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Clinical outcomes after autologous haematopoietic stem cell transplantation in patients with progressive multiple sclerosis

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Chinese Medical Journal 2006年第22期119卷 1851-1855页

作者： XU Juan ji Bing-xin SU Li DONG Hui-qing SUN Xue-jing LIU Cong-yan Department of Haematology Xuanwu Hospital Capital University of Medical Sciences Beijing 100053 China Department of Neurology Xuanwu Hospital Capital University of Medical Sciences Beijing 100053 China

Background Multiple sclerosis （MS） is a continuously disabling disease and it is unresponsive to high dose steroid and immunomodulation with disease progression. The autologous haematopoietic stem cell transplantation （ASCT） has been introduced in the treatment of refractory forms of multiple sclerosis. In this study, the clinical outcomes followed by ASCT were evaluated for patients with progressive MS. Methods Twenty-two patients with secondary progressive MS were treated with ASCT. Peripheral blood stem cells were obtained by leukapheresis after mobilization with granulocyte colony stimulating factor. Etoposide, melphalan, carmustin and cytosine arabinoside were administered as conditioning regimen. Outcomes were evaluated by the expanded disability status scale and progression free survival. No maintenance treatment was administered during a median follow-up of 39 months （range, 6 to 59 months）. Results No death occurred following the treatment. The overall confirmed progression free survival rate was 77% up to 59 months after transplantation which was significantly higher compared with pre-transplantation （P=0.000）. Thirteen patients （59%） had remarkable improvement in neurological manifestations, four （18%） stabilized their disability status and five （23%） showed clinical recurrence of active symptoms. Conclusions ASCT as a therapy is safe and available. It can improve or stabilize neurological manifestations in most patients with progressive MS following failure of conventional therapy.

关键词： multiple sclerosis, chronic progressive autologous haematopoietic stem cell transplantation outcome assessment (health care)

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A New Wall Conditioning Technique Developed on the HT-7 Superconducting Tokamak with a Permanent Magnetic Field

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Chinese Physics Letters 1997年第12期14卷 916-919页

作者： ZHAO Yan-ping LI jian-gang XIE ji-kang MENG Yue-dong WU xin-chao HE Ye-xi XUE Di-ye DENG Xu SHAO Yu-gui Institute of Plasma Physics Chinese Academy of SciencesHefei 230031

A new technique for wall conditioning with a permanent magnetic field has been tested and developed on the HT-7 superconducting tokamak by ion cyclotron range frequency wave *** operation ranges for conditioning and recycling was investigated with different working gas(D_(2),He),toroidal field(0.1-2.5 T)and rf *** experimental results show that its cleaning efficiency is about three times higher than that of glow discharge *** new technique has been used daily during experiments.

关键词： tokamak injection permanent

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Extracorporeal membrane oxygenation for pulmonary hemorrhage in microscopic polyangiitis

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Chinese Medical Journal 2008年第24期121卷 2622-2623页

作者： ZHONG Hua CHEN ji-hua LI Sai-qi jiANG Li-yan LI xin HAN Bao-hui Department of Pulmonology Shanghai Chest Hospital Shanghai 200127 China

Microscopic polyangiitis （MPA） is characterized by an inflammatory process of the vessel walls and is classified according to the smallest vessels involved. Diagnosis is based on clinical manifestations, anti-neutrophil cytoplasmic autoantibody （ANCA） testing, and histology. In this disease, pulmonary hemorrhage is seen in 30% of patients and is associated with an eight-fold increase in mortality. Classically, MPA involves the kidneys and upper and lower respiratory tracts. Due to the perceived risk of increased bleeding secondary to the use of systemic anticoagulation, extra corporeal membrane oxygenation （ECMO） is often not used to treat patients with hemorrhage suffered from MPA. Here we report a case of a 50-year-old woman with MPA that was successfully supported with ECMO.

