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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen xin-ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Dynamic Analysis of Stochastic Friction Systems Using the Generalized Cell Mapping Method

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Computer Modeling in Engineering & Sciences 2020年第1期122卷 49-59页

作者： Shichao Ma xin ning Liang Wang Northwestern Polytechnical University School of Astronautics Xi’an710072China National Key Laboratory of Aerospace Flight Dynamics Xi’an710072China Northwestern Polytechnical University School of Science Xi’an710129China

Friction systems are a kind of typical non-linear dynamical systems in the actual engineering and often generate abundant dynamics *** of non-smooth characteristics,it is difficult to handle these systems by conventional analysis methods *** the same time,random perturbation often affects friction systems and makes these systems more *** this context,we investigate the steady-state stochastic responses and stochastic P-bifurcation of friction systems under random excitations in this *** in order to retain the non-smooth of friction system,the generalized cell mapping(GCM)method is first used to the original stochastic friction systems without any approximate *** verify the accuracy and validate the applicability of the suggested approach,we present two classical nonlinear friction systems,i.e.,Coulomb force model and Dahl force model as ***,this method is in good agreement with the Monte Carlo simulation method and the computation time is greatly *** addition,further discussion finds that the adjustable parameters can induce the stochastic P-bifurcation in the two examples,*** stochastic P-bifurcation phenomena indicate that the stability of the friction system changes very sensitively with the *** of responses analysis and stochastic P-bifurcation has certain significances for the reliability and stability analysis of practical engineering.

关键词： Friction systems non-smooth stochastic responses cell mapping

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A geometry-based framework for modeling the complexity of origami folding

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Theoretical & Applied Mechanics Letters 2021年第3期11卷 115-124页

作者： Samuel Schulman xin ning Department of Aerospace Engineering The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA

This paper presents a quantitative framework to analyze the complexity of folding origami structures from flat *** efforts have realized intricate origami patterns with desired functions such as mechanical properties,packaging efficiency,and deployment ***,the complexity associated with the manufacturing or folding of origami patterns has not been *** how difficult origami structures are to make,and how much time they require to form is crucial information to determining the practical feasibility of origami designs and future applications such as robotic origami assembly in *** this work,we develop this origami complexity metric by modeling the geometric properties and crease formation of the origami structure,from which it outputs crease and pattern complexity values and a prediction of the time to complete the pattern assembly,based on the characteristics of the *** framework is experimentally validated by fabricating various Miura-ori origami paper models.

关键词： Origami folding Framework Miura-ori

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Spring-back deformation in tube bending

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 177-183页

作者： Da-xin E Hua-hui He Xiao-yi Liu Ru-xin ning School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081 China

The spring-back of a bending metal tube was studied through extensive experiments and finite element method （FEM） analysis. An approximate equation for the spring-back angle of bending was deduced. It is noted that the mechanical properties of the material （in a tubular form） are quite different from those found in the standard tensile tests （when the materials are in bar forms）. This is one of the major reasons that result in the discrepancies in the outcomes of experimental study, FEM calculations, and spring-back analysis. It is therefore of crucial importance to study the mechanical properties of the materials in their tubular forms. The experiments and FEM simulations prove that the spring-back angle is significantly affected by the mechanical properties of the materials. The angle decreases accordingly with plastic modulus, but changes inversely with the hardening index and elastic modulus The spring-back angle is also affected by the conditions of tube deformation： it increases accordingly with the relative bending radius but changes inversely with the relative wall thickness. In addition, the spring-back angle increases nonlinearly with the bending angle.

关键词： tube bending spring-back finite element simulation tensile test

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Complex response analysis of a non-smooth oscillator under harmonic and random excitations

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 641-648页

作者： Shichao MA xin ning Liang WANG Wantao JIA Wei XU School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China National Key Laboratory of Aerospace Flight Dynamics Xi’an 710072China School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an 710129China

It is well-known that practical vibro-impact systems are often influenced by random perturbations and external excitation forces,making it challenging to carry out the research of this category of complex systems with non-smooth *** address this problem,by adequately utilizing the stochastic response analysis approach and performing the stochastic response for the considered non-smooth system with the external excitation force and white noise excitation,a modified conducting process has *** the multiple nonlinear parameters,the non-smooth parameters,and the external excitation frequency into consideration,the steady-state stochastic P-bifurcation phenomena of an elastic impact oscillator are *** can be found that the system parameters can make the system stability topology *** effectiveness of the proposed method is verified and demonstrated by the Monte Carlo(MC)***,the conclusions show that the process can be applied to stochastic non-autonomous and non-smooth systems.

关键词： non-autonomous system non-smooth system random excitation

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Postcapture stabilization of space robots considering actuator failures with bounded torques

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Chinese Journal of Aeronautics 2018年第10期31卷 2034-2048页

作者： Xiaokui YUE Teng ZHANG Honghua DAI xin ning Jianping YUAN National Key Laboratory of Aerospace Flight Dynamics (AFDL) Northwestern Polytechnical University School of Astronautics Northwestern Polytechnical University Department of Mechanical Engineering University of Alberta

Space robotics is regarded as one of the most impressing approaches for space debris removal missions. Due to the residual momentum of debris, it is essential to stabilize the base rapidly after capture. This paper presents a novel control strategy for stabilization of a space robot in postcapture considering actuator failures and bounded torques. In the control strategy, the motion of the manipulator is not regarded as a disturbance to the base; in contrast, it is utilized to compensate for the limitation of the control torques by means of an inverse dynamical model of the system. Different scenarios where actuators are external mechanisms or momentum exchange devices have been carried out, and for actuator failures, both single-and two-actuator failures have been considered. Regarding to the performance of actuators, control torques are bounded. In cases that either single or two actuators have failed, the base can be stabilized kinematically when actuators are external mechanisms, but can only be stabilized dynamically when only momentum exchange devices are used. Finally, a space robot with a seven-degree-of-freedom manipulator in postcapture is studied to verify the validity and feasibility of the proposed control scheme. Simulation results show that the whole system can be stabilized rapidly.

