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Network Pharmacology-based Analysis on the Molecular Biological Mechanisms of xin hui Tong Formula in Coronary Heart Disease Treatment

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Digital Chinese Medicine 2019年第2期2卷 86-96页

作者： WU Hua-Ying ZHANG Chen WANG Zhao-Hua ZHANG Shi-Ying LI Jing LI Feng HUANG hui-Yong LI Liang Provincial Key Laboratory of TCM Diagnostics Hunan University of Chinese MedicineChangshaHunan 410208China Department of Cardiology The Hunan Brain HospitalChangshaHunan 410007China Center for Oral/Head & Neck Oncology Research School of DentistryUniversity of CaliforniaLos AngelesCalifornia 90095USA Department of Traditional Chinese Medicine Luohu District People's HospitalShenzhenGuangdong 518001China

Objective To investigate the potential molecular mechanism of xin hui Tong Formula (XHTF) in the treatment of coronary heart disease (CHD) by using network pharmacology and bioinformatics. Methods The targets network of CHD was constructed through Therapeutic Targets Database (TTD) and Drugbank database;The XHTF pharmacodynamic molecule-targets network and the XHTF pharmacodynamic molecule-CHD targets network were explored by the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). And the multi-targets mechanism and molecular regulation network of XHTF in the treatment of CHD were explored from multiple perspectives by Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) database pathway enrichment analysis. Results A total of 88 CHD targets were screened out through the Therapeutic Targets and the Drugbank database. 393 compounds and corresponding 205 drug targets of XHTF were retrieved from TCMSP. A total of 13 known targets directly related to the development of CHD were retrieved from the disease-related databases: TP53, MAPK14, NFKB1, HSPA5, PLG, PTGS2, ADRB1, NOS2, CYP3A4, GRIA2, CYP2A6, GRIA1, PTGS1. XHTF also contained 118 drug targets that directly interact with CHD targets. GO enrichment analysis showed that the biological processes of 13 direct targets proteins were found to be mainly enriched in response to drug, cellular response to biotic stimulus, long-chain fatty acid metabolic process, fatty acid metabolic process and regulation of blood pressure. KEGG pathway enrichment analysis found that XHTF participated in the CHD pathological process mainly through retrograde endocannabinoid signaling, regulation of lipolysis in adipocytes, cAMP signaling pathway, chemical carcinogenesis and other pathways. Conclusions XHTF plays a role in the treatment of CHD through multiple targets and multiple pathways, and provides a scientific basis for the theory of "virtual standard" in the treatment of CH

关键词： xin hui Tong Formula (XHTF) Coronary heart disease Network pharmacology Network analysis Bioinformatics

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Principal components of nuclear mass models

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 65-71页

作者： xin-hui Wu Pengwei Zhao Department of Physics Fuzhou UniversityFuzhou 350108China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Principal component analysis(PCA)is employed to extract the principal components(PCs)present in nuclear mass models for the first *** effects from different nuclear mass models are reintegrated and reorganized in the extracted *** PCs are recombined to build new mass models,which achieve better accuracy than the original theoretical mass *** comparison indicates that using the PCA approach,the effects contained in different mass models can be collaborated to improve nuclear mass predictions.

关键词： nuclear mass principal component analysis nuclear models statistical methods

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Existence of multiple solutions for the laminar flow in a porous channel with suction at both slowly expanding and contracting walls

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 494-501页

作者： xin-hui Si Lian-cunZheng xin-xin Zhang Ying Chao Applied Science School University of Science and Technology Beijing Beijing 100083 China Department of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China Chemical Defense Institute of the PLA Beijing 102205 China

The asymptotic behavior of solutions of a similarity equation for the laminar flow in a porous channel with suction at both expanding and contracting walls has been obtained by using a singular perturbation ***,in the matching process,this solution neglects exponentially small *** take into account these exponentially small terms,a method involving the inclusion of exponentially small terms in a perturbation series was used to find two of the solutions *** series involving the exponentially small terms and expansion ratio predicts dual ***,the result indicates that the expansion ratio has much important influence on the solutions.

