检索结果-南通市图书馆

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of general Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Pharmacological targeting cgAS/STINg/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cgAS/STINg/NF-κB ***,we found that targeting the cgAS/STINg/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cgAS/STINg/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cgAS/STINg functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Fe_(0.8)CoSe_(2) nanosphere coated by N-doped carbon for ultra- high rate potassium selenium battery

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2021年第9期40卷 2455-2463页

作者： xin-xin jia xin-Zhi Yu Bing-An Lu Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China

Potassium-selenium(K-Se) batteries are a promising electrical energy storage candidate because of the cost-effectiveness and material sustainability, yet they suffer from shuttle effect, volume expansion and low powder density. The development of Se-based cathode is an effective way to overcome the above issues. Here we designed a hollow nano-spherical Co-Fe bi-metallic selenide coated with N-doped carbon(denoted as CFS@N-C)as cathode for K-Se batteries. Bimetallic selenide is benefit to improve the conductivity of composite materials;N-doped carbon layer encapsulation effectively inhibits the dissolution of poly-selenides and relieves the volume expansion. The as-prepared K-Se battery exhibits excellent rate performance(300 mAh·g^(-1) at 1000 mA·g^(-1)) and slowcharge/ultrafast-dischargecapability(dischargeat5000 mA·g^(-1) and charge at 100 mA·g^(-1) with ultrahigh capacity of 227 mAh·g^(-1)) with Coulombic efficiency nearly 100%. In addition, the ex-situ high-resolution transmission electron microscopy(HRTEM) images reveal that the charge–discharge mechanism of CFS@N-C is K^(+) replaces the bimetal and forms K_(2)Se. The unique design in this work may provide certain directions on researching for high power density K-storage materials.

关键词： Potassium selenium battery High powder density Excellent rate performance Inhibit shuttle effects Tolerate volume changes

Joint number and DOA estimation via the eigen-beam mCapon method for closely spaced sources

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2015年第12期58卷 217-219页

作者： gAO Yang XU jia jia xin Academy of Equipment School of Information and Electronics Beijing Institute of Technology

Dear editor,The source number and direction of arrival(DOA)estimation are two important subjects in array signal processing[1,2].Many algorithms for estimating these parameters have been proposed in the past

关键词： DOA Joint number and DOA estimation via the eigen-beam mCapon method for closely spaced sources MUSIC

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LgZgD)has therapeutic effects on *** mechanism of LgZgD still remains *** study was to examine the impact of LgZgD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LgZgD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LgZgD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LgZgD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LgZgD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LgZgD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AgXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LgZgD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LgZgD untargeted metabolomics glycerophospholipid metabolism citrate cycle

SiS_(2)/ZnO范德华异质结光催化水分解第一性原理研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第6期42卷 31-36页

作者：李家豪黄欣杨志红南京邮电大学电子与光学工程学院、柔性电子(未来技术)学院南京210023 南京邮电大学理学院南京210023

基于第一性原理方法,研究了SiS_(2)/ZnO范德华异质结的电子结构和光催化性质.结果表明,SiS_(2)/ZnO异质结是带隙值为1.32 eV的半导体材料,表现出交错排列的能带结构.在异质结界面处,形成了从ZnO指向SiS_(2)的内置电场,该内置电场的存在... 详细信息

基于第一性原理方法,研究了SiS_(2)/ZnO范德华异质结的电子结构和光催化性质.结果表明,SiS_(2)/ZnO异质结是带隙值为1.32 eV的半导体材料,表现出交错排列的能带结构.在异质结界面处,形成了从ZnO指向SiS_(2)的内置电场,该内置电场的存在使得SiS_(2)/ZnO异质结中形成了特殊的“Z-型”载流子迁移模式,有利于电子空穴对的有效分离,同时增强了载流子的氧化还原能力.异质结构具有良好的热力学稳定性,且带边位置跨越水的氧化还原电位.与单层材料相比,SiS_(2)/ZnO异质结光吸收谱出现红移现象,表现出更宽的光吸收范围(从可见光到紫外光)及更强的光吸收强度(达到10~5 cm^(-1)量级).另外,通过施加双轴应变,可以有效调控SiS_(2)/ZnO异质结的带隙值.以上结果表明SiS_(2)/ZnO异质结有潜力成为新型光催化剂用于全解水.