关键词： microscopic polyangiitis pulmonary hemorrhage

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Treatment of traumatic brain injury in rats with transplantation of human amniotic cells

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Chinese Medical Journal 2006年第21期119卷 1843-1845页

作者： LU Yi HUI Guo-zhen WU Zhi-yuan GUO Li-he ji Xun-he WU xin Department of Neurosurgery First Affiliated Hospital of Soochow University Suzhou 215006 China Institute of Biochemistry and Cell Biology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Traumatic brain injury （TBI）, which is an important reason of human mortality and morbidity in industrialized countries, still cannot be treated effectively. Since the self-repair capacity of brain is limited, cellular transplantation in TBI may be a therapeutic *** amniotic cells （HACs） from fertilized ovum are able to differentiate into all the tissues of the body. They can not only express the markers of neuronal and glial cells^1 but also synthesize and release the neurotrophic factors.^2 Moreover, transplanted HACs rarely induce immunologic rejection.^3,4 In this study, we investigated whether HAC cultures conditioned by traumatic brain tissue extracts can acquire the phenotype of neuron, and examined the effects of transplanted HACs on the affected hindlimb of rats with TBI.

关键词： brain injuries amnion transplantation rats

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Prediction of high-mobility two-dimensional electron gas at KTaO_3-based heterointerfaces

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Chinese Physics B 2019年第4期28卷 310-316页

作者： Fu-Ning Wang ji-Chao Li Yi Li xin-Miao Zhang Xue-jin Wang Yu-Fei Chen jian Liu Chun-Lei Wang Ming-Lei Zhao Liang-Mo Mei School of Physics Shandong University

First-principles calculations are performed to explore the possibility of generating the two-dimensional electron gas(2 DEG) at the interface between LaGaO_3/KTaO_3 and NdGaO_3/KTaO_3(001) heterostructures. Two different models —i.e., the superlattice model and the thin film model — are used to conduct a comprehensive investigation of the origin of charge carriers. For the symmetric superlattice model, the LaGaO_3(or NdGaO_3) film is nonpolar. The 2 DEG with carrier density on the order of 1014 cm^(-2) originates from the Ta dxy electrons contributed by both LaGaO_3(or NdGaO_3) and KTaO_3. For the thin film model, large polar distortions occur in the LaGaO_3 and NdGaO_3 layer, which entirely screens the built-in electric field and prevents electrons from transferring to the interface. Electrons of KTaO_3 are accumulated at the interface, contributing to the formation of the 2 DEG. All the heterostructures exhibit conducting properties regardless of the film thickness. Compared with the Ti dxy electrons in SrTiO_3-based heterostructures, the Ta dxy electrons have small effective mass and they are expected to move with higher mobility along the interface. These findings reveal the promising applications of 2 DEG in novel nanoelectronic devices.

关键词： 2DEG first-principles calculation interface

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A long follow-up of a patient with bilateral retinoblastoma who underwent globe-preserving therapy and had metastasis after 72mo

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1624-1626页

作者： Yi Zhang Dong-Sheng Huang Wei-Ling Zhang Yi-Zhuo Wang Yan Zhou Pin-Wei Zhang Tao Han jian-Min Ma ji-Tong Shi xin Ge Department of Pediatrics Beijing Tongren HospitalCapital Medical University Department of Ophthalmology Beijing Tongren HospitalCapital Medical University

I am Dr. Yi Zhang, from the Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University,Beijing, China. I would like to describe the metastasis in the left parotid and cervical lymph nodes of a patient with bilateral retinoblastoma 72mo after the initial successful globe-preserving therapies, which included chemotherapy, laser photocoagulation, and cryotherapy.

关键词： A long follow-up of a patient with bilateral retinoblastoma who underwent globe-preserving therapy and had metastasis after 72mo Figure cycle VP

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基于路径积分分子动力学与热力学积分方法的高压氢自由能计算

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物理学报 2015年第18期64卷 14-20页

作者：陈基冯页新李新征王恩哥北京大学量子中心北京100871 北京大学物理学院北京100871

在相图研究中,严格计算一个真实系统在特定温度、压强下的自由能是近年来该领域理论方法发展的前沿.自Mermin提出有限温度密度泛函理论后,在电子结构层面,弱关联系统中人们就其在对自由能贡献的描述己相对完善,但在原子核运动的描述上,... 详细信息

在相图研究中,严格计算一个真实系统在特定温度、压强下的自由能是近年来该领域理论方法发展的前沿.自Mermin提出有限温度密度泛函理论后,在电子结构层面,弱关联系统中人们就其在对自由能贡献的描述己相对完善,但在原子核运动的描述上,热运动与量子运动的非简谐项却总被忽视.本文将路径积分分子动力学与热力学积分结合,对300 GPa下氢晶体Cmca结构中原子核热涨落与量子涨落对自由能的影响进行了分析.发现在100 K核量子涨落非简谐项的贡献约为15 meV每原子,远大于不同结构间静态焓的差别.该研究提醒人们简谐近似在核量子效应描述中可能存在的不准确性(即使在低温下).同时,我们采取的方法也为人们进行自由能的准确计算提供了一个简单有效的手段.

