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Standard-definition White-light,High-definition White-light versus Narrow-band Imaging Endoscopy for detecting Colorectal Adenomas:A Multicenter Randomized Controlled Trial

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Current Medical Science 2024年第3期44卷 554-560页

作者： Chang-wei DUAN Hui-hong ZHAI Hui XIE Xian-zong MA Dong-liang YU Lang YANG xin WANG Yu-fen tang Jie ZHANG Hui SU Jian-qiu SHENG Jun-feng XU Peng JIN Chinese PLA General Hospital and Medical School Beijing100853China department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing100053China department of Gastroenterology The Seventh Medical Center of Chinese PLA General HospitalBeijing100700China Senior department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing100853China

Objective This study aimed to compare the performance of standard-definition white-light endoscopy(SD-WL),high-definition white-light endoscopy(HD-WL),and high-definition narrow-band imaging(HD-NBI)in detecting colorectal lesions in the Chinese *** This was a multicenter,single-blind,randomized,controlled trial with a non-inferiority *** undergoing endoscopy for physical examination,screening,and surveillance were enrolled from July 2017 to december *** primary outcome measure was the adenoma detection rate(ADR),defined as the proportion of patients with at least one adenoma *** associated factors for detecting adenomas were assessed using univariate and multivariate logistic *** Out of 653 eligible patients enrolled,data from 596 patients were *** ADRs were 34.5%in the SD-WL group,33.5%in the HD-WL group,and 37.5%in the HD-NBI group(P=0.72).The advanced neoplasm detection rates(ANDRs)in the three arms were 17.1%,15.5%,and 10.4%(P=0.17).No significant differences were found between the SD group and HD group regarding ADR or ANDR(ADR:34.5%vs.35.6%,P=0.79;ANDR:17.1%vs.13.0%,P=0.16,respectively).Similar results were observed between the HD-WL group and HD-NBI group(ADR:33.5%vs.37.7%,P=0.45;ANDR:15.5%vs.10.4%,P=0.18,respectively).In the univariate and multivariate logistic regression analyses,neither HD-WL nor HD-NBI led to a significant difference in overall adenoma detection compared to SD-WL(HD-WL:OR 0.91,P=0.69;HD-NBI:OR 1.15,P=0.80).Conclusion HD-NBI and HD-WL are comparable to SD-WL for overall adenoma detection among Chinese *** can be concluded that HD-NBI or HD-WL is not superior to SD-WL,but more effective instruction may be needed to guide the selection of different endoscopic methods in the *** study’s conclusions may aid in the efficient allocation and utilization of limited colonoscopy resources,especially advanced imaging technologies.

关键词： standard-definition white-light endoscopy high-definition white-light endoscopy narrow-band imaging colonoscopy colorectal cancer screening adenoma detection rate

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design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie Xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen tang Cheng-xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity wasdetector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model

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Chinese Medical Journal 2024年第12期137卷 1453-1464页

作者： Xia Qiu Hedong Zhang Zhouqi tang Yuxi Fan Wenjia Yuan Chen Feng Chao Chen Pengcheng Cui Yan Cui Zhongquan Qi Tengfang Li Yuexing Zhu Liming Xie Fenghua Peng Tuo deng xin Jiang Longkai Peng Helong Dai Medical College Guangxi UniversityNanningGuangxi 530004China department of Kidney Transplantation Center of Organ TransplantationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China department of Organ Transplantation The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People’s Hospital)ZhengzhouHenan 450000China

Background:Homoharringtonine(HHT)is an effective anti-inflammatory,anti-viral,and anti-tumor protein synthesis inhibitor that has been applied ***,we explored the therapeutic effects of HHT in a mouse heart transplant ***:Healthy C57BL/6 mice were used to observe the toxicity of HHT in the liver,kidney,and hematology.A mouse heart transplantation model was constructed,and the potential mechanism of HHT prolonging allograft survival was evaluated using Kaplan-Meier analysis,immunostaining,and bulk RNA sequencing *** HHT-T cell crosstalk was modeled ex vivo to further verify the molecular mechanism of HHT-induced regulatory T cells(Tregs)***:HHT inhibited the activation and proliferation of T cells and promoted their apoptosis ex *** of 0.5 mg/kg HHT for 10 days significantly prolonged the mean graft survival time of the allografts from 7 days to 48 days(P<0.001)without non-immune *** allografts had long-term survival after continuous HHT treatment for 28 *** significantly reduced lymphocyte infiltration in the graft,and interferon-γ-secreting CD4^(+)and CD8^(+)T cells in the spleen(P<0.01).HHT significantly increased the number of peripheral Tregs(about 20%,P<0.001)and serum interleukin(IL)-10 *** downregulated the expression of T cell receptor(TCR)signaling pathway-related genes(CD4,H2-Eb1,TRAT1,and CD74)and upregulated the expression of IL-10 and transforming growth factor(TGF)-βpathway-related genes and Treg signature genes(CTLA4,Foxp3,CD74,and ICOS).HHT increased CD4^(+)Foxp3^(+)cells and Foxp3 expression ex vivo,and it enhanced the inhibitory function of inducible ***:HHT promotes Treg cell differentiation and enhances Treg suppressive function by attenuating the TCR signaling pathway and upregulating the expression of Treg signature genes and IL-10 levels,thereby promoting mouse heart allograft *** findings may have therapeutic implications for organ tr

