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Study on Yan-xin wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

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TMR Integrative Medicine 2023年第17期7卷 1-9页

作者： Yan-Yan Chen Yan-xin wang Man Wen Zheng Yu Jing-Jing Wu First Clinical Medical College Anhui University of Chinese MedicineHefei 230031China Department of Neurology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China

Background:Professor Yan-xin wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years,and has achieved excellent clinical *** order to better inherit Yan-xin wang’s academic *** purpose of this study is to use clinical data to explore the clinical experience of ***-xin wang in the application of Chinese medicine to treat insomnia patients from the liver,explore the compatibility and medication rules of traditional Chinese medicine,and give more clinical treatment ideas for ***:The general data and prescription information of insomnia patients treated with Chinese herbal medicine by ***-xin wang from January 1,2021,to December 31,2021,were summarized according to the inclusion and exclusion criteria,and the data were subjected to frequency statistics and drug association rules,complex network diagram analysis and cluster ***:A total of 159 patients and prescriptions were included in the study,of which 81.1%were women and 18.9%were men,containing 128 herbs;the highest frequency of use was 91.8%for Bupleuri *** Chinese herbs were used more than 70%of the time,namely Bupleuri Radix,Scutellariae Radix,oyster shell,Glycyrrhizae Radix,Os Draconis,and Ziziphi Spinosae *** top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi,five flavours,and their *** four Qi were mainly calm and warm,the five flavours were mainly bitter and acrid,followed by sweet,and the attributions were mainly to the liver,spleen,and heart *** Chinese medicine association rules set the confidence level>80%and the support level>10%,resulting in 10 two-herb and three-herb associations with the highest confidence level,such as Os Draconis is associated with oyster shell,Platycodonis Radix is associated with Achyranthis Bidentatae Radix,Scutellariae Radix is associated with Bupleuri Radix,Os Draconis,Bupleuri Radix is associated

关键词： data mining insomnia liver-based treatment medication patterns

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui wang Hanyue Zhang Xiou wang Sijia Zhou Bo Ma Yan Luan xin wang xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie Chen Jin-Zhong Yu Fei-Peng Xu Fei-Fei xing De-xin wang Ming-Yan Yang Feng xing Jian wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

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基于智能优化深度网络的档案数据分析方法

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电子设计工程 2025年第1期33卷 41-45页

作者：王馨王琳唐山市妇幼保健院病案室河北唐山063000

为提高档案管理的效率和准确性,提出了一种基于智能优化深度网络的档案数据分析方法。该方法结合了Transformer网络的特征提取能力和灰狼优化算法(Grey Wolf Optimizer,GWO)的参数优化能力,显著提高了档案管理的效率和准确性。将提出的... 详细信息

为提高档案管理的效率和准确性,提出了一种基于智能优化深度网络的档案数据分析方法。该方法结合了Transformer网络的特征提取能力和灰狼优化算法(Grey Wolf Optimizer,GWO)的参数优化能力,显著提高了档案管理的效率和准确性。将提出的方法运用到档案数据的多分类任务中,实验结果表明,通过GWO算法优化后的Transformer-GWO模型在与xgboost分类模型结合时取得了最佳性能,其宏观精确度、宏观召回率和宏观F1分数分别达到0.893、0.878以及0.885,提出的方法有效提升了档案管理的智能化水平。

关键词：档案数据 Transformer 灰狼优化算法分类

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Higher Genus FJRW Theory for Fermat Cubic Singularity

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Acta Mathematica Sinica,English Series 2021年第8期37卷 1179-1204页

作者： xin wang School of Mathematics Shandong UniversityJinan 250100P.R.China

In this paper,we study the higher genus FJRW theory of Fermat cubic singularity with maximal group of diagonal symmetries using Giventai *** results,we prove the finite generation property and holomorphic anomaly equation for the associated FJRW *** general LG-LG mirror theorem,our results also hold for the Saito-Givental theory of the Fermat cubic singularity.

