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Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid

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World Journal of Psychiatry 2020年第7期10卷 150-161页

作者： xin-Yi long Shuang Wang Zhi-Wen Luo Xu Zhang Hong Xu Queen Mary School of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200433China Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Institute of Life Science Nanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Epilepsy is a complex neurological disorder characterized by recurrent,unprovoked seizures resulting from the sudden abnormal discharge of brain *** leads to transient brain dysfunction,manifested by abnormal physical movements and *** can occur at any age,affecting approximately 65 million worldwide,one third of which are still estimated to suffer from refractory *** is an urgent need for further establishment of seizure models in animals,which provides an approach to model epilepsy and could be used to identify novel anti-epileptic therapeutics in the *** To compare three administration modes for establishing a seizure model caused by N-Methyl-D-aspartic acid(NMDA)in *** Three administration routes of NMDA,including immersion,intravitreal injection and intraperitoneal injection,were compared with regard to their effects on inducing seizure-like behaviors in adult *** evaluated neurotoxicity by observing behavioral changes in zebrafish and graded those behaviors with a seizure *** addition,the protective effects of MK-801(Dizocilpine)and natural active constituent resveratrol against NMDA-induced alterations were *** The three NMDA-administration methods triggered different patterns of the epileptic process in adult *** scores were increased after increasing NMDA concentration regardless of the mode of ***,the curve of immersion continuously rose to a high plateau(after 50 min),while the curves of intravitreal injection and intraperitoneal injection showed a spike in the early stage(10-20 min)followed by a steady decrease in seizure ***,pretreatment with resveratrol and MK-801 significantly delayed seizure onset time and lowered seizure *** By comparing the three methods of administration,intravitreal injection of NMDA was the most suitable for establishing an acute epileptic model in ***,intraperitoneal i

关键词： Seizure Zebrafish N-Methyl-D-aspartic acid Administration modes

Biogenic volatile organic compounds dominated the near-surface ozone generation in Sichuan Basin,China,during fall and wintertime

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Journal of Environmental Sciences 2024年第7期141卷 215-224页

作者： Dasheng Huang Qing Li Yan Han Shi-Yong Xia Jiawei Zhou Hanxiong Che Keding Lu Fumo Yang xin long Yang Chen Research Center for Atmospheric Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China College of Resources and Environment Chongqing SchoolUniversity of the Chinese Academy of Sciences(UCAS Chongqing)Chongqing 400714China College of Environmental and Chemical Engineering Chongqing Three Gorges UniversityChongqing 404199China Key Laboratory for Urban Habitat Environmental Science and Technology School of Environment and EnergyPeking University Shenzhen Graduate SchoolLishui RoadNanshan DistrictShenzhen 518055China SKL-ESPC and BIC-ESAT College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China College of Architecture&Environment Sichuan UniversityChengdu 610065China

The complex air pollution driven by both Ozone(O_(3))and fine particulate matter(PM2.5)sig nificantly influences the air quality in the Sichuan Basin(SCB).Understanding the O_(3)for mation during autumn and winter is necessary to understand the atmospheric oxidative ***,continuous in-site field observations were carried out during the late summer,early autumn and winter of 2020 in a rural area of *** total volatile organic compounds(VOCs)concentration reported by a Proton-Transfer-Reaction Time-of Flight Mass Spectrometry(PTR-ToF-MS)were 13.66±9.75 ppb,5.50±2.64 ppb,and 9.41±5.11 ppb in late summer,early autumn and winter,*** anthropogenic VOCs(AVOCs)and biogenic VOCs(BVOCs)were 8.48±7.92 ppb and 5.18±2.99 ppb in late sum mer,3.31±1.89 ppb and 2.19±0.93 ppb in autumn,and 6.22±3.99 ppb and 3.20±1.27ppb in winter.A zero-dimensional atmospheric box model was employed to investigate the sensitivity of O_(3)-precursors by relative incremental reactivity(RIR).The RIR values of AV OCs,BVOCs,carbon monoxide(CO),and nitrogen oxides(NOx)were 0.31,0.71,0.09,and-0.36 for late summer,0.24,0.59,0.22,and-0.38 for early autumn,and 0.30,0.64,0.33 and-0.70 for winter,and the results showed that the O_(3)formation of sampling area was in the VOC-limited region,and O_(3)was most sensitive to BVOCs(with highest RIR values,>0.6)This study can be helpful in understanding O_(3)formation and interpreting the secondary formation of aerosols in the winter.