关键词： Heart transplantation Homoharringtonine Immunosuppressive agents T-lymphocytes,Regulatory Graft acceptance

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弱电网下提高并网变流器稳定性的导纳重塑方法

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中国电机工程学报 2024年第15期44卷 6123-6135,I0024页

作者：唐欣李珍唐凯璇何洋屈贝岳雨霏电网防灾减灾全国重点实验室(长沙理工大学) 湖南省长沙市410114

并网变流器接入弱电网易发生振荡问题,基于无源性理论提出一种导纳重塑控制策略来提高系统稳定性能,使并网系统在中低频段不受电网等值阻抗的影响。首先,为了便于构造严格正实的变流器导纳矩阵,将变流器导纳模型分解为两个子系统进行分... 详细信息

并网变流器接入弱电网易发生振荡问题,基于无源性理论提出一种导纳重塑控制策略来提高系统稳定性能,使并网系统在中低频段不受电网等值阻抗的影响。首先,为了便于构造严格正实的变流器导纳矩阵,将变流器导纳模型分解为两个子系统进行分析,找出可重塑的控制环节;然后,基于正实方法设计了外环重塑矩阵M和内环重塑矩阵N,使并网系统在中低频段内渐进稳定。此外,导纳重塑后的系统是一个对称系统即单输入单输出系统,可方便求取系统的稳定裕度。仿真和实验均验证了所提导纳重塑方法在提高系统稳定性和简化系统稳定性分析的可行性和有效性。

关键词：弱电网正实方法导纳重塑系统稳定性单输入单输出

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A novel deep generative model for mRNA vaccine development: designing 5′ UTRs with N1-methyl-pseudouridine modification

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1814-1826页

作者： Xiaoshan tang Miaozhe Huo Yuting Chen Hai Huang Shugang Qin Jiaqi Luo Zeyi Qin xin Jiang Yongmei Liu xing Duan Ruohan Wang Lingxi Chen Hao Li Na Fan Zhongshan He Xi He Bairong Shen Shuai Cheng Li Xiangrong Song Institute of Systems Genetics Department of Critical Care MedicineFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China department of Computer Science City University of Hong KongHong Kong 99907China department of Biology Brandeis UniversityBostonMA 02453USA

Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA ***,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'*** discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'*** response,we developed a novel machine learning-based tool,Smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in *** tailored loss function and network architecture enable Smart5UTR to overcome limitations inherent in existing *** a result,Smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine ***,Smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the delta and Omicron variants of SARS-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.

关键词： mRNA vaccine Machine learning 5'UTR mRNA design Sequence design N1-Methyl-pseudouridine COVID-19 SARS-CoV-2

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基于图卷积神经网络的室内穿墙无源目标检测算法

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电子学报 2024年第2期52卷 614-625页

作者：杨小龙唐婷李兆玉唐鑫星重庆邮电大学通信与信息工程学院重庆400065

针对室内穿墙场景下目标状态差异而导致的信道状态信息(Channel State Information,CSI)功率谱密度在时序发生相应变化规律的不同,本文提出了一种基于图卷积神经网络(Graph Convolutional Neural,GCN)的室内穿墙无源目标检测算法.不同... 详细信息

针对室内穿墙场景下目标状态差异而导致的信道状态信息(Channel State Information,CSI)功率谱密度在时序发生相应变化规律的不同,本文提出了一种基于图卷积神经网络(Graph Convolutional Neural,GCN)的室内穿墙无源目标检测算法.不同于传统的基于CSI的统计特征实现目标检测的相关系统,该算法从CSI的图域出发,基于CSI时频图特征构建得到GCN图结构后,使用可实现对复杂图中各节点进行分类的GCN作为分类器,提高了室内复杂环境下目标检测的性能.该方法在对原始CSI进行异常值去除和小波阈值去噪的基础上,利用短时傅里叶变换得到每个子载波上CSI幅值的时频图;然后根据各子载波CSI时频图特点,将存在能量的频率平均分为5个频段,再计算每个频段的平均功率谱密度,并在每个时序对其进行排序;最后基于对平均功率谱密度排序后各频段索引的变化规律构造GCN图,并将其邻接矩阵和特征矩阵输入GCN网络中进行训练,最终实现图节点特征与目标状态的一一映射.实验结果表明,在玻璃墙和砖墙场景下,本文提出的算法能够很好地刻画目标状态不同而导致的CSI功率谱密度变化规律的差异,且其平均检测准确率均高于现有的R-TTWD(Robust device-free Through-The-Wall detection)和TWMD(The-Wall Moving detection)目标检测算法.