关键词： SiS_(2)/ZnO Z-型范德华异质结光催化电子结构第一性原理

Distributed collaborative complete coverage path planning based on hybrid strategy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第2期35卷 463-472页

作者： ZHANg jia DU xin DONg Qichen xin Bin School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing Institute of TechnologyBeijing 100081China

Collaborative coverage path planning(CCPP) refers to obtaining the shortest paths passing over all places except obstacles in a certain area or space. A multi-unmanned aerial vehicle(UAV) collaborative CCPP algorithm is proposed for the urban rescue search or military search in outdoor *** to flexible control of small UAVs, it can be considered that all UAVs fly at the same altitude, that is, they perform search tasks on a two-dimensional plane. Based on the agents’ motion characteristics and environmental information, a mathematical model of CCPP problem is established. The minimum time for UAVs to complete the CCPP is the objective function, and complete coverage constraint, no-fly constraint, collision avoidance constraint, and communication constraint are considered. Four motion strategies and two communication strategies are designed. Then a distributed CCPP algorithm is designed based on hybrid strategies. Simulation results compared with patternbased genetic algorithm(PBgA) and random search method show that the proposed method has stronger real-time performance and better scalability and can complete the complete CCPP task more efficiently and stably.

关键词： multi-agent cooperation unmanned aerial vehicles(UAV) distributed algorithm complete coverage path planning(CCPP)

Fractures interaction and propagation mechanism of multi-cluster fracturing on laminated shale oil reservoir

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2600-2613页

作者： jia-xin Lv Bing Hou Department of Petroleum Engineering China University of Petroleum(Beijing)at KaramayKaramay834000XinjiangChina Key Laboratory of Petroleum Engineering Ministry of EducationChina University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

The continental shale reservoirs of Jurassic Lianggaoshan Formation in Sichuan Basin contain thin lamina,which is characterized by strong plasticity and developed longitudinal shell limestone *** improve the production efficiency of reservoirs by multi-cluster fracturing,it is necessary to consider the unbalanced propagation of hydraulic fractures and the penetration effect of *** paper constructed a numerical model of multi-fracture propagation and penetration based on the finite element coupling cohesive zone method;considering the construction cluster spacing,pump rate,lamina strength and other parameters studied the influencing factors of multi-cluster fracture interaction propagation;combined with AE energy data and fracture mode reconstruction method,quantitatively characterized the comprehensive impact of the strength of thin interlayer rock interfaces on the initiation and propagation of fractures that penetrate layers,and accurately predicted the propagation pattern of hydraulic fractures through laminated shale oil *** results revealed that in the process of multi-cluster fracturing,the proportion of shear damage is low,and mainly occurs in bedding fractures activated by outer *** the cluster spacing enhances the fracture system's penetration ability,though it lowers the activation efficiency of *** high plasticity of the limestone interlayer may impact the vertical propagation distance of the main *** the interface strength is beneficial to the reconstruction of the fracture height,but the interface communication effect is *** selection of layers with moderate lamina strength for fracturing stimulation,increasing the pump rate during fracturing and setting the cluster spacing reasonably are beneficial to improve the effect of reservoir stimulation.

关键词： Laminated shale Multi-cluster fracturing Cross-layer Cohesive zone model Acoustic emission technique

A general two-phase mixture model for sediment-laden flow in open channel

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2022年第2期34卷 286-298页

作者： jia-xing Li xin Chen Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing100083China

This work extends the sediment-laden mixture model with consideration of the turbulence damping and particle wake effects under the framework of improved efficiency and *** mixture model consists of the continuity and momentum equations for the sediment-laden mixture,and the continuity equation for the sediment.A theoretical formula is derived for the relative velocity between the water and sediment phases,with consideration of the effects of the pressure gradient,the shear stress and the lift force.A modified expression of the particle wake effect,inducing the local turbulence enhancement around the sediment particle,is employed to improve the turbulent diffusion of the coarse *** k_(m)-ε_(m) model is proposed to close the mixture turbulence,with the turbulence damping effect due to the high sediment concentration expressed by the density-stratification term without an empirical *** k_(m)-ε_(m) turbulence model requires smaller computational work and offers better results than an empirical density-stratification turbulence model in high sediment concentration ***,with the proposed mixture model,the sediment transport in the open channel under a wide range of sediment sizes and concentrations can be revealed with the results in good agreement with experimental data for the velocity,the sediment concentration and the turbulent kinetic energy.

关键词： Sediment-laden flow two-phase mixture model particle wake effect turbulence damping effect density stratification