关键词： VOCs PTR-MS Model Ozone

Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： ANGUO WU JIAO YAN TING SU CHI FENG xin long YIRU PAN RUPEI YE TIAN XIA HANAN long JIANMING WU XIULI XIAO Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China School of Basic Medical Sciences Southwest Medical UniversityLuzhou646000China School of Clinical Medical Sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic ***(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer *** its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently *** study investigates PAL’s inhibitory effects on breast cancer using both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)*** at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug ***ﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A ***,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway *** TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size *** conclusion,the PAL and TRA combination emerges as a promising strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

Transition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines

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Organic Chemistry Frontiers 2022年第1期9卷 109-116页

作者： Li-Wen Sun Zi-Lun Yu xin-long Luo Mengtao Ma Zhi-Liang Shen Xue-Qiang Chu Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China Department of Chemistry and Materials Science College of ScienceNanjing Forestry UniversityNanjing 210037China

An efficient defluorinative net-[3+3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was *** present reaction proceeded successfully under transition-metal-free conditions to form two new C–N bonds and a new heterocyclic ring through a sequence of hydroamination,defluorination,and *** desired pyrimidines could be obtained with good functional group tolerance and moderate to good ***,the distinctive fluorine effects of perfluoroalkyl substituents are vital for tuning the reactivity of alkynes for the anticipated defluorinative *** pendantπsystem would lower associated bond dissociation energy significantly compared to that of a nonactivated C(sp^(3))–F bond.

关键词： cyclization pyrimidine Transition

Synthesis and Antiproliferative Activity of Novel [1,2,4]Triazolo[1,5-a]pyrimidine-7-amine Derivatives

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Chemical Research in Chinese Universities 2009年第4期25卷 474-479页

作者： ZHAI xin ZHANG Cun-long HE Lei LI Qi WANG Jiu-liang SHEN Xiao-li GONG Ping Key Laboratory of New Drugs Design and Discovery of Liaoning Province School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel N-anilino-2-substituted-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines,Bel-7402 and *** of the compounds inhibited the cell proliferation at a low *** compounds,VI5,VI7,VI10,and VI12―VI15,possessed marked antiproliferative activity superior to that of *** these seven initial hits,compound VI10 was the most active.

关键词： Triazolo[ 1,5-a]pyrimidines Antiproliferative activity Anticancer

Trace element and Nd isotope analyses of apatite in granitoids and metamorphosed granitoids from the eastern Central Asian Orogenic Belt:Implications for petrogenesis and post-magmatic alteration

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Geoscience Frontiers 2023年第2期14卷 71-85页

作者： xin-Yu long Jie Tang Wen-Liang Xu Chen-Yang Sun Jin-Peng Luan Shuai Xiong Xiao-Ming Zhang College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural Resources of ChinaChangchun 130061China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China State Key Laboratory of Superhard Materials Jilin UniversityChangchun 130012China

We present in situ trace element and Nd isotopic data of apatites from metamorphosed and metasomatized(i.e.,altered)and unaltered granitoids in the Songnen and Jiamusi massifs in the eastern Central Asian Orogenic Belt,with the aim of fingerprinting granitoid petrogenesis,including both the magmatic and post-magmatic evolution *** from altered granitoids(AG)and unaltered granitoids(UG)are characterized by distinct textures and geochemical *** from AG have irregular rim overgrowths and complex internal textures,along with low contents of rare earth elements(REEs),suggesting the re-precipitation of apatite during epidote crystallization and/or leaching of REEs from apatite by metasomatic ***(t)values of the these apatites are decoupled from zircon eHf(t)values for most samples,which can be attributed to the higher mobility of Nd as compared to Sm in certain *** from UG are of igneous origin based on their homogeneous or concentric zoned textures and coupled Nd-Hf isotopic *** element variations in igneous apatite are controlled primarily by the geochemical composition of the parental melt,fractional crystallization of other REEbearing minerals,and changes in partition *** contents and Eu/Eu^(*) values of apatites from UG correlate with whole-rock Sr and SiO2 contents,highlighting the effects of plagioclase fractionation during magma *** from UG can be subdivided into four groups based on REE *** 1 apatites have REE patterns similar to the host granitoids,but are slightly enriched in middle REEs,reflecting the influence of the parental melt composition and REE *** 2 apatites exhibit strong light REE depletions,whereas Group 3 apatites are depleted in middle and heavy REEs,indicative of the crystallization of epidote-group minerals and hornblende before and/or during apatite crystallization,*** 4 apatites are depleted in heavy REEs,but e

关键词： Eastern CAOB Granitoid petrogenesis Apatite geochemistry Fluid-induced alteration Nd-Hf isotopic decoupling Crustal assimilation

Interfacial Electronic Modulation of Dual-Monodispersed Pt–Ni_(3)S_(2) as Efficacious Bi-Functional Electrocatalysts for Concurrent H_(2) Evolution and Methanol Selective Oxidation

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Nano-Micro Letters 2024年第4期16卷 415-431页