关键词： laminar flow porous channels multiple solutions singular perturbation method

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Estimating energy release performance of oxidizer-activated aluminum fuel particles under ultrafast stimulus

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Defence Technology（防务技术） 2023年第5期23卷 92-99页

作者： Ya-ru Li hui Ren xin-zhou Wu hui-xin Wang Xi-long Yu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China State Key Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of SciencesBeijing100190China

Aluminum(Al) particles are good fuel additives to improve the energy output performances of explosives. Under detonation environment, reaction delay of Al particles plays a key role in the energy release efficiency. Up to date, reaction delay of Al particles is still limited by the efficiency of mass and heat transfer from oxidizers to Al particles. To address this issue, a homogeneous fuel-oxidizer assembly has recently become a promising strategy. In this work, oxidizer-activated Al fuel particles(ALG) were prepared with glycidyl azide polymer(GAP) as the oxidizer. The ALG was in uniform spherical shape and core-shell structure with shell layer of around 5 nm which was observed by scanning electron microscope and transmission electron microscope. The localized nanoscale mid-IR measurement detected the uniform distribution of characteristic absorption bond of GAP in the shell layer which confirmed the homogenous fuel-oxidizer structure of ALG. A thermal gravimetric analysis of ALG at ultrafast heating rate of 1000℃/min under argon atmosphere was conducted. The decomposition of GAP finished much earlier than that of GAP at heating rate of 10℃/min. Under ultrafast high laser fluence, the reaction response of ALG was characterized and compared with that of micro-sized Al(μAl). With the increase of laser energy, the propagation distance of the shock wave increased. However, the velocity histories were nearly the same when energies were lower than 299 mJ or higher than 706 mJ. The propagation distance of the shock wave for ALG was 0.5 mm larger than that for μAl at 2.1 μs. The underwater explosion showed the peak pressure and the shock wave energy of the ALG-based explosive were both higher than those of the μAl-based explosive at 2.5 m. This study shows the feasibility to improve the energy release of Al-based explosives via using the oxidizer-activated Al fuel particles with energetic polymer as the oxidizer.

关键词： Aluminum Glycidyl azide polymer Laser Detonation Explosive Ultrafast stimulus

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Classical Chinese Herbal Formulas in the Treatment of Coronary Heart Disease: A Narrative Review

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Chinese Journal of Integrative Medicine 2021年第1期27卷 70-79页

作者： LU xin-hui LI Jun Southern Branch of Guang'anmen Hospital China Academyof Chinese Medical SciencesBeijing(102618)China Department of Cardiology Guang'anmen HospitalChinaAcademy of Chinese Medical SciencesBeijing(100053)China

Objective:To summarize the current evidence for 8 frequently prescribed Chinese herbal formulas(CHF)as treatments for angina pectoris in patients with coronary heart disease(CHD)and the associated adverse ***:Seven electronic databases were screened from their inception through July 2018 for all evidence related to classical CHF for the treatment of patients with ***:CHF improves CHD outcomes in terms of angina pectoris,electrocardiogram results,Chinese medicine syndromes and biomarkers *** combination of CHF and Western medicine(WM)is more effective on CHD than WM *** use of CHF to treat CHD shows the same or better clinical effects as the use of WM *** 8 investigated CHF do not induce hepatic and renal toxicity or other serious adverse ***:The safety and efficacy of 8 frequently prescribed herbal formulas for treating CHD have been confirmed in many *** findings of these studies are positive but should be interpreted cautiously due to the poor methodological quality of the randomized controlled trials(RCTs)and *** high-quality,multi-center,large-sample RCTs should be performed to confirm these results.