关键词： Wi-Fi 信道状态信息穿墙目标检测短时傅里叶变换图卷积神经网络

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风格捕捉:基于人工智能技术的优秀传统文化数字化实践

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包装工程 2024年第10期45卷 168-173页

作者：唐欣冯乔广州美术学院广州510261

目的厘清峇迪艺术所面临的传承与发展困境,分析当前勾连人工智能技术与峇迪艺术时所存在的不足,解决人工智能技术在传承与发展峇迪艺术时所面临的问题。方法在马来西亚所进行的为期3个月的田野调查中,与当地蜡染坊艺术家进行了深度访谈... 详细信息

目的厘清峇迪艺术所面临的传承与发展困境,分析当前勾连人工智能技术与峇迪艺术时所存在的不足,解决人工智能技术在传承与发展峇迪艺术时所面临的问题。方法在马来西亚所进行的为期3个月的田野调查中,与当地蜡染坊艺术家进行了深度访谈;梳理个人新媒体艺术作品“神经元蜡染”的创作经验。结果开发了一套基于机器学习算法的卷积神经网络作画系统——“神经元蜡染”,它能够让体验者通过便利的人机交互方式,将线下的普通画作实时转化为具有传统峇迪风格的在线艺术作品,具象了体验者的想法并将其呈现在数字界面中,实现了人工智能、生成艺术与传统峇迪工艺的双向互动。结论“神经元蜡染”不仅以数字化的手段为峇迪艺术提供了更加多元的表现方法,实现了古老技艺的传承和发展;还消除了时间和空间所带来的传播局限性,以蜡染为媒介增强了不同文化之间的交往、交流和交融。

关键词：峇迪蜡染工艺人工智能数字化发展新媒体传播

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激光散斑衬比成像技术在慢性脑缺血动物模型中的应用研究进展

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中国比较医学杂志 2024年第2期34卷 154-160页

作者：唐鑫谭洁湖南中医药大学针灸推拿与康复学院长沙410208

激光散斑衬比成像技术采用可视化、可量化的方法实时动态测量组织或器官的微循环血流量。因其活体检测、实时成像及操作简单等优点,已在微循环检测的多个领域中应用。慢性脑缺血动物模型主要通过减少双侧颈总动脉向大脑输送血流量的方... 详细信息

激光散斑衬比成像技术采用可视化、可量化的方法实时动态测量组织或器官的微循环血流量。因其活体检测、实时成像及操作简单等优点,已在微循环检测的多个领域中应用。慢性脑缺血动物模型主要通过减少双侧颈总动脉向大脑输送血流量的方法造模,可造成脑供血长期不足。激光散斑衬比成像技术可通过对慢性脑缺血动物模型皮层脑血流量、侧支循环开放、神经血管耦合反应等进行观察分析,从而判断动物模型造模是否成功及干预方法对其的治疗效果。本文就激光散斑衬比成像技术在慢性脑缺血动物模型中的应用及其优缺点进行总结,以期为临床治疗和科研提供新思路。

关键词：激光散斑衬比成像慢性脑缺血动物模型综述

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中国城乡居民养老保险的收入差距调节效应

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北京理工大学学报（社会科学版） 2024年第3期26卷 144-157页

作者：李宏唐新东北财经大学公共管理学院辽宁大连116025

城乡居民基本养老保险作为社会养老保险体系的核心组成部分,理应在更好解决“老有所养”的同时,发挥出进一步破解城乡二元格局、调节收入分配和缩小城乡差距的功能与效果。基于相关年份分省面板数据和中国家庭追踪调查(CFPS)数据,对现... 详细信息

城乡居民基本养老保险作为社会养老保险体系的核心组成部分,理应在更好解决“老有所养”的同时,发挥出进一步破解城乡二元格局、调节收入分配和缩小城乡差距的功能与效果。基于相关年份分省面板数据和中国家庭追踪调查(CFPS)数据,对现阶段城乡居民基本养老保险收入差距调节效应,结合宏观和微观两个视角逐步进行了实证检验与分析探讨。研究结果表明,在全国层面上,现阶段城乡居民基本养老保险发展与城乡收入差距之间存在显著非线性关系,并且呈现出先扩大而后缩小的“倒U形”轨迹;同时,微观检验也部分地验证了这一结果。为此提出:(1)应高度重视城乡居民基本养老保险的收入分配调节功能与差异化发展趋势;(2)应逐步完善城乡居民基本养老保险的缴费和待遇调整机制;(3)应通过高质量发展和促进农民和弱势群体收入增长来更好地发挥城乡居民基本养老保险的消除老年贫困和收入分配调节功能。

关键词：城乡居民基本养老保险城乡居民收入收入差距调节

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Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

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Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-Hao Chen Han Yi Min Xiao Pin-Jing Cheng xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun tang Wen Luo Bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

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