关键词： FJRW theory Saito-Givental theroy mirror symmetry finite generation holomorphic anomaly equation

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A genus-4 topological recursion relation for Gromov-Witten invariants

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Science China Mathematics 2020年第1期63卷 101-112页

作者： xin wang Department of Mathematics Shandong University

In this paper,we give a new genus-4 topological recursion relation for Gromov-Witten invariants of compact symplectic manifolds via Pixton’s relations on the moduli space of *** an application,we prove that Pixton’s... 详细信息

关键词： topological recursion relation moduli space of curves Gromov-Witten invariants

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顾客契合研究综述

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江苏商论 2025年第1期 15-21页

作者：王欣玥郑州大学管理学院河南郑州450001

结合国内外研究现状,本文从顾客契合的定义、测量、研究模型等方面对国内外现有研究进行综述。针对顾客契合这一研究热点,运用内容分析法对概念进行探讨。从国内外文献中筛选出有影响力的20个顾客契合进行分析,经过选择样本、构建类目... 详细信息

结合国内外研究现状,本文从顾客契合的定义、测量、研究模型等方面对国内外现有研究进行综述。针对顾客契合这一研究热点,运用内容分析法对概念进行探讨。从国内外文献中筛选出有影响力的20个顾客契合进行分析,经过选择样本、构建类目系统、信度检验、结果分析等过程,凝练总结顾客契合的概念。

关键词：顾客契合内容分析法概念界定

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Quasi-modularity and Holomorphic Anomaly Equation for the Twisted Gromov–Witten Theory: O(3) over P^2

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Acta Mathematica Sinica,English Series 2019年第12期35卷 1945-1962页

作者： xin wang Department of Mathematics Shandong University

In this paper,we prove quasi-modularity property for the twisted Gromov–Witten theory of O(3)over P^***,we derive its holomorphic anomaly equation.

关键词： Quasi-modularity holomorphic anomaly equation twisted Gromov-Witten theory

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Integrated energy view of wastewater treatment:A potential of electrochemical biodegradation

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Frontiers of Environmental Science & Engineering 2022年第4期16卷 153-156页

作者： Yuqing Yan xin wang MOE Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control/College of Environmental Science and Engineering Nankai UniversityTianjin 300350China

It has been more than one century since the activated sludge process was *** its proven stability and reliability,the energy(especially the electrical energy)use in wastewater treatment should evolve to meet the increasingly urgent demand of energy *** paper discusses how the energy utilized in conventional biological wastewater treatment can be altered by switching the indirect energy input to a direct electricity injection,which is achieved by the elecfrode integration providing extra thermodynamic driving force to *** using electrodes instead of oxygen as terminal electron acceptors,the electrical energy can be utilized more efficiently,and the key of direct use of electrical energy in biodegradation is the development of highly active electroactive biofilm and the increase of electron transfer between microbes and the ***,the synergy of different microbial electrochemical units has additional benefit in energy and resource recovery,making wastewater treatment more sustainable.

关键词： Biological wastewater treatment Integrated energy view Electroactive bacteria Extracellular electron transfer

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On the validity of microscopic calculations of double-quantum-dot spin qubits based on Fock-Darwin states

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 36-43页

作者： GuoXuan Chan xin wang Department of Physics City University of Hong KongHong Kong SARChina City University of Hong Kong Shenzhen Research Institute Shenzhen 51805Z China

We consider two typical approximations that are used in the microscopic calculations of double-quantum dot spin qubits, namely,the Heitler-London(HL) and the Hund-Mulliken(HM) approximations, which use linear combinations of Fock-Darwin states to approximate the two-electron states under the double-well confinement potential. We compared these results to a case in which the solution to a one-dimensional Schr ¨odinger equation was exactly known and found that typical microscopic calculations based on Fock-Darwin states substantially underestimate the value of the exchange interaction, which is the key parameter that controls the quantum dot spin qubits. This underestimation originates from the lack of tunneling of Fock-Darwin states, which is accurate only in the case with a single potential well. Our results suggest that the accuracies of the current two-dimensional molecularorbit-theoretical calculations based on Fock-Darwin states should be revisited since underestimation could only deteriorate in dimensions that are higher than one.

关键词： spin qubits double quantum dots exchange interaction

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