关键词： Chinese herbal formulas coronary heart disease complementary and alternative medicine review

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Symmetry Breaking Ground States of Bose-Einstein Condensates in 1D Double Square Well and Optical Lattice Well

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Communications in Theoretical Physics 2005年第5期43卷 814-818页

作者： YUANQing-xin DINGGuo-hui DepartmentofPhysics ShanghaiJiaoTongUniversityShanghai200240China

We investigate the phenomena of symmetry breaking and phase transition in theground state of Bose-Einstein condensates (BECs) trapped in a double square well and in an opticallattice well, respectively. By using standing-wave expansion method, we present symmetric andasymmetric ground state solutions of nonlinear Schroedinger equation (NLSE) with a symmetric doublesquare well potential for attractive nonlinearity. In particular, we study the ground state wavefunction's properties by changing the depth of potential and atomic interactions (here we restrictourselves to the attractive regime). By using the Fourier grid Hamiltonian method, we also reveal aphase transition of BECs trapped in one-dimensional optical lattice potential.

关键词： Bose-Einstein condensates symmetry breaking state phase transition

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Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He xin-hui Chen hui Li Kai-hua Shi hui-wen Xiong xin Xiang Li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

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Plasticity improvement of(Cu_(43)Zr_(48)Al_(9))_(98)Y_(2)bulk metallic glass composites by dispersed Ta particles

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China Foundry 2022年第3期19卷 275-280页

作者： Ke Yang Bing Li xin Wang xin-hui Fan School of Materials Science and Chemical Engineering Xi'an Technological UniversityXi'an 710021China

(Cu_(43)Zr_(48)Al_(9))_(98)Y_(2)-based bulk metallic glass composites(BMGCs)with dispersed Ta particles(3vol.%,6vol.%,9vol.%)were successfully fabricated through suction *** thermal properties,microstructure,and mechanical properties of the BMGCs were systematically *** particles are homogeneously dispersed in the amorphous *** particle reinforced BMGCs exhibit similar thermal properties and glass-forming ability with the Cu_(43)Zr_(48)Al_(9))_(98)Y_(2)base *** test results show that the BMGC with 9vol.%Ta particles has superior mechanical performance with up to 15.7%compressive plastic strain,2,216 MPa yield strength,and 2,260 MPa fracture strength at room *** homogeneously distributed Ta particles act as discrete obstacles in the amorphous matrix,restricting the highly localized shear *** results in the formation of multiple shear bands around the Ta-rich particles,which lowers the stress concentration,allowing the shear band to propagate further and improve plasticity.

关键词： bulk metallic glass composites Ta particles mechanical properties microstructure

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Automorphisms on the Poset of Products of Two Projections

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Acta Mathematica Sinica,English Series 2019年第8期35卷 1393-1401页

作者： xin hui WANG Guo xing JI School of Mathematics and Information Science Shaanxi Normal University

Let H be a complex Hilbert space with dim H ≥ 3 and B(H) the algebra of all bounded linear opera tors on H. Let ≤° be the diamond order on B(H), that is, for A, B ∈B(H), we say that A ≤° B if R(A)■ R(B), R(A^*)■ R(B^*) and AA^*A= AB^*A. Put Λ={PQ : P、Q ∈B(H) are projections}. In this paper, the relationship between Λ and ≤° is revealed and then the form of automorphisms of the poset (Λ,≤°) is given.

关键词： Partial order diamond order product of two projections automorphism

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Spring-back deformation in tube bending

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 177-183页

作者： Da-xin E Hua-hui He Xiao-yi Liu Ru-xin Ning School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081 China

The spring-back of a bending metal tube was studied through extensive experiments and finite element method （FEM） analysis. An approximate equation for the spring-back angle of bending was deduced. It is noted that the mechanical properties of the material （in a tubular form） are quite different from those found in the standard tensile tests （when the materials are in bar forms）. This is one of the major reasons that result in the discrepancies in the outcomes of experimental study, FEM calculations, and spring-back analysis. It is therefore of crucial importance to study the mechanical properties of the materials in their tubular forms. The experiments and FEM simulations prove that the spring-back angle is significantly affected by the mechanical properties of the materials. The angle decreases accordingly with plastic modulus, but changes inversely with the hardening index and elastic modulus The spring-back angle is also affected by the conditions of tube deformation： it increases accordingly with the relative bending radius but changes inversely with the relative wall thickness. In addition, the spring-back angle increases nonlinearly with the bending angle.

关键词： tube bending spring-back finite element simulation tensile test

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