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声学学报 1987年第2期 151-154页

作者：裘辛方韩嗣康中国科学院声学研究所

当频率高于10kHz时，海水的声吸收主要是硫酸镁的化学驰豫声吸收和纯水的吸收，多年来，由Schulkin和Marsh所提出的海水声吸收公式得到了广泛的应用，不过，早在1965

关键词：化学弛豫弛豫频率硫酸镁硫酸盐海水温度关系声吸收声性质

Existence of Solutions for a Quasilinear Schr?dinger Equation with Potential Vanishing

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Acta Mathematicae Applicatae Sinica 2023年第3期39卷 696-706页

作者： Yan-fang XUE Jian-xin han xin-cai ZHU School of Mathematics and Statistics Xinyang Normal UniversityHenan 464000China

We study the following quasilinear Schrodinger equation-△u+V(x)u-△(u^(2))u=K(x)g(u),x∈R^(3),where the nonlinearity g(u)is asymptotically cubic at infinity,the potential V(x)may vanish at *** appropriate assumptions... 详细信息

关键词： quasilinear SchrOdinger equation vanishing potential asymptotically cubic mountain pass theorem

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-han Yu Yi-Hua Wang Yi-xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Dynamical properties of the Haldane chain with bond disorder

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Frontiers of physics 2022年第3期17卷 43-51页

作者： Jing-Kai fang Jun-han Huang han-Qing Wu Dao-xin Yao Center for Neutron Science and Technology School of PhysicsSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China

By using Lanczos exact diagonalization and quantum Monte Carlo combined with stochastic analytic continuation,we study the dynamical properties of the S=1 antiferromagnetic Heisenberg chain with different strengths of bond *** the weak disorder region,we find weakly coupled bonds which can induce additional low-energy excitation below the one-magnon *** the disorder increases,the average Haldane gap closes at δ_(∆)~0.5 with more and more low-energy excitations coming *** the critical disorder strength δ_(C)~1,the system reaches a random-singlet phase with prominent sharp peak atω=0 and broad continuum atω>0 of the dynamic spin structure *** addition,we analyze the distribution of random spin domains and numerically find three kinds of domains hosting effective spin-1/2 quanta or spin-1 sites in ***“spins”can form the weakly coupled longrange singlets due to quantum fluctuation which contribute to the sharp peak atω=0.

关键词： Haldane chain Heisenberg model magnetic excitation quantum phase transition random singlet disorder exact diagonalization quantum Monte Carlo

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干细胞的趋电性迁移及机制

中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin xin Lu Bing-Chun Yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Design and investigation of dopingless double-gate line tunneling transistor: Analog performance, linearity, and harmonic distortion analysis

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Chinese Physics B 2020年第10期29卷 556-565页

作者： Hui-fang Xu xin-Feng han Wen Sun Institute of Electrical and Electronic Engineering Anhui Science and Technology UniversityFengyang 233100China

The tunnel field-effect transistor (TFET) is proposed by using the advantages of dopingless and line-tunneling technology. The line tunneling is created due to the fact that the gate electric field is aligned with the tunneling direction, which dramatically enhances tunneling area and tunneling current. Moreover, the effects of the structure parameters such as the length between top gate and source electrode, the length between top gate and drain electrode, the distance between bottom gate and drain electrode, and the metal position on the on-state current, electric field and energy band are investigated and optimized. In addition, analog/radio-frequency performance and linearity characteristics are studied. All results demonstrate that the proposed device not only enhances the on/of current ratio and reduces the subthreshold swing, but also offers eight times improvement in cut-off frequency and gain band product as compared with the conventional point tunneling dopingless TFET, at the same time;it shows better linearity and small distortions. This proposed device greatly enhances the potential of applications in dopingless TFET.

关键词： dopingless tunnel field effect transistor line tunneling lincarity parameters

单层Janus Ga_(2)SSe光催化水解性质的第一性原理研究

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原子与分子物理学报 2025年第3期42卷 45-51页

作者：胡新华廖杨芳贵州省贵阳市乌当区第四中学贵阳550018 贵州师范大学物理与电子科学学院贵阳550025

光催化水解制氢为解决能源危机和环境污染问题提供了一种可行的策略.本文通过第一性原理计算,提出了单层Janus Ga_(2)SSe是一种有效的水解光催化剂.结构稳定性分析表明,单层Janus Ga_(2)SSe具有能量和动力学稳定性.电子性质表明,单层Jan... 详细信息

光催化水解制氢为解决能源危机和环境污染问题提供了一种可行的策略.本文通过第一性原理计算,提出了单层Janus Ga_(2)SSe是一种有效的水解光催化剂.结构稳定性分析表明,单层Janus Ga_(2)SSe具有能量和动力学稳定性.电子性质表明,单层Janus Ga_(2)SSe属于间接带隙半导体,有利于降低载流子的复合几率.光催化性能分析表明,单层Janus Ga_(2)SSe的能带边缘位置适合PH=0~14宽范围的光催化水解.此外,单层Janus Ga_(2)SSe具有较高的紫外光和可见光吸收、较大的内建电场、较小的载流子有效质量保证了光生载流子有效分离并快速迁移到反应活性位点参与水的氧化还原反应.研究结果为单层Janus Ga_(2)SSe的合成及其作为水解光催化剂的潜在应用提供了有价值的理论指导.

关键词： Janus材料光催化水解第一性原理

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin