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Portal vein thrombosis in a noncirrhotic patient after hemihepatectomy:A case report and review of literature

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World Journal of Clinical Cases 2022年第20期10卷 7130-7137页

作者： Shu-Bin Zhang Zi-Xuan Hu Zhong-Qiang xing Ang Li xin-bo zhou Jian-Hua Liu Department of Hepatobiliary Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Hepatobiliary Surgery The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Portal vein thrombosis(PVT)is a condition caused by hemodynamic *** may be noted in the portal vein system when there is an inflammatory stimulus in the abdominal ***,PVT is rarely reported after *** present,related guidelines and major expert opinions tend to consider vitamin K antagonists or low-molecular weight heparin(LMWH)as the standard *** based on research,direct oral anticoagulants may be more effective and safe for noncirrhotic PVT and are also beneficial by reducing the recurrence rate of *** SUMMARY A 51-year-old woman without any history of disease felt discomfort in her right upper abdomen for 20 d,with worsening for 7 ***-enhanced computed tomography(CECT)of the upper abdomen showed right liver intrahepatic cholangiocarcinoma with multiple intrahepatic metastases but not to the left ***,she underwent right hepatic and caudate *** week after surgery,the patient underwent a CECT scan,due to nausea,vomiting,and abdominal *** in the left branch and main trunk of the portal vein and near the confluence of the splenic vein was *** using LMWH for 22 d,CECT showed no filling defect in the portal vein *** Although PVT after hepatectomy is rare,it needs to be prevented during the perioperative period.

关键词： Portal vein thrombosis Hemihepatectomy Anticoagulation Noncirrhosis Low-molecular weight heparin Case report

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia zhou bo Ma Yan Luan xin Wang xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao xin-bo zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-zhou Li Wei-Quan Xu Jia-Bao Liao Wei-bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Primordial Black Holes and Cosmic String Loop

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Chinese Physics Letters 1996年第4期13卷 317-320页

作者： CHENG Hong-bo LI xin-zhou East China Institute for Theoretical Physics Shanghai 200237 School of Science East China University of Science and TechnologyShanghai 200237 Department of Physics Shanghai Teacher's UniversityShanghai 200234

The elliptic loop equation of cosniic string is studied in the Minkowski space and during the radiation-dominated era in the Robertson-Walker universe.A remarkable fact about this equation is that a loop may never con... 详细信息

关键词： equation radius circular

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng Li bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules in live cells and in vivo

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 4-33页

作者： Yongqing zhou xin Wang Wei Zhang bo Tang Ping Li College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano Probes(Ministry of Education)Institutes of Biomedical SciencesShandong Normal UniversityJinan 250014China

The interrelationships and synergistic regulations of bioactive molecules play pivotal roles in physiological and pathological processes involved in the initiation and development of some diseases,such as cancer and neurodegenerative and cardiovascular ***,the simultaneous,accurate and timely detection of two bioactive molecules is crucial to explore their roles and pathological mechanisms in related *** imaging associated with small molecular probes has been widely used in the imaging of bioactive molecules in living cells and in vivo due to its excellent performances,including high sensitivity and selectivity,noninvasive properties,real-time and high spatial temporal *** organic molecule fluorescent probes have been successively developed to simultaneously monitor two biomolecules to uncover their synergistic relationships in living ***,in this review,we focus on summarizing the design strategies,classifications,and bioimaging applications of dual-response fluorescent probes over the past ***,future research directions in this field are proposed.

关键词： bioactive molecules fluorescent probes in living cells and in vivo review

DC performance and AC loss of cable-in-conduit conductors for International Thermonuclear Experimental Reactor

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Nuclear Science and Techniques 2016年第3期27卷 176-185页

作者： Wei zhou xin-Yu Fang Jin Fang bo Liu School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Electrical and Computer Engineering University of VictoriaVictoriaBC V8W2Y2Canada Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

A reliable prediction of AC loss is essential for the application of International Thermonuclear Experimental Reactor(ITER) cable-in-conduit conductors(CICCs);however,the calculation of AC loss of ITER CICCs is a cumbersome task due to the complicated geometry of the multistage cables and the extreme operating conditions in *** this paper,we described the models developed for hysteresis and coupling loss calculation,which can be suitable for the construction of ITER magnetic ***,we compared the results of theoretical analysis with the SULTAN test result to evaluate the numerical model we *** addition,we introduced the n-value and AC loss with transport current for CICCs based on the DC measurement results at SULTAN,which lays the foundation for the further study.

关键词：国际热核聚变实验堆交流损耗电缆导体电缆导管直流测量 ITER计划国际热核实验反应堆性能

Casimir Energies on a Twisted Two-Torus

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Chinese Physics Letters 2001年第9期18卷 1163-1166页

作者： CHENG Hong-bo LI xin-zhou Department of Physics Shanghai Teachers UniversityShanghai 2002342 Institute for Theoretical Physics East China University of Science and TechnologyShanghai 200237

We consider a twisted massless multiplet on a two-torus, one side with a normal boundary and the other with a twisted boundary. The Casimir energy is calculated and regularized by means of the Epstein-Hurwitz-type zeta-function introduced by Elizalde. The resulting dimensions of spacetime for the twisted case may be *** results are compared with those of the untwisted case. Since twisted Casimir energy is lower than untwisted energy, the untwisted case may change into the twisted state in the spacetime.

关键词： twisted Casimir integers