关键词：路径积分分子动力学热力学积分高压氢

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Brief Discussion on the Satellite Navigation Information Application and Service Mode of China Title

Brief Discussion on the Satellite Navigation Information App...

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第四届中国卫星导航学术年会

作者： Cao ji Dong Shi xin Sun Wei jie Su Ran Ran Beijing Satellite Navigation Center

With the rapid development of the global satellite navigation system, navigation information in global industries has been a wide range of applications, the traditional autonomous navigation and communication means has been unable to fully meet the need of the social parties to the satellite navigation service. Based on the analysis and comparison of the existing satellite navigation system information application model, combining the reality need of the country industry and the characteristic of COMPASS’s short message communication function, the paper proposed the satellite navigation information application and service mode and development direction for China.

关键词： satellite navigation system Navigation Information Application Service Mode

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STUDY ON RESONANT FREQUENCY AND IMPEDANCE PROPERTIES OF FILM BULK ACOUSTIC RESONATOR

STUDY ON RESONANT FREQUENCY AND IMPEDANCE PROPERTIES OF FILM...

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2013全国压电和声波理论及器件技术研讨会

作者： Wen-Liang ZHANG De-jin HUANG xin-Yi LUO ji WANG School of Mechanical Engineering＆Mechanics Ningbo University

Based on the fundamental piezoelastic theory,the vibration equation of layered FBAR under sine excitation voltage was *** unknown constants were calculated with boundary and continuity *** expressions of electrical impedance were obtained from the electrical potential and *** series and parallel resonance frequency are then calculated when the electrical impedance tends to infinite and *** bandwidth and effective electromechanical coupling factor are calculated from the series and parallel resonance *** Bragg reflection layers will reduce the loss of mechanical energy.

关键词： FBAR SMR frequency impedance Bragg reflector

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Preparation and study of modified glass flake coating for the performance of anticorrosion

Preparation and study of modified glass flake coating for th...

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第九届全国表面工程大会暨第四届全国青年表面工程论坛

作者： xin Zhang ji-hai Xu jia-min Shao Xue-dong Wu Ningbo Institute of Materials Technology & Engineering Chinese Academy of Sciences

本文采用吸水率与失重实验进行对比;腐蚀浸泡实验与电化学测试方法进行对比,并采用扫描电镜对玻璃鳞片以及防腐材料聚苯硫醚在防腐涂料中的排布进行观察,研究了经添加表面改性的玻璃鳞片以及聚苯硫醚粉末后防腐涂料的防腐蚀行为,并对其... 详细信息

本文采用吸水率与失重实验进行对比;腐蚀浸泡实验与电化学测试方法进行对比,并采用扫描电镜对玻璃鳞片以及防腐材料聚苯硫醚在防腐涂料中的排布进行观察,研究了经添加表面改性的玻璃鳞片以及聚苯硫醚粉末后防腐涂料的防腐蚀行为,并对其防腐机理进行研究,结果表明:添加了经表面改性后的玻璃鳞片后的防腐涂层比未经改性前的防腐涂层,其防腐蚀性能大大提高,涂层的抗渗透性以及耐腐蚀性都有较大程度的改善,涂层在40%的硫酸中浸泡100天后涂层仍保持完好。另外扫描电镜观察结果表明,玻璃鳞片在防腐涂层中呈重叠交错排布,形成类迷宫式的结构,可有效减缓水分子以及腐蚀性液体的渗入速度,聚苯硫醚加入后,由于其粒径远小于玻璃鳞片的直径,因此可以有效分散在重叠的玻璃鳞片交错相接的间隙,利用其本身具有的良好的疏水性能,在间隙中形成毛细管疏水屏蔽效应,从而可以进一步有效阻止腐蚀性液体的侵蚀,可以在原来减缓渗入速度的基础上再进一步形成阻止屏蔽效应而大大提高涂层的耐腐蚀性能。

关键词：玻璃鳞片聚苯硫醚乙烯基树脂电化学阻抗耐腐蚀性耐渗透性

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