on the viscosity, specific resistance, and the floc size distribution of the sludge.

关键词： integrated wastewater treatment system sludge reduction wastewater treatment Tubificidae

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Coordination states of metal ions in molten salts and their characterization methods

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International Journal of Minerals,Metallurgy and Materials 2023年第7期30卷 1261-1277页

作者： xin song Shaolong Li Shanshan Liu Yong Fan Jilin He Jianxun song School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou 450001China College of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China

The macroscopic characteristics of molten salts are governed by their *** on the structures of molten salts provides the foundation for a full understanding of the physicochemical properties of molten salts as well as a deeper analysis of the microscopic electrolysis process in molten *** about the microstructure of matter can be obtained with the help of several speculative and experimental *** this review,the advantages and disadvantages of the various test procedures used to determine the microstructures of molten salts are *** typical coordination configurations of metal ions in molten salt systems are also ***,the impact of temperature,anions,cations,and metal oxides(O2-)on the structures of molten salts is discussed in *** accuracy and completeness of the information on molten salt structures need to be investigated by the integration of multiple methods and interdisciplinary *** on the microstructure and coordination of molten salts deepens the understanding of the elementary elements of the microstructure of *** paper,which is based on the review of the coordination states of metal ions in molten salts,is hoped to inspire researchers to explore the inter-relationship between the microstructure and macroscopic properties of materials.

关键词： microstructure salts coordination

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Two Theorems on the Commutativity of Arbitrary Rings

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Acta Mathematica Sinica,English Series 2001年第1期17卷 133-140页

作者： Chang Lin FU xin song YANG Department of Mathematics Harbin Univrsity of Science and Technology

We prove a theorem on the commutativity of the PI ring and use it to generalize a famous theorem of Herstein.

关键词： PI rings Commutativity Strong property F_k

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Study on the role of copper converter slag in simultaneously removing SO_(2)and NO_(x)using KMnO_(4)/copper converter slag slurry

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Journal of Environmental Sciences 2021年第10期33卷 33-43页

作者： Jiacheng Bao Kai Li Ping Ning Chi Wang xin song Yansu Luo xin Sun Faculty of Environment Science and Engineering Kunming University of Science and TechnologyKunming 650500China Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China

To achieve"waste controlled by waste",a novel wet process using KMnO_(4)/copper converter slag slurry for simultaneously removing SO_(2)and NO_(x)from acid-making tail gas was *** the solid-liquid separation for copper slag slurry,the liquid-phase part has a critical influence on removing NO_(x)and SO_(2).Also,the leached metal ions played a crucial role in the absorption of SO_(2)and NO_(x).Subsequently,the effects of single/multi-metal ions on NO_(x)removal was *** results showed that the leached metal from copper converter slag(Al^(3+),Cu^((2+),and Mg^((2+))and KMnO_(4)had a synergistic effect on NO_(x)removal,thereby improving the NO_(x)removal *** Fe^(2+) had an inhibitory effect on the NO_(x)removal owing to the reaction between Fe^(2+) and KMnO_(4),thereby consuming the KMnO_(4).Besides,SO_(2)was converted to SO_(4)^(2-) completely partly due to the liquid catalytic oxidation by metal *** XRD and XPS results indicated that the Fe(Ⅱ)species(Fe_(2)SiO_(4),Fe_(3)O_(4))in copper slag can react with H+ions with the generation of Fe^(2+),and further consumed the KMnO_(4),thereby resulting in a decrease in the NO_(x)*** characterization of the slags and solutions before and after reaction led us to propose the possible *** role of copper slag is as follows:(1)the alkaline substances in copper slag can absorb SO_(2)and NO_(2)by KMnO_(4)oxidation.(2)copper slag may function as a catalyst to accelerate SO_(2)conversion and improve NO_(x)removal by synergistic effect between leached metal ions and KMnO_(4).

关键词： Copper slag slurry Metal ions Desulfurization Denitrification Reaction mechanism

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Effect of internal defects on tensile strength in SLM additively-manufactured aluminum alloys by simulation

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Chinese Journal of Aeronautics 2023年第10期36卷 485-497页

作者： xin song Bowen FU xin CHEN Jiazhen ZHANG Tong LIU Chunpeng YANG Yifan YE School of Mechanical Power Engineering Harbin University of Science and TechnologyHarbin 150080China COMAC Beijing Aircraft Technology Research Institute Beijing 102211China

This research investigates the effect of internal defects on the tensile strength of Selective Laser Melting(SLM)additively-manufactured aluminum alloy(AlSi10Mg)test parts used for civil aircraft light weight design.A Finite Element Analysis(FEA)model containing internal defects was established by combining test data and the stress concentration factor comparison *** effect of variation in the number,location and shape of defects on the finite element results was *** results show that it is reasonable to use spherical defect *** finite element modeling and analysis methods are also applied to the study of the effect of internal defects on tensile strength in additive manufacturing of other metallic *** to the FEA results of single defects at different scales,the formula for calculating the weakening degree of tensile strength applicable to the defective area of less than 15%was *** result of the procedure is reliable and *** research results can guide the selection of process parameters for the additive manufacturing of aluminum ***,the research results can promote the application of metal additive manufacturing in designing light-weight civil aircraft structures.

关键词： Additive manufacturing Internal defects Tensile strength Elasticity FEA Simulation experiments

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