关键词： Actuator failure Attitude control Bounded torque Postcapture Space robot

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Low Temperature Impact Toughness and Fracture Analysis of EN-GJS-400-18-LT Ductile Iron under Instrumented Impact Load

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Journal of Iron and Steel Research International 2015年第9期22卷 864-869页

作者： xin-ning ZHANG Ying-dong QU Rong-de LI School of Materials Science and Engineering Shenyang University of Technology

The impact toughness of EN-GJS-400-18-LT ductile iron was measured by Charpy V-notch impact test at temperature between-80 and 20℃.The fracture properties were tested under instrumented impact *** impact fracture energy,crack initiation and propagation energy,dynamic loads and the ductile to brittle temperature were ***-dimensional reconstruction of impact fracture morphology was accomplished by confocal laser scanning *** results of quantitative fractography indicate that cleavage fracture produces flatter fracture surfaces accompanying with less absorbed energy during the impact fracture *** indicates that fracture roughness has a close relationship with crack propagation energy at low temperature.

关键词： graphite nodule ductile to brittle transition cleavage fracture deformation twin three-dimensional reconstruction

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A Recursive DRL-Based Resource Allocation Method for Multibeam Satellite Communication Systems

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Chinese Journal of Electronics 2024年第5期33卷 1286-1295页

作者： Haowei MENG ning xin Hao QIN Di ZHAO State Key Laboratory of Integrated Services Networks Xidian University China Academy of Space Technology Institute of Telecommunication Satellite

Optimization-based radio resource management(RRM) has shown significant performance gains on high-throughput satellites(HTSs). However, as the number of allocable on-board resources increases, traditional RRM is difficult to apply in real satellite systems due to its intense computational complexity. Deep reinforcement learning(DRL) is a promising solution for the resource allocation problem due to its model-free advantages. Nevertheless, the action space faced by DRL increases exponentially with the increase of communication scale, which leads to an excessive exploration cost of the algorithm. In this paper, we propose a recursive frequency resource allocation algorithm based on long-short term memory(LSTM) and proximal policy optimization(PPO), called PPO-RA-LOOP,where RA means resource allocation and LOOP means the algorithm outputs actions in a recursive manner. Specifically, the PPO algorithm uses LSTM network to recursively generate sub-actions about frequency resource allocation for each beam, which significantly cuts down the action space. In addition, the LSTM-based recursive architecture allows PPO to better allocate the next frequency resource by using the generated sub-actions information as a prior knowledge, which reduces the complexity of the neural network. The simulation results show that PPO-RA-LOOP achieved higher spectral efficiency and system satisfaction compared with other frequency allocation algorithms.

关键词： Knowledge engineering Spectral efficiency Simulation Satellite broadcasting Neural networks Performance gain Resource management

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Congenital agenesis of seminal vesicle

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Asian Journal of Andrology 2005年第4期7卷 449-452,页

作者： Hong-Fei Wu Di Qiao Li-xin Qian ning-Hong Song ning-Han Feng Li-xin Hua Wei Zhang Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Congenital agenesis of the seminal vesicle （CASV） is frequently associated with congenital absence of the vas deferens （CAVD） or ipsilateral congenital vasoureteral communication. We reported two cases of a rare condition that the vas deferens open ectopically into Mullerian duct cyst associated with agenesis of the ipsilateral seminal vesicle. The diagnosis was confirmed by vasography. Transurethral unroofing of the Mullerian duct cyst was performed in both patients with favourable results, however, assisted reproductive technology （ART） was still necessary for them to father children.

关键词： seminal vesicle vas deferens congenital abnormalities vasography

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Association between the presence of H pylori in the liver and hepatocellular carcinoma: A meta-analysis

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World Journal of Gastroenterology 2008年第2期14卷 307-312页

作者： Shi-Ying Xuan Yong-ning xin An-Jin Chen Quan-Jiang Dong xin Qiang ning Li Ming-Hua Zheng Hua-Shi Guan College of Medicine and Pharmaceutics Ocean University of China Qingdao 266003Shandong Province China Qiaodao Municipal Hospital Qingdao University Medical College Qingdao 266021 Shandong Province China Department of Microbiology School of MedicineQingdao University Qingdao 266021 Shandong Province China Department of Infection and Liver Disease The First Affiliated Hospital of Wenzhou Medical CollegeWenzhou 325000 Zhejiang Province China

AIM： To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma （HCC）. METHODS： We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified under our selection criteria. A metaanalysis was carried out by a biostatistician according to the Cochrane Reviewers＇ Handbook recommended by The Cochrane Collaboration. RESULTS： Nine case-control studies and one retrospective cross sectional study were included in the final analysis. Overall the prevalence of H pylori infection was 53.3% （129 of 242） in cases and 10.4% （29 of 280） in controls, and the summary odds ratio for the association of H pylori infection with the risk for HCC （using the fixed-effects model, which accounted for the homogeneity across the 10 studies） was determined to be 13.63 （95% CI, 7.90-23.49）. CONCLUSION： Our analysis showed a positive association between F1 pylori infection and the risk of HCC, with an indication of possible publication bias and possible confounders due to study designs that showed results of less pronounced associations.

关键词： H pylori Hepatocellular carcinoma Meta-analysis Publication bias

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