作者： Qianqian Zhao Bin Zhao xin long Renfei Feng Mohsen Shakouri Alisa Paterson Qunfeng Xiao Yu Zhang Xian‑Zhu Fu Jing‑Li Luo Shenzhen Key Laboratory of Energy Electrocatalytic Materials Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Canadian Light Source Inc. SaskatoonSK S7N 0X4Canada Instrumental Analysis Center of Shenzhen University(Lihu Campus) Shenzhen UniversityShenzhen 518055People’s Republic of China

Constructing the efficacious and applicable bifunctional electrocatalysts and establishing out the mechanisms of organic electro-oxidation by replacing anodic oxygen evolution reaction(OER) are critical to the development of electrochemicallydriven technologies for efficient hydrogen production and avoid CO_(2) emission. Herein, the hetero-nanocrystals between monodispersed Pt(~ 2 nm) and Ni_(3)S_(2)(~ 9.6 nm) are constructed as active electrocatalysts through interfacial electronic modulation, which exhibit superior bi-functional activities for methanol selective oxidation and H_(2) generation. The experimental and theoretical studies reveal that the asymmetrical charge distribution at Pt–Ni_(3)S_(2) could be modulated by the electronic interaction at the interface of dual-monodispersed heterojunctions, which thus promote the adsorption/desorption of the chemical intermediates at the interface. As a result, the selective conversion from CH_(3)OH to formate is accomplished at very low potentials(1.45 V) to attain 100 m A cm^(-2) with high electronic utilization rate(~ 98%) and without CO_(2) emission. Meanwhile, the Pt–Ni_(3)S_(2) can simultaneously exhibit a broad potential window with outstanding stability and large current densities for hydrogen evolution reaction(HER) at the cathode. Further, the excellent bi-functional performance is also indicated in the coupled methanol oxidation reaction(MOR)//HER reactor by only requiring a cell voltage of 1.60 V to achieve a current density of 50 m A cm^(-2) with good reusability.

关键词： Dual-monodispersed heterostructure Electronic interactive modulation Reaction mechanism Methanol oxidation reaction Hydrogen generation

Urban dust in the Guanzhong Basin of China: A case study of urban dust pollution based on satellite data and WRF-Dust model

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Urban dust in the Guanzhong Basin of China: A case study of ...

Two polyoxovanadoborates with over 100 nuclei assembled from a {V_(14)Co_(12)B_(72)} cluster

第八届全国大气细及超细粒子技术研讨会暨PM_(2.5)源谱交流会

作者： long xin

Urban dust pollution becomes a major environmental problem due to rapid construction activities in China. However, it is very difficult to construct an urban dust inventory, owing to its small horizontal scale and strong temporal/spatial variability. A new method was proposed to calculate regional distributions of urban constructions, croplands and barrens using various satellite remote sensing data. It provides a new perspective to quantify regional assessment of urban dust on aerosol pollution, which is seldom quantified and reported, especially for regional constructions. Thereafter, the detailed distribution of the urban dust sources is applied in a dynamical/aerosol model(WRF-Dust) to assess the effect of dust sources on aerosol pollution. The result shows that by including the detailed dust sources, the calculated dust concentration averaged for 17 sites in the GZ Basin is significantly improved. In addition, the correlation coefficient between the calculated and measured dust concentrations is improved from 0.17 to 0.57, suggesting that the model has a better presentation in spatial variability. Further analysis shows that construction source is the major source(42%) of the dust at the urban sites.

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Science China Chemistry 2024年第8期67卷 2578-2585页

作者： Shuang-Xue Wu Yu-Jiao Dong Yang Yang Chao Qin Chun-Yi Sun Wei Guan xin-long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130013China Key Laboratory of Advanced Materials of Tropical Island Resources Hainan UniversityHaikou 570228China

Combining theoretical prediction and experimental exploration, the first sandwich-type polyoxovanadoborate(POVB) with an odd number of nuclei, [V_(11)B_(26)O_(73)(OH)_(10)]^(8-)(1), was discovered under hydrothermal conditions. Density-functional theory(DFT)gives a rationalization for the existence of this structure and the structural feature is consistent with the {V_NB_(2N+X)}(X = 2, 4, 6, 8)general formula. Excitingly, when Co and 1,10-phenanthroline(phen) are introduced into the synthesis of vanadoborates system,a 100-nuclei [Co_6(phen)_(10)(H_(2)O)_8][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·28H_(2)O(2) and a 102-nuclei [Co_6(phen)_(14)(H_(2)O)_(4)][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·23H_(2)O(3) with the same core structure of [V_(14)Co_(12)B_(72)]^(12-)are obtained. The vase-shaped [V_(14)Co_(12)B_(72)] polyanion is a multilayered sandwich-type structure containing seven distinct structural layers and is the largest known POVB. Furthermore, 2demonstrates exceptional thermal and chemical stability and serves as an efficient and stable catalyst for the photoreduction of carbon dioxide.

关键词： boronate metallic materials polyoxovanadoborates density functional theory photocatalysis CO_(2)reduction